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  1. Article: Thrombingenerierungsprofil bei Faktor-V-Leiden-Trägern ohne Thrombose

    Billoir, P.

    Vasomed

    2019  Volume 31, Issue 2, Page(s) 95

    Language German
    Document type Article
    ZDB-ID 1113360-0
    ISSN 0942-1181 ; 0935-9729
    Database Current Contents Medicine

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    Zs.A 3069: Show issues Location:
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  2. Article ; Online: Pulmonary vascular obstruction increases the risk of recurrent thrombotic events after cessation of anticoagulation in unprovoked pulmonary embolism: A retrospective cohort study.

    Stichelbout, Romain / Sinzogan Eyoum, Calliste / Billoir, Paul / Benhamou, Ygal / Demeyere, Matthieu / Miranda, Sebastien

    Vascular medicine (London, England)

    2024  , Page(s) 1358863X241239648

    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Letter
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X241239648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Place du test de génération de thrombine dans les maladies auto-immunes.

    Billoir, P / Le Cam Duchez, V / Miranda, S / Richard, V / Benhamou, Y

    La Revue de medecine interne

    2021  Volume 42, Issue 12, Page(s) 862–868

    Abstract: Thrombin generation assay (TGA) is a useful tool to evaluate the initiation, propagation and inhibition of coagulation. TGA is a global test that is used to assess hemorrhagic risk in hemophilia patients, but it can also be used to study hypercoagulable ... ...

    Title translation Thrombin generation assay in autoimmune disease.
    Abstract Thrombin generation assay (TGA) is a useful tool to evaluate the initiation, propagation and inhibition of coagulation. TGA is a global test that is used to assess hemorrhagic risk in hemophilia patients, but it can also be used to study hypercoagulable states. The interest of TGA is to screen for cardiovascular risk, which is regularly associated with autoimmune disease (AID) such as antiphospholipid syndrome. Indeed, TGA has been used to evaluate hypercoagulability in patients with antiphospholipid syndrome treated with rivaroxaban versus warfarin. In other AIDs without thrombotic events, TGA measurement is elevated, mainly in rheumatoid arthritis (RA), systemic lupus erythematosus and Behçet's disease. These findings in RA are correlated with the inflammatory activity of the disease. In systemic lupus erythematosus and Behçet's disease, TGA appears to reflect disease activity. In conclusion, TGA remains relatively under used in the clinical evaluation of AID, but it could play a greater role in the evaluation of certain potentially thrombogenic treatments in AID. Finally, TGA helps measuring AID activity, due to the clearlink between coagulation and inflammation, despite some limitations of interpretation mainly due to a lack of standardization.
    MeSH term(s) Antiphospholipid Syndrome/diagnosis ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/epidemiology ; Blood Coagulation ; Humans ; Rivaroxaban ; Thrombin
    Chemical Substances Rivaroxaban (9NDF7JZ4M3) ; Thrombin (EC 3.4.21.5)
    Language French
    Publishing date 2021-06-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2021.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Évaluation d’un test d’orientation diagnostique de thrombopénie induite à l’héparine : validation d’un délai différé de réalisation du test.

    Billoir, Paul / Barbay, Virginie / Fresel, Marielle / Brunel, Sabine / Duchez, Véronique Le Cam

    Annales de biologie clinique

    2023  Volume 81, Issue 3, Page(s) 248–254

    Abstract: Heparin-induced thrombocytopenia (HIT) is a rare, iatrogenic condition, characterized by its potential severity and diagnostic difficulties. The diagnosis is based on a set of arguments allowing the calculation of a pre-test score pointing to HIT. There ... ...

    Title translation Evaluation of a diagnostic test for heparin-induced thrombocytopenia: validation of a delayed test time.
    Abstract Heparin-induced thrombocytopenia (HIT) is a rare, iatrogenic condition, characterized by its potential severity and diagnostic difficulties. The diagnosis is based on a set of arguments allowing the calculation of a pre-test score pointing to HIT. There are rapid diagnostic tests for suspected HIT. Among these, the STic Expert® HIT has a good sensitivity to detect HIT. However, it must be performed within 2 hours after sampling. The aim of this study was to evaluate a delayed STic Expert® HIT test at 8 hours and in frozen plasma. Thirty-six patients were prospectively included for HIT testing between April 01, 2018, and July 1, 2022, at the University Rouen Hospital. For any request for HIT testing, an analysis by STic Expert® HIT was performed within 2 hours and 8 hours post-sampling. Any positive result was confirmed by a functional test, platelet aggregation with heparin, release of 14C-serotonin assay (SRA), and immunological assay by a research for anti-platelet factor 4 IgG antibodies. Twenty-three patients had a STic Expert® HIT. Sixteen presented platelet aggregations in the presence of heparin and had a positive anti-PF4 test, 17 had a positive SRA. Six patients had no HIT. For the test performed within 2 hours of collection, the Se = 100%, Sp = 68.42%, PPV = 73.91%, and NPV = 100%. The X2 = 18.21 with p < 0.001. For the test performed at 8 hours post sampling, the Se = 100%, Sp = 68.42%, PPV = 73.91% and NPV = 100%. The X2 = 18.21 with p < 0.001. In conclusion, we have demonstrated that the STic Expert® can be used to perform an HIT diagnostic test 8 hours after sampling and on thawed plasma. However, this study needs to be confirmed on a larger number of samples.
    MeSH term(s) Humans ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis ; Heparin/adverse effects ; Antibodies/pharmacology ; Platelet Aggregation ; Platelet Factor 4/adverse effects ; Serotonin ; Diagnostic Tests, Routine ; Anticoagulants/adverse effects
    Chemical Substances Heparin (9005-49-6) ; Antibodies ; Platelet Factor 4 (37270-94-3) ; Serotonin (333DO1RDJY) ; Anticoagulants
    Language French
    Publishing date 2023-04-14
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2023.1810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Endothelial Progenitor Cells in Autoimmune Disorders.

    Feugray, Guillaume / Miranda, Sébastien / Le Cam Duchez, Véronique / Bellien, Jérémy / Billoir, Paul

    Stem cell reviews and reports

    2023  Volume 19, Issue 8, Page(s) 2597–2611

    Abstract: Circulating endothelial progenitor cells (EPCs) were first described in 1997 by Asahara et al. as "putative endothelial cells" from human peripheral blood. The study of endothelial progenitors is also intensifying in several pathologies associated with ... ...

    Abstract Circulating endothelial progenitor cells (EPCs) were first described in 1997 by Asahara et al. as "putative endothelial cells" from human peripheral blood. The study of endothelial progenitors is also intensifying in several pathologies associated with endothelial damage, including diabetes, myocardial infarction, sepsis, pulmonary arterial hypertension, obstructive bronchopneumopathy and transplantation. EPCs have been studied in several autoimmune diseases with endothelial involvement such as systemic lupus erythematosus, thrombotic thrombocytopenic purpura, antineutrophil cytoplasmic antibodies, vasculitis, rheumatoid arthritis, Goujerot-Sjögren and antiphospholipid syndrome. Factors involved in endothelial damage are due to overexpression of pro-inflammatory cytokines and/or autoantibodies. Management of these pathologies, particularly the long-term use of glucocorticoids and methotrexate, promote atherosclerosis. A lack of standardized assessment of the number and function of EPCs represents a serious challenge for the use of EPCs as prognostic markers of cardiovascular diseases (CVD). The objective of this review was to describe EPCs, their properties and their involvement in several autoimmune diseases.
    MeSH term(s) Humans ; Endothelial Progenitor Cells ; Autoimmune Diseases/therapy ; Arthritis, Rheumatoid ; Cytokines ; Myocardial Infarction
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-023-10617-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Central serous chorioretinopathy and antiphospholipid syndrome: Three cases report.

    Billoir, Paul / Michon, Adrien / Darnige, Luc

    Lupus

    2020  Volume 30, Issue 3, Page(s) 514–517

    Abstract: Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by recurrent venous or arterial thrombotic events and pregnancy morbidity, with persistently presence of antiphospholipid antibodies (aPL). We report three cases of central ... ...

    Abstract Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by recurrent venous or arterial thrombotic events and pregnancy morbidity, with persistently presence of antiphospholipid antibodies (aPL). We report three cases of central serous chorioretinopathy (CSC) associated with APS.
    MeSH term(s) Adult ; Antibodies, Antiphospholipid/immunology ; Antiphospholipid Syndrome/complications ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/etiology ; Female ; Humans ; Male ; Middle Aged
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2020-12-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/0961203320979736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Quel bilan devant une haemolacria ? À propos d’un cas et revue de la littérature.

    Billoir, P / Feugray, G / Chrétien, M H / Fresel, M / Le Cam Duchez, V

    La Revue de medecine interne

    2019  Volume 41, Issue 5, Page(s) 339–342

    Abstract: Introduction: Hemolacria is a rare hemorrhagic syndrome characterized by bloody tears. The most common etiologies are inflammation, infection or laceration. However, other rarer diseases may also cause this clinical manifestation.: Case report: We ... ...

    Title translation Bloody tears: About a case and a review of the literature.
    Abstract Introduction: Hemolacria is a rare hemorrhagic syndrome characterized by bloody tears. The most common etiologies are inflammation, infection or laceration. However, other rarer diseases may also cause this clinical manifestation.
    Case report: We describe the case of a 14-year-old male patient hospitalized for hemolacria. A history of von Willebrand disease was present in his family, diagnosed in his mother and sister, but absent in our patient. A vitamin C dosage was obtained in our patient and revealed scurvy consecutive to malnutrition. After having excluded other bleeding symptoms like bruises we retained vitamin C deficiency as the etiology of the hemorrhagic syndrome.
    Conclusion: Bloody tears are a rare clinical manifestation and the etiology may be difficult to determine. Bloody tears are a rare clinical manifestation of hemorrhagic syndrome. To determine the underlying etiology, screening should consider all possible causes including the rarest.
    MeSH term(s) Adolescent ; Diagnosis, Differential ; Eye Hemorrhage/diagnosis ; Eye Hemorrhage/etiology ; Humans ; Male ; Malnutrition/complications ; Malnutrition/diagnosis ; Scurvy/diagnosis ; Scurvy/etiology ; Syndrome ; Tears
    Language French
    Publishing date 2019-12-24
    Publishing country France
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2019.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dabigatran-reversal failure using standard dose of idarucizumab: a systematic review and meta-analysis of cases.

    Melicine, Sophie / Billoir, Paul / Faille, Dorothée / Grove, Erik Lerkevang / Lê, Minh P / Ajzenberg, Nadine / Smadja, David M / Gendron, Nicolas

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 5, Page(s) 100201

    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.100201
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  9. Article ; Online: Lactate dehydrogenase and hemolysis index to predict vaso-occlusive crisis in sickle cell disease.

    Feugray, Guillaume / Dumesnil, Cécile / Grall, Maximilien / Benhamou, Ygal / Girot, Helene / Fettig, Julie / Brunel, Valery / Billoir, Paul

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 21198

    Abstract: Sickle cell disease (SCD) is an inherited hemoglobinopathy disorder associated with chronic hemolysis. A major complication is vaso-occlusive crisis (VOC), associating frequent hospitalization, morbidity and mortality. The aim of this study was to ... ...

    Abstract Sickle cell disease (SCD) is an inherited hemoglobinopathy disorder associated with chronic hemolysis. A major complication is vaso-occlusive crisis (VOC), associating frequent hospitalization, morbidity and mortality. The aim of this study was to investigate whether hemolysis biomarkers were able to predict VOC risk in adult patients with SCD requiring hospitalization within 1 year. This single-center prospective study included adult patients with SCD at steady state or during VOC. A total of 182 patients with SCD were included, 151 at steady state and 31 during VOC. Among the 151 patients at steady state 41 experienced VOC within 1 year (median: 3.0 months [2.0-6.5]). We observed an increase of lactate dehydrogenase (LDH) (p = 0.01) and hemolysis index (HI) (p = 0.0043) during VOC compared to steady state. Regarding patients with VOC requiring hospitalization, LDH (p = 0.0073) and HI (p = 0.04) were increased. In unadjusted logistic regression, LDH > median (> 260 U/L) (RR = 3.6 [1.29-10.88], p = 0.0098) and HI > median (> 8 UA/L) (RR = 3.13 [1.91-5.33]; p < 0.001) were associated with VOC. The association of LDH > 260 U/L and HI > 12 UA/L presented a sensitivity of 90%, and a specificity of 72.9% to predict VOC. The association of LDH and HI cut-off was able to predict VOC risk in SCD.
    MeSH term(s) Adult ; Humans ; Hemolysis ; L-Lactate Dehydrogenase ; Prospective Studies ; Volatile Organic Compounds ; Anemia, Sickle Cell/complications
    Chemical Substances L-Lactate Dehydrogenase (EC 1.1.1.27) ; Volatile Organic Compounds
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-48324-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hypercoagulability evaluation in congenital red blood cell disorders using thrombin generation assay.

    Feugray, Guillaume / Grall, Maximilien / Dumesnil, Cécile / Benhamou, Ygal / Brunel, Valery / Le Cam Duchez, Véronique / Lahary, Agnès / Billoir, Paul

    Thrombosis research

    2023  Volume 227, Page(s) 82–85

    MeSH term(s) Humans ; Thrombin ; Anemia, Sickle Cell ; Erythrocytes ; Thrombophilia/complications ; Thrombophilia/diagnosis
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2023.03.008
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