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Book ; Thesis: Präatherosklerotische Gefäßveränderungen bei Sarkoidose

Biener, Leonie

2018

Institution	Rheinische Friedrich-Wilhelms-Universität Bonn
Author's details	Leonie Biener
Language	German
Size	87 Seiten, Illustrationen, Diagramme
Publishing place	Bonn
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2018
HBZ-ID	HT019699183
Database	Catalogue ZB MED Medicine, Health

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Article: Pulmonale Hypertonie bei Lungenerkrankungen

Biener, Leonie / Pizarro, Carmen / Skowasch, Dirk

Aktuelle Kardiologie

2023 Volume 12, Issue 01, Page(s) 57–61

Abstract: Die pulmonale Hypertonie (PH) ist eine häufige Komorbidität von Lungenerkrankungen wie der chronisch obstruktiven Lungenerkrankung oder der idiopathischen pulmonalen Fibrose und geht mit einer erhöhten Letalität einher. Die pulmonalarterielle ... ...

Abstract	Die pulmonale Hypertonie (PH) ist eine häufige Komorbidität von Lungenerkrankungen wie der chronisch obstruktiven Lungenerkrankung oder der idiopathischen pulmonalen Fibrose und geht mit einer erhöhten Letalität einher. Die pulmonalarterielle Hypertonie (PAH) ist hingegen eine seltene Erkrankung, ebenfalls mit hoher Letalität. Durch das häufig ältere und komorbide Patientengut der PAH ergeben sich Subgruppen, die sich hinsichtlich ihres Therapieansprechens und der Letalität von typischen PAH-Patienten unterscheiden. In den letzten Jahren hat sich gezeigt, dass sich neben dem kardialen bzw. Linksherzphänotyp auch ein pulmonaler bzw. kardiopulmonaler Phänotyp abgrenzen lässt. Die Differenzierung zu einer schwergradigen PH bei Lungengrunderkrankung kann schwierig sein und ist aufgrund der unterschiedlichen Therapiestrategien Expertenzentren vorbehalten.
Keywords	Lungenerkankungen ; PAH ; pulmonale Hypertonie ; pulmonary hypertension ; lung disease ; PAH
Language	German
Publishing date	2023-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2654127-0
ISSN	2193-5211 ; 2193-5203
ISSN (online)	2193-5211
ISSN	2193-5203
DOI	10.1055/a-1989-1785
Database	Thieme publisher's database

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Article ; Online: Impact of short-term pausing of oral corticosteroids on blood eosinophil count in patients with severe asthma.

Biener, Leonie / Milger, Katrin / Suhling, Hendrik / Korn, Stephanie / Pizarro, Carmen / Skowasch, Dirk

Pneumologie (Stuttgart, Germany)

2022 Volume 77, Issue 6, Page(s) 357–362

Abstract: Background: The peripheral blood eosinophil count (BEC) is a well-established and easily accessible biomarker for asthma patients and crucial for the therapeutic decision regarding monoclonal antibody (mAB) therapy. Oral corticosteroid therapy ... ...

Title translation	Auswirkungen einer kurzzeitigen Unterbrechung der oralen Kortikosteroidtherapie auf die Anzahl der Eosinophilen im Blut bei Patienten mit schwergradigem Asthma bronchiale.
Abstract	Background: The peripheral blood eosinophil count (BEC) is a well-established and easily accessible biomarker for asthma patients and crucial for the therapeutic decision regarding monoclonal antibody (mAB) therapy. Oral corticosteroid therapy frequently hinders the correct evaluation of BEC in patients with severe asthma, but a discontinuation of such therapy frequently comes along with severe side effects. Therefore, we examined the effect of a short 24-hour pause of OCS treatment on BEC in patients with severe asthma and followed-up whether patients with a then increased eosinophil count benefited from mAB-therapy, as expected. Methods: In this multicentre study we retrospectively included 24 patients with severe asthma and OCS therapy and determined their BEC count. Ten patients, where BEC count was obtained in the morning before taking medication (a de-facto 24-hour OCS pause), were assigned to group 1. Fourteen patients, where BEC was obtained after OCS tapering were assigned to group 2. Those who then received mAB treatment were followed up for treatment response (OCS dose, annual acute exacerbations, increase in forced expiratory volume in one second [FEV Results: We included 24 patients with a median age of 60.5 [IQR: 17.3] years. Regarding all baseline characteristics except FEV Conclusion: After just a short 24-hour pause of OCS therapy it was possible to demask a relevant eosinophilia in asthma patients, without risking severe side effects. In this manner, we enabled the possibility of achieving successful targeted mAB-therapy, according to the patient's individual asthma phenotype.
MeSH term(s)	Humans ; Eosinophils ; Anti-Asthmatic Agents/therapeutic use ; Retrospective Studies ; Asthma/diagnosis ; Asthma/drug therapy ; Adrenal Cortex Hormones ; Eosinophilia/drug therapy
Chemical Substances	Anti-Asthmatic Agents ; Adrenal Cortex Hormones
Language	English
Publishing date	2022-11-16
Publishing country	Germany
Document type	Multicenter Study ; Journal Article
ZDB-ID	607630-0
ISSN	1438-8790 ; 0934-8387
ISSN (online)	1438-8790
ISSN	0934-8387
DOI	10.1055/a-1956-8800
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Article ; Online: Impact of interstitial lung disease on left ventricular myocardial function.

Stumpf, Max Jonathan / Wirtz, Marina Michaela Luise / Fleddermann, Max Fabian / Biener, Leonie / Weinhold, Leonie / Weber, Marcel / Schaefer, Christian Alexander / Nickenig, Georg / Skowasch, Dirk / Pizarro, Carmen

PloS one

2024 Volume 19, Issue 2, Page(s) e0286423

Abstract: Background: Interstitial lung disease (ILD) comprises a wide variety of pulmonary parenchymal disorders within which progressive fibrosing ILD (PF-ILD) constitutes a phenotypic subset. By use of speckle tracking-based strain analysis we aimed to ... ...

Abstract	Background: Interstitial lung disease (ILD) comprises a wide variety of pulmonary parenchymal disorders within which progressive fibrosing ILD (PF-ILD) constitutes a phenotypic subset. By use of speckle tracking-based strain analysis we aimed to evaluate the degree of left ventricular (LV) dysfunction in progressive vs. non-progressive fibrosing ILD (non-PF-ILD). Methods: A total of 99 ILD patients (mean age 63.7 ± 13.5 years, 37.4% female), composed of 50 PF-ILD and 49 non-PF-ILD patients, and 33 controls were prospectively enrolled and underwent conventional and speckle tracking echocardiography. Additional laboratory and pulmonary function testing, as well as six-minute walk test were performed. Results: As compared to the non-PF-ILD cohort, PF-ILD patients exhibited a significantly impaired forced vital capacity (2.4 ± 1.0l vs. 3.1 ± 0.9l, p = 0.002), diffusion capacity for carbon monoxide (DLCO, 25.6 ± 16.3% predicted vs. 43.6 ± 16.67% predicted, p <0.001) and exercise capacity response as measured by the six-minute walk test distance (268.1 ± 178.2m vs. 432.6 ± 94.2m, p <0.001). Contrary to conventional echocardiographic LV parameters, both regional and global longitudinal LV strain measurements were significantly altered in ILD patients as compared to controls. No differences in LV strain were found between both patient groups. Significant correlations were observed between global longitudinal strain, on the one hand, and systemic inflammation markers, total lung capacity (TLC) and DLCO, on the other hand (high-sensitivity C-reactive protein: Pearson´s r = -0.30, p< 0.001; interleukin-6: Pearson´s r = -0.26, p = 0.007; TLC % predicted: Pearson´s r = 0.22, p = 0.02; DLCO % predicted: Pearson´s r = 0.21, p = 0.02). Conclusions: ILD is accompanied by LV dysfunction. LV functionality inversely correlates with the severity of the restrictive ventilatory defect and inflammation marker levels. These observations support the assumption of persistent low-grade systemic inflammation that may link systemic cardiovascular function to ILD status.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Male ; Lung Diseases, Interstitial/complications ; Vital Capacity ; Ventricular Function, Left ; Respiratory Function Tests ; Ventricular Dysfunction, Left ; Inflammation/complications ; Lung ; Retrospective Studies
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0286423
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Article ; Online: 22-jähriger Mann mit Verdacht auf Lungenkrebs.

Biener, Leonie / Thomas, Daniel / Tolkach, Yuri / Skowasch, Dirk

Deutsche medizinische Wochenschrift (1946)

2019 Volume 144, Issue 1, Page(s) 13–14

Title translation	22-Year-Old Man with Suspected Lung Cancer.
MeSH term(s)	Adult ; Diagnosis, Differential ; Histocytochemistry ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Sarcoidosis, Pulmonary/diagnostic imaging ; Sarcoidosis, Pulmonary/pathology ; Tomography, X-Ray Computed ; Young Adult
Language	German
Publishing date	2019-01-02
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-0740-0117
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Article: Impact of short-term pausing of oral corticosteroids on blood eosinophil count in patients with severe asthma

Biener, Leonie / Milger, Katrin / Suhling, Hendrik / Korn, Stephanie / Pizarro, Carmen / Skowasch, Dirk

Pneumologie

2022 Volume 77, Issue 06, Page(s) 357–362

Abstract	Background: The peripheral blood eosinophil count (BEC) is a well-established and easily accessible biomarker for asthma patients and crucial for the therapeutic decision regarding monoclonal antibody (mAB) therapy. Oral corticosteroid therapy frequently hinders the correct evaluation of BEC in patients with severe asthma, but a discontinuation of such therapy frequently comes along with severe side effects. Therefore, we examined the effect of a short 24-hour pause of OCS treatment on BEC in patients with severe asthma and followed-up whether patients with a then increased eosinophil count benefited from mAB-therapy, as expected. Methods: In this multicentre study we retrospectively included 24 patients with severe asthma and OCS therapy and determined their BEC count. Ten patients, where BEC count was obtained in the morning before taking medication (a de-facto 24-hour OCS pause), were assigned to group 1. Fourteen patients, where BEC was obtained after OCS tapering were assigned to group 2. Those who then received mAB treatment were followed up for treatment response (OCS dose, annual acute exacerbations, increase in forced expiratory volume in one second [FEV 1 ] and asthma control test [ACT]) after ≥3 months. Results: We included 24 patients with a median age of 60.5 [IQR: 17.3] years. Regarding all baseline characteristics except FEV 1 (l), both groups did not differ significantly. Among all 24 patients, after pausing OCS therapy for 2 [5.5] days the BEC increased significantly from 125.0/μl [125] to 300/μl [232.5] (p<0.001). In both individual groups BEC increased significantly as well (150 [123] to 325 [305], p=0.005 and 70 [150] to 280 [255], p<0.001), with no significant difference for increase (BEC +170/µl [205.0] vs. +195 [222.5], p=0.886). Of all 24 patients, 13 (54.2%) reached eosinophil levels ≥300/µl, while 12 of them had not exceeded this threshold before. Subsequently, 20 patients (83.3%) received mAB-therapy with 55.5% demonstrating a good treatment response within 6 [1.5] months. The response rate in patients with BEC count ≥300/µl was even higher (75.0%). There was no difference in the treatment response rate between group 1 and 2 (p=0.092). Conclusion: After just a short 24-hour pause of OCS therapy it was possible to demask a relevant eosinophilia in asthma patients, without risking severe side effects. In this manner, we enabled the possibility of achieving successful targeted mAB-therapy, according to the patient’s individual asthma phenotype.
Keywords	Asthma ; Eosinophile ; Antikörper ; orale Kortikosteroide ; schwergradiges Asthma ; asthma ; blood eosinophils ; antibody therapy ; oral corticosteroid therapy ; severe asthma
Language	English
Publishing date	2022-11-16
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	607630-0
ISSN	1438-8790 ; 0934-8387
ISSN (online)	1438-8790
ISSN	0934-8387
DOI	10.1055/a-1956-8800
Database	Thieme publisher's database

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Article: High prevalence of peripheral and carotid artery disease in patients with interstitial lung diseases.

Stumpf, Max Jonathan / Fleddermann, Max Fabian / Wirtz, Marina Michaela Luise / Biener, Leonie / Weinhold, Leonie / Schahab, Nadjib / Weber, Marcel / Nickenig, Georg / Skowasch, Dirk / Schaefer, Christian Alexander / Pizarro, Carmen

VASA. Zeitschrift fur Gefasskrankheiten

2023 Volume 52, Issue 3, Page(s) 198–205

MeSH term(s)	Humans ; Pulmonary Fibrosis ; Prevalence ; Disease Progression ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/pathology ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/epidemiology
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	120977-2
ISSN	1664-2872 ; 0301-1526
ISSN (online)	1664-2872
ISSN	0301-1526
DOI	10.1024/0301-1526/a001068
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Article: 22-jähriger Mann mit Verdacht auf Lungenkrebs

Biener, Leonie / Thomas, Daniel / Tolkach, Yuri / Skowasch, Dirk

DMW - Deutsche Medizinische Wochenschrift

2019 Volume 144, Issue 01, Page(s) 13–14

Language	German
Publishing date	2019-01-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-0740-0117
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Article: Impact of prior smoking exposure and COPD comorbidity on treatment response to monoclonal antibodies in patients with severe asthma.

Morobeid, Heba / Pizarro, Carmen / Biener, Leonie / Ulrich-Merzenich, Gudrun / Kütting, Daniel / Nickenig, Georg / Skowasch, Dirk

ERJ open research

2021 Volume 7, Issue 3

Abstract: Patients suffering from severe asthma may benefit from an antibody treatment irrespective of their status as an ex- ... ...

Abstract	Patients suffering from severe asthma may benefit from an antibody treatment irrespective of their status as an ex-smoker
Language	English
Publishing date	2021-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00190-2021
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Article ; Online: Endoscopic Lung Volume Reduction in COPD: The Impact of Coil Implantation on Patients' Physical Activity.

Biener, Leonie / Skowasch, Dirk / Hollmann, Sophia / Schreiber, Tina / Nickenig, Georg / Fimmers, Rolf / Pizarro, Carmen

Respiration; international review of thoracic diseases

2019 Volume 99, Issue 2, Page(s) 177–180

Abstract: Endoscopic lung volume reduction (ELVR) is an emerging therapy option for the treatment of severe emphysema in COPD. To which extent patients profit from lung volume reduction via coils (LVRC) regarding morbidity, mortality, and quality of life is not ... ...

Abstract	Endoscopic lung volume reduction (ELVR) is an emerging therapy option for the treatment of severe emphysema in COPD. To which extent patients profit from lung volume reduction via coils (LVRC) regarding morbidity, mortality, and quality of life is not clear yet. In this monocentric prospective cohort study, 13 COPD patients with severe emphysema (residual volume [RV] >225%) were enrolled at the University Hospital of Bonn. Activity measurements were assessed by a validated accelerometer wristband. By LVRC, RV could be reduced by 0.13 L to 5.54 ± 1.29 L. We could show a clinically relevant improvement in patients' physical activity after LVRC, measured as daily step count (497.7 ± 72.6 vs. 1,913.7 ± 182.7 steps/day, p = 0.03) and mean daily active energy expenditure (714.4 ± 73.6 vs. 2,321.3 ± 163.9 joules, p = 0.03). This improvement in physical activity is possibly associated with a positive effect on patients' morbidity and mortality.
MeSH term(s)	Accelerometry ; Aged ; Bronchoscopy ; Cohort Studies ; Energy Metabolism ; Exercise ; Exercise Tolerance ; Female ; Humans ; Male ; Middle Aged ; Pneumonectomy ; Prospective Studies ; Prosthesis Implantation ; Pulmonary Emphysema/physiopathology ; Pulmonary Emphysema/surgery ; Residual Volume ; Treatment Outcome ; Walk Test
Language	English
Publishing date	2019-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000504678
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