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  1. Article: An alternative to radiation hybrid mapping for large-scale genome analysis in barley

    Masoudi-Nejad, A / Nasuda, S / Bihoreau, M.T / Waung, R / Endo, T.R

    Molecular genetics and genomics : MGG. 2005 Dec., v. 274, no. 6

    2005  

    Abstract: The presence of a monosomic gametocidal chromosome (GC) in a barley chromosome addition line of common wheat generates structural aberrations in the barley chromosome as well as in the wheat chromosomes of gametes lacking the GC. A collection of ... ...

    Abstract The presence of a monosomic gametocidal chromosome (GC) in a barley chromosome addition line of common wheat generates structural aberrations in the barley chromosome as well as in the wheat chromosomes of gametes lacking the GC. A collection of structurally aberrant barley chromosomes is analogous to a panel of radiation hybrid (RH) mapping and is valuable for high-throughput physical mapping. We developed 90 common wheat lines (GC lines) containing aberrant barley 7H chromosomes induced by a gametocidal chromosome, 2C. DNAs isolated from these GC lines provided a panel of 7H chromosomal fragments in a wheat genetic background, comparable with RH mapping panels in mammals. We used this 7H GC panel and the methodology for RH mapping to physically map PCR-based barley markers, SSRs and AFLPs, onto chromosome 7H, relying on polymorphism between the 7H chromosome and the wheat genome. We call this method GC mapping. This study describes a novel adaptation and combination of methods of inducing chromosomal rearrangements to produce physical maps of markers. The advantages of the presented method are similar to RH mapping in that non-polymorphic markers can be used and the mapping panels can be relatively easily obtained. In addition, mapping results are cumulative when using the same mapping set with new markers. The GC lines will be available from the National Bioresources Project-KOMUGI (http://www.nbrp.jp/index.jsp).
    Keywords Hordeum vulgare ; barley ; intergeneric hybridization ; Triticum aestivum ; wheat ; chromosome addition ; chromosome aberrations ; chromosomes ; physical chromosome mapping ; genetic markers ; microsatellite repeats ; amplified fragment length polymorphism ; loci
    Language English
    Dates of publication 2005-12
    Size p. 589-594.
    Document type Article
    ISSN 1617-4615
    DOI 10.1007/s00438-005-0052-1
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  2. Article ; Online: Genetic dissection of region around the Sa gene on rat chromosome 1: evidence for multiple loci affecting blood pressure.

    Frantz, S / Clemitson, J R / Bihoreau, M T / Gauguier, D / Samani, N J

    Hypertension (Dallas, Tex. : 1979)

    2001  Volume 38, Issue 2, Page(s) 216–221

    Abstract: A region with a major effect on blood pressure (BP) is located on rat chromosome 1 in the vicinity of the Sa gene, a candidate gene for BP regulation. Previously, we observed a single linkage peak for BP in this region in second filial generation rats ... ...

    Abstract A region with a major effect on blood pressure (BP) is located on rat chromosome 1 in the vicinity of the Sa gene, a candidate gene for BP regulation. Previously, we observed a single linkage peak for BP in this region in second filial generation rats derived from a cross of the spontaneously hypertensive rat (SHR) with the Wistar-Kyoto rat (WKY), and we have reported the isolation of the region containing the BP effect in reciprocal congenic strains (WKY.SHR-Sa) and (SHR.WKY-Sa) derived from these animals. Here, we report the further genetic dissection of this region. Two congenic substrains each were derived from WKY.SHR-Sa (WISA1 and WISA2) and SHR.WKY-Sa (SISA1 and SISA2) by backcrossing to WKY and SHR, respectively. Although there was some overlap of the introgressed regions retained in the various substrains, the segments in WISA1 and SISA1 did not overlap. Furthermore, although the Sa allele in WISA1, WISA2, and SISA2 remained donor in origin, recombination in SISA1 reverted it back to the recipient (SHR) allele. Surprisingly, all 4 substrains demonstrated a highly significant BP difference compared with that of their respective parental strain, which was of a magnitude similar to those seen in the original congenic strains. The findings strongly indicate that there are at least 2 quantitative trait loci (QTLs) affecting BP in this region of rat chromosome 1. Furthermore, the BP effect seen in SISA1 indicates that at least a proportion of the BP effect of this region of rat chromosome 1 cannot be due to the Sa gene. SISA1 contains an introgressed segment of <3 cM, and this will facilitate the physical mapping of the BP QTL(s) located within it and the identification of the susceptibility-conferring genes. Our observations serve to illustrate the complexity of QTL dissection and the care needed to interpret findings from congenic studies.
    MeSH term(s) Animals ; Animals, Congenic ; Blood Pressure ; Chromosome Mapping ; Coenzyme A Ligases ; Genes ; Genetic Predisposition to Disease ; Hypertension/genetics ; Proteins/genetics ; Quantitative Trait, Heritable ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY
    Chemical Substances Proteins ; Acsm3 protein, rat (EC 6.2.1.-) ; Coenzyme A Ligases (EC 6.2.1.-)
    Language English
    Publishing date 2001-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/01.hyp.38.2.216
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  3. Article: Linkage mapping of the neuronal nitric oxide synthase gene (Nos1) to rat chromosome 12.

    Deng, A Y / Rapp, J P / Kato, H / Bihoreau, M T

    Mammalian genome : official journal of the International Mammalian Genome Society

    1995  Volume 6, Issue 11, Page(s) 824

    MeSH term(s) Animals ; Base Sequence ; Chromosome Mapping ; Female ; Male ; Molecular Sequence Data ; Neurons/enzymology ; Nitric Oxide Synthase/genetics ; Polymerase Chain Reaction ; Rats
    Chemical Substances Nitric Oxide Synthase (EC 1.14.13.39)
    Language English
    Publishing date 1995-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/bf00539015
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  4. Article: Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.

    Wallis, R H / Wallace, K J / Collins, S C / McAteer, M / Argoud, K / Bihoreau, M T / Kaisaki, P J / Gauguier, D

    Diabetologia

    2004  Volume 47, Issue 6, Page(s) 1096–1106

    Abstract: Aims/hypothesis: Genetic investigations in the spontaneously diabetic (Type 2) Goto Kakizaki (GK) rat have identified quantitative trait loci (QTL) for diabetes-related phenotypes. The aims of this study were to refine the chromosomal mapping of a QTL ( ...

    Abstract Aims/hypothesis: Genetic investigations in the spontaneously diabetic (Type 2) Goto Kakizaki (GK) rat have identified quantitative trait loci (QTL) for diabetes-related phenotypes. The aims of this study were to refine the chromosomal mapping of a QTL ( Nidd/gk5) identified in chromosome 8 of the GK rat and to define a pathophysiological profile of GK gene variants underlying the QTL effects in congenics.
    Methods: Genetic linkage analysis was carried out with chromosome 8 markers genotyped in a GKxBN F2 intercross previously used to map diabetes QTL. Two congenic strains were designed to contain GK haplotypes in the region of Nidd/gk5 transferred onto a Brown Norway (BN) genetic background, and a broad spectrum of diabetes phenotypes were characterised in the animals.
    Results: Results from QTL mapping suggest that variations in glucose-stimulated insulin secretion in vivo, and in body weight are controlled by different chromosome 8 loci (LOD3.53; p=0.0004 and LOD4.19; p=0.00007, respectively). Extensive physiological screening in male and female congenics at 12 and 24 weeks revealed the existence of GK variants at the locus Nidd/gk5, independently responsible for significantly enhanced insulin secretion and increased levels of plasma triglycerides, phospholipids and HDL, LDL and total cholesterol. Sequence polymorphisms detected between the BN and GK strains in genes encoding ApoAI, AIV, CIII and Lipc do not account for these effects.
    Conclusions/interpretation: We refined the localisation of the QTL Nidd/gk5 and its pathophysiological characteristics in congenic strains derived for the locus. These congenic strains provide novel models for testing the contribution of a subset of GK alleles on diabetes phenotypes and for identifying diabetes susceptibility genes.
    MeSH term(s) Animals ; Animals, Congenic/genetics ; Animals, Congenic/metabolism ; Blood Glucose/analysis ; Body Weight ; Cholesterol/metabolism ; Chromosome Mapping/methods ; Chromosomes, Mammalian/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Disease Models, Animal ; Female ; Genetic Linkage/genetics ; Genetic Predisposition to Disease/genetics ; Genome ; Genotype ; Insulin/blood ; Insulin/metabolism ; Insulin Secretion ; Lipids/blood ; Male ; Molecular Sequence Data ; Phenotype ; Quantitative Trait Loci/genetics ; Rats ; Rats, Inbred BN/genetics ; Rats, Inbred BN/metabolism ; United Kingdom
    Chemical Substances Blood Glucose ; Insulin ; Lipids ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2004-05-26
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-004-1416-5
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  5. Article: Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats.

    Kato, N / Hyne, G / Bihoreau, M T / Gauguier, D / Lathrop, G M / Rapp, J P

    Mammalian genome : official journal of the International Mammalian Genome Society

    1999  Volume 10, Issue 3, Page(s) 259–265

    Abstract: The Dahl salt-sensitive rat is one of the principal animal models of hereditary hypertension. Genome-wide searches were undertaken to detect quantitative trait loci (QTLs) that influence blood pressure, cardiac mass, and body weight in four F2 ... ...

    Abstract The Dahl salt-sensitive rat is one of the principal animal models of hereditary hypertension. Genome-wide searches were undertaken to detect quantitative trait loci (QTLs) that influence blood pressure, cardiac mass, and body weight in four F2 populations derived from Dahl salt-sensitive rats and different inbred normotensive control strains of rat. We detected three QTLs associated with one or more of the phenotypes, using a stringent statistical criterion for linkage (p < 0.00003). These included a novel QTL linked to blood pressure on rat Chromosome (Chr) 12, and another QTL on rat Chr 3 linked to body weight. A QTL on rat Chr 10 for which linkage to blood pressure has been described in other crosses was found to be a principal determinant of blood pressure and cardiac mass in some but not all of the crosses examined here. Three other regions showed evidence of linkage to these phenotypes with a less stringent statistical criterion of linkage at QTLs previously reported in other studies. As part of our study, microsatellite markers have been developed for three candidate genes for investigation in hypertension, and the genes have been localized by linkage mapping. These are: the rat Gs alpha subunit (Gnas) gene, the alpha-1B adrenergic receptor (Adra1b), and the Na+, K+-ATPase beta2 subunit (Atp1b2) gene.
    MeSH term(s) Animals ; Base Sequence ; Blood Pressure/genetics ; DNA Primers ; Female ; Genetic Linkage ; Genotype ; Male ; Quantitative Trait, Heritable ; Rats ; Rats, Inbred Strains ; Species Specificity
    Chemical Substances DNA Primers
    Language English
    Publishing date 1999-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s003359900983
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  6. Article ; Online: Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes

    Esteve-Codina, A. / Hofer, T.P. / Burggraf, D. / Heiss-Neumann, M.S. / Gesierich, W. / Boland, A. / Olaso, R. / Bihoreau, M.-T. / Deleuze, J.-F. / Moeller, W. / Schmid, O. / Soler Artigas, M. / Renner, K. / Hohlfeld, J.M. / Welte, T. / Fuehner, T. / Jerrentrup, L. / Koczulla, A.R. / Greulich, T. /
    Prasse, A. / Müller-Quernheim, J. / Gupta, S. / Brightling, C. / Subramanian, D.R. / Parr, D.G. / Kolsum, U. / Gupta, V. / Barta, I. / Döme, B. / Strausz, J. / Stendardo, M. / Piattella, M. / Boschetto, P. / Korzybski, D. / Gorecka, D. / Nowinski, A. / Dabad, M. / Fernández-Callejo, M. / Endesfelder, D. / Castell, W. zu / Hiemstra, P.S. / Venge, P. / Noessner, E. / Griebel, T. / Heath, S. / Singh, D. / Gut, I. / Ziegler-Heitbrock, L.

    2021  

    Abstract: Art. 12848, 14 S. ... Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from ... ...

    Abstract Art. 12848, 14 S.

    Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from 312 stringently defined ex-smoker patients. Compared to healthy controls there were for males 40 differentially expressed genes (DEGs) and 73 DEGs for females with only 26 genes shared. The gene ontology (GO) term ""response to bacterium"" was shared, with several different DEGs contributing in males and females. Strongly upregulated genes TCN1 and CYP1B1 were unique to males and females, respectively. For male emphysema (E)-dominant and airway disease (A)-dominant COPD (defined by computed tomography) the term ""response to stress"" was found for both sub-phenotypes, but this included distinct up-regulated genes for the E-sub-phenotype (neutrophil-related CSF3R, CXCL1, MNDA) and for the A-sub-phenotype (macrophage-related KLF4, F3, CD36). In E-dominant disease, a cluster of mitochondria-encoded (MT) genes forms a signature, able to identify patients with emphysema features in a confirmation cohort. The MT-CO2 gene is upregulated transcriptionally in bronchial epithelial cells with the copy number essentially unchanged. Both MT-CO2 and the neutrophil chemoattractant CXCL1 are induced by reactive oxygen in bronchial epithelial cells. Of the female DEGs unique for E- and A-dominant COPD, 88% were detected in females only. In E-dominant disease we found a pronounced expression of mast cell-associated DEGs TPSB2, TPSAB1 and CPA3. The differential genes discovered in this study point towards involvement of different types of leukocytes in the E- and A-dominant COPD sub-phenotypes in males and females.

    11

    Nr.1
    Keywords 610 ; 620
    Subject code 610
    Language English
    Publishing country de
    Document type Article ; Online
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  7. Article: Chromosomal assignment of nineteen rat microsatellite markers to various chromosomes by linkage analysis.

    Sverdlov, V E / Dukhanina, O I / Choi, C / Bihoreau, M T / Dene, H / Rapp, J P

    Mammalian genome : official journal of the International Mammalian Genome Society

    1998  Volume 9, Issue 3, Page(s) 243–245

    MeSH term(s) Animals ; Base Sequence ; Chromosome Mapping ; Chromosomes ; DNA, Complementary ; Genetic Linkage ; Microsatellite Repeats ; Molecular Sequence Data ; Rats
    Chemical Substances DNA, Complementary
    Language English
    Publishing date 1998-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s003359900734
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  8. Article: Integrated genetic mapping of 64 rat microsatellite markers from different sources.

    Courvoisier, H / Bihoreau, M T / Gauguier, D / Plomion, C / Mormède, P / Moisan, M P

    Mammalian genome : official journal of the International Mammalian Genome Society

    1997  Volume 8, Issue 4, Page(s) 282–283

    MeSH term(s) Animals ; Chromosome Mapping ; Genetic Linkage ; Microsatellite Repeats ; Polymorphism, Genetic ; Rats
    Language English
    Publishing date 1997-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s003359900411
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  9. Article: Contribution possible de l'hyperglycémie in utero aux troubles de l'homéostasie glucidique à l'âge adulte.

    Ktorza, A / Gauguier, D / Bihoreau, M T / Berthault, M F / Marfaing, P / Penicaud, L

    Journees annuelles de diabetologie de l'Hotel-Dieu

    1997  , Page(s) 55–68

    Title translation Possible contribution of hyperglycemia in utero to glucose homeostasis disorders in the adult.
    MeSH term(s) Adult ; Animals ; Blood Glucose/metabolism ; Disease Models, Animal ; Female ; Homeostasis ; Humans ; Hyperglycemia/epidemiology ; Pregnancy ; Pregnancy Complications/epidemiology ; Prenatal Exposure Delayed Effects
    Chemical Substances Blood Glucose
    Language French
    Publishing date 1997
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 603984-4
    ISSN 0075-4439
    ISSN 0075-4439
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  10. Article: Gestational hyperglycaemia and insulin release by the fetal rat pancreas in vitro: effect of amino acids and glyceraldehyde.

    Bihoreau, M T / Ktorza, A / Picon, L

    Diabetologia

    1986  Volume 29, Issue 7, Page(s) 434–439

    Abstract: Unrestrained pregnant rats were infused with glucose during the last week of pregnancy to produce slight or high gestational hyperglycaemia. Control rats were infused with distilled water. Insulin secretion of the fetuses at term was studied in vitro ... ...

    Abstract Unrestrained pregnant rats were infused with glucose during the last week of pregnancy to produce slight or high gestational hyperglycaemia. Control rats were infused with distilled water. Insulin secretion of the fetuses at term was studied in vitro using a perifusion system. Compared with controls, perifused pancreases of slightly hyperglycaemic fetuses showed a similar pattern of insulin secretion in response to 10 mmol/l leucine. Arginine-induced insulin secretion at 20 mmol/l was higher than in controls. In both groups, 10 mmol/l alpha-ketoisocaproate had a poor stimulatory effect on insulin release, and 5 mmol/l D-glyceraldehyde was ineffective in eliciting insulin secretion. In highly hyperglycaemic fetuses all the secretagogues, with the exception of arginine, which induced a sustained monophasic insulin secretory response, had no effect on insulin release. These data show that long-term exposure of fetal B cells to high plasma glucose levels in utero suppresses or alters further insulin secretory response not only to glucose but also to other nutrient secretagogues. The partially spared insulin secretory response to arginine suggests that the defect may concern stimulus-secretion coupling rather than insulin releasing machinery.
    MeSH term(s) Amino Acids/pharmacology ; Animals ; Female ; Glyceraldehyde/pharmacology ; Hyperglycemia/physiopathology ; In Vitro Techniques ; Insulin/metabolism ; Insulin Secretion ; Islets of Langerhans/embryology ; Islets of Langerhans/metabolism ; Keto Acids/pharmacology ; Pregnancy ; Rats ; Secretory Rate/drug effects
    Chemical Substances Amino Acids ; Insulin ; Keto Acids ; Glyceraldehyde (367-47-5)
    Language English
    Publishing date 1986-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/bf00506535
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