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Article ; Online: Magnetic Iron Oxide Nanoparticles Coated with Polyethylene and Gold as a Suitable Carrier for Doxorubicin and its Effect on Mcf-7 Breast Cancer Cells

Fateme Sadeghi Nodoushan / Fatemeh Hakimian / Bibi Fatemeh Haghiralsadat

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 31, Iss 10, Pp 7156-

2024 Volume 7168

Abstract: Introduction: Nanotechnology always seeks to provide new solutions for targeted delivery of chemotherapy drugs, in order to increase the quality of cancer treatment and reduce the side effects of chemotherapy. The aim of this study was to load the ... ...

Abstract	Introduction: Nanotechnology always seeks to provide new solutions for targeted delivery of chemotherapy drugs, in order to increase the quality of cancer treatment and reduce the side effects of chemotherapy. The aim of this study was to load the anticancer drug doxorubicin on Magnetic iron oxide nanoparticles were subjected to physico-chemical evaluation for their effect on MCF-7 cells. Methods: This research was a descriptive-analytical study. In this laboratory research, iron oxide nanoparticles were first synthesized by precipitation method. Then they were coated with polyethylene imine and gold. After loading the drug doxorubicin into the magnetic iron oxide nanoparticles, the physiochemical parameters of the nanosystem from the point of view of insertion efficiency, drug release profile under similar conditions of healthy and cancer cells, size, zeta potential and morphology were determined. Results: The magnetic nanocarriers had a diameter of 90 nm and a zeta potential of 66.7 mV. The maximum release of the drug from the nanosystem at 37°C, pH=7.4 and 42°C, pH=5.4 and after 48 hourswas 48% and 66%, respectively. The SEM analysis showed the spherical morphology and the absence of chemical interaction between the nanosystem and the drug. The investigation of the performance of the nanosystem indicated an increase in the toxicity of encapsulated doxorubicin compared to free doxorubicin at similar concentrations on the MCF_7 strain. Conclusion: The results of this research showed that the magnetic iron oxide nanoparticle system, while having appropriate physiochemical characteristics, does not change the chemical nature of the drug and can be a suitable and semi-targeted carrier for the anticancer drug doxorubicin.
Keywords	drug carriers ; iron oxide magnetic nanoparticles ; doxorubicin ; anticancer ; drug release ; Medicine (General) ; R5-920
Subject code	500
Language	Persian
Publishing date	2024-01-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fabrication, characterization and evaluation of anti-cancer and antibacterial properties of nanosystems containing Hedera Helix aqueous extracts

Milad Akhlaghi / Mohammad Taebpour / Mahboubeh Sharafaldini / Omid Javani / Bibi Fatemeh Haghiralsadat / Fatemeh Oroojalian / Shima Shadani / Davood Tofighi

Nanomedicine Journal, Vol 9, Iss 1, Pp 43-

2022 Volume 56

Abstract: In this study we synthesized and characterized nanoniosome containing Hedera Helix extract to evaluate its therapeutic properties on breast cancer cells in order to provide a new effective treatment strategy with low side effects for the treatment of ... ...

Abstract	In this study we synthesized and characterized nanoniosome containing Hedera Helix extract to evaluate its therapeutic properties on breast cancer cells in order to provide a new effective treatment strategy with low side effects for the treatment of this malignancy in the clinical stage. After extracting the Hedera helix by Soxhlet method, different formulations of noisomes containing the extract were synthesized and after investigating the load and release rate of the drug by spectrophotometry, the optimal formulation was selected. Then other physiochemical properties of nanosystems such as size and zeta potential by DLS method, system interaction and extract by FTIR method, system response to temperature and pH stimuli by spectrophotometry, nanoparticle morphology using SEM and AFM microscope, the stability of nanoparticles over 6 months and the antimicrobial properties of the system compared to the free form of extract were examined. Finally, the cellular uptake of nanosystem by flow cytometry microscope and its toxicity on MCF-7 and BT-474 breast cancer cell lines, MCF-10A breast normal cell line and HFF cell line were evaluated by MTT method. Results showed that the synthesized nanosystems with a size of 75.1 nm and PDI of 0.345 with a zeta potential of -20.6 ± 0.44 mV were morphologically suitable and had no interaction between niosomes and extracts. Also, the Encapsulation Efficiency in the system was 80.1 ± 2.2% and the drug release rate from the nanosystem was 57.2% in 72 hours. The stability of the system during 6 months and the response of the system to various stimuli was also appropriate. Also, encapsulation of the extract not only improved its antimicrobial properties compared to the extract, but also increased its anti-cancer effect on cancer cells although the nanosystem had no toxic effect on normal cells.
Keywords	nanosystems ; nanoniosome ; anti-cancer ; nanotechnology ; hedera helix ; Medicine (General) ; R5-920
Subject code	500
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and Evaluation of Lipid-based Nanoparticle Containing Ginger Extract against Aspergillus Species

Vahid Yakhchi / Shabnam Jahanizadeh / Fatemeh Yazdian / Hamid Rashedi / Bibi Fatemeh Haghiralsadat

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 28, Iss 6, Pp 2766-

2020 Volume 2780

Abstract: Introduction: Loading the active ingredients of medicinal plants in lipid nanoparticles reduces the reaction of the active substance with the surrounding environment, such as water and oxygen, and reduces the intensity of transmission or evaporation to ... ...

Abstract	Introduction: Loading the active ingredients of medicinal plants in lipid nanoparticles reduces the reaction of the active substance with the surrounding environment, such as water and oxygen, and reduces the intensity of transmission or evaporation to the external environment. In this study, intended to enhance efficacy of ginger extract, encapsulation in nanoliponiosome synthesized by thin-film hydration method were done and their antifungal effect on the growth of Aspergillus flavus and Aspergillus parasiticus were studied. Methods: In this experimental laboratory study, derivation was done using Soxhlet extractor method. Antifungal activity of ginger extract was specific by disc diffusion and microplate dilution methods. The inhibitory effect of extract was investigated. Physiochemical characteristics and structural characterization of nanoparticle were evaluated from the perspective of in vitro efficiency, drug release, nanoparticle size, zeta potential, surface morphology and FTIR (Fourier-transform infrared spectroscopy), DLS (Dynamic light scattering) and finally SEM (Scanning electron microscope) spectra. Results: FTIR investigations showed ginger extract and nanoliponiosome had no chemical interaction leading to change the functional groups. SEM microscope showed the spherical mprphology of particles and average particles size of 73nm. Ginger extract was loaded into the nanoliponiosome with a yield of 71%. It was also found out that ginger extract had a stronger antifungal effect against Aspergillus flavus fungus compared to the Aspergillus parasiticus fungus. At both 37°C and 42°C, the release of ginger extract was higher at pH of 4.5 compared to neutral pH (7.4). Conclusion: Nanoliponiosomes containing ginger extract with good physicochemical properties, increased drug stability and good release control can be promising antifungal agents with high antifungal effects and low side effects.
Keywords	ginger extract ; nano liponiosome ; aspergillus flavus ; aspergillus parasiticus ; antifungal ; Medicine (General) ; R5-920
Subject code	540
Language	Persian
Publishing date	2020-08-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Designing and optimization of liposomal nano-carriers containing Nepeta persica extract and study of its cytotoxicity on the breast cancer cell line (MCF-7)

Farzaneh Barakat / Fatemeh Aboee-Mehrizi / Bibi Fatemeh Haghiralsadat / Mahmood Dehghani Ashkezari

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 27, Iss 2, Pp 1202-

2019 Volume 1215

Abstract: Introduction: Studies have shown that plant compounds have significant anticancer effects that if the challenges of using them are resolved, Can be the successor to the synthetic compounds commonly used in cancer therapy. Therefore, in this study, the ... ...

Abstract	Introduction: Studies have shown that plant compounds have significant anticancer effects that if the challenges of using them are resolved, Can be the successor to the synthetic compounds commonly used in cancer therapy. Therefore, in this study, the liposomal nano- carriers containing Nepeta persica extract have been investigated in order to improve the physicochemical characteristics and evaluation of its antitumor properties. Methods: The present study is a kind experimental study. Liposomal vesicles were prepared using SPC, cholesterol and PEG by thin-film method and the Nepeta persica extract was loaded into the liposomes. Their physicochemical characteristics were evaluated using Zeta Sizer, FTIR, SEM, and the release pattern of the extract was calculated at 37 oC and 42 oC. At the end, the toxicity of this nano-carriers containing the extract on the MCF-7 cell line of breast cancer has been studied. Results: The results of the study showed that the nano-carriers containing the extract had an encapsulation efficiency of 67/11±5/74%, size of 116/9 nm, and -13.24 ± 1.01mV zeta potential, spherical morphology and controlled release. Also, the results of the toxicity of this nano-carrier containing the extract indicate that the liposomal extract has a higher toxicity to the MCF-7 cell line than the free extract. Conclusion: The results of this study show that nano-liposomes containing Nepeta persica extract, mean while having appropriate physiochemical properties, reduce the survival of breast cancer cells compared to non-liposomal extracts, and thus can be a good carriers for delivery of Nepeta persica extract to breast cancer cell.
Keywords	Nepeta persica ; Lipospme ; Breast Neoplasm ; MCF-7 Cells ; Medicine (General) ; R5-920
Subject code	616
Language	Persian
Publishing date	2019-06-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A new study on synthesize and optimization of PEGylated LipoNiosomal nanocarriers containing curcumin for use in cancer chemotherapy

Elham Sasani / Hashem Shahi Malmir / Fatemeh Daneshmand / Mohammad Majdizadeh / Bibi Fatemeh Haghiralsadat

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 26, Iss 6, Pp 528-

2018 Volume 541

Abstract: Introdution: Chemotherapy is one of most effective methods to fight metastatic tumors. Its non- targeting has many side effects. The aim of this study was to investigate various formulations of Lipo-Niosomal hybrid system to achieve an optimized and ... ...

Abstract	Introdution: Chemotherapy is one of most effective methods to fight metastatic tumors. Its non- targeting has many side effects. The aim of this study was to investigate various formulations of Lipo-Niosomal hybrid system to achieve an optimized and targeted formulation to provide proper function as a complementary drug in cancer chemotherapy. Methods: The present study was an experimental study. Five Lipo-Niosome systems with different formulations containing DPPC, Cholesterol, and Span60 were synthesized using thin-film method. Three formulations were chosen based on the entrapped efficiency of curcumin and their release profile was investigated in order to choose the final formula. In the following, the final formula was optimized by DSPE-mPEG(2000) and after calculating, the curcumin release profile in simulated environment of healthy and cancerous cells; physiochemical characteristics of the final formula determined by ZetaSizer, FTIR and SEM instruments. Results: Final formulation of curcumin PEGylated lipo-niosome had 147.5 nm size, 98.12%±1.85 entrapment, -8.90 mV zeta potential, and 0.176 of PDI. The maximum release of the drug for this nanosystem in an environment similar to healthy cells was 19.02% and 24.88% in cancerous cells. FTIR and SEM investigations show drug and nanocarrier had no chemical interaction leading to change the functional groups and its particles have a spherical morphology. Conclusion: The findings of this study along with confirming the system to be semi-targeting, shows that carrier released entrapped drug with continuous and controlled rate without any change in chemical nature of the drug. It appears the nanoscale size and the low anionic charge of the system is an indication of its high cellular uptake.
Keywords	Drug Carriers ; Niosome ; Curcumin ; Nanoparticles ; Drug Liberation ; Medicine (General) ; R5-920
Language	Persian
Publishing date	2018-10-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Formulation of a therapeutic cationic liposome-siRNA complex for development to fight osteosarcoma

Bibi Fatemeh Haghiralsadat / Ghasem Amoabediny / Samira Naderinezhad / Farzane Morteza-Ratki / Behrouz Zandieh Doulabi

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 26, Iss 12, Pp 1027-

2018 Volume 1037

Abstract: Introdution: Cationic liposomes have been presented for gene delivery as an alternative vector instead of viral vectors. A major challenge associated with siRNA delivery is the instability of liposomes, which is still a serious problem. The aim of this ... ...

Abstract	Introdution: Cationic liposomes have been presented for gene delivery as an alternative vector instead of viral vectors. A major challenge associated with siRNA delivery is the instability of liposomes, which is still a serious problem. The aim of this study was to provide an appropriate formulation to overcome this instability. Methods: In the present study (Scientific-Fundamental, Experimental-Laboratory Study), liposomal formulation containing soy phosphatidylcholine, cationic DOTAP, cholesterol and polyethylene glycole was synthesized by thin-film hydration method and the siRNA were loaded on liposomes through incubation. In the following; the optimization of siRNA loading was on the agenda. Then the parameters related to size, zeta potential, polydispersity index and lon-term stability of siRNA-liposomes complex were reported. The Data were analyzed by GraphPad Prism version 7 Software. All data were repeated three times and reported as mean±standard deviation. Results: In this study we were able to produce siRNA lipoplex with high loading efficiency of siRNA. The produced nanoparticles did not agglomerate and were stable at 4 oC for 3 months. This nanosystem could successfully deliver siRNA to normal bone cells. Studies have shown that the blank system (no gene) had no toxicity. Conclusion: The prepared PEGylated liposomes have a great potential for delivery of siRNA to bone cells
Keywords	SiRNA lipoplex ; Physico-chemical characterization ; Intracellular uptake ; Cellular viability ; Medicine (General) ; R5-920
Subject code	500
Language	Persian
Publishing date	2018-04-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation and Study of Nano-Niosomes Containing Doxorubicin and Evaluation of its Toxicity on Acute Myeloblastic Leukemia Cell Line KG-1

Fatemeh Bahrami-Banan / Mohammad Hasan Sheikhha / Nasrin Ghasemi / Mohammad Majdizadeh / Bibi Fatemeh Haghiralsadat

پیاورد سلامت, Vol 12, Iss 4, Pp 309-

2018 Volume 323

Abstract: Backgrounds and Aim: One of the effective strategies for targeting chemotherapy in the treatment of cancer is the use of lipid nano-carriers. In this study, an optimal formulation of niosomal drug containing doxorubicin has been developed to better fight ...

Abstract	Backgrounds and Aim: One of the effective strategies for targeting chemotherapy in the treatment of cancer is the use of lipid nano-carriers. In this study, an optimal formulation of niosomal drug containing doxorubicin has been developed to better fight cancer cells. Material and Methods: Niosomal vesicles were prepared using phosphatidylcholine (22%), span60 (52/5%), cholesterol (22/5%) and DSPE-PEG2000 (5%) by thin-film method. Doxorubicin were loaded into the niosomes using inactive loading method. Their physico-chemical features were assayed using Zeta-Sizer, FTIR and SEM, and drug release amount was calculated at 37° C and 44° C. At the end, the toxicity of the nano drug carrier system was measured on the KG-1 cell line of the bone marrow cancer by MTT method. Results: Niosomal vesicles containing Doxorubicin showed the size of 160.37±65.2 nm, 94.18% drug encapsulation efficiency -58.11± 1.24 mV of zeta potential and polydispersity index (PDI) of 0.234±0.02 The prepared niosomal system presented drug controlled release and FTIR investigation showed almost no interaction between nano-carrier containing drug and the drug itself. As well, morphological examination of nano-carriers using SEM microscopy revealed that they have spherical structures. Also, cellular studies showed that drug toxicity was higher in encapsulated conditions compared to non-encapsulated conditions. Conclusion:The results of this study, meanwhile confirming the proper physicochemical characteristics of the system and being Slow-release system indicate that this nano-carrier anionic increases the toxicity of the drug for the KG-1 cell line of the bone marrow, thus, this niosomal nano-carrier can be a suitable carrier for drug delivery to cancer cells.
Keywords	niosome ; neoplasm ; doxorubicin ; bone marrow ; kg-1 cell line ; Public aspects of medicine ; RA1-1270
Subject code	540
Language	Persian
Publishing date	2018-11-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and optimization of niosomal carriers containing doxorubicin in order to achieve a final formulation with high potential in cancer cells temperature and acidity

Hashem Shahi Malmir / Seyed Mehdi Kalantar / Elham Sasani / Morteza Asgari / Mohammad Majdizadeh / Bibi Fatemeh Haghiralsadat

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 26, Iss 10, Pp 879-

2019 Volume 894

Abstract: Introdution: Doxorubicin is one of the most commonly used drugs in chemotherapy with many side effects; this fact has limited its use. In the present study, based on the knowledge of pharmaceutical nanocarriers, various formulations of the niosomal form ... ...

Abstract	Introdution: Doxorubicin is one of the most commonly used drugs in chemotherapy with many side effects; this fact has limited its use. In the present study, based on the knowledge of pharmaceutical nanocarriers, various formulations of the niosomal form of this drug were synthesized and surface optimizations were applied to the final selected formulation. Methods: The present study was an experimental study. Various formulations of niosomal systems were synthesized by the method of thin-film hydration and using Tween60 and cholesterol. Doxorubicin was encapsulated through niosome inactively. In the following, optimizations were made based on choosing two formulas out of six experimentally, then the effects of adding Tween20, DSPE-mPEG(2000) polymer and cationic phospholipid of DOTAP (respectively) was investigated. Then, physiochemical properties of nanocarriers were determined from the perspective of encapsulation efficiency, drug release profile under healthy and cancerous cells condition, hydrodynamic diameter, Poly Dispersity Index, zeta potential, morphology and Infrared spectroscopy(IR) spectrum. To plot the graphs and express the data Origin and Excel software were used, respectively. Results: The optimized final niosome formula had 98.59 nm in diameter, 91.8±0.43, -3.5mV zeta potential and 0.196 PDI. The maximum release of drug from the nanocarrier under conditions of healthy and cancerous cells (37°C, pH=7.4 and 42°C, pH=5.4) after 48 hours was 62.3% and 76.5% respectively. Field Emission Scanning Electron Microscope and IR assessments revealed spherical morphology and the absence of chemical interaction between nanocarrier and drug. Conclusion: The findings of this study prove this drug carrier to be semi-targeting. It also shows that niosome by specializing the drug delivery increases the effectiveness of drug and the life quality of patient while reducing the side effects, all without any change in the chemical nature of the drug.
Keywords	Drug Carriers ; Niosome ; Doxorubicin ; Anticancer ; Drug Liberation ; Medicine (General) ; R5-920
Subject code	660
Language	Persian
Publishing date	2019-01-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study of anti-cancer effects of Curcumin; formulation of Curcumin-loaded nano carrier and its toxicity effect on MCF-7 Cell line.

masoud zare shehneh / seyed mehdi kalantar / Mohammad Hasan Sheikhha / amir asri kojabad / bibi fatemeh Haghiralsadat

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 27, Iss 1, Pp 1175-

2019 Volume 1186

Abstract: Introdution: Nanotechnology introduced new methods to chemotherapy drugs delivery into cancer cells to reduce the side effect of drugs it increases the quality of cancer treatment and reduces the side effects of chemotherapy. . In this study, different ... ...

Abstract	Introdution: Nanotechnology introduced new methods to chemotherapy drugs delivery into cancer cells to reduce the side effect of drugs it increases the quality of cancer treatment and reduces the side effects of chemotherapy. . In this study, different lipid formulations of nucliposomes containing curcumin was prepared by thin-layer method and evaluated for chemical-physical evaluation on MCF-7 cell line. Methods: This study was a descriptive-analytic. Various formulations of liposomes prepared from Span 60, SPC and cholesterol. Curcumin was loaded in the liposomes. Final liposome formulation selected and PEGylated. The Optimal formulation characterized by DLS, FT-IRT, Fe-SEM and SEM. Statistical analysis was performed with Prism6 software. Results: The average size of liposomes, encapsulation efficacy of liposomal loaded curcumin and Zeta potential was about 63.9 nm, -41mV and .58, respectively. Liposomes exhibited the slowest release rate in normal and turmeric cell culture condition. To compare the function of free curcumin in similar concentrations, liposomal curcumin formulation was toxic to MCF7 Cell line. Conclusion: The present study shows that an optimally optimized nanoliposome with curcumin having appropriate physicochemical properties, improving drug toxicity in cancerous cell lines and increasing drug stability can be a good vector for drug delivery to breast cancer cells. Conclusion: The present study shows that an optimally optimized nanoliposome with curcumin having appropriate physicochemical properties, improving drug toxicity in cancerous cell lines and increasing drug stability can be a good vector for drug delivery to breast cancer cells.
Keywords	Liposome ; Curcumin ; Breast_cancer ; MCF7 ; Medicine (General) ; R5-920
Subject code	610
Language	Persian
Publishing date	2019-05-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A new strategy in improving therapeutic indexes of medicinal herbs

Mohammad Majdizadeh / Saeed Rezaei Zarchi / Afsaneh Alsadat Movahedpour / Hashem Shahi Malmir / Elham Sasani / Bibi Fatemeh Haghiralsadat

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 25, Iss 11, Pp 853-

preparation and characterization of nano-liposomes containing Mentha piperita essential oil

2018 Volume 864

Abstract: Introduction: Herbal Compound and their essential oils possess high antimicrobial, antioxidant, and anti-tumor properties, but conventional prescribing of them faces serious challenges. Liposomal nano-carrier is one of the common pharmaceutical ... ...

Abstract	Introduction: Herbal Compound and their essential oils possess high antimicrobial, antioxidant, and anti-tumor properties, but conventional prescribing of them faces serious challenges. Liposomal nano-carrier is one of the common pharmaceutical strategies to overcome these challenges. In this study, slow-released liposomal system containing Mentha piperita’s essential oil was prepared in order to improve its antimicrobial, antioxidant and antitumor properties. Methods: Liposomal vesicles were prepared using phosphatidylcholine (80%) and cholesterol (20%) by thin-film method. Mentha piperita’s essential oil were loaded into the liposomes using inactive loading method. Their physico-chemical features were assayed using Zeta-Sizer, FTIR and SEM, and at the end, the essential oil release amount was calculated at 37° C. Results: Liposomal vesicles containing Mentha piperita’s essential oil showed the size of 247 13.39 nm, 61.38% ± 2.7 essential oil encapsulation efficiency, -34.54 0.74 mV of zeta potential and polydispersity index (PDI) of 0.32 .01. The prepared liposomal system presented essential oil controlled release and FTIR and SEM investigation showed no interaction between nanocarrier and the essential oil and the carriers have spherical structures. Conclusion: In the present study, Mentha piperita’s essential oil encapsulated in liposomal carriers and its physicochemical properties investigated. The results confrimed the slow-releasing ability of system and also showed that the anionic nanosystem increased the essential oil’s stability without any change in its chemical nature. Taken together, liposomal nanocarrier could be a potent and suitable carrier for the essential oil.
Keywords	Liposome ; Medicinal herbs ; Mentha piperita ; Plant Oils ; Medicine (General) ; R5-920
Subject code	571
Language	Persian
Publishing date	2018-02-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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