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  1. Article ; Online: Effectiveness of Facebook Groups and Pages on Participant Recruitment Into a Randomized Controlled Trial During the COVID-19 Pandemic: Descriptive Study.

    Wong, Kirstie H T W / Lau, Wallis C Y / Man, Kenneth K C / Bilbow, Andrea / Ip, Patrick / Wei, Li

    Journal of medical Internet research

    2023  Volume 25, Page(s) e46190

    Abstract: Background: In response to the unprecedented challenges posed by the COVID-19 pandemic, conventional recruitment approaches were halted, causing the suspension of numerous clinical trials. Previously, Facebook (Meta Platforms, Inc) has emerged as a ... ...

    Abstract Background: In response to the unprecedented challenges posed by the COVID-19 pandemic, conventional recruitment approaches were halted, causing the suspension of numerous clinical trials. Previously, Facebook (Meta Platforms, Inc) has emerged as a promising tool for augmenting participant recruitment. While previous research has explored the use of Facebook for surveys and qualitative studies, its potential for recruiting participants into randomized controlled trials (RCTs) remains underexplored.
    Objective: This study aimed to comprehensively examine the effectiveness of using Facebook groups and pages to facilitate participant recruitment during the COVID-19 pandemic for an RCT on the effectiveness of a remote parenting program, 1-2-3 Magic, in families who have children with attention-deficit/hyperactivity disorder (ADHD) in the United Kingdom.
    Methods: We disseminated 5 Facebook posts with an attached digital flyer across 4 prominent ADHD UK support groups and pages run by the National Attention Deficit Disorder Information and Support Services, reaching an audience of around 16,000 individuals over 2 months (January 7 to March 4, 2022). Eligibility criteria mandated participants to be parents or caregivers of a child with diagnosed ADHD aged 12 years or younger, be residing in the United Kingdom, have access to stable internet, and have a device with the Zoom (Zoom Video Communications) app. Participants were required to have never attended 1-2-3 Magic training previously. Prospective participants expressed their interest through Microsoft Forms (Microsoft Corporation). The trial aimed to recruit 84 parents. It is important to note that the term "parent" or "caregiver" in the RCT and in this study within a trial refers to anybody who has legal responsibility for the child.
    Results: Overall, 478 individuals registered their interest through Microsoft Forms within the stipulated 2-month window. After the eligibility check, 135 participants were contacted for a baseline meeting through Zoom. The first 84 participants who attended a baseline meeting and returned a completed consent form were enrolled. Subsequently, another 16 participants were added, resulting in a final sample of 100 participants. This recruitment strategy incurred negligible expenses and demanded minimal human resources. The approach yielded favorable outcomes by efficiently attracting eligible participants in a condensed time frame, transcending geographical barriers throughout the United Kingdom, which would have been tedious to achieve through traditional recruitment methods.
    Conclusions: Our experience demonstrated that digital flyers posted in the targeted Facebook groups were a cost-effective and quick method for recruiting for an RCT, which opened during the COVID-19 pandemic when lockdown restrictions were in place in the United Kingdom. Trialists should consider this low-cost recruitment intervention for trials going forward, and in the case of a global pandemic, this novel recruitment method enabled the trial to continue where many have failed.
    Trial registration: International Standard Randomized Controlled Trial Number (ISRCTN) 15281572; https://www.isrctn.com/ISRCTN15281572.
    MeSH term(s) Child ; Humans ; COVID-19 ; Social Media ; Communicable Disease Control ; Parenting ; Parents/education ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-10-17
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1438-8871
    ISSN (online) 1438-8871
    ISSN 1438-8871
    DOI 10.2196/46190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pharmacological and non-pharmacological interventions for adults with ADHD: protocol for a systematic review and network meta-analysis.

    Cortese, Samuele / Del Giovane, Cinzia / Chamberlain, Samuel / Philipsen, Alexandra / Young, Susan / Bilbow, Andrea / Cipriani, Andrea

    BMJ open

    2022  Volume 12, Issue 3, Page(s) e058102

    Abstract: Introduction: It is unclear how pharmacological and non-pharmacological interventions compare with each other in terms of efficacy and tolerability for core symptoms and additional problems in adults with attention-deficit/hyperactivity disorder (ADHD). ...

    Abstract Introduction: It is unclear how pharmacological and non-pharmacological interventions compare with each other in terms of efficacy and tolerability for core symptoms and additional problems in adults with attention-deficit/hyperactivity disorder (ADHD). We aim to conduct the first network meta-analysis (NMA) comparing pharmacological and non-pharmacological interventions (or their combinations) in adults with ADHD.
    Methods and analysis: We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for NMAs. We will search a broad set of electronic databases/registries and contact drug companies and experts in the field to retrieve published and unpublished randomised controlled trials (RCTs) (parallel or cross-over) of medications (either licensed or unlicensed) and any non-pharmacological intervention in adults (≥18 years) with ADHD. Primary outcomes will be: (1) change in severity of ADHD core symptoms, and (2) acceptability (all-cause discontinuation). Secondary outcomes will include tolerability (drop-out due to side effects) and change in the severity of emotional dysregulation, executive dysfunctions and quality of life. The risk of bias in each individual RCT included in the NMA will be assessed using the Cochrane Risk of Bias tool-version 2. We will evaluate the transitivity assumption comparing the distribution of possible effect modifiers across treatment comparisons. We will perform Bayesian NMA for each outcome with random-effects model in OpenBUGS. Pooled estimates of NMA will be obtained using the Markov Chains Monte Carlo method. We will judge the credibility in the evidence derived from the NMA using the CINeMA tool (which includes assessment of publication bias). We will conduct a series of sensitivity analyses to assess the robustness of the findings.
    Ethics and dissemination: As this is the protocol for an aggregate-data level NMA, ethical approval will not be required. Results will be disseminated at national/international conferences and in peer-reviewed journals.
    Prospero registration number: CRD42021265576.
    MeSH term(s) Adult ; Attention Deficit Disorder with Hyperactivity/psychology ; Attention Deficit Disorder with Hyperactivity/therapy ; Humans ; Meta-Analysis as Topic ; Network Meta-Analysis ; Quality of Life ; Systematic Reviews as Topic
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-058102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sharing knowledge about ADHD comorbidity: lessons learned.

    Pawley, Adam / Mostert, Jeanette C / Bilbow, Andrea / Reif, Andreas / Vasquez, Alejandro Arias / Kuntsi, Jonna / Franke, Barbara

    Neuroscience and biobehavioral reviews

    2022  Volume 135, Page(s) 104586

    MeSH term(s) Attention Deficit Disorder with Hyperactivity/epidemiology ; Comorbidity ; Humans ; Information Dissemination ; Knowledge
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2022.104586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Barriers to and Facilitators of Using Remote Measurement Technology in the Long-Term Monitoring of Individuals With ADHD: Interview Study.

    Denyer, Hayley / Deng, Qigang / Adanijo, Abimbola / Asherson, Philip / Bilbow, Andrea / Folarin, Amos / Groom, Madeleine J / Hollis, Chris / Wykes, Til / Dobson, Richard Jb / Kuntsi, Jonna / Simblett, Sara

    JMIR formative research

    2023  Volume 7, Page(s) e44126

    Abstract: Background: Remote measurement technology (RMT) has the potential to address current research and clinical challenges of attention-deficit/hyperactivity disorder (ADHD) symptoms and its co-occurring mental health problems. Despite research using RMT ... ...

    Abstract Background: Remote measurement technology (RMT) has the potential to address current research and clinical challenges of attention-deficit/hyperactivity disorder (ADHD) symptoms and its co-occurring mental health problems. Despite research using RMT already being successfully applied to other populations, adherence and attrition are potential obstacles when applying RMT to a disorder such as ADHD. Hypothetical views and attitudes toward using RMT in a population with ADHD have previously been explored; however, to our knowledge, there is no previous research that has used qualitative methods to understand the barriers to and facilitators of using RMT in individuals with ADHD following participation in a remote monitoring period.
    Objective: We aimed to evaluate the barriers to and facilitators of using RMT in individuals with ADHD compared with a group of people who did not have a diagnosis of ADHD. We also aimed to explore participants' views on using RMT for 1 or 2 years in future studies.
    Methods: In total, 20 individuals with ADHD and 20 individuals without ADHD were followed up for 10 weeks using RMT that involved active (questionnaires and cognitive tasks) and passive (smartphone sensors and wearable devices) monitoring; 10 adolescents and adults with ADHD and 12 individuals in a comparison group completed semistructured qualitative interviews at the end of the study period. The interviews focused on potential barriers to and facilitators of using RMT in adults with ADHD. A framework methodology was used to explore the data qualitatively.
    Results: Barriers to and facilitators of using RMT were categorized as health-related, user-related, and technology-related factors across both participant groups. When comparing themes that emerged across the participant groups, both individuals with and without ADHD experienced similar barriers and facilitators in using RMT. The participants agreed that RMT can provide useful objective data. However, slight differences between the participant groups were identified as barriers to RMT across all major themes. Individuals with ADHD described the impact that their ADHD symptoms had on participating (health-related theme), commented on the perceived cost of completing the cognitive tasks (user-related theme), and described more technical challenges (technology-related theme) than individuals without ADHD. Hypothetical views on future studies using RMT in individuals with ADHD for 1 or 2 years were positive.
    Conclusions: Individuals with ADHD agreed that RMT, which uses repeated measurements with ongoing active and passive monitoring, can provide useful objective data. Although themes overlapped with previous research on barriers to and facilitators of engagement with RMT (eg, depression and epilepsy) and with a comparison group, there are unique considerations for people with ADHD, for example, understanding the impact that ADHD symptoms may have on engaging with RMT. Researchers need to continue working with people with ADHD to develop future RMT studies for longer periods.
    Language English
    Publishing date 2023-06-30
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/44126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Remote Administration of ADHD-Sensitive Cognitive Tasks: A Pilot Study.

    Sun, Shaoxiong / Denyer, Hayley / Sankesara, Heet / Deng, Qigang / Ranjan, Yatharth / Conde, Pauline / Rashid, Zulqarnain / Bendayan, Rebecca / Asherson, Philip / Bilbow, Andrea / Groom, Madeleine / Hollis, Chris / Folarin, Amos A / Dobson, Richard J B / Kuntsi, Jonna

    Journal of attention disorders

    2023  Volume 27, Issue 9, Page(s) 1040–1050

    Abstract: Objective: We assessed the feasibility and validity of remote researcher-led administration and self-administration of modified versions of two cognitive tasks sensitive to ADHD, a four-choice reaction time task (Fast task) and a combined Continuous ... ...

    Abstract Objective: We assessed the feasibility and validity of remote researcher-led administration and self-administration of modified versions of two cognitive tasks sensitive to ADHD, a four-choice reaction time task (Fast task) and a combined Continuous Performance Test/Go No-Go task (CPT/GNG), through a new remote measurement technology system.
    Method: We compared the cognitive performance measures (mean and variability of reaction times (MRT, RTV), omission errors (OE) and commission errors (CE)) at a remote baseline researcher-led administration and three remote self-administration sessions between participants with and without ADHD (
    Results: The most consistent group differences were found for RTV, MRT and CE at the baseline researcher-led administration and the first self-administration, with 8 of the 10 comparisons statistically significant and all comparisons indicating medium to large effect sizes.
    Conclusion: Remote administration of cognitive tasks successfully captured the difficulties with response inhibition and regulation of attention, supporting the feasibility and validity of remote assessments.
    MeSH term(s) Humans ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Pilot Projects ; Reaction Time/physiology ; Attention/physiology ; Neuropsychological Tests ; Cognition/physiology
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547231172763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol.

    Denyer, Hayley / Ramos-Quiroga, J Antoni / Folarin, Amos / Ramos, Carolina / Nemeth, Petra / Bilbow, Andrea / Woodward, Euan / Whitwell, Susannah / Müller-Sedgwick, Ulrich / Larsson, Henrik / Dobson, Richard Jb / Kuntsi, Jonna

    BMC psychiatry

    2022  Volume 22, Issue 1, Page(s) 813

    Abstract: Background: Emerging evidence points at substantial comorbidity between adult attention deficit hyperactivity disorder (ADHD) and cardiometabolic diseases, but our understanding of the comorbidity and how to manage cardiometabolic disease in adults with ...

    Abstract Background: Emerging evidence points at substantial comorbidity between adult attention deficit hyperactivity disorder (ADHD) and cardiometabolic diseases, but our understanding of the comorbidity and how to manage cardiometabolic disease in adults with ADHD is limited. The ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA) project uses remote measurement technology to obtain real-world data from daily life to assess the extent to which ADHD medication treatment and physical activity, individually and jointly, may influence cardiometabolic risks in adults with ADHD. Our second main aim is to obtain valuable real-world data on adherence to pharmacological treatment and its predictors and correlates during daily life from adults with ADHD.
    Methods: ART-CARMA is a multi-site prospective cohort study within the EU-funded collaboration 'TIMESPAN' (Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients) that will recruit 300 adults from adult ADHD waiting lists. The participants will be monitored remotely over a period of 12 months that starts from pre-treatment initiation. Passive monitoring, which involves the participants wearing a wrist-worn device (EmbracePlus) and downloading the RADAR-base Passive App and the Empatica Care App on their smartphone, provides ongoing data collection on a wide range of variables, such as physical activity, sleep, pulse rate (PR) and pulse rate variability (PRV), systolic peaks, electrodermal activity (EDA), oxygen saturation (SpO2), peripheral temperature, smartphone usage including social connectivity, and the environment (e.g. ambient noise, light levels, relative location). By combining data across these variables measured, processes such as physical activity, sleep, autonomic arousal, and indicators of cardiovascular health can be captured. Active remote monitoring involves the participant completing tasks using a smartphone app (such as completing clinical questionnaires or speech tasks), measuring their blood pressure and weight, or using a PC/laptop (cognitive tasks). The ART system is built on the RADAR-base mobile-health platform.
    Discussion: The long-term goal is to use these data to improve the management of cardiometabolic disease in adults with ADHD, and to improve ADHD medication treatment adherence and the personalisation of treatment.
    MeSH term(s) Adult ; Humans ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/psychology ; Cardiometabolic Risk Factors ; Prospective Studies ; Medication Adherence ; Cardiovascular Diseases ; Multicenter Studies as Topic
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-022-04429-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Randomized Controlled Trial Evaluating the Efficacy of a Psychoeducation Program for Families of Children and Adolescents With ADHD in the United Kingdom: Results After a 6-Month Follow-Up.

    Ferrin, Maite / Perez-Ayala, Viviana / El-Abd, Samaa / Lax-Pericall, Teresa / Jacobs, Brian / Bilbow, Andrea / Taylor, Eric

    Journal of attention disorders

    2016  Volume 24, Issue 5, Page(s) 768–779

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adolescent ; Attention Deficit Disorder with Hyperactivity/therapy ; Child ; Follow-Up Studies ; Humans ; Parents ; Treatment Outcome ; United Kingdom
    Language English
    Publishing date 2016-02-02
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/1087054715626509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan.

    Franke, Barbara / Michelini, Giorgia / Asherson, Philip / Banaschewski, Tobias / Bilbow, Andrea / Buitelaar, Jan K / Cormand, Bru / Faraone, Stephen V / Ginsberg, Ylva / Haavik, Jan / Kuntsi, Jonna / Larsson, Henrik / Lesch, Klaus-Peter / Ramos-Quiroga, J Antoni / Réthelyi, János M / Ribases, Marta / Reif, Andreas

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2018  Volume 28, Issue 10, Page(s) 1059–1088

    Abstract: Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but ...

    Abstract Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. Both in childhood and adulthood, ADHD is characterised by substantial comorbidity including substance use, depression, anxiety, and accidents. However, course and symptoms of the disorder and the comorbidities may fluctuate and change over time, and even age of onset in childhood has recently been questioned. Available evidence to date is poor and largely inconsistent with regard to the predictors of persistence versus remittance. Likewise, the development of comorbid disorders cannot be foreseen early on, hampering preventive measures. These facts call for a lifespan perspective on ADHD from childhood to old age. In this selective review, we summarise current knowledge of the long-term course of ADHD, with an emphasis on clinical symptom and cognitive trajectories, treatment effects over the lifespan, and the development of comorbidities. Also, we summarise current knowledge and important unresolved issues on biological factors underlying different ADHD trajectories. We conclude that a severe lack of knowledge on lifespan aspects in ADHD still exists for nearly every aspect reviewed. We encourage large-scale research efforts to overcome those knowledge gaps through appropriately granular longitudinal studies.
    MeSH term(s) Aging ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/genetics ; Attention Deficit Disorder with Hyperactivity/psychology ; Attention Deficit Disorder with Hyperactivity/therapy ; Comorbidity ; Humans
    Language English
    Publishing date 2018-09-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2018.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan

    Franke, Barbara / Michelini, Giorgia / Asherson, Philip / Banaschewski, Tobias / Bilbow, Andrea / Buitelaar, Jan K. / Cormand, Bru / Faraone, Stephen V. / Ginsberg, Ylva / Haavik, Jan / Kuntsi, Jonna / Larsson, Henrik / Lesch, Klaus-Peter / Antoni Ramos-Quiroga, J. / Réthelyi, János M. / Ribases, Marta / Reif, Andreas

    European Neuropsychopharmacology

    2018  Volume 28, Issue 10, Page(s) 1059–1088

    Abstract: Abstract not released by ... ...

    Title translation Schnell leben, jung sterben? Ein Überblick über die Entwicklungslinien von ADHS über die Lebensspanne.
    Abstract Abstract not released by publisher
    Keywords Attention Deficit Disorder with Hyperactivity ; Aufmerksamkeitsstörung mit Hyperaktivität ; Cognitive Impairment ; Comorbidity ; Disease Course ; Genetics ; Genetik ; Gesundheitliche Folgen ; Health Outcomes ; Ko-Morbidität ; Kognitive Beeinträchtigung ; Krankheitsverlauf ; Lebensspanne ; Life Span ; Therapie ; Treatment
    Language English
    Document type Article
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2018.08.001
    Database PSYNDEX

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