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  1. Article ; Online: Author Correction: Disease modification in inflammatory skin disorders: opportunities and challenges.

    Bieber, Thomas

    Nature reviews. Drug discovery

    2023  Volume 22, Issue 11, Page(s) 935

    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-023-00790-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Disease modification in inflammatory skin disorders: opportunities and challenges.

    Bieber, Thomas

    Nature reviews. Drug discovery

    2023  Volume 22, Issue 8, Page(s) 662–680

    Abstract: Progress in understanding of the mechanisms underlying chronic inflammatory skin disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options with the primary goal of alleviating symptoms. In addition, this knowledge has ... ...

    Abstract Progress in understanding of the mechanisms underlying chronic inflammatory skin disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options with the primary goal of alleviating symptoms. In addition, this knowledge has the potential to inform on new strategies aimed at inducing deep and therapy-free remission, that is, disease modification, potentially impacting on associated comorbidities. However, to reach this goal, key areas require further exploration, including the definitions of disease modification and disease activity index, further understanding of disease mechanisms and systemic spillover effects, potential windows of opportunity, biomarkers for patient stratification and successful intervention, as well as appropriate study design. This Perspective article assesses the opportunities and challenges in the discovery and development of disease-modifying therapies for chronic inflammatory skin disorders.
    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Psoriasis/drug therapy
    Language English
    Publishing date 2023-07-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-023-00735-0
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  3. Article ; Online: In search of the Holy Grail in atopic dermatitis: Will dupilumab become the first disease-modifying atopic dermatitis drug?

    Bieber, Thomas

    The Journal of allergy and clinical immunology

    2023  Volume 151, Issue 3, Page(s) 694–696

    MeSH term(s) Humans ; Dermatitis, Atopic ; Antibodies, Monoclonal, Humanized ; Antibodies, Monoclonal ; Treatment Outcome ; Severity of Illness Index
    Chemical Substances dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-01-21
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.12.824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Atopic dermatitis

    Bieber, Thomas

    2009  

    Author's details ed. by Thomas Bieber
    Keywords Dermatitis, Atopic / physiopathology ; Dermatitis, Atopic / therapy ; Dermatitis, Atopic / immunology ; Atopic dermatitis ; Endogenes Ekzem
    Subject Essentielles Ekzem ; Essenzielles Ekzem ; Konstitutionelles Ekzem ; Ekzema atopicum ; Atopisches Ekzem ; Dermatitis atopica ; Atopische Dermatitis ; Neurodermitis ; Neurodermitis constitutionalis
    Subject code 616.521
    Language English
    Size IX, 466 S. : Ill.
    Edition 2. ed.
    Publisher Informa Healthcare
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes index
    HBZ-ID HT015844556
    ISBN 978-1-4200-7798-8 ; 1-4200-7798-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 3318 order for loan Magazin

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  5. Book ; Thesis: Toll-like Rezeptoren – Expressionsprofil auf myeloiden Zellen

    Sundheimer, Cathrin / Bieber, Thomas

    Ein potentieller Biomarker in der Dermatologie

    2021  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details vorgelegt von Cathrin Franka Sundheimer, geb. Jüngling ; 1. Gutachter: Prof. Dr. med. Dr. ès. sci Prof. h.c. Thomas Bieber
    Language German
    Size 109 Seiten, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
    HBZ-ID HT020836869
    Database Catalogue ZB MED Medicine, Health

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    2021 D 146 order for loan Magazin

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  6. Book: Personalized treatment options in dermatology

    Bieber, Thomas / Nestle, Frank

    2015  

    Author's details Thomas Bieber ; Ftrank Nestle ed
    Keywords Dermato-oncology ; Heterogeneous phenotypes ; Field cancerization ; Targeted therapies ; Gene-environment interactions ; Dermatologie ; Individualisierte Medizin
    Subject Personalisierte Medizin ; Individualmedizin ; Patientenindividuelle Medizin ; Patientenindividuelle Therapie ; Maßgeschneiderte Pharmakotherapie ; Personalised medicine ; Präzisionsmedizin
    Language English
    Size V, 146 S. : Ill., graph. Darst., 254 mm x 178 mm
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018592697
    ISBN 978-3-662-45839-6 ; 3-662-45839-X ; 9783662458402 ; 3662458403
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 1147 available for loan (reading room) Lesesaal EG

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  7. Article ; Online: Atopic dermatitis: an expanding therapeutic pipeline for a complex disease.

    Bieber, Thomas

    Nature reviews. Drug discovery

    2021  Volume 21, Issue 1, Page(s) 21–40

    Abstract: Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains challenging to treat owing to the limited response to available therapies. However, ... ...

    Abstract Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains challenging to treat owing to the limited response to available therapies. However, recent advances in understanding of disease mechanisms have led to the discovery of novel potential therapeutic targets and drug candidates. In addition to regulatory approval for the IL-4Ra inhibitor dupilumab, the anti-IL-13 inhibitor tralokinumab and the JAK1/2 inhibitor baricitinib in Europe, there are now more than 70 new compounds in development. This Review assesses the various strategies and novel agents currently being investigated for AD and highlights the potential for a precision medicine approach to enable prevention and more effective long-term control of this complex disease.
    MeSH term(s) Animals ; Dermatitis, Atopic/drug therapy ; Humans ; Pharmaceutical Preparations/administration & dosage ; Precision Medicine/methods
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-08-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-021-00266-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: AhR Modulating Agent for the Topical Therapy of Plaque Psoriasis.

    Bieber, Thomas

    The New England journal of medicine

    2021  Volume 385, Issue 24, Page(s) 2295–2296

    MeSH term(s) Administration, Topical ; Humans ; Psoriasis/drug therapy
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2116301
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  9. Article ; Online: [No title information]

    Bieber, Thomas

    Drug research

    2020  Volume 70, Issue S 01, Page(s) S30–S31

    Title translation Der lange Weg zur personalisierten Medizin in der Allergologie.
    Language German
    Publishing date 2020-11-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1119-2827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Atopic dermatitis

    Bieber, Thomas

    2002  

    Author's details ed. by Thomas Bieber
    Keywords Dermatitis, Atopic / physiopathology ; Dermatitis, Atopic / therapy ; Dermatitis, Atopic / immunology ; Atopic dermatitis ; Endogenes Ekzem
    Subject Essentielles Ekzem ; Essenzielles Ekzem ; Konstitutionelles Ekzem ; Ekzema atopicum ; Atopisches Ekzem ; Dermatitis atopica ; Atopische Dermatitis ; Neurodermitis ; Neurodermitis constitutionalis
    Subject code 616.521
    Language English
    Size XIV, 633 S. : Ill.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes index
    HBZ-ID HT013389201
    ISBN 0-8247-0742-7 ; 978-0-8247-0742-2
    Database Catalogue ZB MED Medicine, Health

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