Article ; Online: Synthesis of salicylic acid from wintergreen oil by green chemistry overcomes its cytotoxicity in keratinocyte cells and teratogenicity in zebrafish embryos.
Toxicology mechanisms and methods
2024 Volume 34, Issue 2, Page(s) 203–213
Abstract: Salicylic acid topical is used to treat variety of skin conditions. However, salicylic acid in these products is generated through industrial synthesis and has been shown to negatively impact fetal development and cause congenital abnormalities. We ... ...
| Abstract | Salicylic acid topical is used to treat variety of skin conditions. However, salicylic acid in these products is generated through industrial synthesis and has been shown to negatively impact fetal development and cause congenital abnormalities. We hypothesized that teratogenic effects reported in salicylic acid can be prevented by naturally synthesizing salicylic acid from wintergreen oil using green chemistry method. For this purpose, we investigated the effects of natural salicylic acid (NSA) synthesized from wintergreen oil using green chemistry and synthetic salicylic acid (SSA) on keratinocyte cell (HaCaT) proliferation and zebrafish embryo development. NSA structures were analyzed by |
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| MeSH term(s) | Animals ; Zebrafish ; Salicylic Acid/toxicity ; Salicylic Acid/metabolism ; Embryo, Nonmammalian ; Keratinocytes ; Oils, Volatile ; Plant Extracts ; Salicylates |
| Chemical Substances | wintergreen oil (68917-75-9) ; Salicylic Acid (O414PZ4LPZ) ; Oils, Volatile ; Plant Extracts ; Salicylates |
| Language | English |
| Publishing date | 2024-01-29 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2081252-8 |
| ISSN | 1537-6524 ; 1537-6516 ; 1051-7235 |
| ISSN (online) | 1537-6524 |
| ISSN | 1537-6516 ; 1051-7235 |
| DOI | 10.1080/15376516.2023.2272184 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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