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  1. AU="Biju George"
  2. AU="Heudorf, Ursel"
  3. AU="Rorat, Marta"
  4. AU="Grimm, Freddy A"
  5. AU="Ao, Jun-Li" AU="Ao, Jun-Li"
  6. AU="Hijazi, Amjad" AU="Hijazi, Amjad"
  7. AU="Leonidov, Atanas"
  8. AU="Wright, D M" AU="Wright, D M"
  9. AU="Zahra Shova, Fatema Tuj"
  10. AU="Wan-Xia Yang"
  11. AU="Theiß, Janine"
  12. AU="Romanov, L V"
  13. AU="Demertzis, Konstantinos"
  14. AU="Berking, Helmuth"
  15. AU="Shea, Puigi Catherine"
  16. AU="Dragana Tričković-Vukić"
  17. AU="Schilpp, Carolin"
  18. AU="Sasaki, Shugo"
  19. AU=Saito Hazime AU=Saito Hazime
  20. AU="King, Kindra M"
  21. AU="Prousi, George S" AU="Prousi, George S"
  22. AU="Bredov, Denis V" AU="Bredov, Denis V"
  23. AU="Saeki, Harumi"
  24. AU="Pillière, Rémy"
  25. AU="Gurung, Janita"
  26. AU=O'Malley Dennis P
  27. AU="Khlestkina, Maria S"
  28. AU="Ebina-Shibuya, Risa"
  29. AU="Vogel, Ida"
  30. AU="Facchiano, Angelo"
  31. AU="Tara Rava Zolnikov"
  32. AU="Akther, Tahmina"
  33. AU=Chung Eugene S
  34. AU=Josephson M E

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  1. Artikel ; Online: Changing trends of accidental poisoning in children over the last two decades

    Machinary Puthenpurayil Jayakrishnan / Padinharath Krishnakumar / Madathil Govindaraj Geeta / Biju George

    Indian Journal of Community Medicine, Vol 46, Iss 2, Pp 350-

    2021  Band 351

    Schlagwörter Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: How do patients and physicians perceive immune thrombocytopenia (ITP) as a disease? Results from Indian analysis of ITP World Impact Survey (I-WISh)

    Prantar Chakrabarti / Biju George / Chandrakala Shanmukhaiah / Lalit Mohan Sharma / Shashank Udupi / Waleed Ghanima

    Journal of Patient-Reported Outcomes, Vol 6, Iss 1, Pp 1-

    2022  Band 14

    Abstract: Abstract Purpose Immune thrombocytopenia (ITP) is primarily considered a bleeding disorder; its impact on patients’ health-related quality of life (HRQoL) is under-recognized. We aimed to assess how aligned patient and physician perceptions are regarding ...

    Abstract Abstract Purpose Immune thrombocytopenia (ITP) is primarily considered a bleeding disorder; its impact on patients’ health-related quality of life (HRQoL) is under-recognized. We aimed to assess how aligned patient and physician perceptions are regarding ITP-associated symptoms, HRQoL, and disease management in India. Methods Patients and physicians (hematologists/hemato-oncologists) from India who participated in the global ITP World Impact Survey (I-WISh) were included in this subgroup analysis (survey). Physicians were recruited via a local, third party recruiter in India. In addition to completing a survey themselves, physicians were asked to invite consulting patients on a consecutive basis to complete a survey. All surveys were completely independently by the respondents online in English. The respondents took 30 min to complete the questionnaire. Patients also completed the newly developed ITP Life Quality Index (ILQI) that included 10 questions on the impact of ITP on the following: work or studies, time taken off work or education, ability to concentrate, social life, sex life, energy levels, ability to undertake daily tasks, ability to provide support, hobbies, and capacity to exercise. Results A total of 65 patients and 21 physicians were included in this study. Average disease duration from diagnosis-to-survey-completion was 5.3 years. The most severe symptoms reported by patients at diagnosis were menorrhagia (15 of 19 patients [79%]), anxiety surrounding unstable platelet counts (17 of 28 patients [61%]), and fatigue (27 of 46 patients [59%]); these were also the key symptoms they wanted to be resolved. In contrast, physicians perceived petechiae (19 of 21 patients [90%]), bleeding-from-gums (8 of 21 patients [86%]), and purpura (16 of 21 patients [76%]) as the most common symptoms. While the important treatment goals for patients were healthy blood counts (42 of 65 patients [65%]), improved QoL (35 of 65 patients [54%]), and prevention of worsening of ITP (33 of 65 patients [51%]), physicians’ ...
    Schlagwörter Disease management ; Health-related quality of life (HRQoL) ; Immune thrombocytopenia (ITP) ; India ; ITP World Impact Survey (I-WISh) ; ITP symptoms ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: An Evidence Practice Gap in Antiemetic Prescription with Chemotherapy

    Chepsy C-Philip / Biju George

    Journal of Pharmaceutical Care, Vol 2, Iss 1, Pp 22-

    2015  Band 26

    Abstract: Background : Chemotherapy induced nausea and vomiting is an added distress to patients burdened by the illness. In an effort to tackle the emetogenic potential of the agents, guidelines have been proposed to maintain uniformity in prescription and ... ...

    Abstract Background : Chemotherapy induced nausea and vomiting is an added distress to patients burdened by the illness. In an effort to tackle the emetogenic potential of the agents, guidelines have been proposed to maintain uniformity in prescription and improvement in patient tolerance; but their utility and practice is not consistent. The aim of this clinical audit was to assess the antiemetic.practice and investigate the adherence to antiemetic clinical practice guideline Methods: We performed an audit of the antiemetic practices in our tertiary referral centre. A.questionnaire based interview was completed at the outpatient visit to tabulate the data Results: 99 (81.8%) patients received chemotherapy of at least low emetogenic risk. 83 (84%) patients received prophylaxis which was appropriate in 65% based on the our centre’s antiemetic regimen. This was however inappropriate in 76% of patients based on the international practice.parameters Conclusions: Guidelines are not uniformly representative of all populations and modifications toguidelines based on local data are required to ensure success of such policies. There exist evidence-.practice gaps in antiemetic policies
    Schlagwörter Nausea Vomiting Chemotherapy Antiemetics ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-10-01T00:00:00Z
    Verlag Research Center for Rational Use of Drugs (RCRUD)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: COVID-19 infection among health care workers in a tertiary care teaching hospital in Kerala – India

    Priya Chandran / M P Lilabi / Bina Thomas / Biju George / Nimin Hafeez / Ardra Merin George / Milu Elizabeth Cyriac

    Journal of Family Medicine and Primary Care, Vol 11, Iss 1, Pp 245-

    2022  Band 250

    Abstract: Health care workers are at the frontline for management and containment of COVID-19 infection which has put them at additional risk of the disease. Infection and subsequent quarantine of contacts among HCW may produce considerable strain on the health ... ...

    Abstract Health care workers are at the frontline for management and containment of COVID-19 infection which has put them at additional risk of the disease. Infection and subsequent quarantine of contacts among HCW may produce considerable strain on the health care system. It is essential that we study the modes by which HCW may get infected in the work environment. Methods: All HCW testing positive for SARS COV 2 from 1st March 2020 to 31st Jan 2021 were included in the study. Data regarding possible source of infection, details of symptoms along with demographic details were collected. Results: A total of 390 health-care workers tested positive for SARS CoV-2 in the institution. The mean age of affected health-care workers was 32.82 (±10.6) years (range 20–65 years), and 61.3% were female 33% of the positive HCW were doctors and 19.5% nurses. 29% of the infections occurred during patient care of which majority were from the non-COVID areas of the hospital. Interactions with infected colleagues constituted 27.4% of the infections. Symptomatics constituted 67% and the predominant symptoms included Fever, myalgia and severe headache. 57.2% of those followed up reported persistence of symptoms, commonly fatigue (53%), dyspnea on exertion (48%) and myalgia (18%). Conclusion and Recommendation: Infection control practices in non-COVID areas of the hospital needs to be stepped up. Adherence to masking and personal protection during clinical interactions and with colleagues needs to be maintained. Physical distancing at workplace and during mealtimes needs to be ensured by the system.
    Schlagwörter covid-19 ; health care workers ; sars cov-2 ; transmission ; Medicine ; R
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Patterns of Renal Dysfunction and Profile of Kidney Biopsies in Hematopoietic Stem Cell Transplant Recipients.

    John, Elenjickal Elias / Roy, Sanjeet / Devasia, Anup J / Karuppusami, Reka / Jose, Nisha / Mani, Selvin Sundar Raj / Eapen, Jeethu Joseph / Yusuf, Sabina / Thomas, Athul / Valson, Anna T / David, Vinoi George / Mathews, Vikram / Biju George / Varughese, Santosh / Alexander, Suceena

    Glomerular diseases

    2023  Band 3, Heft 1, Seite(n) 98–115

    Abstract: Introduction: Post hematopoietic stem cell transplant (HSCT), kidney can be subjected to injury by various causes. Of these, graft versus host disease (GvHD) affecting the kidney is an under-recognized entity with no clear guidelines on its diagnosis, ... ...

    Abstract Introduction: Post hematopoietic stem cell transplant (HSCT), kidney can be subjected to injury by various causes. Of these, graft versus host disease (GvHD) affecting the kidney is an under-recognized entity with no clear guidelines on its diagnosis, clinicopathological manifestations, and outcomes.
    Material and methods: Out of 2,930 patients who underwent HSCT at our center between 2005 and 2020, kidney biopsy was performed in 19 allogenic and 5 autologous recipients.
    Results: The mean age of the cohort at transplant was 33.2 ± 7 years, and 15 (62%) were males. Median time to kidney biopsy from HSCT was 14 (IQR, 9-30) months. Aplastic anemia was the most common underlying hematological disease (54.2%). All 19 allogenic recipients were classified based on clinicopathological manifestations into either thrombotic microangiopathy (TMA, 12/19 [63%]) or nephrotic syndrome (NS, 7/19 [37%]) pattern. Glomerular tuft "mesangiolysis" was the dominant pattern of injury noted in 9/12 cases of TMA pattern. There was a predominance of acute microangiopathic changes restricted primarily to the glomerular compartment. Of the 7 patients with NS pattern, membranous nephropathy was seen in 4 (57%) and minimal change disease in 3 (43%) patients. Thirty-nine percent (7/18) stained positive for C4d which was predominantly glomerular. Allogenic recipients who did not receive immunosuppression (IS) for renal disease had a lower eGFR at biopsy, a longer latency between withdrawal of GvHD prophylaxis and biopsy, and were significantly at a higher risk of kidney failure (IS: 2/11, 18.1% vs. no IS: 2/6, 33.3%,
    Conclusion: Renal GvHD can present with or without "associated extra-renal GvHD" after a prolonged period of withdrawal of GvHD prophylaxis, requiring careful diagnostic vigilance and consideration of IS.
    Sprache Englisch
    Erscheinungsdatum 2023-03-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2673-3633
    ISSN (online) 2673-3633
    DOI 10.1159/000529699
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics

    Amal Paul / Uday Kulkarni / Bijesh Yadav / Fouzia N. Aboobacker / Anup J. Devasia / Anu Korula / Aby Abraham / Biju George / Paul V. George / Alok Srivastava

    PLoS ONE, Vol 18, Iss

    2023  Band 11

    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics.

    Amal Paul / Uday Kulkarni / Bijesh Yadav / Fouzia N Aboobacker / Anup J Devasia / Anu Korula / Aby Abraham / Biju George / Paul V George / Alok Srivastava

    PLoS ONE, Vol 18, Iss 11, p e

    2023  Band 0293452

    Abstract: Aims Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated "ex-thalassaemics". Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart ... ...

    Abstract Aims Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated "ex-thalassaemics". Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart failure-related morbidity and mortality is unknown. The aim of this study was to assess the prevalence and predictors of subclinical left ventricular (LV) dysfunction in an apparently normal ex-thalassaemic population. Methods We conducted a single centre cross-sectional study among 62 ex-thalassaemic patients, who had undergone HSCT for β-thalassaemia major at our centre. The primary outcome variable was LV systolic dysfunction, as assessed by 1) LV global longitudinal strain (GLS) derived by 2D speckle tracking echocardiography and 2) LV ejection fraction (EF) derived by 2D Simpsons Biplane method. Results Among the 62 patients included in the study, 7 [11.3%] were found to have LV systolic dysfunction, all of which were subclinical. Of these, 4 [6.5%] had abnormal GLS and LVEF, 2 [3.2%] had abnormal GLS with normal LVEF, and 1 [1.6%] had abnormal LVEF with low normal mean GLS. There were no statistically significant predictors of LV dysfunction in this cohort. Conclusion There was a high prevalence of subclinical myocardial dysfunction in the ex-thalassaemic population reiterating the need for close follow up of these patients. 2D Speckle tracking echocardiography-derived LV global longitudinal strain is an effective tool in detecting subclinical myocardial dysfunction in this cohort.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Outcome of iron reduction therapy in ex-thalassemics.

    Fouzia N Aboobacker / Gaurav Dixit / Kavitha M Lakshmi / Anu Korula / Aby Abraham / Biju George / Vikram Mathews / Alok Srivastava

    PLoS ONE, Vol 16, Iss 1, p e

    2021  Band 0238793

    Abstract: There is limited data on iron reduction therapy (IRT) after successful allogeneic haematopoietic stem cell transplantation (aHSCT) for patients with thalassemia major (TM). We present the long term outcome of IRT in 149 patients with TM who underwent ... ...

    Abstract There is limited data on iron reduction therapy (IRT) after successful allogeneic haematopoietic stem cell transplantation (aHSCT) for patients with thalassemia major (TM). We present the long term outcome of IRT in 149 patients with TM who underwent aHSCT during January, 2001-December, 2012. The median age was 7 years (range:1-18) and 92 (61.7%) belonged to Pesaro class 3 with a median ferritin at aHSCT of 2480ng/ml (range:866-8921). IRT was reinitiated post-aHSCT at a median of 14 months (range:5-53) post aHSCT with phlebotomy alone in 10 (6.7%) patients or iron chelation alone in 60 (40.3%) patients while 79 (53%) were treated with the combination. Reduction in serum ferritin/month [absolute quantity (ng/ml/month) was as follows: 87 (range:33-195), 130 (range:17-1012) and 147 (range:27.7-1427) in the phlebotomy, chelation and combination therapy groups, respectively (p = 0.038). With a median follow up of 80 months (range:37-182), target ferritin level of <300ng/ml was achieved in 59(40%) while a level <500ng/ml was achieved in 88 patients (59%) in a median duration of 41 months of IRT (range: 3-136). Patients in class III risk category and higher starting serum ferritin levels (>2500ng/ml) were associated with delayed responses to IRT. Our data shows that IRT may be needed for very long periods in ex-thalassaemics to achieve target ferritin levels and should therefore be carefully planned and initiated as soon as possible after aHSCT. A combination of phlebotomy and iron chelators is more effective in reducing iron overload.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Draft genome sequences data of rare Salmonella enterica sub sp. enterica serovar Ceyco and serovar Hillegersberg isolated from diarrheal patients in India

    Jobin John Jacob / Tharani Priya T / Dhanalakshmi Solaimalai / Yesudoss M / Jansi Rani Malaiyappan / Tanya Rachel / Aravind V / Monisha Priya T / Praveena Jeslin / Biju George / Balaji Veeraraghavan

    Data in Brief, Vol 41, Iss , Pp 107875- (2022)

    2022  

    Abstract: We report here the draft genome sequence of two rare Salmonella serotypes, isolated from human faecal samples in India. The isolates were identified as Salmonella enterica subsp. enterica serovar Ceyco and serovar Hillegersberg by Wole genome sequencing ( ...

    Abstract We report here the draft genome sequence of two rare Salmonella serotypes, isolated from human faecal samples in India. The isolates were identified as Salmonella enterica subsp. enterica serovar Ceyco and serovar Hillegersberg by Wole genome sequencing (WGS) based serotype prediction. The genomic similarity of study isolates was identified by clustering with the global collection of Salmonella sp. available in EnteroBase and SISTR based on their cgMLST profile. Phylogenetic analysis showed the study isolates were closer to S. Detmold and other unknown serovars from serogroup D2. The information generated from genome sequencing of two rare S. enterica serovar will improve the overall understanding of the epidemiology of this clinically relevant pathogen.
    Schlagwörter Non-Typhoidal Salmonella ; Whole genome sequencing ; Genomics ; Diarrhea ; India ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  10. Artikel: Understanding surface water–groundwater interactions for managing large irrigation schemes in the multi-country Fergana valley, Central Asia

    Ibrakhimov, Mirzakhayot / Biju George / Umar Waqas Liaqat / Usman Khalid Awan

    Elsevier B.V. Agricultural water management. 2018 Mar. 31, v. 201

    2018  

    Abstract: Traditionally, surface water supplies are the sole sources to satisfy crop water requirements in large irrigation schemes such as those in the Fergana Valley, Central Asia. Recent studies indicate that 23–30% of these requirements are met from shallow ... ...

    Abstract Traditionally, surface water supplies are the sole sources to satisfy crop water requirements in large irrigation schemes such as those in the Fergana Valley, Central Asia. Recent studies indicate that 23–30% of these requirements are met from shallow groundwater, but this is not usually quantified. To manage favorable groundwater levels – i.e., without increasing soil salinity and nutrient leaching and reducing crop yields – information on, and quantification of, groundwater recharge and discharge rates at large spatial and temporal scales, as well as understanding their mechanisms of interaction, is indispensable. With the aim to quantify groundwater recharge, discharge and their interaction, a conceptual water balance model at a scale of a Water Consumers’ Association was established on a monthly basis for a 10-year period. Average groundwater recharge was estimated as 780 ± 75.7 mm, representing 62% of surface water supplies. The highest average annual recharge (930 mm) driven by excessive precipitation and water supply was in 2010 and the lowest (667–726 mm) was in years of lower water availability: 2006–2008 and 2012. The net groundwater recharge was 82.4 ± 79 mm, and determined the groundwater level fluctuations. The highest positive net groundwater recharge rate (247 mm) and the shallowest groundwater level (123 cm) also occurred in 2010. The negative net recharge in 2006 (–11 mm), 2008 (–41 mm) and 2012 (–5 mm) indicated deeper groundwater levels during these periods. The groundwater recharge values were excessively high even for this large irrigation scheme. To save limited freshwater resources, groundwater discharge should be reduced, with one option being to reduce excessive drainage outflow.
    Schlagwörter crop yield ; drainage ; freshwater ; groundwater ; groundwater recharge ; irrigation management ; leaching ; models ; soil salinity ; surface water ; water requirement ; water supply ; water table ; Central Asia
    Sprache Englisch
    Erscheinungsverlauf 2018-0331
    Umfang p. 99-106.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 751144-9
    ISSN 1873-2283 ; 0378-3774
    ISSN (online) 1873-2283
    ISSN 0378-3774
    DOI 10.1016/j.agwat.2018.01.016
    Datenquelle NAL Katalog (AGRICOLA)

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