LIVIVO - Search results -

Search results

Result 1 - 10 of total 412

Search options

Article: CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome.

Celli, Ludovica / Gasparini, Patrizia / Biino, Ginevra / Zannini, Laura / Cardano, Miriana

2024 Volume 14, Issue 1, Page(s) 15

Abstract: Background: Sexual dimorphism represents a key concept in the comprehension of molecular processes guiding several sex-specific physiological and pathological mechanisms. It has been reported that genes involved in many disorders show a sex-dependent ... ...

Abstract	Background: Sexual dimorphism represents a key concept in the comprehension of molecular processes guiding several sex-specific physiological and pathological mechanisms. It has been reported that genes involved in many disorders show a sex-dependent expression pattern. Moreover, the loss of Y chromosome (LOY), found to be a physiological age-driven phenomenon, has been linked to many neurodegenerative and autoimmune disorders, and to an increased cancer risk. These findings drove us towards the consideration that LOY may cause the de-regulation of disease specific networks, involving genes located in both autosomal and sex chromosomes. Results: Exploiting the CRISPR/Cas9 and RNA-sequencing technologies, we generated a Y-deficient human cell line that has been investigated for its gene expression profile. Our results showed that LOY can influence the transcriptome displaying relevant enriched biological processes, such as cell migration regulation, angiogenesis and immune response. Interestingly, the ovarian follicle development pathway was found enriched, supporting the female-mimicking profile of male Y-depleted cells. Conclusion: This study, besides proposing a novel approach to investigate sex-biased physiological and pathological conditions, highlights new roles for the Y chromosome in the sexual dimorphism characterizing human health and diseases. Moreover, this analysis paves the way for the research of new therapeutic approaches for sex dimorphic and LOY-related diseases.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-024-01198-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Effects of Baby Swimming on Motor and Cognitive Development: A Pilot Trial.

Borioni, Federica / Biino, Valentina / Tinagli, Valeria / Pesce, Caterina

Perceptual and motor skills

2022 Volume 129, Issue 4, Page(s) 977–1000

Abstract: Contact with water, even from birth, may be an important experience for child development. In this work, we aimed to investigate if baby swimming might influence infant development in motor and cognitive domains. We assigned infants to either a 10-week ... ...

Abstract	Contact with water, even from birth, may be an important experience for child development. In this work, we aimed to investigate if baby swimming might influence infant development in motor and cognitive domains. We assigned infants to either a 10-week baby swimming intervention (
MeSH term(s)	Child Development/physiology ; Cognition/physiology ; Humans ; Infant ; Motor Skills/physiology ; Pilot Projects ; Swimming/physiology
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Controlled Clinical Trial ; Journal Article
ZDB-ID	204507-2
ISSN	1558-688X ; 0031-5125
ISSN (online)	1558-688X
ISSN	0031-5125
DOI	10.1177/00315125221090203
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1088: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Gross motor coordination in relation to weight status: a longitudinal study in children and pre-adolescents.

Biino, Valentina / Pellegrini, Barbara / Zoppirolli, Chiara / Lanza, Massimo / Gilli, Federica / Giuriato, Matteo / Schena, Federico

Frontiers in public health

2023 Volume 11, Page(s) 1242712

Abstract: Introduction: Gross Motor Coordination (GMC) is crucial for the adequate development of motor competence. Our purpose in this semi-longitudinal study was to evaluate the influence of BMI on GMC in children and pre-adolescents of both sexes, across ... ...

Abstract	Introduction: Gross Motor Coordination (GMC) is crucial for the adequate development of motor competence. Our purpose in this semi-longitudinal study was to evaluate the influence of BMI on GMC in children and pre-adolescents of both sexes, across school years (classes). Methods: We evaluated 117 subjects (aged 8-13 years) belonging to three different cohorts for 4 consecutive years, providing data over 6 years (classes). GMC was assessed through the Körperkoordinationstest für Kinder (KTK) test. Class and weight status effects were then evaluated by dividing the subjects into a normal weight group and an overweight group based on their weight status. Results: A significant increase across classes was found for BMI ( Discussion: The level of competence and its development are strictly dependent on weight status during childhood and pre-adolescence. The present investigation suggests that the adequate development of GMC requires not only targeted physical education programs but also the promotion of healthy habits aimed at maintaining a normal weight status during childhood and pre-adolescence.
MeSH term(s)	Male ; Child ; Female ; Humans ; Adolescent ; Overweight ; Body Mass Index ; Longitudinal Studies ; Motor Activity ; Age Factors
Language	English
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1242712
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: An Adapted Questionnaire Tailored for Assessing the Risk of Vitamin D Deficiency in Children That Is Proving Useful in Guiding Clinical Interventions.

Calcaterra, Valeria / Cena, Hellas / De Giuseppe, Rachele / Biino, Ginevra / Grazi, Roberta / Manuelli, Matteo / Zanelli, Sara / Tagi, Veronica / Vincenti, Alessandra / Zuccotti, Gianvincenzo / Fabiano, Valentina

Nutrients

2024 Volume 16, Issue 7

Abstract: Background: The identification of vitamin D (VitD) deficiency in pediatric populations is essential for preventive healthcare. We refined and tested the Evaluation of Deficiency Questionnaire (EVIDENCe-Q) for its utility in detecting VitD insufficiency ... ...

Abstract	Background: The identification of vitamin D (VitD) deficiency in pediatric populations is essential for preventive healthcare. We refined and tested the Evaluation of Deficiency Questionnaire (EVIDENCe-Q) for its utility in detecting VitD insufficiency among children. Patients and methods: We enrolled 201 pediatric patients (aged between 3 and 18 years). Clinical evaluation and serum vitamin D levels were assessed in all subjects. The EVIDENCe-Q was updated to incorporate factors influencing VitD biosynthesis, intake, assimilation, and metabolism, with scores spanning from 0 (optimal) to 36 (poor). Results: We established scores for severe deficiency (<10 mg/dL) at 20, deficiency (<20 mg/dL) at 22, and insufficiency (<30 mg/dL) at 28. A score of 20 or greater was determined as the optimal cut-off for distinguishing VitD deficient from sufficient statuses, as evidenced by ROC curve analysis AUC = 0.7066; SE = 0.0841; sensitivity 100%, 95% CI 0.561-1. The most accurate alignment was seen with VitD insufficiency, defined as 25-OH-D3 < 20 ng/mL. Conclusions: This study confirms that the EVIDENCe-Q is a valid instrument for assessing the risk of vitamin D deficiency and insufficiency in children. It offers a practical approach for determining the need for clinical intervention and dietary supplementation of VitD in the pediatric population.
MeSH term(s)	Humans ; Child ; Child, Preschool ; Adolescent ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/epidemiology ; Vitamin D ; Vitamins ; Ergocalciferols ; Calcifediol
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Ergocalciferols ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16070971
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Gross motor coordination in relation to weight status

Valentina Biino / Barbara Pellegrini / Chiara Zoppirolli / Massimo Lanza / Federica Gilli / Matteo Giuriato / Federico Schena

Frontiers in Public Health, Vol

a longitudinal study in children and pre-adolescents

2023 Volume 11

Abstract: IntroductionGross Motor Coordination (GMC) is crucial for the adequate development of motor competence. Our purpose in this semi-longitudinal study was to evaluate the influence of BMI on GMC in children and pre-adolescents of both sexes, across school ... ...

Abstract	IntroductionGross Motor Coordination (GMC) is crucial for the adequate development of motor competence. Our purpose in this semi-longitudinal study was to evaluate the influence of BMI on GMC in children and pre-adolescents of both sexes, across school years (classes).MethodsWe evaluated 117 subjects (aged 8–13 years) belonging to three different cohorts for 4 consecutive years, providing data over 6 years (classes). GMC was assessed through the Körperkoordinationstest für Kinder (KTK) test. Class and weight status effects were then evaluated by dividing the subjects into a normal weight group and an overweight group based on their weight status.ResultsA significant increase across classes was found for BMI (p < 0.001) and KTK raw score (p < 0.001) and a decrease was found for KTK normalized score (MQ) (p = 0.043). Significantly lower MQ values were found for girls. Absolute GMC increased across the years and there was no difference between boys and girls. Correlations between GMC scores and BMI were negative and significant in 5 of 6 classes. It was confirmed that overweight subjects had lower MQ and RAW values than normal-weight subjects, with no class-by-weight status interaction.DiscussionThe level of competence and its development are strictly dependent on weight status during childhood and pre-adolescence. The present investigation suggests that the adequate development of GMC requires not only targeted physical education programs but also the promotion of healthy habits aimed at maintaining a normal weight status during childhood and pre-adolescence.
Keywords	KTK ; longitudinal ; BMI ; children ; pre-adolescence ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Gross motor coordination and their relationship with body mass and physical activity level during growth in Children aged 8-11 years old: a longitudinal and allometric approach.

Giuriato, Matteo / Lovecchio, Nicola / Carnevale Pellino, Vittoria / Mieszkowski, Jan / Kawczyński, Adam / Nevill, Alan / Biino, Valentina

PeerJ

2022 Volume 10, Page(s) e13483

Abstract: Background: Gross motor coordination (GMC) is fundamental to the harmonious development of physical skills during the growth of children. This research aimed to explore the developmental changes in GMC during childhood, having controlled for the ... ...

Abstract	Background: Gross motor coordination (GMC) is fundamental to the harmonious development of physical skills during the growth of children. This research aimed to explore the developmental changes in GMC during childhood, having controlled for the differences in children's body size and shape using a longitudinal, allometric scaling methodology. Methods: A total of 104 children from North-East Italy of third-fourth- and fifth-grade students and each participant were tested for three consequently years. Subjects performed the short version of korperkoordinationstest fur kinder (KTK3) and the anthropometric characteristics were simultaneously collected. The physical activity questionnaire (PAQ-C) was used to evaluate the weekly physical engagement. Results: Ontogenetic multiplicative models suggested nonlinear associations with GMC across the children's developmental years. Linear physique was a significant predictor associated with the development of GMC across time. PAQ-C was significantly associated with GMC from 8 to 13 years old. Conclusion: Growth does not respect linear trends. A greater lean body mass could be assessed as a reliable predictor of GMC in children. The crucial period of life to improve the GMC is 8-10 years, while stabilization becomes evident from 10 to 13 years.
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.13483
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Screening Questionnaire for Vitamin D Insufficiency in Children with Obesity.

Calcaterra, Valeria / Cena, Hellas / Biino, Ginevra / Grazi, Roberta / Bortoni, Giulio / Braschi, Valentina / Tomasinelli, Chiara Elena / Schneider, Laura / Zuccotti, Gianvincenzo

Children (Basel, Switzerland)

2022 Volume 9, Issue 11

Abstract: Non-invasive screening tools to identify children at high risk of vitamin D (VitD) deficiency are proactive measures in preventive care. Recently, a validated questionnaire (Evaluation dEficieNCy Questionnaire, EVIDENCe-Q) for identifying newly diagnosed ...

Abstract	Non-invasive screening tools to identify children at high risk of vitamin D (VitD) deficiency are proactive measures in preventive care. Recently, a validated questionnaire (Evaluation dEficieNCy Questionnaire, EVIDENCe-Q) for identifying newly diagnosed VitD-insufficient adults has been developed. We tested the EVIDENCe-Q modified for children with obesity and evaluated the correlation between VitD and questionnaire scores to adapt this tool to the pediatric population. We enrolled 120 children with obesity (BMI ≥ 2). Clinical evaluation and VitD levels were considered. The modified EVIDENCe-Q included information regarding factors affecting control of VitD, with scores ranging between 0 (best) and 36 (worst). VitD and adiposity indices were inversely correlated. The threshold values for identifying severe deficiency (<10 mg/dL), deficiency (<20 mg/dL) and insufficiency (<30 mg/dL) were scores of 21, 19 and 23, respectively. According to those thresholds, the prevalence of severe deficiency, deficiency and insufficiency was 47.5%, 69.2% and 23.3%, respectively; the best accuracy was obtained with a questionnaire score cut-off of 19 for the VitD deficiency level. A novel simple screening tool such as the modified EVIDENCe-Q would be useful in clinical practice to identify potential cases of hypovitaminosis D and select at-risk patients. Considering the limited accuracy and specificity of our results, for the pediatric population a dedicated tool should be created. Phases of childhood and the role of adipose tissue could be considered in the definition of a questionnaire intended for pediatric patients with obesity.
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9111685
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Effects of sports experience on children's gross motor coordination level.

Biino, Valentina / Giustino, Valerio / Gallotta, Maria Chiara / Bellafiore, Marianna / Battaglia, Giuseppe / Lanza, Massimo / Baldari, Carlo / Giuriato, Matteo / Figlioli, Flavia / Guidetti, Laura / Schena, Federico

Frontiers in sports and active living

2023 Volume 5, Page(s) 1310074

Abstract: Background: Gross motor coordination (GMC) development could be influenced by age, gender, weight status, geographical area, living setting, home environment, socio-economic status, sports practice.: Purpose: To verify whether practicing sports and ... ...

Abstract	Background: Gross motor coordination (GMC) development could be influenced by age, gender, weight status, geographical area, living setting, home environment, socio-economic status, sports practice. Purpose: To verify whether practicing sports and practicing different sports could influence children's GMC level. Methods: A total of 295 children aged 8-11 years were involved in the study and divided into 5 groups in relation to the sport they practiced: gymnastics group ( Results: Children practicing sports showed significantly higher RS and MQ score than children of control group (203.14 ± 38.55 vs. 163.63 ± 43.50 and 98.56 ± 15.79 vs. 83.01 ± 16.71, respectively; Conclusions: The performance model and therefore the specialized training that each sport discipline required, could justified the differences in children's GMC level among sports groups. Thus, coaches should plan individualized interventions and choose activity contents to support children's GMC development.
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article
ISSN	2624-9367
ISSN (online)	2624-9367
DOI	10.3389/fspor.2023.1310074
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The Effect of Crackers Enriched with Camelina Sativa Oil on Omega-3 Serum Fatty Acid Composition in Older Adults: A Randomized Placebo-Controlled Pilot Trial.

De Giuseppe, R / Di Napoli, I / Tomasinelli, C E / Vincenti, A / Biino, G / Sommella, E / Ferron, L / Campiglia, P / Ferrara, F / Casali, P M / Cena, H

The journal of nutrition, health & aging

2023 Volume 27, Issue 6, Page(s) 463–471

Abstract: Background: Camelina sativa oil is one of the richest dietary sources of omega-3, with polyunsaturated fatty acids amounts of over 50%, linolenic acid content of around 40-45%, and linoleic acid of about 15%. Moreover, this oil is a valuable source of ... ...

Abstract	Background: Camelina sativa oil is one of the richest dietary sources of omega-3, with polyunsaturated fatty acids amounts of over 50%, linolenic acid content of around 40-45%, and linoleic acid of about 15%. Moreover, this oil is a valuable source of antioxidants which provide oxidative stability. All those features raise interest in considering Camelina oil as an alternative and sustainable oil source providing stable omega-3-rich emulsions for functional food production. Objectives: The present study aimed to investigate the effects of Camelina oil-enriched crackers on serum omega-3 concentration, inflammatory markers and serum lipid profile. Design: Randomized placebo-controlled pilot trial. Setting: Research and Development Center (Complife Italia s.r.l.). Participants: Sixty-six free-living older volunteers (aged≥65 years). Intervention: Older adults were enrolled and randomly assigned to one of two groups: the camelina group or the placebo group. Subjects consumed daily 35 g of crackers (Camelina enriched crackers or placebo ones) twice daily for 12 weeks. Measurements: Serum polyunsaturated fatty acid profile, inflammatory status and serum lipid panel parameters were recorded pre and post-intervention. Results: In the camelina group, alpha-linolenic acid serum concentration was significantly higher (p<0.01) compared to the placebo group at the end of the study. Concerning inflammatory plasma markers, a significant mean pro-inflammatory interleukin-18 plasma concentration decrease in the placebo group compared to the camelina one was observed (p<0.05). No significant differences in other mean inflammatory markers concentrations post-intervention were noted in either group. Lastly, examining the change in lipid profile, it is noteworthy that a higher reduction of total cholesterol, low-density lipoprotein and triglycerides in the camelina group post-intervention, despite the lack of statistical significance. Conclusion: Camelina oil significantly elevated the serum alpha-linolenic acid concentration with no significant changes in inflammatory markers and lipid profile.
MeSH term(s)	Humans ; Aged ; Fatty Acids, Omega-3 ; alpha-Linolenic Acid/pharmacology ; Pilot Projects ; Fatty Acids, Unsaturated ; Triglycerides
Chemical Substances	Fatty Acids, Omega-3 ; alpha-Linolenic Acid (0RBV727H71) ; Fatty Acids, Unsaturated ; Triglycerides
Language	English
Publishing date	2023-06-28
Publishing country	France
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-023-1925-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 7466: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Body composition and resting energy expenditure in women with anorexia nervosa: Is hyperactivity a protecting factor?

Manuelli, Matteo / Blundell, John E / Biino, Ginevra / Cena, Hellas

Clinical nutrition ESPEN

2018 Volume 29, Page(s) 160–164

Abstract: Background: In subjects with anorexia nervosa (AN) physical exercise may cause or even prevent weight loss, body composition alterations and adaptive thermogenesis. To investigate the influence of behavioral patterns on body composition and energy ... ...

Abstract	Background: In subjects with anorexia nervosa (AN) physical exercise may cause or even prevent weight loss, body composition alterations and adaptive thermogenesis. To investigate the influence of behavioral patterns on body composition and energy expenditure in women with AN, we conducted a retrospective analysis in 62 patients with AN referring to our outpatients' clinic. Materials and methods: We assessed anthropometric measurement of weight, height, and BMI; body composition was assessed by bioelectrical impedance analysis; resting energy expenditure was measured through indirect calorimetry. Patients' characteristics were assessed at the time of first evaluation. Results: The subjects were both restricting type (ANR, n = 39) and binge-eating/purging type (ANBP, n = 23) according to DSM-5. We observed a lower reactance (58.63 (11.9) vs. 66.5 (15.5) Ohm, p < 0.05) and higher total body water in ANR subjects. No differences were found in phase angle, fat mass or fat-free mass, nor in REE measures. Within ANR subgroup, we identified two behavioral patterns, with or without physical hyperactivity. Compared to dieting and fasting subjects, hyperactive subjects showed higher phase angle [5.6 (0.7) vs. 4.8 (0.8), p < 0.05], lower fat-free mass [82.5 (6.8) vs. 89.9 (7.5)%, p < 0.05], greater proportion of fat mass [17.5 (6.8) vs. 10.1 (7.5)%, p < 0.05] and body cell mass [46.6 (5.1) vs. 42.5 (5.5)%, p < 0.05]. Finally, hyperactive subjects had greater BMI than dieting or fasting subjects [18.2 (1.7) vs. 15.8 (1.7), p < 0.005]. Conclusion: With limitations due to the small sample size, hyperactive subjects show body composition and energy metabolism features that seem protective in terms of prognosis.
MeSH term(s)	Adult ; Anorexia Nervosa/complications ; Anthropometry ; Body Composition ; Body Mass Index ; Body Weight ; Calorimetry, Indirect ; Energy Metabolism ; Exercise ; Feeding Behavior ; Female ; Humans ; Prognosis ; Rest ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2018-11-20
Publishing country	England
Document type	Journal Article
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2018.10.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED