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  1. Article ; Online: Th17/Treg imbalance in patients with primary hyperaldosteronism and resistant hypertension.

    Imiela, Anna M / Mikołajczyk, Tomasz P / Siedliński, Mateusz / Dobrowolski, Piotr / Konior-Rozlachowska, Anna / Wróbel, Aleksandra / Biernat-Kałuża, Edyta / Januszewicz, Magdalena / Guzik, Bartłomiej / Guzik, Tomasz J / Januszewicz, Andrzej / Prejbisz, Aleksander

    Polish archives of internal medicine

    2021  Volume 132, Issue 3

    Abstract: Introduction: Inflammation plays a pivotal role in blood pressure regulation. Data on experimental models of hypertension and hypertensive patients reflect the imbalance between T regulatory (Treg) and Th17 effector cells (Th17).: Objectives: The aim ...

    Abstract Introduction: Inflammation plays a pivotal role in blood pressure regulation. Data on experimental models of hypertension and hypertensive patients reflect the imbalance between T regulatory (Treg) and Th17 effector cells (Th17).
    Objectives: The aim of this study was to quantify peripheral blood Treg lymphocytes and Th17 subsets in individuals with primary hyperaldosteronism (PHA) and resistant hypertension (RHT) presenting with elevated blood pressure levels and augmented cardiovascular risk when compared with normotensive controls (CTRL).
    Patients and methods: Twenty CTRL participants, 21 patients with PHA, and 20 patients with RHT were enrolled. Plasma renin and angiotensin II, serum aldosterone concentration, ambulatory blood pressure monitoring (ABPM), echocardiography, clinical data, and phenotype of peripheral blood cells were assessed.
    Results: There were no statistically significant differences in terms of age and sex between the groups. Similar systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels in ABPM were observed in individuals with PHA and RHT. PHA patients had lower angiotensin II and 4‑fold higher aldosterone concentrations than CTRL patients. Both, PHA and RHT were associated with cardiac hypertrophy and coronary artery disease. RHT patients presented a significantly higher CD4+IL‑17A+ T cell number when compared with PHA and CTRL ones. The number of CD4+CD25+FOXP3+ T cells did not differ between patients with secondary hypertension and normotensive controls. Finally, positive correlations between the data on 24 h SBP and the content of CD4+IL‑17A+ and CD4+CD25+FOXP3+ in the PHA were found.
    Conclusions: Elevated 24 h SBP in PHA was associated with the increased numbers of CD4+IL‑17 and CD4+CD25+FOXP3+ T cells.
    MeSH term(s) Aldosterone ; Angiotensin II ; Blood Pressure Monitoring, Ambulatory ; Forkhead Transcription Factors/genetics ; Humans ; Hyperaldosteronism/complications ; Hypertension ; Interleukin-17 ; T-Lymphocytes, Regulatory
    Chemical Substances Forkhead Transcription Factors ; Interleukin-17 ; Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2021-12-10
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sex differences in trauma symptoms, body image and intensity of pain in a Polish sample of patients suffering from chronic pain.

    Rzeszutek, Marcin / Oniszczenko, Włodzimierz / Schier, Katarzyna / Biernat-Kałuża, Edyta / Gasik, Robert

    Psychology, health & medicine

    2016  Volume 21, Issue 7, Page(s) 827–835

    Abstract: The main goal of the current study was to investigate sex differences in the relationship between the level of trauma symptoms appearing in posttraumatic stress disorder (PTSD) and intensity of pain in a sample of 300 Polish patients suffering from ... ...

    Abstract The main goal of the current study was to investigate sex differences in the relationship between the level of trauma symptoms appearing in posttraumatic stress disorder (PTSD) and intensity of pain in a sample of 300 Polish patients suffering from chronic pain, specifically rheumatoid arthritis and lower back pain. We also focused on participants' body image with body esteem as a mediator. To assess the intensity of pain among participants, we used the Numerical Rating Scale. The level of trauma symptoms was assessed with the PTSD Factorial Version Inventory. To measure body image among participants, we used the Body Esteem Scale. The results of our study suggest that trauma symptoms and body image dimensions were significant predictors of pain intensity among men suffering from chronic pain. Moreover, trauma symptoms and age were significant predictors of pain intensity among women suffering from chronic pain. Finally, we demonstrated that sex differentiates the reaction to chronic pain.
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1477841-5
    ISSN 1465-3966 ; 1354-8506
    ISSN (online) 1465-3966
    ISSN 1354-8506
    DOI 10.1080/13548506.2015.1111393
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  3. Article ; Online: Pain intensity, temperament traits and social support as determinants of trauma symptoms in patients suffering from rheumatoid arthritis and low-back pain.

    Rzeszutek, Marcin / Oniszczenko, Włodzimierz / Schier, Katarzyna / Biernat-Kałuża, Edyta / Gasik, Robert

    International journal of rheumatic diseases

    2016  Volume 19, Issue 4, Page(s) 412–419

    Abstract: Aim: The main goal of our study was to investigate the relationship between age, duration of pain, pain intensity, temperament traits as postulated by the Regulative Theory of Temperament (RTT), social support dimensions and the level of trauma symptoms, ...

    Abstract Aim: The main goal of our study was to investigate the relationship between age, duration of pain, pain intensity, temperament traits as postulated by the Regulative Theory of Temperament (RTT), social support dimensions and the level of trauma symptoms, as appear in post-traumatic stress disorder (PTSD) in a sample of 300 patients suffering from chronic pain in two groups comprised of 150 patients with a clinical diagnosis of rheumatoid arthritis (RA) and 150 patients with a clinical diagnosis of low-back pain (LBP). They were analyzed together as a one group of 300 patients with chronic pain.
    Method: Temperament was measured with the Formal Characteristics of Behaviour - Temperament Inventory (FCB-TI). Social support was tested with the Berlin Social Support Scales (BSSS). The Numerical Rating Scale (NRS-11) was used to measure pain intensity. The level of trauma symptoms was assessed with the Post-Traumatic Stress Disorder Factorial Version Inventory (PTSDF).
    Results: The results of our study suggest that the intensity of pain, participants' age, Emotional Reactivity and Sensory Sensitivity as temperament traits, need for support, and actually received social support were related to the level of trauma symptoms. The sum of the squared semi-partial correlations showed that all six variables (age, pain intensity, Emotional Reactivity, Sensory Sensitivity, need for support and actually received support), account for 20% of the variance of general trauma symptoms level.
    Conclusion: The importance of temperament traits, social support and trauma symptoms should be taken into an account in psychotherapy accompanying pharmacotherapy for pain.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Arthralgia/diagnosis ; Arthralgia/physiopathology ; Arthralgia/psychology ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/physiopathology ; Arthritis, Rheumatoid/psychology ; Chronic Pain/diagnosis ; Chronic Pain/physiopathology ; Chronic Pain/psychology ; Cross-Sectional Studies ; Emotions ; Female ; Humans ; Low Back Pain/diagnosis ; Low Back Pain/physiopathology ; Low Back Pain/psychology ; Male ; Middle Aged ; Pain Measurement ; Pain Perception ; Pain Threshold ; Social Support ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/physiopathology ; Stress Disorders, Post-Traumatic/psychology ; Surveys and Questionnaires ; Temperament ; Time Factors ; Young Adult
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.12784
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  4. Article ; Online: Temperament traits, social support, and trauma symptoms among HIV/AIDS and chronic pain patients.

    Rzeszutek, Marcin / Oniszczenko, Włodzimierz / Schier, Katarzyna / Biernat-Kałuża, Edyta / Gasik, Robert

    International journal of clinical and health psychology : IJCHP

    2015  Volume 16, Issue 2, Page(s) 137–146

    Abstract: The main goal of our study was to investigate and compare the relationship between temperament traits postulated by the Regulative Theory of Temperament (RTT) and social support dimensions with the level of trauma symptoms, as appear in posttraumatic ... ...

    Abstract The main goal of our study was to investigate and compare the relationship between temperament traits postulated by the Regulative Theory of Temperament (RTT) and social support dimensions with the level of trauma symptoms, as appear in posttraumatic stress disorder (PTSD), in an HIV/AIDS patient sample [HIV+ (
    Language English
    Publishing date 2015-12-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2208162-8
    ISSN 2174-0852 ; 1697-2600
    ISSN (online) 2174-0852
    ISSN 1697-2600
    DOI 10.1016/j.ijchp.2015.10.001
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  5. Article ; Online: Gout, Hyperuricemia, and Crystal-Associated Disease Network Consensus Statement Regarding Labels and Definitions for Disease Elements in Gout.

    Bursill, David / Taylor, William J / Terkeltaub, Robert / Kuwabara, Masanari / Merriman, Tony R / Grainger, Rebecca / Pineda, Carlos / Louthrenoo, Worawit / Edwards, N Lawrence / Andrés, Mariano / Vargas-Santos, Ana Beatriz / Roddy, Edward / Pascart, Tristan / Lin, Ching-Tsai / Perez-Ruiz, Fernando / Tedeschi, Sara K / Kim, Seoyoung C / Harrold, Leslie R / McCarthy, Geraldine /
    Kumar, Nitin / Chapman, Peter T / Tausche, Anne-Kathrin / Vazquez-Mellado, Janitzia / Gutierrez, Marwin / da Rocha Castelar-Pinheiro, Geraldo / Richette, Pascal / Pascual, Eliseo / Fisher, Mark C / Burgos-Vargas, Ruben / Robinson, Philip C / Singh, Jasvinder A / Jansen, Tim L / Saag, Kenneth G / Slot, Ole / Uhlig, Tillmann / Solomon, Daniel H / Keenan, Robert T / Scire, Carlo Alberto / Biernat-Kaluza, Edyta / Dehlin, Mats / Nuki, George / Schlesinger, Naomi / Janssen, Matthijs / Stamp, Lisa K / Sivera, Francisca / Reginato, Anthony M / Jacobsson, Lennart / Lioté, Frédéric / Ea, Hang-Korng / Rosenthal, Ann / Bardin, Thomas / Choi, Hyon K / Hershfield, Michael S / Czegley, Christine / Choi, Sung Jae / Dalbeth, Nicola

    Arthritis care & research

    2018  Volume 71, Issue 3, Page(s) 427–434

    Abstract: Objective: The language currently used to describe gout lacks standardization. The aim of this project was to develop a consensus statement on the labels and definitions used to describe the basic disease elements of gout.: Methods: Experts in gout ( ... ...

    Abstract Objective: The language currently used to describe gout lacks standardization. The aim of this project was to develop a consensus statement on the labels and definitions used to describe the basic disease elements of gout.
    Methods: Experts in gout (n = 130) were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach consensus on the labeling and definitions for the basic disease elements of gout. Disease elements and labels in current use were derived from a content analysis of the contemporary medical literature, and the results of this analysis were used for item selection in the Delphi exercise and face-to-face consensus meeting.
    Results: There were 51 respondents to the Delphi exercise and 30 attendees at the face-to-face meeting. Consensus agreement (≥80%) was achieved for the labels of 8 disease elements through the Delphi exercise; the remaining 3 labels reached consensus agreement through the face-to-face consensus meeting. The agreed labels were monosodium urate crystals, urate, hyperuric(a)emia, tophus, subcutaneous tophus, gout flare, intercritical gout, chronic gouty arthritis, imaging evidence of monosodium urate crystal deposition, gouty bone erosion, and podagra. Participants at the face-to-face meeting achieved consensus agreement for the definitions of all 11 elements and a recommendation that the label "chronic gout" should not be used.
    Conclusion: Consensus agreement was achieved for the labels and definitions of 11 elements representing the fundamental components of gout etiology, pathophysiology, and clinical presentation. The Gout, Hyperuricemia, and Crystal-Associated Disease Network recommends the use of these labels when describing the basic disease elements of gout.
    MeSH term(s) Consensus ; Crystal Arthropathies/classification ; Crystal Arthropathies/diagnosis ; Delphi Technique ; Gout/classification ; Gout/diagnosis ; Humans ; Hyperuricemia/classification ; Hyperuricemia/diagnosis ; Uric Acid/analysis
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2018-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.23607
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  6. Article ; Online: Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout.

    Bursill, David / Taylor, William J / Terkeltaub, Robert / Abhishek, Abhishek / So, Alexander K / Vargas-Santos, Ana Beatriz / Gaffo, Angelo Lino / Rosenthal, Ann / Tausche, Anne-Kathrin / Reginato, Anthony / Manger, Bernhard / Sciré, Carlo / Pineda, Carlos / van Durme, Caroline / Lin, Ching-Tsai / Yin, Congcong / Albert, Daniel Arthur / Biernat-Kaluza, Edyta / Roddy, Edward /
    Pascual, Eliseo / Becce, Fabio / Perez-Ruiz, Fernando / Sivera, Francisca / Lioté, Frédéric / Schett, Georg / Nuki, George / Filippou, Georgios / McCarthy, Geraldine / da Rocha Castelar Pinheiro, Geraldo / Ea, Hang-Korng / Tupinambá, Helena De Almeida / Yamanaka, Hisashi / Choi, Hyon K / Mackay, James / ODell, James R / Vázquez Mellado, Janitzia / Singh, Jasvinder A / Fitzgerald, John D / Jacobsson, Lennart T H / Joosten, Leo / Harrold, Leslie R / Stamp, Lisa / Andrés, Mariano / Gutierrez, Marwin / Kuwabara, Masanari / Dehlin, Mats / Janssen, Matthijs / Doherty, Michael / Hershfield, Michael S / Pillinger, Michael / Edwards, N Lawrence / Schlesinger, Naomi / Kumar, Nitin / Slot, Ole / Ottaviani, Sebastien / Richette, Pascal / MacMullan, Paul A / Chapman, Peter T / Lipsky, Peter E / Robinson, Philip / Khanna, Puja P / Gancheva, Rada N / Grainger, Rebecca / Johnson, Richard J / Te Kampe, Ritch / Keenan, Robert T / Tedeschi, Sara K / Kim, Seoyoung / Choi, Sung Jae / Fields, Theodore R / Bardin, Thomas / Uhlig, Till / Jansen, Tim / Merriman, Tony / Pascart, Tristan / Neogi, Tuhina / Klück, Viola / Louthrenoo, Worawit / Dalbeth, Nicola

    Annals of the rheumatic diseases

    2019  Volume 78, Issue 11, Page(s) 1592–1600

    Abstract: Objective: There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.: Methods: A content analysis of ... ...

    Abstract Objective: There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout.
    Methods: A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions.
    Results: The content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus).
    Conclusion: Consensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.
    MeSH term(s) Consensus ; Gout/classification ; Humans ; Hyperuricemia/classification ; Terminology as Topic
    Language English
    Publishing date 2019-09-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2019-215933
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