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  1. Article ; Online: Clinical course and outcomes of patients with asthma hospitalized for severe acute respiratory syndrome coronavirus 2 pneumonia: A single-center, retrospective study.

    Lombardi, Carlo / Roca, Elena / Bigni, Barbara / Cottini, Marcello / Passalacqua, Giovanni

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 125, Issue 6, Page(s) 707–709

    MeSH term(s) Asthma/complications ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/therapy ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/virology ; Comorbidity ; Disease Management ; Disease Susceptibility ; Humans ; Patient Outcome Assessment ; Retrospective Studies ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-01
    Publishing country United States
    Document type Letter
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.07.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Takotsubo Syndrome Associated with COVID-19.

    Roca, Elena / Lombardi, Carlo / Campana, Marco / Vivaldi, Oscar / Bigni, Barbara / Bertozzi, Bruno / Passalacqua, Giovanni

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 5, Page(s) 1665

    Abstract: Objective: The availability of public health information for optimised supportive care is critical during the COVID-19 pandemic. We describe the first case of COVID-19 complicated by Takotsubo cardiomyopathy.: Materials and methods: We report the ... ...

    Abstract Objective: The availability of public health information for optimised supportive care is critical during the COVID-19 pandemic. We describe the first case of COVID-19 complicated by Takotsubo cardiomyopathy.
    Materials and methods: We report the clinical, laboratory and radiological findings of a patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
    Results: The nasopharyngeal swab was positive for SARS-CoV-2 and x-ray images demonstrated pathognomonic pneumonia. The patient developed tachycardia and the echocardiogram confirmed the diagnosis of Takotsubo cardiomyopathy.
    Conclusions: Doctors should be aware of the need to thoroughly study this new infection in order to understand its underlying mechanisms and related complications.
    Learning points: We report the first case of Takotsubo cardiomyopathy associated with COVID-19.We discuss a rare presentation in the current pandemic.COVID-19 can be associated with cardiac complications, even after the onset of pneumonia, and so strict monitoring of these patients is essential.
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bilateral carotid artery dissection in a SARS-CoV-2 infected patient: causality or coincidence?

    Morassi, Mauro / Bigni, Barbara / Cobelli, Milena / Giudice, Lodoviga / Bnà, Claudio / Vogrig, Alberto

    Journal of neurology

    2020  Volume 267, Issue 10, Page(s) 2812–2814

    MeSH term(s) Betacoronavirus ; Brain Neoplasms/complications ; COVID-19 ; Carotid Artery, Internal, Dissection/complications ; Coronavirus Infections/complications ; Humans ; Male ; Middle Aged ; Oligodendroglioma/complications ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-09984-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
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  4. Article: Clinical course and outcomes of patients with asthma hospitalized for severe acute respiratory syndrome coronavirus 2pneumonia: A single-center, retrospective study

    Lombardi, Carlo / Roca, Elena / Bigni, Barbara / Cottini, Marcello / Passalacqua, Giovanni

    Ann. allergy asthma immunol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #706116
    Database COVID19

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  5. Article ; Online: Asthmatic patients in COVID-19 outbreak: Few cases despite many cases.

    Caminati, Marco / Lombardi, Carlo / Micheletto, Claudio / Roca, Elena / Bigni, Barbara / Furci, Fabiana / Girelli, Domenico / Senna, Gianenrico / Crisafulli, Ernesto

    The Journal of allergy and clinical immunology

    2020  Volume 146, Issue 3, Page(s) 541–542

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Inpatients ; Pandemics ; Pneumonia, Viral ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2020.05.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.92: Show issues Location:
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  6. Article: Takotsubo syndrome associated with COVID-19

    Roca, Elena / Lombardi, Carlo / Campana, Marco / Vivaldi, Oscar / Bigni, Barbara / Bertozzi, Bruno / Passalacqua, Giovanni

    Eur. J. Case Rep. Intern. Med.

    Abstract: Objective: The availability of public health information for optimised supportive care is critical during the COVID-19 pandemic. We describe the first case of COVID-19 complicated by Takotsubo cardiomyopathy. Materials and Methods: We report the clinical, ...

    Abstract Objective: The availability of public health information for optimised supportive care is critical during the COVID-19 pandemic. We describe the first case of COVID-19 complicated by Takotsubo cardiomyopathy. Materials and Methods: We report the clinical, laboratory and radiological findings of a patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Results: The nasopharyngeal swab was positive for SARS-CoV-2 and x-ray images demonstrated pathognomonic pneumonia. The patient developed tachycardia and the echocardiogram confirmed the diagnosis of Takotsubo cardiomyopathy. Conclusions: Doctors should be aware of the need to thoroughly study this new infection in order to understand its underlying mechanisms and related complications.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #265273
    Database COVID19

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  7. Article: Bilateral carotid artery dissection in a SARS-CoV-2 infected patient: causality or coincidence?

    Morassi, Mauro / Bigni, Barbara / Cobelli, Milena / Giudice, Lodoviga / Bnà, Claudio / Vogrig, Alberto

    J Neurol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #596745
    Database COVID19

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  8. Article ; Online: Bilateral carotid artery dissection in a SARS-CoV-2 infected patient

    Morassi, Mauro / Bigni, Barbara / Cobelli, Milena / Giudice, Lodoviga / Bnà, Claudio / Vogrig, Alberto

    Journal of Neurology

    causality or coincidence?

    2020  Volume 267, Issue 10, Page(s) 2812–2814

    Keywords Neurology ; Clinical Neurology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-09984-0
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Immune and cellular damage biomarkers to predict COVID-19 mortality in hospitalized patients.

    Lombardi, Carlo / Roca, Elena / Bigni, Barbara / Bertozzi, Bruno / Ferrandina, Camillo / Franzin, Alberto / Vivaldi, Oscar / Cottini, Marcello / D'Alessio, Andrea / Del Poggio, Paolo / Conte, Gian Marco / Berti, Alvise

    Current research in immunology

    2021  Volume 2, Page(s) 155–162

    Abstract: Early prediction of COVID-19 in-hospital mortality relies usually on patients' preexisting comorbidities and is rarely reproducible in independent cohorts. We wanted to compare the role of routinely measured biomarkers of immunity, inflammation, and ... ...

    Abstract Early prediction of COVID-19 in-hospital mortality relies usually on patients' preexisting comorbidities and is rarely reproducible in independent cohorts. We wanted to compare the role of routinely measured biomarkers of immunity, inflammation, and cellular damage with preexisting comorbidities in eight different machine-learning models to predict mortality, and evaluate their performance in an independent population. We recruited and followed-up consecutive adult patients with SARS-Cov-2 infection in two different Italian hospitals. We predicted 60-day mortality in one cohort (development dataset, n = 299 patients, of which 80% was allocated to the development dataset and 20% to the training set) and retested the models in the second cohort (external validation dataset, n = 402). Demographic, clinical, and laboratory features at admission, treatments and disease outcomes were significantly different between the two cohorts. Notably, significant differences were observed for %lymphocytes (p < 0.05), international-normalized-ratio (p < 0.01), platelets, alanine-aminotransferase, creatinine (all p < 0.001). The primary outcome (60-day mortality) was 29.10% (n = 87) in the development dataset, and 39.55% (n = 159) in the external validation dataset. The performance of the 8 tested models on the external validation dataset were similar to that of the holdout test dataset, indicating that the models capture the key predictors of mortality. The shap analysis in both datasets showed that age, immune features (%lymphocytes, platelets) and LDH substantially impacted on all models' predictions, while creatinine and CRP varied among the different models. The model with the better performance was model 8 (60-day mortality AUROC 0.83 ± 0.06 in holdout test set, 0.79 ± 0.02 in external validation dataset). The features that had the greatest impact on this model's prediction were age, LDH, platelets, and %lymphocytes, more than comorbidities or inflammation markers, and these findings were highly consistent in both datasets, likely reflecting the virus effect at the very beginning of the disease.
    Language English
    Publishing date 2021-09-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2555
    ISSN (online) 2590-2555
    DOI 10.1016/j.crimmu.2021.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Asthmatic patients in COVID-19 outbreak: Few cases despite many cases

    Caminati, Marco / Lombardi, Carlo / Micheletto, Claudio / Roca, Elena / Bigni, Barbara / Furci, Fabiana / Girelli, Domenico / Senna, Gianenrico / Crisafulli, Ernesto

    J Allergy Clin Immunol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610654
    Database COVID19

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