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  1. Article ; Online: Effect of heterogeneous substrate adhesivity of follower cells on speed and tension profile of leader cells in primary keratocyte collective cell migration

    Madhura Chakraborty / Baishali Mukherjee / Nanditha Nalinakshan / Arikta Biswas / Rajesh Kumble Nayak / Bidisha Sinha

    Biology Open, Vol 11, Iss

    2022  Volume 3

    Abstract: In single keratocyte motility, membrane tension is reported to be high at cell-fronts and believed to establish front coherence. To understand role of membrane mechanics in collective cell migration, we study membrane height fluctuations in cell sheets ... ...

    Abstract In single keratocyte motility, membrane tension is reported to be high at cell-fronts and believed to establish front coherence. To understand role of membrane mechanics in collective cell migration, we study membrane height fluctuations in cell sheets from fish scales using interference reflection microscopy (IRM). We report the monolayer to have cells lacking substrate adhesion and show that such ‘non-sticky’ cells can form bridges between leader cells and far-away follower cells. Do such interactions alter motility and membrane mechanics in such leaders? We find non-significant, but reduced speed for leaders with ‘non-sticky’ followers in comparison to other leaders. Cells show high phenotypic variability in their membrane fluctuation tension profiles. On average, this tension is found to be lower at cell fronts than the mid-section. However, leaders with non-sticky followers are more prone to display higher tension at their front and have a negative correlation between cell speed and front-mid tension difference. Thus, we conclude that intracellular tension gradients are heterogeneous in cell sheets and substrate adhesivity of followers can control the coupling of the gradient to cell speed.
    Keywords tension gradient ; membrane fluctuations ; adhesion ; collective cell migration ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Connexin 43 mediated collective cell migration is independent of Golgi orientation

    Madhav Sharma / Suvam Mukherjee / Archana Kumari Shaw / Anushka Mondal / Amrutamaya Behera / Jibitesh Das / Abhishek Bose / Bidisha Sinha / Jayasri Das Sarma

    Biology Open, Vol 12, Iss

    2023  Volume 10

    Keywords collective cell migration ; connexin 43 ; golgi orientation ; hela 43 ; hela wt ; secretory trafficking ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Use of a multi-method approach to rapidly assess the impact of public health policies at the state and local level

    Elizabeth L. Seaman / Jennifer Kreslake / Katrina F. Trivers / Fatma Romeh M. Ali / Jamie Cordova / Sarah Mills / Bidisha Sinha / Brian King / Donna Vallone

    BMC Public Health, Vol 23, Iss 1, Pp 1-

    a case study of flavored e-cigarette policies

    2023  Volume 9

    Abstract: Abstract Background E-cigarettes are the most-commonly used tobacco product by youth since 2014. To prevent youth access and use of e-cigarettes, many U.S. states and localities have enacted policies over a relatively short period of time. The adoption ... ...

    Abstract Abstract Background E-cigarettes are the most-commonly used tobacco product by youth since 2014. To prevent youth access and use of e-cigarettes, many U.S. states and localities have enacted policies over a relatively short period of time. The adoption of these policies has necessitated timely data collection to evaluate impacts. Methods To assess the impact of flavored e-cigarette policies in select states and local jurisdictions across the United States, a multi-method, complementary approach was implemented from July 2019 to present, which includes analyses of cross-sectional online surveys of young people ages 13–24 years with retail sales data. Results From February 2020 through February 2023, cross-sectional surveys have been conducted in three cities, one county, and eight states where policy changes have been enacted or are likely to be enacted. Data collection occurred every six months to provide near real-time data and examine trends over time. Additionally, weekly retail sales data were aggregated to showcase monthly sales trends at the national level and for the selected states. Discussion This rapid and efficient method of coupling online survey data with retail sales data provides a timely and effective approach for monitoring a quickly changing tobacco product landscape, particularly for states and localities where rapidly-available data is often not available. This approach can also be used to monitor other health behaviors and relevant policy impacts.
    Keywords Policy evaluation methods ; Rapidly-available data ; E-Cigarettes ; Public aspects of medicine ; RA1-1270
    Subject code 333
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

    Melissa Dewulf / Darius Vasco Köster / Bidisha Sinha / Christine Viaris de Lesegno / Valérie Chambon / Anne Bigot / Mona Bensalah / Elisa Negroni / Nicolas Tardif / Joanna Podkalicka / Ludger Johannes / Pierre Nassoy / Gillian Butler-Browne / Christophe Lamaze / Cedric M. Blouin

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 13

    Abstract: Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that ... ...

    Abstract Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that dystrophy related Cav3 mutant myotubes have reduced caveolae and upregulated IL6 signaling.
    Keywords Science ; Q
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

    Melissa Dewulf / Darius Vasco Köster / Bidisha Sinha / Christine Viaris de Lesegno / Valérie Chambon / Anne Bigot / Mona Bensalah / Elisa Negroni / Nicolas Tardif / Joanna Podkalicka / Ludger Johannes / Pierre Nassoy / Gillian Butler-Browne / Christophe Lamaze / Cedric M. Blouin

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 13

    Abstract: Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that ... ...

    Abstract Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that dystrophy related Cav3 mutant myotubes have reduced caveolae and upregulated IL6 signaling.
    Keywords Science ; Q
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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