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  1. Article ; Online: Quantitative Analysis of the Human Semen Phosphorometabolome by

    Serrano, Rebeca / Martin-Hidalgo, David / Bilbao, Jon / Bernardo-Seisdedos, Ganeko / Millet, Oscar / Garcia-Marin, Luis J / Bragado, Maria Julia

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Phosphorus-containing metabolites occupy a prominent position in cell pathways. The phosphorometabolomic approach in human sperm samples will deliver valuable information as new male fertility biomarkers could emerge. This study analyzed, ... ...

    Abstract Phosphorus-containing metabolites occupy a prominent position in cell pathways. The phosphorometabolomic approach in human sperm samples will deliver valuable information as new male fertility biomarkers could emerge. This study analyzed, by
    MeSH term(s) Humans ; Male ; Semen/metabolism ; Phosphorylcholine/metabolism ; Sperm Motility ; Spermatozoa/metabolism ; Asthenozoospermia/metabolism ; Phosphorus/metabolism ; Semen Analysis ; Organophosphates
    Chemical Substances acetyl phosphate (590-54-5) ; Phosphorylcholine (107-73-3) ; Phosphorus (27YLU75U4W) ; Organophosphates
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metabolic Landscape of the Mouse Liver by Quantitative

    Bernardo-Seisdedos, Ganeko / Bilbao, Jon / Fernández-Ramos, David / Lopitz-Otsoa, Fernando / Gutierrez de Juan, Virginia / Bizkarguenaga, Maider / Mateos, Borja / Fondevila, Marcos F / Abril-Fornaguera, Jordi / Diercks, Tammo / Lu, Shelly C / Nogueiras, Rubén / Mato, José M / Millet, Oscar

    Hepatology (Baltimore, Md.)

    2021  Volume 74, Issue 1, Page(s) 148–163

    Abstract: Background and aims: The liver plays a central role in all metabolic processes in the body. However, precise characterization of liver metabolism is often obscured by its inherent complexity. Phosphorylated metabolites occupy a prominent position in all ...

    Abstract Background and aims: The liver plays a central role in all metabolic processes in the body. However, precise characterization of liver metabolism is often obscured by its inherent complexity. Phosphorylated metabolites occupy a prominent position in all anabolic and catabolic pathways. Here, we develop a
    Approach and results: We applied this technique to define the metabolic landscape in livers from a mouse model of the rare disease disorder congenital erythropoietic porphyria (CEP) as well as two well-known murine models of nonalcoholic steatohepatitis: one genetic, methionine adenosyltransferase 1A knockout mice, and the other dietary, mice fed a high-fat choline-deficient diet. We report alterations in the concentrations of phosphorylated metabolites that are readouts of the balance between glycolysis, gluconeogenesis, the pentose phosphate pathway, the tricarboxylic acid cycle, and oxidative phosphorylation and of phospholipid metabolism and apoptosis. Moreover, these changes correlate with the main histological features: steatosis, apoptosis, iron deposits, and fibrosis. Strikingly, treatment with the repurposed drug ciclopirox improves the phosphoromic profile of CEP mice, an effect that was mirrored by the normalization of liver histology.
    Conclusions: In conclusion, these findings indicate that NMR-based phosphoromics may be used to unravel metabolic phenotypes of liver injury and to identify the mechanism of drug action.
    MeSH term(s) Animals ; Disease Models, Animal ; Feasibility Studies ; Female ; Humans ; Hydrophobic and Hydrophilic Interactions ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Magnetic Resonance Spectroscopy ; Male ; Metabolome/drug effects ; Metabolome/physiology ; Metabolomics/methods ; Mice ; Mice, Transgenic ; Models, Animal ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/pathology ; Phosphorus ; Phosphorylation/drug effects
    Chemical Substances Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31676
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
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  3. Article ; Online: Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function.

    Gonzalez-Rellan, Maria J / Parracho, Tamara / Heras, Violeta / Rodriguez, Amaia / Fondevila, Marcos F / Novoa, Eva / Lima, Natalia / Varela-Rey, Marta / Senra, Ana / Chantada-Vazquez, Maria D P / Ameneiro, Cristina / Bernardo, Ganeko / Fernandez-Ramos, David / Lopitz-Otsoa, Fernando / Bilbao, Jon / Guallar, Diana / Fidalgo, Miguel / Bravo, Susana / Dieguez, Carlos /
    Martinez-Chantar, Maria L / Millet, Oscar / Mato, Jose M / Schwaninger, Markus / Prevot, Vincent / Crespo, Javier / Frühbeck, Gema / Iruzubieta, Paula / Nogueiras, Ruben

    Molecular metabolism

    2023  Volume 75, Page(s) 101776

    Abstract: Objective: O-GlcNAcylation is a post-translational modification that directly couples the processes of nutrient sensing, metabolism, and signal transduction, affecting protein function and localization, since the O-linked N-acetylglucosamine moiety ... ...

    Abstract Objective: O-GlcNAcylation is a post-translational modification that directly couples the processes of nutrient sensing, metabolism, and signal transduction, affecting protein function and localization, since the O-linked N-acetylglucosamine moiety comes directly from the metabolism of glucose, lipids, and amino acids. The addition and removal of O-GlcNAc of target proteins are mediated by two highly conserved enzymes: O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) and O-GlcNAcase (OGA), respectively. Deregulation of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer, diabetes, and cardiovascular diseases. The contribution of deregulated O-GlcNAcylation to the progression and pathogenesis of NAFLD remains intriguing, and a better understanding of its roles in this pathophysiological context is required to uncover novel avenues for therapeutic intervention. By using a translational approach, our aim is to describe the role of OGT and O-GlcNAcylation in the pathogenesis of NAFLD.
    Methods: We used primary mouse hepatocytes, human hepatic cell lines and in vivo mouse models of steatohepatitis to manipulate O-GlcNAc transferase (OGT). We also studied OGT and O-GlcNAcylation in liver samples from different cohorts of people with NAFLD.
    Results: O-GlcNAcylation was upregulated in the liver of people and animal models with steatohepatitis. Downregulation of OGT in NAFLD-hepatocytes improved diet-induced liver injury in both in vivo and in vitro models. Proteomics studies revealed that mitochondrial proteins were hyper-O-GlcNAcylated in the liver of mice with steatohepatitis. Inhibition of OGT is able to restore mitochondrial oxidation and decrease hepatic lipid content in in vitro and in vivo models of NAFLD.
    Conclusions: These results demonstrate that deregulated hyper-O-GlcNAcylation favors NAFLD progression by reducing mitochondrial oxidation and promoting hepatic lipid accumulation.
    MeSH term(s) Humans ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Down-Regulation ; Acetylglucosamine/metabolism ; Mitochondria/metabolism ; Hepatocytes/metabolism ; Lipids
    Chemical Substances O-GlcNAc transferase (EC 2.4.1.-) ; Acetylglucosamine (V956696549) ; Lipids
    Language English
    Publishing date 2023-07-13
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2708735-9
    ISSN 2212-8778 ; 2212-8778
    ISSN (online) 2212-8778
    ISSN 2212-8778
    DOI 10.1016/j.molmet.2023.101776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis

    Fernández-Ramos, David / Lopitz-Otsoa, Fernando / Delacruz-Villar, Laura / Bilbao, Jon / Pagano, Martina / Mosca, Laura / Bizkarguenaga, Maider / Serrano-Macia, Marina / Azkargorta, Mikel / Iruarrizaga-Lejarreta, Marta / Sot, Jesús / Tsvirkun, Darya / van Liempd, Sebastiaan Martijn / Goni, Felix M / Alonso, Cristina / Martínez-Chantar, María Luz / Elortza, Felix / Hayardeny, Liat / Lu, Shelly C /
    Mato, José M

    World journal of gastroenterology

    2020  Volume 26, Issue 34, Page(s) 5101–5117

    Abstract: Background: Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. In a phase IIb clinical ... ...

    Abstract Background: Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis (NASH), 52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c, an indicator of glycemic control.
    Aim: To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model [induced with a 0.1% methionine and choline deficient diet (0.1MCD)] after treatment with Aramchol.
    Methods: Isolated primary mouse hepatocytes were incubated with 20 μmol/L Aramchol or vehicle for 48 h. Subsequently, analyses were performed including Western blot, proteomics by mass spectrometry, and fluxomic analysis with
    Results: Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes. This translated into changes in the content of their downstream targets including proteins involved in fatty acid (FA) synthesis and oxidation [P-ACCα/β(S79), SCD1, CPT1A/B, HADHA, and HADHB], oxidative phosphorylation (NDUFA9, NDUFB11, NDUFS1, NDUFV1, ETFDH, and UQCRC2), tricarboxylic acid (TCA) cycle (MDH2, SUCLA2, and SUCLG2), and ribosome (P-p70S6K[T389] and P-S6[S235/S236]). Flux experiments with
    Conclusion: Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1, which in turn activate FA β-oxidation and oxidative phosphorylation.
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Animals ; Cholic Acids ; Disease Models, Animal ; Glucose/metabolism ; Homeostasis ; Humans ; Lipid Metabolism ; Lipids ; Liver/metabolism ; Male ; Methionine ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Cholic Acids ; Lipids ; Methionine (AE28F7PNPL) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2) ; aramchol (QE1Q24M65Y)
    Language English
    Publishing date 2020-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v26.i34.5101
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Journal: Eusko bibliografia

    Bilbao, Jon

    1982  

    Title variant Anuario de bibliografia vasca ; Eusko bibliographia / Anuario
    Author's details Consejo de Cultura de la Diputación Foral de Alava. Dir.: Jon Bilbao
    Dates of publication 1.1981(1982)[?]
    Publisher Consejo
    Publishing place Vitoria-Gasteiz
    Document type Journal
    Database Former special subject collection: coastal and deep sea fishing

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  6. Journal: Eusko bibliographia

    Bilbao, Jon

    diccionario de bibliografia vasca

    (Bis 10.1961/75: Enciclopedia general ilustrada del País Vasco ; Enciclopedia general ilustrada del País Vasco)

    1970  

    Title variant Enciclopedia general ilustrada del País Vasco ; Enciclopedia general ilustrada del País Vasco / C ; Eusko-bibliographia
    Author's details Jon Bilbao
    Series title Bis 10.1961/75: Enciclopedia general ilustrada del País Vasco
    Enciclopedia general ilustrada del País Vasco
    Keywords Baskenland
    Language Spanish
    Dates of publication 1.1970 - 8.1978u.Suppl.1961/75; Suppl. 9.1961/75(1980) - 11.1961/75(1987); 1976/80(1985/87) -
    Publisher Auñamendi ; Servicio Ed. Univ. del País Vasco
    Publishing place San Sebastian ; Bilbao
    Document type Journal
    Note Bis 10.1961/75: Enciclopedia general ilustrada del País Vasco : C
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article ; Online: O-GlcNAcylated p53 in the liver modulates hepatic glucose production.

    Gonzalez-Rellan, Maria J / Fondevila, Marcos F / Fernandez, Uxia / Rodríguez, Amaia / Varela-Rey, Marta / Veyrat-Durebex, Christelle / Seoane, Samuel / Bernardo, Ganeko / Lopitz-Otsoa, Fernando / Fernández-Ramos, David / Bilbao, Jon / Iglesias, Cristina / Novoa, Eva / Ameneiro, Cristina / Senra, Ana / Beiroa, Daniel / Cuñarro, Juan / Dp Chantada-Vazquez, Maria / Garcia-Vence, Maria /
    Bravo, Susana B / Da Silva Lima, Natalia / Porteiro, Begoña / Carneiro, Carmen / Vidal, Anxo / Tovar, Sulay / Müller, Timo D / Ferno, Johan / Guallar, Diana / Fidalgo, Miguel / Sabio, Guadalupe / Herzig, Stephan / Yang, Won Ho / Cho, Jin Won / Martinez-Chantar, Maria Luz / Perez-Fernandez, Roman / López, Miguel / Dieguez, Carlos / Mato, Jose M / Millet, Oscar / Coppari, Roberto / Woodhoo, Ashwin / Fruhbeck, Gema / Nogueiras, Ruben

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 5068

    Abstract: p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we hypothesized that p53 could be linked to ... ...

    Abstract p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we hypothesized that p53 could be linked to glucose maintenance. We show here that upon starvation hepatic p53 is stabilized by O-GlcNAcylation and plays an essential role in the physiological regulation of glucose homeostasis. More specifically, p53 binds to PCK1 promoter and regulates its transcriptional activation, thereby controlling hepatic glucose production. Mice lacking p53 in the liver show a reduced gluconeogenic response during calorie restriction. Glucagon, adrenaline and glucocorticoids augment protein levels of p53, and administration of these hormones to p53 deficient human hepatocytes and to liver-specific p53 deficient mice fails to increase glucose levels. Moreover, insulin decreases p53 levels, and over-expression of p53 impairs insulin sensitivity. Finally, protein levels of p53, as well as genes responsible of O-GlcNAcylation are elevated in the liver of type 2 diabetic patients and positively correlate with glucose and HOMA-IR. Overall these results indicate that the O-GlcNAcylation of p53 plays an unsuspected key role regulating in vivo glucose homeostasis.
    MeSH term(s) Acetylglucosamine/metabolism ; Animals ; Base Sequence ; Caloric Restriction ; Cell Line ; Colforsin/pharmacology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Epinephrine/metabolism ; Glucagon/metabolism ; Glucocorticoids/metabolism ; Gluconeogenesis/drug effects ; Glucose/metabolism ; Glycosylation ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Hydrocortisone/metabolism ; Hyperglycemia/complications ; Hyperglycemia/metabolism ; Insulin Resistance ; Intracellular Signaling Peptides and Proteins/metabolism ; Liver/drug effects ; Liver/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/complications ; Obesity/metabolism ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Promoter Regions, Genetic/genetics ; Protein Binding/drug effects ; Protein Stability/drug effects ; Pyruvic Acid/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription, Genetic/drug effects ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Mice
    Chemical Substances Glucocorticoids ; Intracellular Signaling Peptides and Proteins ; RNA, Messenger ; Tumor Suppressor Protein p53 ; Colforsin (1F7A44V6OU) ; Pyruvic Acid (8558G7RUTR) ; Glucagon (9007-92-5) ; Pck1 protein, mouse (EC 4.1.1.32) ; Phosphoenolpyruvate Carboxykinase (GTP) (EC 4.1.1.32) ; Glucose (IY9XDZ35W2) ; Acetylglucosamine (V956696549) ; Hydrocortisone (WI4X0X7BPJ) ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2021-08-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-25390-0
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  8. Book: Amerikanuak

    Douglass, William A / Bilbao, Jon

    los vascos en el Nuevo Mundo

    1985  

    Title translation Amerikanuak <span.>
    Author's details William A. Douglass y Jon Bilbao
    Language Spanish
    Size 599 S, Ill
    Publisher Servicio Ed., Univ. del País Vasco
    Publishing place Lejona
    Document type Book
    ISBN 847585074X ; 9788475850740
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book: Amerikanuak

    Douglass, William A / Bilbao, Jon

    Basques in the New World

    (The Basque series)

    1975  

    Author's details William A. Douglass and Jon Bilbao
    Series title The Basque series
    Language English
    Size xiv, 519 p., [24] leaves of plates, ill, 22 cm
    Publisher University of Nevada Press
    Publishing place Reno
    Document type Book
    Note Bibliography: p. [459]-490 ; Includes index
    ISBN 0874170435 ; 9780874170436
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book: Enciclopedia general ilustrada del Pais Vasco

    Estornés Lasa, Bernardo / Bilbao, Jon
    Keywords Baskenland ; Enzyklopädie
    Publisher Ed. Auñamendi; San Sebastian
    Document type Book
    HBZ-ID HT004573364
    ISBN 84-7025-147-3 ; 978-84-7025-147-4
    Database Central Library of Sport Science of the German Sport University Cologne

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