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Book: Der Weg zum gesunden Huf

Biernat, Jochen / Rasch, Konstanze

die neue Huflehre

2003

Author's details	Jochen Biernat ; Konstanze Rasch
Language	German
Size	146 S. : Ill., graph. Darst.
Edition	2. Aufl.
Publisher	Müller Rüschlikon
Publishing place	Cham
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT015221685
ISBN	3-275-01469-2 ; 978-3-275-01469-9
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Shelf mark	Loan status	Location
078/936	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: A current view on Tau protein phosphorylation in Alzheimer's disease.

Wegmann, Susanne / Biernat, Jacek / Mandelkow, Eckhard

Current opinion in neurobiology

2021 Volume 69, Page(s) 131–138

Abstract: The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites. Tau in healthy neurons carries multiple phosphate groups, mostly in its ... ...

Abstract	The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites. Tau in healthy neurons carries multiple phosphate groups, mostly in its microtubule assembly domain. Elevated phosphorylation and aggregation of Tau are widely considered pathological hallmarks in Alzheimer's disease (AD) and other tauopathies, triggering the quest for Tau posttranslational modifications in the disease context. However, the phosphorylation patterns of physiological and pathological Tau are surprisingly similar and heterogenous, making it difficult to identify specific modifications as therapeutic targets and biomarkers for AD. We present a concise summary of - and view on - important previous and recent advances in Tau phosphorylation analysis in the context of AD.
MeSH term(s)	Alzheimer Disease ; Humans ; Phosphorylation ; Protein Processing, Post-Translational ; Tauopathies ; tau Proteins/metabolism
Chemical Substances	tau Proteins
Language	English
Publishing date	2021-04-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2021.03.003
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Article: Relationships between Heart Chamber Morphology or Function and Respiratory Parameters in Patients with HFrEF and Various Types of Sleep-Disordered Breathing.

Simionescu, Karolina / Łoboda, Danuta / Adamek, Mariusz / Wilczek, Jacek / Gibiński, Michał / Gardas, Rafał / Biernat, Jolanta / Gołba, Krzysztof S

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 21

Abstract: Sleep-disordered breathing (SDB), i.e., central sleep apnea (CSA) and obstructive sleep apnea (OSA), affects the prognosis of patients with heart failure with reduced ejection fraction (HFrEF). The study assessed the relationships between heart chamber ... ...

Abstract	Sleep-disordered breathing (SDB), i.e., central sleep apnea (CSA) and obstructive sleep apnea (OSA), affects the prognosis of patients with heart failure with reduced ejection fraction (HFrEF). The study assessed the relationships between heart chamber size or function and respiratory parameters in patients with HFrEF and various types of SDB. The 84 participants were patients aged 68.3 ± 8.4 years (80% men) with an average left ventricular ejection fraction (LVEF) of 25.5 ± 6.85% who qualified for cardioverter-defibrillator implantation with or without cardiac resynchronization therapy. SDB, defined by an apnea-hypopnea index (AHI) ≥ five events/hour, was diagnosed in 76 patients (90.5%); SDB was severe in 31 (36.9%), moderate in 26 (31.0%), and mild in 19 (22.6%). CSA was the most common type of SDB (64 patients, 76.2%). A direct proportional relationship existed only in the CSA group between LVEF or stroke volume (SV) and AHI (
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13213309
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Article ; Online: Transvenous lead extraction safety and efficacy in infected and noninfected patients using mechanical-only tools: Prospective registry from a high-volume center.

Gładysz-Wańha, Sylwia / Joniec, Michał / Wańha, Wojciech / Piłat, Eugeniusz / Drzewiecka, Anna / Gardas, Rafał / Biernat, Jolanta / Węglarzy, Andrzej / Gołba, Krzysztof S

Heart rhythm

2023 Volume 21, Issue 4, Page(s) 427–435

Abstract: Background: Transvenous lead extraction (TLE) is a well-established treatment option for patients with cardiac implantable electronic devices (CIED) complications.: Objective: The purpose of this study was to evaluate the safety and efficacy of TLE ... ...

Abstract	Background: Transvenous lead extraction (TLE) is a well-established treatment option for patients with cardiac implantable electronic devices (CIED) complications. Objective: The purpose of this study was to evaluate the safety and efficacy of TLE in CIED infection and non-CIED infection patients. Methods: Consecutive patients who underwent TLE between 2016 and 2022 entered the EXTRACT Registry. Models of prediction were constructed for periprocedural clinical and procedural success and the incidence of major complications, including death in 30 days. Results: The registry enrolled 504 patients (mean age 66.6 ± 12.8 years; 65.7% male). Complete procedural success was achieved in 474 patients (94.0%) and clinical success in 492 patients (97.6%). The total number of major and minor complications was 16 (3.2%) and 51 (10%), respectively. Three patients (0.6%) died during the procedure. New York Heart Association functional class IV and C-reactive protein levels defined before the procedure were independent predictors of any major complication, including death in 30 days in CIED infection patients. The time since the last preceding procedure and platelet count before the procedure were independent predictors of any major complication, including death in 30 days in non-CIED infection patients. Conclusions: TLE is safe and successfully performed in most patients, with a low major complication rate. CIED infection patients demonstrate better periprocedural clinical success and complete procedural success. However, CIED infection predicts higher 30-day mortality compared with non-CIED infection patients. Predictors of any major complication, including death in 30 days, differ between CIED infection and non-CIED infection patients.
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Female ; Pacemaker, Artificial/adverse effects ; Defibrillators, Implantable/adverse effects ; Treatment Outcome ; Device Removal/methods ; Heart Diseases/etiology ; Registries ; Retrospective Studies
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2023.12.015
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Article ; Online: Severe sleep apnea as a predictor of failure to respond to cardiac resynchronization therapy.

Łoboda, Danuta / Wilczek, Jacek / Simionescu, Karolina / Biernat, Jolanta / Jadczyk, Tomasz / Wojakowski, Wojciech / Gołba, Krzysztof S

Heart & lung : the journal of critical care

2023 Volume 59, Page(s) 102–108

Abstract: Background: The response to cardiac resynchronization therapy (CRT) is suboptimal in one-third of patients.: Objectives: The study aimed to evaluate the impact of sleep-disordered breathing (SDB) on the CRT-induced left ventricular (LV) reverse ... ...

Abstract	Background: The response to cardiac resynchronization therapy (CRT) is suboptimal in one-third of patients. Objectives: The study aimed to evaluate the impact of sleep-disordered breathing (SDB) on the CRT-induced left ventricular (LV) reverse remodeling and response for CRT in patients with ischemic congestive heart failure (CHF). Methods: A total of 37 patients aged 65.43 years (SD 6.05), seven of whom were females, were treated with CRT according to class I European Society of Cardiology recommendations. Clinical evaluation, polysomnography, and contrast echocardiography were performed twice during the six-month follow-up (6M-FU) to assess the effect of CRT. Results: In 33 patients (89.1%), sleep-disordered breathing (SDB), predominantly central sleep apnea (70.3%) was observed. This include nine patients (24.3%) with an apnea-hypopnea index (AHI) of >30 events/hour. During the 6M-FU, 16 patients (47.1%) responded to CRT by reducing LV end-systolic volume index (LVESVi) by ≥15%. We stated a directly proportional linear relationship between AHI value and LV volume: LVESVi p = 0.004, and LV end-diastolic volume index p = 0.006. Conclusions: Pre-existing severe SDB can impair the LV volumetric response to CRT even in an optimally selected group with class I indications for resynchronization, which may have an impact on long-term prognosis.
MeSH term(s)	Female ; Humans ; Male ; Cardiac Resynchronization Therapy ; Sleep Apnea Syndromes/therapy ; Heart Failure/complications ; Heart Failure/therapy ; Prognosis ; Echocardiography ; Ventricular Remodeling ; Treatment Outcome
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2023.01.018
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Article ; Online: Melanoma metastasis of the heart: Case report of an atypical metastatic location.

Sajdok, Mateusz / Kawa, Michał / Miszczyk, Marcin / Błach, Anna / Chrabański, Olgierd / Soral, Tomasz / Śmietana, Adam / Stadnik, Daniel / Musik, Paulina / Biernat, Jolanta / Deja, Marek / Gołba, Krzysztof S

Kardiologia polska

2024 Volume 81, Issue 12, Page(s) 1290–1292

MeSH term(s)	Humans ; Melanoma/pathology ; Heart Neoplasms/secondary
Language	English
Publishing date	2024-01-08
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/v.kp.97945
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Article: The Effects of His Bundle Pacing Compared to Classic Resynchronization Therapy in Patients with Pacing-Induced Cardiomyopathy.

Gardas, Rafal / Golba, Krzysztof S / Soral, Tomasz / Biernat, Jolanta / Kulesza, Piotr / Sajdok, Mateusz / Zub, Kamil

Journal of clinical medicine

2022 Volume 11, Issue 19

Abstract: Pacing-induced cardiomyopathy (PICM) is among the most common right ventricular pacing complications. Upgrading to cardiac resynchronization therapy (CRT) is the recommended treatment option. Conduction system pacing with His bundle pacing (HBP) has the ... ...

Abstract	Pacing-induced cardiomyopathy (PICM) is among the most common right ventricular pacing complications. Upgrading to cardiac resynchronization therapy (CRT) is the recommended treatment option. Conduction system pacing with His bundle pacing (HBP) has the potential to restore synchronous ventricular activation and can be an alternative to biventricular pacing (BVP). Patients with PICM scheduled for a system upgrade to CRT were included in the prospective cohort study. Either HBP or BVP was used for CRT. Electrocardiographic, clinical, and echocardiographic measurements were recorded at baseline and six-month follow-up. HBP was successful in 44 of 53 patients (83%). Thirty-nine patients with HBP and 22 with BVP completed a 6-month follow-up. HBP led to a higher reduction in QRS duration than BVP, 118.3 ± 14.20 ms vs. 150.5 ± 18.64 ms, p < 0.0001. The improvement in New York Heart Association (NYHA) class by one or two was more common in patients with HBP than those with BiV (p = 0.04). Left ventricular ejection fraction (LVEF) improved in BVP patients from 32.9 ± 7.93% to 43.9 ± 8.07%, p < 0.0001, and in HBP patients from 34.9 ± 6.45% to 48.6 ± 7.73%, p < 0.0001. The improvement in LVEF was more considerable in HBP patients than in BVP patients, p = 0.019. The improvement in clinical outcomes and left ventricle reverse remodeling was more significant with HBP than BVP. HBP can be a valid alternative to BVP for upgrade procedures in PICM patients.
Language	English
Publishing date	2022-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11195723
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Article ; Online: The usefulness of His bundle pacing in a heterogeneous population of patients with impaired left ventricular systolic function.

Gardas, Rafal / Golba, Krzysztof S / Loboda, Danuta / Biernat, Jolanta / Soral, Tomasz / Kulesza, Piotr / Sajdok, Mateusz / Zub, Kamil

Cardiology journal

2022

Abstract: Background: His bundle pacing (HBP) maintains a physiological activation pattern of ventricular activation, and in patients with intraventricular conduction delay (IVCD) it can normalize wide QRS duration.: Methods: A total of 181 patients from the ... ...

Abstract	Background: His bundle pacing (HBP) maintains a physiological activation pattern of ventricular activation, and in patients with intraventricular conduction delay (IVCD) it can normalize wide QRS duration. Methods: A total of 181 patients from the HBP registry were enrolled into a the study, which was conducted at the Department of Electrocardiology in Katowice, Poland. The patients had left ventricular ejection fraction (LVEF) < 50% and were implanted between November 2015 and April 2019. The HBP indications were as follows: 1) bradycardia and atrioventricular conduction disturbances with expected high pacing burden, 2) IVCD, LVEF ≤ 35%, with an indication for resynchronization therapy, 3) the need to upgrade to resynchronization therapy due to pacing-induced cardiomyopathy. Pacing parameters and echocardiographic and clinical data were assessed for up to 2 years of follow-up (FU). Results: His bundle pacing was successful in 154 (85.1%) patients. Eighty-two patients completed a 6-month FU. The mean age was 70.6 ± 9.23 years, and 79% were males. At 6 months FU LVEF improved from 35.3 ± 8.22% to 43.1 ± 10.14% (p < 0.0001), and indexed left ventricular end-systolic volume (LVESVi) decreased from 63.1 ± 25.21 mL/m² to 51.9 ± 22.79 mL/m² (p < 0.0001). In 53.1%, the LVESVi reduction was greater than 15%. The improvement in LVEF and LVESVi was also observed after 24 months of FU. Conclusions: His bundle pacing in permanently paced patients when LVEF is reduced below 50% is associated with improvement in LVEF and reverse left ventricle remodeling.
Language	English
Publishing date	2022-08-23
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2488680-4
ISSN	1898-018X ; 1897-5593
ISSN (online)	1898-018X
ISSN	1897-5593
DOI	10.5603/CJ.a2022.0079
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Article ; Online: Socioeconomic status and cardiovascular health in the changing world.

Gołba, Krzysztof S / Biernat, Jolanta

Cardiology journal

2015 Volume 22, Issue 5, Page(s) 477–478

MeSH term(s)	Cardiovascular Diseases ; Health Status ; Humans ; Risk Factors ; Social Class ; Socioeconomic Factors
Language	English
Publishing date	2015
Publishing country	Poland
Document type	Comment ; Editorial
ZDB-ID	2488680-4
ISSN	1897-5593 ; 1897-5593
ISSN (online)	1897-5593
ISSN	1897-5593
DOI	10.5603/CJ.2015.0066
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Article ; Online: Disease-Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates.

Savastano, Adriana / Flores, David / Kadavath, Harindranath / Biernat, Jacek / Mandelkow, Eckhard / Zweckstetter, Markus

Angewandte Chemie (International ed. in English)

2020 Volume 60, Issue 2, Page(s) 726–730

Abstract: Cellular condensation of intrinsically disordered proteins (IDPs) through liquid-liquid phase separation (LLPS) allows dynamic compartmentalization and regulation of biological processes. The IDP tau, which promotes the assembly of microtubules and is ... ...

Abstract	Cellular condensation of intrinsically disordered proteins (IDPs) through liquid-liquid phase separation (LLPS) allows dynamic compartmentalization and regulation of biological processes. The IDP tau, which promotes the assembly of microtubules and is hyperphosphorylated in Alzheimer's disease, undergoes LLPS in solution and on the surface of microtubules. Little is known, however, about the influence of tau phosphorylation on its ability to nucleate microtubule bundles in conditions of tau LLPS. Herein, we show that unmodified tau as well as tau phosphorylated at disease-associated epitopes condense into liquid-like droplets. Although tubulin partitioned into and reached high concentrations inside all tau droplets, it was unable to grow into microtubules form the inside of droplets formed by tau phosphorylated at the AT180 epitope (T231/S235). In contrast, neither phosphorylation of tau in the repeat domain nor at its tyrosine residues inhibited the assembly of tubulin from tau droplets. Because LLPS of IDPs has been shown to promote different types of cytoskeletal assembly, our study suggests that IDP phosphorylation might be a broadly used mechanism for the modulation of condensate-mediated cytoskeletal assembly.
MeSH term(s)	Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Humans ; Microscopy, Fluorescence ; Mutagenesis, Site-Directed ; Nuclear Magnetic Resonance, Biomolecular ; Phosphorylation ; Protein Binding ; Tubulin/chemistry ; Tubulin/metabolism ; tau Proteins/chemistry ; tau Proteins/genetics ; tau Proteins/metabolism
Chemical Substances	Tubulin ; tau Proteins
Language	English
Publishing date	2020-11-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202011157
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