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Article ; Online: Radioembolization Planning With Dual-Isotope Acquisition of 166 Ho-Labeled Microparticles and 99m Tc-Mebrofenin.

Czibor, Sándor / Bibok, András / Horváthy, Dénes / Fábián, Krisztián / Györke, Tamás

2023 Volume 48, Issue 8, Page(s) 719–721

Abstract: Abstract: A 76-year-old man with hepatocellular carcinoma was referred for liver radioembolization. Given a prior left hemihepatectomy, it was clinically important to consider potentially irradiated healthy liver at planning. Thus, at the SPECT/CT ... ...

Abstract	Abstract: A 76-year-old man with hepatocellular carcinoma was referred for liver radioembolization. Given a prior left hemihepatectomy, it was clinically important to consider potentially irradiated healthy liver at planning. Thus, at the SPECT/CT imaging of the scout dose 166 Ho-microparticles before injected superselectively in the right hepatic artery, 99m Tc-mebrofenin was injected intravenously, and functional volumetry SPECT was performed simultaneously. Based on the 2 image sets, the nonirradiated healthy liver was calculated as 1589 mL (functional liver reserve of 85.5% on 99m Tc-mebrofenin SPECT). Posttreatment dosimetry calculations showed optimal normal tissue and tumor absorbed doses, and the patient is clinically well after 3 months.
MeSH term(s)	Male ; Humans ; Aged ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/drug therapy ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/drug therapy ; Tomography, Emission-Computed, Single-Photon/methods ; Yttrium Radioisotopes/therapeutic use ; Isotopes ; Embolization, Therapeutic
Chemical Substances	mebrofenin (7PV0B6ED98) ; Yttrium Radioisotopes ; Isotopes
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004732
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Article: Situs Inversus Totalis: A Clinical Review.

Eitler, Katalin / Bibok, András / Telkes, Gábor

International journal of general medicine

2022 Volume 15, Page(s) 2437–2449

Abstract: Situs inversus totalis is a rare congenital abnormality characterized by a mirror-image transposition of both the abdominal and the thoracic organs. While this anomaly is known since the ancient times, practicing doctors do not have much experience with ... ...

Abstract	Situs inversus totalis is a rare congenital abnormality characterized by a mirror-image transposition of both the abdominal and the thoracic organs. While this anomaly is known since the ancient times, practicing doctors do not have much experience with it. Laterality is established early in development, and any failure in that process might lead to a wide variety of disorders which may be partial or complete.
Language	English
Publishing date	2022-03-03
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S295444
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Article: Intervenciós radiológiai eljárások szerepe a májdaganatok kezelésében.

Bibok, András / Doros, Attila

Magyar onkologia

2018 Volume 62, Issue 1, Page(s) 45–52

Abstract: Invasive radiological procedures provide more and more therapeutic options for patients with liver cancer. The treatment options previously used as a 2nd/3rd line treatment are making their way to 1st line treatment in selected cases. In this review, the ...

Title translation	Role of interventional radiological procedures in the treatment of liver cancer.
Abstract	Invasive radiological procedures provide more and more therapeutic options for patients with liver cancer. The treatment options previously used as a 2nd/3rd line treatment are making their way to 1st line treatment in selected cases. In this review, the authors take an overview of the interventional radiological procedures used in the most frequent liver neoplasms. There is a rapid development in ablational therapy, especially in the volumetric planning and stereotactic navigation. Using those new devices, the reliability of the ablation can improve a lot. At the field of embolization, new randomized studies were published recently, which can help to choose the right patient group who gains the most from the treatment. Interventional radiology has now an established place in the team of specialists treating malignant liver diseases.
MeSH term(s)	Embolization, Therapeutic ; Humans ; Imaging, Three-Dimensional ; Liver Neoplasms/radiotherapy ; Radiology, Interventional/methods ; Radiosurgery ; Reproducibility of Results
Language	Hungarian
Publishing date	2018-01-26
Publishing country	Hungary
Document type	Journal Article ; Review
ZDB-ID	414033-3
ISSN	0025-0244
ISSN	0025-0244
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Zs.A 5853: Show issues

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Article ; Online: Minimally invasive image-guided therapy of primary and metastatic pancreatic cancer.

Bibok, Andras / Kim, Dae Won / Malafa, Mokenge / Kis, Bela

World journal of gastroenterology

2021 Volume 27, Issue 27, Page(s) 4322–4341

Abstract: Pancreatic cancer is a challenging malignancy with limited treatment options and poor life expectancy. The only curative option is surgical resection, but only 15%-20% of patients are resectable at presentation because more than 50% of patients has ... ...

Abstract	Pancreatic cancer is a challenging malignancy with limited treatment options and poor life expectancy. The only curative option is surgical resection, but only 15%-20% of patients are resectable at presentation because more than 50% of patients has distant metastasis at diagnosis and the rest of them has locally advanced pancreatic cancer (LAPC). The standard of care first line treatment for LAPC patients is chemotherapy with or without radiation therapy. Recent developments in minimally invasive ablative techniques may add to the treatment armamentarium of LAPC. There are increasing number of studies evaluating these novel ablative techniques, including radiofrequency ablation, microwave ablation, cryoablation and irreversible electroporation. Most studies which included pancreatic tumor ablation, demonstrated improved overall survival in LAPC patients. However, the exact protocols are yet to set up to which stage of the treatment algorithm ablative techniques can be added and in what kind of treatment combinations. Patients with metastatic pancreatic cancer has dismal prognosis with 5-year survival is only 3%. The most common metastatic site is the liver as 90% of pancreatic cancer patients develop liver metastasis. Chemotherapy is the primary treatment option for patients with metastatic pancreatic cancer. However, when the tumor is not responding to chemotherapy or severe drug toxicity develops, locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease progression and improve survival in selected patients. During the last decade new therapeutic options arose with the advancement of minimally invasive technologies to treat pancreatic cancer patients. These new therapies have been a topic of increasing interest due to the severe prognostic implications of locally advanced and metastatic pancreatic cancer and the low comorbid risk of these procedures. This review summarizes new ablative options for patients with LAPC and percutaneous liver-directed therapies for patients with liver-dominant metastatic disease.
MeSH term(s)	Ablation Techniques/adverse effects ; Cryosurgery ; Humans ; Liver Neoplasms/surgery ; Liver Neoplasms/therapy ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/therapy ; Radiofrequency Ablation
Language	English
Publishing date	2021-06-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v27.i27.4322
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Zs.A 6039: Show issues

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Article ; Online: Yttrium-90 Radioembolization for Liver-Dominant Metastatic Prostate Cancer: A Case Series.

Bibok, Andras / Kis, Bela / Frakes, Jessica / Hoffe, Sarah / Zhang, Jingsong / Jain, Rohit / Parikh, Nainesh

Journal of vascular and interventional radiology : JVIR

2022 Volume 33, Issue 9, Page(s) 1061–1065

Abstract: Transarterial radioembolization (TARE) with yttrium-90 glass microspheres is widely used to treat primary and secondary malignancies in the liver. However, the safety and efficacy of TARE in patients with liver-dominant metastatic castration-resistant ... ...

Abstract	Transarterial radioembolization (TARE) with yttrium-90 glass microspheres is widely used to treat primary and secondary malignancies in the liver. However, the safety and efficacy of TARE in patients with liver-dominant metastatic castration-resistant prostate cancer (mCRPC) is unknown. A proof-of-concept, retrospective analysis of 7 consecutive patients with liver-dominant mCRPC who were treated with TARE was performed. The median overall survival was 27.2, 32.1, and 108.1 months from the time of TARE, the diagnosis of liver metastases, and initial cancer diagnosis, respectively. The median liver progression-free survival was 7.3 months. No grade 3 or higher adverse effects were noted. TARE was found to be a safe and effective tool for treating patients with liver-dominant mCRPC in this limited cohort.
MeSH term(s)	Carcinoma, Hepatocellular/therapy ; Embolization, Therapeutic/adverse effects ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/radiotherapy ; Male ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Retrospective Studies ; Yttrium Radioisotopes/adverse effects
Chemical Substances	Yttrium Radioisotopes ; Yttrium-90 (1K8M7UR6O1)
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2022.05.023
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Zs.A 3720: Show issues

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Article: Az intervenciós radiológia szerepe a hasi szervek átültetésében.

Bibok, András / Deák, Pál Ákos / Doros, Attila

Orvosi hetilap

2018 Volume 159, Issue 46, Page(s) 1940–1947

Abstract: The transplantation of the abdominal organs has a major role in the treatment of several diseases. All subspecialities affected with the transplantation showed a rapid development in the last decades. The cooperation of the specialists of different ... ...

Title translation	Role of interventional radiology in the transplantation of abdominal solid organs.
Abstract	The transplantation of the abdominal organs has a major role in the treatment of several diseases. All subspecialities affected with the transplantation showed a rapid development in the last decades. The cooperation of the specialists of different segments of medicine provides the success of organ transplantation. Teamwork is necessary throughout the whole process starting from securing the technical background and proper human workforce, followed by the lifelong management of organs and recipients as well. One of the key players of organ transplantation is radiology and interventional radiology - the role of the latter one is discussed in this review, including the minimally invasive treatment of pre- and post-transplantation situations and diseases. Besides vascular and non-vascular interventions, the options of interventional oncology will be mentioned based on international literature and Hungarian experience. Orv Hetil. 2018; 159(46): 1940-1947.
MeSH term(s)	Gastrointestinal Tract/diagnostic imaging ; Gastrointestinal Tract/surgery ; Humans ; Kidney Transplantation/statistics & numerical data ; Liver Transplantation/statistics & numerical data ; Pancreas Transplantation/statistics & numerical data ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/prevention & control ; Radiography, Interventional/statistics & numerical data ; Radiology, Interventional/trends
Language	Hungarian
Publishing date	2018-11-18
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2018.31293
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Zs.B 301: Show issues

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Article: Transarterial Yttrium-90 Glass Microsphere Radioembolization of Chemotherapy-Refractory Breast Cancer Liver Metastases: Results of a Single Institution Retrospective Study.

Barakat, Elie / Bibok, Andras / Rishi, Anupam / Ahmed, Altan / Frakes, Jessica M / Hoffe, Sarah E / Armaghani, Avan J / Soyano, Aixa E / Costa, Ricardo L B / El-Haddad, Ghassan / Choi, Junsung / Kis, Bela

Advances in radiation oncology

2021 Volume 7, Issue 1, Page(s) 100838

Abstract: Purpose: Our purpose was to retrospectively evaluate the safety and efficacy of transarterial hepatic radioembolization (TARE) treatment with yttrium-90 labeled glass microspheres in patients with chemotherapy-refractory breast cancer with liver- ... ...

Abstract	Purpose: Our purpose was to retrospectively evaluate the safety and efficacy of transarterial hepatic radioembolization (TARE) treatment with yttrium-90 labeled glass microspheres in patients with chemotherapy-refractory breast cancer with liver-dominant metastatic disease. Methods and materials: This retrospective single-institution study evaluated 31 female patients (mean age of 59.6 ± 13.2 years) who were treated with TARE. All patients received and progressed on systemic chemotherapy before TARE. Twenty-one patients also had extrahepatic metastases, including 13 patients who had metastases in bones only besides the liver. Survival data were analyzed by Kaplan-Meier method and compared using log-rank test. Imaging response to treatment was determined by Response Evaluation Criteria in Solid Tumors. Results: Median overall survival (OS) from the TARE was 13 months (95% confidence interval, 9.1-16.9 months). The survival probability at 1, 2, and 3 years was 60.1%, 36.7%, and 24.5%, respectively. The median hepatic progression-free survival was 7 months (95% confidence interval, 6.1-7.9 months). There was no 30-day mortality and 3 patients (9.4%) had grade 3 toxicity. Estrogen receptor (ER) positive status predicted prolonged survival (14 months for ER+ vs 9 months for ER-; Conclusions: The treatment of patients with liver-dominant chemotherapy-refractory breast cancer metastases with TARE using yttrium-90 labeled glass microspheres is safe and led to promising hepatic disease control and OS especially in patients with ER+ tumors and in patients without extrahepatic extraosseous metastases.
Language	English
Publishing date	2021-10-29
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2021.100838
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Article ; Online: Role of Radioembolization in the Management of Liver-Dominant Metastatic Renal Cell Carcinoma: A Single-Center, Retrospective Study.

Bibok, Andras / Mhaskar, Rahul / Jain, Rohit / Zhang, Jingsong / Frakes, Jessica / Hoffe, Sarah / El-Haddad, Ghassan / Parikh, Nainesh / Ahmed, Altan / Fishman, Mayer N / Choi, Junsung / Kis, Bela

Cardiovascular and interventional radiology

2021 Volume 44, Issue 11, Page(s) 1755–1762

Abstract: Purpose: The management of Renal cell carcinoma (RCC) patients with liver metastases is challenging. Liver-directed therapy, such as Transarterial radioembolization (TARE), is a reasonable option for these patients; however, its safety and efficacy are ... ...

Abstract	Purpose: The management of Renal cell carcinoma (RCC) patients with liver metastases is challenging. Liver-directed therapy, such as Transarterial radioembolization (TARE), is a reasonable option for these patients; however, its safety and efficacy are not well characterized. This study evaluated the safety and efficacy of TARE in patients with liver-dominant metastatic RCC. Materials and methods: This is a retrospective, single-center study. Thirty-eight patients' medical records were reviewed who underwent TARE between January 1, 2009, and December 31, 2019, in a tertiary cancer center. Two were excluded from further analysis. Thirty-six patients received 51 TARE treatments. Median follow-up time was 18.2 months. Imaging data were evaluated using mRECIST or RECIST 1.1 criteria. Toxicities, treatment responses, liver progression-free survival (LPFS), and median overall survival (OS) were calculated. Univariate and multivariate analyses were conducted to reveal predictors of OS. Results: Median OS from TARE was 19.3 months (95% CI, 22.6-47.4) and from diagnosis of liver metastases was 36.5 months (95% CI: 26.4-49.8). Mild, grade 1 or 2, biochemical toxicity developed in 27 patients (75%). Grade 3-4 toxicity was noted in two patients (5.5%). The objective response rate was 89%; the disease control rate was 94% (21 complete response, 11 partial response, two stable disease, and two progressive disease). Univariate and multivariate analyses showed longer survival in patients who had objective response, lower lung shunt fraction, and better baseline liver function. Conclusions: TARE is safe and effective and led to promising overall survival in patients with liver-dominant metastatic RCC. Level of evidence: Level 3, retrospective cohort study.
MeSH term(s)	Carcinoma, Hepatocellular/therapy ; Carcinoma, Renal Cell/diagnostic imaging ; Carcinoma, Renal Cell/radiotherapy ; Embolization, Therapeutic ; Humans ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/therapy ; Liver ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Retrospective Studies ; Treatment Outcome ; Yttrium Radioisotopes/therapeutic use
Chemical Substances	Yttrium Radioisotopes
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-021-02925-y
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Zs.A 1378: Show issues

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Article ; Online: Diagnosis and Management of a De Novo Urothelial Carcinoma in a Kidney Allograft: A Case Report.

Farkas, Ádám Z / Török, Szilárd / Kovács, János Balázs / Piros, László / Végső, Gyula / Kiss, Gergely / Korda, Dávid / Bibok, András / Hartmann, Erika / Deák, Ákos P / Doros, Attila

Transplantation proceedings

2019 Volume 51, Issue 4, Page(s) 1281–1285

Abstract: Introduction: Following renal transplantation, the incidence of malignancies is 3-5 times higher than that of healthy individuals. Among other type of cancers, the risk of urological tumors is also elevated. However, only a few cases of de novo ... ...

Abstract	Introduction: Following renal transplantation, the incidence of malignancies is 3-5 times higher than that of healthy individuals. Among other type of cancers, the risk of urological tumors is also elevated. However, only a few cases of de novo transitional cell carcinomas occurring in renal allografts have been reported. Case report: A 63-year-old tertiary transplanted male patient was urgently hospitalized for a painless macroscopic hematuria. Ultrasonography revealed pyelectasis and a hematoma in the renal pelvis. A percutaneous nephrostomy tube was inserted. An anterograde pyelography was performed later, where a filling defect was still observable in the location of the previously reported hypoechoic mass. Contrast-enhanced ultrasonography showed enhancement of the lesion. An ultrasound-guided percutaneous biopsy was performed. The histologic evaluation revealed a high-grade transitional cell carcinoma. A whole-body staging computed tomography scan did not show signs of metastatic disease. The renal allograft was surgically removed. No disease progression was observed during the 21-month follow-up period. Conclusions: Painless hematuria and asymptomatic hydronephrosis occurring after kidney transplantation should raise the possibility of urothelial carcinoma in the kidney graft. Contrast-enhanced ultrasound should be considered as a first-line diagnostic modality because it is easily accessible and does not raise concerns about nephrotoxicity or radiation burden.
MeSH term(s)	Allografts/pathology ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/immunology ; Carcinoma, Transitional Cell/pathology ; Humans ; Immunocompromised Host ; Immunosuppression/adverse effects ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/immunology ; Kidney Neoplasms/pathology ; Kidney Transplantation ; Male ; Middle Aged
Language	English
Publishing date	2019-05-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2019.04.011
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