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Article: Primary Cutaneous CD30-Positive Lymphoproliferative Disorders-Current Therapeutic Approaches with a Focus on Brentuximab Vedotin.

Stein, Tomasz / Robak, Tadeusz / Biernat, Wojciech / Robak, Ewa

2024 Volume 13, Issue 3

Abstract: One of the most common subgroups of cutaneous T-cell lymphomas is that of primary cutaneous CD30-positive lymphoproliferative disorders. The group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL), as ... ...

Abstract	One of the most common subgroups of cutaneous T-cell lymphomas is that of primary cutaneous CD30-positive lymphoproliferative disorders. The group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL), as well as some borderline cases. Recently, significant progress has been made in understanding the genetics and treatment of these disorders. This review article summarises the clinical evidence supporting the current treatment options for these diseases. Recent years have seen the introduction of novel agents into clinical practice; most of these target CD30, such as anti-CD30 monoclonal antibodies and conjugated antibodies (brentuximab vedotin), bispecific antibodies and cellular therapies, particularly anti-CD30 CAR-T cells. This paper briefly reviews the biology of CD30 that makes it a good therapeutic target and describes the anti-CD30 therapies that have emerged to date.
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030823
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Article: Great mimicker - a case of occult melanoma displaying ganglioneuroblastic differentiation.

Skrzypkowska, Paulina / Kunc, Michał / Biernat, Wojciech

Contemporary oncology (Poznan, Poland)

2023 Volume 27, Issue 2, Page(s) 118–121

Abstract: Melanomas are known for their diverse morphological features, presenting a diagnostic challenge for pathologists. Uncommon variations of melanoma can exhibit distinct cytological and histomorphological characteristics, including ganglioneuroblastic ... ...

Abstract	Melanomas are known for their diverse morphological features, presenting a diagnostic challenge for pathologists. Uncommon variations of melanoma can exhibit distinct cytological and histomorphological characteristics, including ganglioneuroblastic differentiation. However, this phenomenon is extremely rare, with only a few documented cases. Here, we present a unique case of an occult metastatic melanoma with ganglioneuroblastic differentiation developing in a 76-year-old male. The diagnosis was based on histopathology, immunophenotyping, and molecular testing, which revealed SOX10 positivity and an NRAS mutation. Notably, classic melanoma markers HMB45 and melan-A were negative, highlighting the importance of considering alternative markers. This case emphasizes the significance of immunohistochemistry and molecular investigation in diagnosing melanomas with unusual features and identifying appropriate candidates for immune checkpoint therapy. Additionally, the occurrence of ganglioneuroblastic differentiation further supports a shared histogenetic origin from the neural crest. Improved understanding of such rare variants contributes to accurate diagnosis and optimal management of melanoma patients.
Language	English
Publishing date	2023-08-22
Publishing country	Poland
Document type	Case Reports
ISSN	1428-2526
ISSN	1428-2526
DOI	10.5114/wo.2023.130966
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Article ; Online: Diagnostic test accuracy meta-analysis of PRAME in distinguishing primary cutaneous melanomas from benign melanocytic lesions.

Kunc, Michał / Żemierowska, Natalia / Skowronek, Filip / Biernat, Wojciech

Histopathology

2023 Volume 83, Issue 1, Page(s) 3–14

Abstract: PRAME is a novel immunohistochemical marker that aids the diagnosis of melanocytic lesions. Diffuse PRAME positivity suggests melanoma, whereas benign naevi are negative or only weakly positive. However, the factual diagnostic accuracy of PRAME is not ... ...

Abstract	PRAME is a novel immunohistochemical marker that aids the diagnosis of melanocytic lesions. Diffuse PRAME positivity suggests melanoma, whereas benign naevi are negative or only weakly positive. However, the factual diagnostic accuracy of PRAME is not well established. Moreover, some studies have suggested that the threshold of 3+/50% positive cells may be more useful in practice than the most widely used cut-off (4+/75% of positive cells). Hence, we performed a systematic review and diagnostic accuracy meta-analysis to evaluate sensitivity, specificity, likelihood ratios and optimal threshold for PRAME in distinguishing benign melanocytic proliferations from melanomas. Twenty-six studies were enrolled into the meta-analysis. A total of 2915 melanocytic lesions were analysed. The optimal threshold for PRAME positivity was estimated at 3.11, which translates into 3+ in practice. Sensitivity and specificity calculated from SROC at the 3+ threshold were 0.735 (0.631-0.818) and 0.915 (0.834-0.958), respectively, compared to 0.679 (0.559-0.957) and 0.957 (0.908-0.981) at the 4+ cut-off. In subgroup analysis, the spitzoid subgroup was characterised by the lowest sensitivity and diagnostic odds ratio of PRAME. Our findings indicate that PRAME immunohistochemistry may serve as an ancillary marker to support the diagnosis of melanoma. Nevertheless, the accuracy of PRAME may be lower in spitzoid neoplasms. Our meta-analysis suggests that the 3+/50% threshold might be more useful in practice than the 4+/75% cut-off, as it shows higher sensitivity with retained satisfactory specificity.
MeSH term(s)	Humans ; Melanoma/diagnosis ; Melanoma/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Melanocytes/pathology ; Diagnostic Tests, Routine ; Antigens, Neoplasm/analysis ; Melanoma, Cutaneous Malignant
Chemical Substances	Antigens, Neoplasm ; PRAME protein, human
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.14904
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Article: Skene's gland adenocarcinoma coexisting with infiltrating urothelial carcinoma of the urinary bladder.

Kunc, Michał / Biernat, Wojciech

Polish journal of pathology : official journal of the Polish Society of Pathologists

2021 Volume 72, Issue 2, Page(s) 170–173

Abstract: A 78-year-old woman underwent radical cystectomy due to high-grade infiltrating urothelial carcinoma of the urinary bladder. Histopathological examination of the bladder neck revealed coincidental urothelial carcinoma and tubular neoplasm resembling ... ...

Abstract	A 78-year-old woman underwent radical cystectomy due to high-grade infiltrating urothelial carcinoma of the urinary bladder. Histopathological examination of the bladder neck revealed coincidental urothelial carcinoma and tubular neoplasm resembling prostatic acinar adenocarcinoma. The latter was accompanied by a non-invasive component showing features of high-grade prostatic intraepithelial neoplasia (PIN). The lesion showed immunopositivity for prostate-specific antigen, prostein, and androgen receptor. The diagnosis of Skene's gland adenocarcinoma (SGA) was established. This is the 14th case of SGA in the literature, and the first coexisting with urothelial carcinoma. Our case demonstrates a possible origin of SGA from precursors resembling PIN.
MeSH term(s)	Adenocarcinoma ; Aged ; Carcinoma, Transitional Cell ; Humans ; Male ; Prostatic Neoplasms ; Urethral Neoplasms ; Urinary Bladder Neoplasms
Language	English
Publishing date	2021-09-24
Publishing country	Poland
Document type	Case Reports
ZDB-ID	1283064-1
ISSN	1233-9687 ; 0031-3114
ISSN	1233-9687 ; 0031-3114
DOI	10.5114/pjp.2021.109520
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Article: Juvenile psammomatoid ossifying fibroma.

Radzki, Dominik / Szade, Jolanta / Nowicki, Tomasz / Biernat, Wojciech

Polish journal of pathology : official journal of the Polish Society of Pathologists

2022 Volume 72, Issue 3, Page(s) 277–281

Abstract: Juvenile psammomatoid ossifying fibroma (JPOF) is an uncommon benign and locally aggressive tumor. We report an unusual head tumour with extremely rare extensiveness and aggressivness. The patient was 18-year-old female with three-day-lasting headache ... ...

Abstract	Juvenile psammomatoid ossifying fibroma (JPOF) is an uncommon benign and locally aggressive tumor. We report an unusual head tumour with extremely rare extensiveness and aggressivness. The patient was 18-year-old female with three-day-lasting headache and repetitive oral bleeding. Computed tomography revealed a large, well-circumscribed, expansile mass occupying ethmoid cells, nasal cavities and ventral part of the sphenoid sinus, with extention into the anterior cranial fossa. Pterional craniotomy was carried out. On one-year follow-up recurrence of the lesion was identified and the second surgery was performed. The lesion is under supervision now, due to incomplete removal.
MeSH term(s)	Adolescent ; Bone Neoplasms ; Female ; Fibroma, Ossifying/diagnostic imaging ; Fibroma, Ossifying/surgery ; Humans ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-01-20
Publishing country	Poland
Document type	Case Reports
ZDB-ID	1283064-1
ISSN	1233-9687 ; 0031-3114
ISSN	1233-9687 ; 0031-3114
DOI	10.5114/pjp.2021.111779
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Article: Lost but Not Least-Novel Insights into Progesterone Receptor Loss in Estrogen Receptor-Positive Breast Cancer.

Kunc, Michał / Popęda, Marta / Biernat, Wojciech / Senkus, Elżbieta

Cancers

2021 Volume 13, Issue 19

Abstract: Estrogen receptor α (ERα) and progesterone receptor (PgR) are crucial prognostic and predictive biomarkers that are usually co-expressed in breast cancer (BC). However, 12-24% of BCs present ERα(+)/PgR(-) phenotype at immunohistochemical evaluation. In ... ...

Abstract	Estrogen receptor α (ERα) and progesterone receptor (PgR) are crucial prognostic and predictive biomarkers that are usually co-expressed in breast cancer (BC). However, 12-24% of BCs present ERα(+)/PgR(-) phenotype at immunohistochemical evaluation. In fact, BC may either show primary PgR(-) status (in chemonaïve tumor sample), lose PgR expression during neoadjuvant treatment, or acquire PgR(-) phenotype in local relapse or metastasis. The loss of PgR expression in ERα(+) breast cancer may signify resistance to endocrine therapy and poorer outcomes. On the other hand, ERα(+)/PgR(-) BCs may have a better response to neoadjuvant chemotherapy than double-positive tumors. Loss of PgR expression may be a result of pre-transcriptional alterations (copy number loss, mutation, epigenetic modifications), decreased transcription of the
Language	English
Publishing date	2021-09-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13194755
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Article: Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.

Pęksa, Rafał / Kunc, Michał / Bieńkowski, Michał / Popęda, Marta / Biernat, Wojciech

Polish journal of pathology : official journal of the Polish Society of Pathologists

2022 Volume 73, Issue 2, Page(s) 159–165

Abstract: Terminal deoxynucleotidyl transferase (TdT) is a unique type of DNA polymerase predominantly expressed in precursor lymphoid cells and acute lymphoblastic leukemia. It participates in the junctional diversity of T-cell receptors and immunoglobulins. ... ...

Abstract	Terminal deoxynucleotidyl transferase (TdT) is a unique type of DNA polymerase predominantly expressed in precursor lymphoid cells and acute lymphoblastic leukemia. It participates in the junctional diversity of T-cell receptors and immunoglobulins. Recently, aberrant TdT expression was found in seminomas. Here, we evaluated the expression of TdT in our cohort of germ cell tumors (GCTs) with two anti-TdT antibody clones. We included 173 cases of testicular GCTs, 5 ovarian dysgerminomas, and one gonadoblastoma in the study. Tissue microarrays containing representative tumor samples were constructed and subsequently stained with anti-TdT monoclonal rabbit antibody EP266 (Dako) and TdT rabbit polyclonal antibody (Cell Marque). Expression was assessed with the H-score. No specific nuclear reaction was observed for the polyclonal anti-TdT antibody. The H-score values varied between the histological subtypes for the EP266 antibody. Positive nuclear staining was consistently seen in germ cell neoplasia in situ , seminoma, dysgerminoma, and embryonal carcinoma. Pure tumors had higher TdT H-scores than the mixed ones. Teratomas, yolk sac tumors, and choriocarcinomas were almost uniformly negative. Our study confirms that aberrant expression of TdT by testicular and ovarian GCTs exemplifies a potential diagnostic pitfall in histopathological diagnostics.
MeSH term(s)	Humans ; Male ; Female ; Animals ; Rabbits ; DNA Nucleotidylexotransferase ; Immunohistochemistry ; Biomarkers, Tumor ; Neoplasms, Germ Cell and Embryonal ; Testicular Neoplasms/diagnosis ; Dysgerminoma ; Ovarian Neoplasms/pathology ; DNA-Directed DNA Polymerase
Chemical Substances	DNA Nucleotidylexotransferase (EC 2.7.7.31) ; Biomarkers, Tumor ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
Language	English
Publishing date	2022-11-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1283064-1
ISSN	1233-9687 ; 0031-3114
ISSN	1233-9687 ; 0031-3114
DOI	10.5114/pjp.2022.120098
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Article: Assessment of Cytological Changes in the Oral Mucosa in Young Hematological Patients Treated with Systemic Chemotherapy.

Fiwek, Paula / Irga-Jaworska, Ninela / Wojtylak, Szymon / Biernat, Wojciech / Emerich, Katarzyna / Pomiecko, Dagmara

Journal of clinical medicine

2023 Volume 12, Issue 7

Abstract: Background and objectives: The primary objective of the undertaken study was to determine the morphological changes that occur within the oral epithelium in children undergoing chemotherapy following a diagnosis of hematological malignancies.: ... ...

Abstract	Background and objectives: The primary objective of the undertaken study was to determine the morphological changes that occur within the oral epithelium in children undergoing chemotherapy following a diagnosis of hematological malignancies. Materials and methods: The study group consisted of 18 patients diagnosed with leukemia or lymphoma undergoing treatment with chemotherapy. Swabs (liquid-based cytology) were collected from the oral cavity for microscopic evaluation at baseline, during the chemotherapy cycle with oral mucositis symptoms present, and upon completion of the cycle. Both the neutrophil count and oral mucositis (OM) were registered using the WHO (World Health Organization) scale. The control group included 41 children who were generally healthy. All samples underwent microscopical analyses at the Department of Pathology, Medical University of Gdansk, Poland. Results: A total of 190 cytological preparations were evaluated. The baseline preparations revealed similar cytological images, and the superficial cells of the epithelial layers were seen. A significant ( Conclusions: A decrease in the percentage of superficial epithelial cells with a corresponding increase in the number of intermediate epithelial cells is considered to be a result of toxic damage to the oral mucosa during chemotherapy.
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12072665
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Article ; Online: Carcinoma Cuniculatum of the Lower Leg: A Case Report and Proposed Diagnostic Criteria.

Kunc, Michał / Biernat, Wojciech

The American Journal of dermatopathology

2019 Volume 41, Issue 11, Page(s) 855–857

Abstract: Carcinoma cuniculatum is an infrequent variant of squamous cell carcinoma described for the first time by Ian Aird in 1954. Since then, multiple reports of cutaneous carcinoma cuniculatum have been published at various sites, including palms, soles, ... ...

Abstract	Carcinoma cuniculatum is an infrequent variant of squamous cell carcinoma described for the first time by Ian Aird in 1954. Since then, multiple reports of cutaneous carcinoma cuniculatum have been published at various sites, including palms, soles, buttocks, and lower legs, but most of them did not match to original description. In the current study, we report a unique case of a 69-year-old woman with carcinoma cuniculatum arising in the calf. Moreover, we update the histopathological criteria of cutaneous carcinoma cuniculatum by combining the literature descriptions and the experiences from the current case.
MeSH term(s)	Aged ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Leg ; Skin Neoplasms/pathology
Language	English
Publishing date	2019-09-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000001457
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Article: Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus.

Zapała, Łukasz / Kunc, Michał / Sharma, Sumit / Biernat, Wojciech / Radziszewski, Piotr

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 11

Abstract: The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous ... ...

Abstract	The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous tumor thrombus. The respective data of 91 patients treated with radical surgery in the years 2012-2021 in 2 tertiary referral urological centers were retrieved from local medical databases. Mean calculated 3-year overall survival (OS) reached 70% (mean follow-up 35.3 months). The association between lower LMR and the presence of tumor necrosis (
Language	English
Publishing date	2021-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11112159
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