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Article ; Online: MR imaging of the airways.

Biederer, Juergen

2023 Volume 96, Issue 1146, Page(s) 20220630

Abstract: The need for airway imaging is defined by the limited sensitivity of common clinical tests like spirometry, lung diffusion (DLCO) and blood gas analysis to early changes of peripheral airways and to inhomogeneous regional distribution of lung function ... ...

Abstract	The need for airway imaging is defined by the limited sensitivity of common clinical tests like spirometry, lung diffusion (DLCO) and blood gas analysis to early changes of peripheral airways and to inhomogeneous regional distribution of lung function deficits. Therefore, X-ray and computed tomography (CT) are frequently used to complement the standard tests.As an alternative, magnetic resonance imaging (MRI) offers radiation-free lung imaging, but at lower spatial resolution. Non-contrast enhanced MRI shows healthy airways down to the first subsegmental level/4
MeSH term(s)	Humans ; Lung/diagnostic imaging ; Pulmonary Disease, Chronic Obstructive ; Asthma/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Respiration
Language	English
Publishing date	2023-03-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20220630
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Book: Thoraxdiagnostik

Wormanns, Dag / Biederer, Jürgen / Rehbock, Beate

(Referenz-Reihe Radiologie)

2017

Author's details	Dag Wormanns ; unter Mitarbeit von Jürgen Biederer und Beate Rehbock
Series title	Referenz-Reihe Radiologie
Keywords	Brustorgan ; Krankheit ; Radiologische Diagnostik
Subject	Diagnostische Radiologie ; Strahlendiagnostik ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Brusteingeweide ; Brustkorborgan ; Thoraxorgan
Language	German
Size	360 Seiten, Illustrationen, Diagramme, 28 cm x 21 cm
Publisher	George Thieme Verlag
Publishing place	Stuttgart
Publishing country	Germany
Document type	Book
Note	Zugang zur Internetausgabe über Code
HBZ-ID	HT018935766
ISBN	978-3-13-169591-8 ; 3-13-169591-9 ; 9783131696014 ; 9783132400603 ; 313169601X ; 3132400602
Database	Catalogue ZB MED Medicine, Health

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2016 A 2367	available for loan (reading room)	Lesesaal EG
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Article ; Online: Using Lung MRI and Elastic Registration to Assess Pulmonary Fibrosis.

Biederer, Juergen

Radiology

2019 Volume 291, Issue 2, Page(s) 493–494

MeSH term(s)	Humans ; Idiopathic Pulmonary Fibrosis ; Lung ; Magnetic Resonance Imaging ; Scleroderma, Systemic
Language	English
Publishing date	2019-03-05
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2019190233
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Book ; Thesis: Differenzierung der elektrophysiologischen Merkmale cerebellärer Körnerzellen in der Ontogenese

Biederer, Jürgen

Patch-Clamp-Untersuchungen an Primärkulturen aus Hühnerembryonen

1996

Author's details	vorgelegt von Jürgen Biederer
Language	German
Size	59 Bl. : Ill., graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Kiel, Univ., Diss., 1996
HBZ-ID	HT007246931
Database	Catalogue ZB MED Medicine, Health

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96 E 1667	order for loan	Magazin

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Article ; Online: Ultrasonography of the Lung.

Radzina, Maija / Biederer, Jürgen

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

2019 Volume 191, Issue 10, Page(s) 909–923

Abstract: Background: High diagnostic accuracy, increasing clinical experience and technical improvements are good reasons to consider lung ultrasound (US) for the assessment of pleural and pulmonary diseases. In the emergency room and in intensive care, it is ... ...

Title translation	Ultraschall der Lunge.
Abstract	Background: High diagnostic accuracy, increasing clinical experience and technical improvements are good reasons to consider lung ultrasound (US) for the assessment of pleural and pulmonary diseases. In the emergency room and in intensive care, it is well acknowledged, but application in other settings is rare. The aim of this review is to update potential users in general radiology about the diagnostic scope of lung US and to encourage more frequent use of this generally underestimated lung imaging modality. Method: Literature review was done independently by the two authors in MEDLINE (via PubMed) covering a time span from 2002 until 2017 using free text and Medical Subject Headings/MeSH. Article selection for the bibliography was based on consensus according to relevance and evidence. Results and conclusion: The technical prerequisites include a standard ultrasound unit with a suitable transducer. Pleural effusion and pneumothorax, atelectasis, interstitial edema, pneumonia, exacerbated chronic obstructive pulmonary disease/asthma and pulmonary embolism can be distinguished by particular ultrasound signs, artifacts and their combinations. A highly standardized selection of access points and terminology for the description of imaging findings contributes to high diagnostic accuracy even in challenging patients and settings. Besides the assessment of acute respiratory failure in the emergency room, lung US may be used for monitoring interstitial fluid accumulation in volume therapy and for the diagnosis of pneumonia or the assessment of pleural effusion and pleurisy in a routine outpatient setting. Last but not least, the increasing concerns about medical radiation exposure warrant a more extensive use of this sometimes underestimated modality as a cost-, time- and radiation-saving alternative or valuable adjunct to the standard imaging modalities. Key points: · Lung US is a safe, quick and readily available method with options for dynamic imaging of respiratory function.. · Proper selection of technical parameters customized to the clinical question and standardized terminology for the precise description and interpretation of the imaging signs regarding patient history determine its diagnostic accuracy.. · In dyspnea lung US differentiates pneumothorax, lung edema, pneumonia, pulmonary embolism, atelectasis and pleural effusion.. · In intensive care, lung US allows monitoring of lung ventilation and fluid administration.. · It saves radiation exposure in serial follow-up, in pregnancy and pediatric radiology.. Citation format: · Radzina M, Biederer J, Ultrasonography of the Lung. Fortschr Röntgenstr 2019; 191: 909 - 923.
MeSH term(s)	Acute Disease ; Chronic Disease ; Humans ; Lung/diagnostic imaging ; Lung Diseases/diagnostic imaging ; Pleural Diseases/diagnostic imaging ; Point-of-Care Testing ; Pulmonary Embolism/diagnostic imaging ; Thoracic Wall/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2019-04-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	554830-5
ISSN	1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
ISSN (online)	1438-9010
ISSN	0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
DOI	10.1055/a-0881-3179
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Article ; Online: Practical protocol for lung magnetic resonance imaging and common clinical indications.

Sodhi, Kushaljit Singh / Ciet, Pierluigi / Vasanawala, Shreyas / Biederer, Juergen

Pediatric radiology

2021 Volume 52, Issue 2, Page(s) 295–311

Abstract: Imaging speed, spatial resolution and availability have made CT the favored cross-sectional imaging modality for evaluating various respiratory diseases of children - but only for the price of a radiation exposure. MRI is increasingly being appreciated ... ...

Abstract	Imaging speed, spatial resolution and availability have made CT the favored cross-sectional imaging modality for evaluating various respiratory diseases of children - but only for the price of a radiation exposure. MRI is increasingly being appreciated as an alternative to CT, not only for offering three-dimensional (3-D) imaging without radiation exposure at only slightly inferior spatial resolution, but also for its superior soft-tissue contrast and exclusive morpho-functional imaging capacities beyond the scope of CT. Continuing technical improvements and experience with this so far under-utilized modality contribute to a growing acceptance of MRI for an increasing number of indications, in particular for pediatric patients. This review article provides the reader with practical easy-to-use protocols for common clinical indications in children. This is intended to encourage pediatric radiologists to appreciate the new horizons for applications of this rapidly evolving technique in the field of pediatric respiratory diseases.
MeSH term(s)	Child ; Humans ; Lung/diagnostic imaging ; Magnetic Resonance Imaging ; Thorax
Language	English
Publishing date	2021-05-26
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s00247-021-05090-z
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Article ; Online: Metal Artifact Reduction in Photon-Counting Detector CT: Quantitative Evaluation of Artifact Reduction Techniques.

Skornitzke, Stephan / Mergen, Victor / Biederer, Jürgen / Alkadhi, Hatem / Do, Thuy D / Stiller, Wolfram / Frauenfelder, Thomas / Kauczor, Hans-Ulrich / Euler, André

Investigative radiology

2023 Volume 59, Issue 6, Page(s) 442–449

Abstract: Objectives: With the introduction of clinical photon-counting detector computed tomography (PCD-CT) and its novel reconstruction techniques, a quantitative investigation of different acquisition and reconstruction settings is necessary to optimize ... ...

Abstract	Objectives: With the introduction of clinical photon-counting detector computed tomography (PCD-CT) and its novel reconstruction techniques, a quantitative investigation of different acquisition and reconstruction settings is necessary to optimize clinical acquisition protocols for metal artifact reduction. Materials and methods: A multienergy phantom was scanned on a clinical dual-source PCD-CT (NAEOTOM Alpha; Siemens Healthcare GmbH) with 4 different central inserts: water-equivalent plastic, aluminum, steel, and titanium. Acquisitions were performed at 120 kVp and 140 kVp (CTDI vol 10 mGy) and reconstructed as virtual monoenergetic images (VMIs; 110-150 keV), as T3D, and with the standard reconstruction "none" (70 keV VMI) using different reconstruction kernels (Br36, Br56) and with as well as without iterative metal artifact reduction (iMAR). Metal artifacts were quantified, calculating relative percentages of metal artifacts. Mean CT numbers of an adjacent water-equivalent insert and different tissue-equivalent inserts were evaluated, and eccentricity of metal rods was measured. Repeated-measures analysis of variance was performed for statistical analysis. Results: Metal artifacts were most prevalent for the steel insert (12.6% average artifacts), followed by titanium (4.2%) and aluminum (1.0%). The strongest metal artifact reduction was noted for iMAR (with iMAR: 1.4%, without iMAR: 10.5%; P < 0.001) or VMI (VMI: 110 keV 2.6% to 150 keV 3.3%, T3D: 11.0%, and none: 16.0%; P < 0.001) individually, with best results when combining iMAR and VMI at 110 keV (1.2%). Changing acquisition tube potential (120 kV: 6.6%, 140 kV: 5.2%; P = 0.33) or reconstruction kernel (Br36: 5.5%, Br56: 6.4%; P = 0.17) was less effective. Mean CT numbers and standard deviations were significantly affected by iMAR (with iMAR: -3.0 ± 21.5 HU, without iMAR: -8.5 ± 24.3 HU; P < 0.001), VMI (VMI: 110 keV -3.6 ± 21.6 HU to 150 keV -1.4 ± 21.2 HU, T3D: -11.7 ± 23.8 HU, and none: -16.9 ± 29.8 HU; P < 0.001), tube potential (120 kV: -4.7 ± 22.8 HU, 140 kV: -6.8 ± 23.0 HU; P = 0.03), and reconstruction kernel (Br36: -5.5 ± 14.2 HU, Br56: -6.8 ± 23.0 HU; P < 0.001). Both iMAR and VMI improved quantitative CT number accuracy and metal rod eccentricity for the steel rod, but iMAR was of limited effectiveness for the aluminum rod. Conclusions: For metal artifact reduction in PCD-CT, a combination of iMAR and VMI at 110 keV demonstrated the strongest artifact reduction of the evaluated options, whereas the impact of reconstruction kernel and tube potential was limited.
MeSH term(s)	Artifacts ; Phantoms, Imaging ; Tomography, X-Ray Computed/methods ; Tomography, X-Ray Computed/instrumentation ; Metals ; Photons ; Radiographic Image Interpretation, Computer-Assisted/methods ; Reproducibility of Results ; Radiographic Image Enhancement/methods ; Humans ; Sensitivity and Specificity ; Algorithms
Chemical Substances	Metals
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80345-5
ISSN	1536-0210 ; 0020-9996
ISSN (online)	1536-0210
ISSN	0020-9996
DOI	10.1097/RLI.0000000000001036
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Article: Echo time-dependent observed T1 and quantitative perfusion in chronic obstructive pulmonary disease using magnetic resonance imaging.

Triphan, Simon M F / Konietzke, Marilisa / Biederer, Jürgen / Eichinger, Monika / Vogelmeier, Claus F / Jörres, Rudolf A / Kauczor, Hans-Ulrich / Heußel, Claus P / Jobst, Bertram J / Wielpütz, Mark O

Frontiers in medicine

2024 Volume 10, Page(s) 1254003

Abstract: Introduction: Due to hypoxic vasoconstriction, perfusion is interesting in the lungs. Magnetic Resonance Imaging (MRI) perfusion imaging based on Dynamic Contrast Enhancement (DCE) has been demonstrated in patients with Chronic Obstructive Pulmonary ... ...

Abstract	Introduction: Due to hypoxic vasoconstriction, perfusion is interesting in the lungs. Magnetic Resonance Imaging (MRI) perfusion imaging based on Dynamic Contrast Enhancement (DCE) has been demonstrated in patients with Chronic Obstructive Pulmonary Diseases (COPD) using visual scores, and quantification methods were recently developed further. Inter-patient correlations of echo time-dependent observed T Methods: 22 patients (age 68.0 ± 6.2) with COPD were examined using morphological MRI, inversion recovery multi-echo 2D ultra-short TE (UTE) in 1-2 slices for T Results: Inter-patient correlations were strongest on average at TE Discussion: The inter-patient correlations of T
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1254003
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Article: Capturing COPD heterogeneity: anomaly detection and parametric response mapping comparison for phenotyping on chest computed tomography.

Almeida, Silvia D / Norajitra, Tobias / Lüth, Carsten T / Wald, Tassilo / Weru, Vivienn / Nolden, Marco / Jäger, Paul F / von Stackelberg, Oyunbileg / Heußel, Claus Peter / Weinheimer, Oliver / Biederer, Jürgen / Kauczor, Hans-Ulrich / Maier-Hein, Klaus

Frontiers in medicine

2024 Volume 11, Page(s) 1360706

Abstract: Background: Chronic obstructive pulmonary disease (COPD) poses a substantial global health burden, demanding advanced diagnostic tools for early detection and accurate phenotyping. In this line, this study seeks to enhance COPD characterization on chest ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) poses a substantial global health burden, demanding advanced diagnostic tools for early detection and accurate phenotyping. In this line, this study seeks to enhance COPD characterization on chest computed tomography (CT) by comparing the spatial and quantitative relationships between traditional parametric response mapping (PRM) and a novel self-supervised anomaly detection approach, and to unveil potential additional insights into the dynamic transitional stages of COPD. Methods: Non-contrast inspiratory and expiratory CT of 1,310 never-smoker and GOLD 0 individuals and COPD patients (GOLD 1-4) from the COPDGene dataset were retrospectively evaluated. A novel self-supervised anomaly detection approach was applied to quantify lung abnormalities associated with COPD, as regional deviations. These regional anomaly scores were qualitatively and quantitatively compared, per GOLD class, to PRM volumes (emphysema: PRM Results: Initial t-Distributed Stochastic Neighbor Embedding (t-SNE) visualization of the self-supervised latent space highlighted distinct spatial patterns, revealing clear separations between regions with and without emphysema and air trapping. Four stable clusters were identified among this latent space by the PCA and Cluster Analysis. As the GOLD stage increased, PRM Conclusion: Our study highlights the synergistic utility of the anomaly detection approach and traditional PRM in capturing the nuanced heterogeneity of COPD. The observed disparities in spatial patterns, cluster dynamics, and correlations with PFTs underscore the distinct - yet complementary - strengths of these methods. Integrating anomaly detection and PRM offers a promising avenue for understanding of COPD pathophysiology, potentially informing more tailored diagnostic and intervention approaches to improve patient outcomes.
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1360706
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Article ; Online: Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial.

Nauck, Sebastian / Pohl, Moritz / Jobst, Bertram J / Melzig, Claudius / Meredig, Hagen / Weinheimer, Oliver / Triphan, Simon / von Stackelberg, Oyunbileg / Konietzke, Philip / Kauczor, Hans-Ulrich / Heußel, Claus P / Wielpütz, Mark O / Biederer, Jürgen

European radiology

2024

Abstract: Objectives: A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway disease and emphysema.: Methods: A total of 601 participants with COPD from 15 ...

Abstract	Objectives: A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway disease and emphysema. Methods: A total of 601 participants with COPD from 15 sites underwent same-day morpho-functional chest MRI and paired inspiratory-expiratory CT. Two readers systematically scored bronchial wall thickening, bronchiectasis, centrilobular nodules, air trapping and lung parenchyma defects in each lung lobe and determined COPD phenotype. A third reader acted as adjudicator to establish consensus. Inter-modality and inter-reader agreement were assessed using Cohen's kappa (im-κ and ir-κ). Results: The mean combined MRI score for bronchiectasis/bronchial wall thickening was 4.5/12 (CT scores, 2.2/12 for bronchiectasis and 6/12 for bronchial wall thickening; im-κ, 0.04-0.3). Expiratory right/left bronchial collapse was observed in 51 and 47/583 on MRI (62 and 57/599 on CT; im-κ, 0.49-0.52). Markers of small airways disease on MRI were 0.15/12 for centrilobular nodules (CT, 0.34/12), 0.94/12 for air trapping (CT, 0.9/12) and 7.6/12 for perfusion deficits (CT, 0.37/12 for mosaic attenuation; im-κ, 0.1-0.41). The mean lung defect score on MRI was 1.3/12 (CT emphysema score, 5.8/24; im-κ, 0.18-0.26). Airway-/emphysema/mixed COPD phenotypes were assigned in 370, 218 and 10 of 583 cases on MRI (347, 218 and 34 of 599 cases on CT; im-κ, 0.63). For all examined features, inter-reader agreement on MRI was lower than on CT. Conclusion: Concordance of MRI and CT for phenotyping of COPD in a multi-centre setting was substantial with variable inter-modality and inter-reader concordance for single diagnostic key features. Clinical relevance statement: MRI of lung morphology may well serve as a radiation-free imaging modality for COPD in scientific and clinical settings, given that its potential and limitations as shown here are carefully considered. Key points: • In a multi-centre setting, MRI and CT showed substantial concordance for phenotyping of COPD (airway-/emphysema-/mixed-type). • Individual features of COPD demonstrated variable inter-modality concordance with features of pulmonary hypertension showing the highest and bronchiectasis showing the lowest concordance. • For all single features of COPD, inter-reader agreement was lower on MRI than on CT.
Language	English
Publishing date	2024-02-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-024-10610-0
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