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  1. Article ; Online: MRI appearance of combined hepatocellular cholangiocarcinoma.

    Billet, Nicolas / Grégory, Jules / Ronot, Maxime

    Diagnostic and interventional imaging

    2022  Volume 103, Issue 12, Page(s) 625–626

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Cholangiocarcinoma/diagnostic imaging ; Cholangiocarcinoma/pathology ; Bile Duct Neoplasms/diagnostic imaging ; Bile Duct Neoplasms/pathology ; Magnetic Resonance Imaging ; Bile Ducts, Intrahepatic/diagnostic imaging ; Retrospective Studies ; Contrast Media
    Chemical Substances Contrast Media
    Language English
    Publishing date 2022-10-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 2648283-6
    ISSN 2211-5684 ; 2211-5684
    ISSN (online) 2211-5684
    ISSN 2211-5684
    DOI 10.1016/j.diii.2022.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Imaging-guided prognostic score-based approach to assess the benefits of combotherapy versus monotherapy with immune checkpoint inhibitors in metastatic MSI-H colorectal cancer patients.

    Barbe, Rémy / Belkouchi, Younes / Menu, Yves / Cohen, Romain / David, Clemence / Kind, Michele / Harguem, Sana / Dawi, Lama / Hadchiti, Joya / Selhane, Fatine / Billet, Nicolas / Ammari, Samy / Bertin, Ambroise / Lawrance, Littisha / Cervantes, Baptiste / Hollebecque, Antoine / Balleyguier, Corinne / Cournede, Paul-Henry / Talbot, Hugues /
    Lassau, Nathalie / Andre, Thierry

    European journal of cancer (Oxford, England : 1990)

    2024  Volume 202, Page(s) 114020

    Abstract: Background: This retrospective study determined survival responses to immune checkpoint inhibitors (ICIs), comparing mono- (mono) and combo-immunotherapy (combo) in patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) ...

    Abstract Background: This retrospective study determined survival responses to immune checkpoint inhibitors (ICIs), comparing mono- (mono) and combo-immunotherapy (combo) in patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) by analyzing quantitative imaging data and clinical factors.
    Methods: One hundred fifty patients were included from two centers and divided into training (n = 105) and validation (n = 45) cohorts. Radiologists manually annotated chest-abdomen-pelvis computed tomography and calculated tumor burden. Progression-free survival (PFS) was assessed, and variables were selected through Recursive Feature Elimination. Cutoff values were determined using maximally selected rank statistics to binarize features, forming a risk score with hazard ratio-derived weights.
    Results: In total, 2258 lesions were annotated with excellent reproducibility. Key variables in the training cohort included: total tumor volume (cutoff: 73 cm
    Conclusions: A score based on total tumor volume, lesion count, the presence of peritoneal carcinomatosis, and age can guide MSI-H mCRC treatment decisions, allowing oncologists to identify suitable candidates for mono and combo ICI therapies.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Prognosis ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/drug therapy ; Peritoneal Neoplasms/drug therapy ; Retrospective Studies ; Reproducibility of Results ; Colonic Neoplasms/drug therapy ; Microsatellite Instability ; DNA Mismatch Repair
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.114020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Learning from the machine: AI assistance is not an effective learning tool for resident education in chest x-ray interpretation.

    Chassagnon, Guillaume / Billet, Nicolas / Rutten, Caroline / Toussaint, Thibault / Cassius de Linval, Quentin / Collin, Mégane / Lemouchi, Leila / Homps, Margaux / Hedjoudje, Mohamed / Ventre, Jeanne / Gregory, Jules / Canniff, Emma / Regnard, Nor-Eddine / Bennani, Souhail / Revel, Marie-Pierre

    European radiology

    2023  Volume 33, Issue 11, Page(s) 8241–8250

    Abstract: Objectives: To assess whether a computer-aided detection (CADe) system could serve as a learning tool for radiology residents in chest X-ray (CXR) interpretation.: Methods: Eight radiology residents were asked to interpret 500 CXRs for the detection ... ...

    Abstract Objectives: To assess whether a computer-aided detection (CADe) system could serve as a learning tool for radiology residents in chest X-ray (CXR) interpretation.
    Methods: Eight radiology residents were asked to interpret 500 CXRs for the detection of five abnormalities, namely pneumothorax, pleural effusion, alveolar syndrome, lung nodule, and mediastinal mass. After interpreting 150 CXRs, the residents were divided into 2 groups of equivalent performance and experience. Subsequently, group 1 interpreted 200 CXRs from the "intervention dataset" using a CADe as a second reader, while group 2 served as a control by interpreting the same CXRs without the use of CADe. Finally, the 2 groups interpreted another 150 CXRs without the use of CADe. The sensitivity, specificity, and accuracy before, during, and after the intervention were compared.
    Results: Before the intervention, the median individual sensitivity, specificity, and accuracy of the eight radiology residents were 43% (range: 35-57%), 90% (range: 82-96%), and 81% (range: 76-84%), respectively. With the use of CADe, residents from group 1 had a significantly higher overall sensitivity (53% [n = 431/816] vs 43% [n = 349/816], p < 0.001), specificity (94% [i = 3206/3428] vs 90% [n = 3127/3477], p < 0.001), and accuracy (86% [n = 3637/4244] vs 81% [n = 3476/4293], p < 0.001), compared to the control group. After the intervention, there were no significant differences between group 1 and group 2 regarding the overall sensitivity (44% [n = 309/696] vs 46% [n = 317/696], p = 0.666), specificity (90% [n = 2294/2541] vs 90% [n = 2285/2542], p = 0.642), or accuracy (80% [n = 2603/3237] vs 80% [n = 2602/3238], p = 0.955).
    Conclusions: Although it improves radiology residents' performances for interpreting CXRs, a CADe system alone did not appear to be an effective learning tool and should not replace teaching.
    Clinical relevance statement: Although the use of artificial intelligence improves radiology residents' performance in chest X-rays interpretation, artificial intelligence cannot be used alone as a learning tool and should not replace dedicated teaching.
    Key points: • With CADe as a second reader, residents had a significantly higher sensitivity (53% vs 43%, p < 0.001), specificity (94% vs 90%, p < 0.001), and accuracy (86% vs 81%, p < 0.001), compared to residents without CADe. • After removing access to the CADe system, residents' sensitivity (44% vs 46%, p = 0.666), specificity (90% vs 90%, p = 0.642), and accuracy (80% vs 80%, p = 0.955) returned to that of the level for the group without CADe.
    MeSH term(s) Humans ; Artificial Intelligence ; X-Rays ; Internship and Residency ; Radiography, Thoracic ; Radiography
    Language English
    Publishing date 2023-08-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10043-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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