Article ; Online: Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
2018 Volume 9, Issue 1, Page(s) 5052
Abstract: Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta- ... ...
| Abstract | Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. |
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| MeSH term(s) | Asians ; Blood Pressure/genetics ; Blood Pressure/physiology ; Europe ; Female ; Genetic Loci/genetics ; Genome-Wide Association Study ; Humans ; Linkage Disequilibrium/genetics ; Male ; Polymorphism, Single Nucleotide/genetics ; Racial Groups/genetics ; Whites |
| Language | English |
| Publishing date | 2018-11-28 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2553671-0 |
| ISSN | 2041-1723 ; 2041-1723 |
| ISSN (online) | 2041-1723 |
| ISSN | 2041-1723 |
| DOI | 10.1038/s41467-018-07345-0 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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