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  1. Article ; Online: Effects of coal mining and tunnel excavation on groundwater flow system in karst areas by modeling

    Qing-shan Li / Xiao-bing Kang / Mo Xu / Bang-yan Mao

    Journal of Groundwater Science and Engineering, Vol 11, Iss 4, Pp 391-

    A case study in Zhongliang Mountain, Chongqing, Southwest China

    2023  Volume 407

    Abstract: A karst groundwater system ranks among the most sensitive and vulnerable types of groundwater systems. Coal mining and tunnel excavation can greatly change the natural hydrogeological flow system, groundwater-dependent vegetation, soil, as well as ... ...

    Abstract A karst groundwater system ranks among the most sensitive and vulnerable types of groundwater systems. Coal mining and tunnel excavation can greatly change the natural hydrogeological flow system, groundwater-dependent vegetation, soil, as well as hydrology of surface water systems. Abandoned coal mine caves and proposed highway tunnels may have significant influences on groundwater systems. This study employs MODFLOW, a 3D finite-difference groundwater model software, to simulate the groundwater system's response to coal mining and tunnel excavation impact in Zhongliang Mountain, Chongqing, from 1948 to 2035. The results show a regional decline in groundwater levels within the study area following mining and tunnel construction. The groundwater flow system in the study area evolves from the Jialing River groundwater flow system to encompass the Jialing River, Moxinpo highway tunnel, Moxinpo, and the Liujiagou coal mine cave groundwater flow systems between 1948 and 2025. With the completion of tunnel construction, the groundwater level at the top of the tunnel is gradually restored to the water level in the natural state. The model also predicts groundwater level variations between 2025 and 2035. The groundwater level will rise further initially, however, it may take about 10 years for the system to stabilize and reach a new equilibrium. In light of these findings, it is advised that changes in groundwater flow systems caused by tunnel construction should be modeled prior to the practical construction. This approach is crucial for evaluating potential engineering and environmental implications.
    Keywords human activities ; aquifer system ; evolution of groundwater system ; numerical modeling ; Ecology ; QH540-549.5 ; Engineering geology. Rock mechanics. Soil mechanics. Underground construction ; TA703-712
    Subject code 550
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Groundwater Science and Engineering Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Retraction: Down-regulation of MRPS23 inhibits LPS-induced proliferation and invasion

    Liu, Ai-Guo / Xu, Ke-Lin / Wang, Wei-Lin / Zhou, Bing-Kang / Guo, Qing-Gong

    RSC advances

    2023  Volume 13, Issue 33, Page(s) 23346

    Abstract: This retracts the article DOI: 10.1039/C8RA08973F.]. ...

    Abstract [This retracts the article DOI: 10.1039/C8RA08973F.].
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Retraction of Publication
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra90071a
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  3. Article ; Online: Potential Mechanisms of Shu Gan Jie Yu Capsule in the Treatment of Mild to Moderate Depression Based on Systemic Pharmacology and Current Evidence

    Taiping Li / Tian Qiu / Yanyan Zeng / Bing Kang / Xianglong Tang / Ning Yang / Hong Xiao

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Abstract: Background. Shu Gan Jie Yu (SGJY) capsule has a good effect on relieving depressive symptoms in China. However, the mechanism of action is still unclear. Therefore, systemic pharmacology and molecular docking approaches were used to clarify its ... ...

    Abstract Background. Shu Gan Jie Yu (SGJY) capsule has a good effect on relieving depressive symptoms in China. However, the mechanism of action is still unclear. Therefore, systemic pharmacology and molecular docking approaches were used to clarify its corresponding antidepressant mechanisms. Methods. Traditional Chinese Medicine Database and Analysis Platform (TCMSP), the Encyclopedia of Traditional Chinese Medicine (ETCM), and Swiss Target Prediction servers were used to screen and predict the bioactive components of the SGJY capsule and their antidepressive targets. Mild to moderate depression (MMD) related genes were obtained from GeneCards and DisGeNET databases. A network of bioactive components-therapeutic targets of the SGJY capsule was established by STRING 11.5 and Cytoscape 3.9.0 software. Gene function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed by utilizing Database for Annotation, Visualization, and Integrated Discovery (DAVID) platform. Active components were taken to dock with the hypothetical proteins by iGEMDOCK and SwissDock, and the docking details were visually displayed by UCSF Chimera software. Then, the related research literature of the SGJY capsule was reviewed, summarized, sorted, and analyzed, including experimental evidence and clinical experience. Results. Seven active components and 45 intersection targets were included in the study. PPI network had genuinely uncovered the potential therapeutic targets, such as AKT1, HSP90AA1, ESR1, EGFR, and PTGS2. KEGG pathway analysis showed that the mechanism of the SGJY capsule on MMD was mainly involved in the PI3K-Akt signaling pathway. Conclusions. In this study, we have successfully predicted the biochemically active constituents, potential therapeutic targets, and comprehensively predicted the related drug-gene interaction of the SGJY capsule for treating MMD and provided a basis for subsequent experiments.
    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
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  4. Article ; Online: Genetic Analysis of a Case of Sotos Syndrome with Suspected Germinal Mosaicism in Mother.

    Hai, Xiao / Liangjie, Guo / Qian, Zhang / Tao, Li / Hongdan, Wang / Bing, Kang / Ke, Yang / Qiannan, Guo / Dong, Wu / Shixiu, Liao

    Applied biochemistry and biotechnology

    2023  Volume 195, Issue 10, Page(s) 5792–5801

    Abstract: This study is to identify the pathogenic mutation of a child with Sots syndrome and provide prenatal diagnosis for his pregnant mother. Chromosome microarray technology was used to detect whether there were minor deletions/duplication in patients' ... ...

    Abstract This study is to identify the pathogenic mutation of a child with Sots syndrome and provide prenatal diagnosis for his pregnant mother. Chromosome microarray technology was used to detect whether there were minor deletions/duplication in patients' chromosomes. The gene mutation of patients was screened by next-generation sequencing technology, and it was verified by Sanger sequencing. Prenatal diagnosis of the fetus was conducted according to the selected pathogenic sites, and genetic counseling was conducted for her parents. Chromosome microarray results showed that there was no minor deletion in a chromosome 5q35 region, and the second-generation sequencing results showed that there was a c.4138delG heterozygous mutation in the patient's NSD1 gene, and the pathogenic of this mutation was not reported in related databases. Sanger sequencing found that there was a c.4138delG heterozygous mutation in the NSD1 gene of the patient and her parents' genotype at this locus was wild type. The prenatal gene test results indicated that there was heterozygous mutation of NSD1 gene c.4138delG in the fetus, so it was suggested to terminate the pregnancy. Gentling results indicated that the fetus and the patient inherited the same maternal chromosome 5. The heterozygous mutation of NSD1 gene c.4138delG is the pathogenic mutation of this Sots syndrome patient, and the mother may be germinal mosaicism.
    MeSH term(s) Humans ; Child ; Female ; Sotos Syndrome/diagnosis ; Sotos Syndrome/genetics ; Sotos Syndrome/pathology ; Histone-Lysine N-Methyltransferase/genetics ; Histone Methyltransferases/genetics ; Mothers ; Mosaicism ; Phenotype
    Chemical Substances Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Histone Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04377-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Pattern Recognition Analysis of Metabolites in Escherichia coli Based on ESI-Orbitrap Mass Spectrometry.

    Wang, Rui-Yu / Yan, Yang-Yang / Li, Bei / Fan, Xing / Gu, Bing / Zhou, Yuan / Sun, Bing-Kang

    Chemistry & biodiversity

    2023  Volume 20, Issue 5, Page(s) e202201153

    Abstract: To achieve rapid detection of carbapenem-resistant Escherichia coli strains, a pattern recognition method based on electrospray ionization Orbitrap mass spectrometry (ESI-Orbitrap MS) was used for the analysis of drug-resistant, and sensitive strains of ... ...

    Abstract To achieve rapid detection of carbapenem-resistant Escherichia coli strains, a pattern recognition method based on electrospray ionization Orbitrap mass spectrometry (ESI-Orbitrap MS) was used for the analysis of drug-resistant, and sensitive strains of metabolites were analyzed. Results of five clustering methods applied to analytical data of metabolites were evaluated using iso-phenotypic coefficients. The effectiveness of three methods, principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) and orthogonal partial least squares discriminant analysis (OPLS-DA), was compared. Univariate statistics such as t-test and fold change were also used to examine the screened differential information. Both PLS-DA and OPLS-DA could achieve rapid identification of strain classes, and OPLS-DA was more powerful in screening 96 significantly different ions. This work is expected to be useful for rapid and accurate identification of strains.
    MeSH term(s) Spectrometry, Mass, Electrospray Ionization/methods ; Escherichia coli ; Discriminant Analysis ; Cluster Analysis ; Principal Component Analysis ; Metabolomics/methods ; Chromatography, High Pressure Liquid/methods
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202201153
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  6. Article ; Online: Rapid Identification of Polypeptide from Carbapenem-Resistant and Susceptible Escherichia coli via Orbitrap-MS and Pattern Recognition Analyses.

    Sun, Bing-Kang / Wang, Rui-Yu / Li, Bei / Fan, Xing / Zhou, Yuan / Gu, Bing / Yan, Yang-Yang

    Chemistry & biodiversity

    2022  Volume 19, Issue 9, Page(s) e202200118

    Abstract: A rapid and accurate analytical method was established to identify CREC and CSEC. Orbitrap-MS was used to detect the polypeptide of CREC and CSEC strains, and MS data were analyzed by pattern recognition analyses such as hierarchical cluster analysis ( ... ...

    Abstract A rapid and accurate analytical method was established to identify CREC and CSEC. Orbitrap-MS was used to detect the polypeptide of CREC and CSEC strains, and MS data were analyzed by pattern recognition analyses such as hierarchical cluster analysis (HCA), principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal partial least squares discriminant analysis (OPLS-DA). HCA based on the farthest distance method could well distinguish the two types of E. coli, and the cophenetic correlation coefficient of the farthest distance method was 0.901. Comparing the results of PCA, PLS-DA, and OPLS-DA, OPLS-DA exhibited the highest accuracy in predicting the CREC and CSEC strains. A total of 26 compounds were identified, and six of the compounds were the highly significant difference between the two types of strains. MS combined with pattern recognition can achieve a more comprehensive and efficient statistical analysis of complex biological samples.
    MeSH term(s) Carbapenems ; Chromatography, High Pressure Liquid ; Discriminant Analysis ; Escherichia coli ; Least-Squares Analysis ; Peptides ; Principal Component Analysis
    Chemical Substances Carbapenems ; Peptides
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202200118
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  7. Article ; Online: CT-Based Radiomics Score Can Accurately Predict Esophageal Variceal Rebleeding in Cirrhotic Patients

    Dongxiao Meng / Yingnan Wei / Xiao Feng / Bing Kang / Ximing Wang / Jianni Qi / Xinya Zhao / Qiang Zhu

    Frontiers in Medicine, Vol

    2021  Volume 8

    Abstract: Purpose: This study aimed to develop a radiomics score (Rad-score) extracted from liver and spleen CT images in cirrhotic patients to predict the probability of esophageal variceal rebleeding.Methods: In total, 173 cirrhotic patients were enrolled in ... ...

    Abstract Purpose: This study aimed to develop a radiomics score (Rad-score) extracted from liver and spleen CT images in cirrhotic patients to predict the probability of esophageal variceal rebleeding.Methods: In total, 173 cirrhotic patients were enrolled in this retrospective study. A total of 2,264 radiomics features of the liver and spleen were extracted from CT images. Least absolute shrinkage and selection operator (LASSO) Cox regression was used to select features and generate the Rad-score. Then, the Rad-score was evaluated by the concordance index (C-index), calibration curves, and decision curve analysis (DCA). Kaplan–Meier analysis was used to assess the risk stratification ability of the Rad-score.Results: Rad-scoreLiver, Rad-scoreSpleen, and Rad-scoreLiver−Spleen were independent risk factors for EV rebleeding. The Rad-scoreLiver−Spleen, which consisted of ten features, showed good discriminative performance, with C-indexes of 0.853 [95% confidence interval (CI), 0.776–0.904] and 0.822 (95% CI, 0.749–0.875) in the training and validation cohorts, respectively. The calibration curve showed that the predicted probability of rebleeding was very close to the actual probability. DCA verified the usefulness of the Rad-scoreLiver−Spleen in clinical practice. The Rad-scoreLiver−Spleen showed good performance in stratifying patients into high-, intermediate- and low-risk groups in both the training and validation cohorts. The C-index of the Rad-scoreLiver−Spleen in the hepatitis B virus (HBV) cohort was higher than that in the non-HBV cohort.Conclusion: The radiomics score extracted from liver and spleen CT images can predict the risk of esophageal variceal rebleeding and stratify cirrhotic patients accordingly.
    Keywords portal hypertension ; non-invasive ; computed tomography ; radiomics ; esophageal variceal rebleeding ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Generating Topological Structure of Floorplans from Room Attributes

    Yu, Yin / Will, Hutchcroft / Naji, Khosravan / Ivaylo, Boyadzhiev / Yun, Fu / Bing, Kang Sing

    2022  

    Abstract: Analysis of indoor spaces requires topological information. In this paper, we propose to extract topological information from room attributes using what we call Iterative and adaptive graph Topology Learning (ITL). ITL progressively predicts multiple ... ...

    Abstract Analysis of indoor spaces requires topological information. In this paper, we propose to extract topological information from room attributes using what we call Iterative and adaptive graph Topology Learning (ITL). ITL progressively predicts multiple relations between rooms; at each iteration, it improves node embeddings, which in turn facilitates generation of a better topological graph structure. This notion of iterative improvement of node embeddings and topological graph structure is in the same spirit as \cite{chen2020iterative}. However, while \cite{chen2020iterative} computes the adjacency matrix based on node similarity, we learn the graph metric using a relational decoder to extract room correlations. Experiments using a new challenging indoor dataset validate our proposed method. Qualitative and quantitative evaluation for layout topology prediction and floorplan generation applications also demonstrate the effectiveness of ITL.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2022-04-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Depth director: a system for adding depth to movies.

    Ward, B / Sing Bing Kang / Bennett, E P

    IEEE computer graphics and applications

    2011  Volume 31, Issue 1, Page(s) 36–48

    Abstract: Depth Director is an interactive system for converting 2D footage to 3D. It integrates recent computer vision advances with specialized tools that let users accurately recreate or stylistically manipulate 3D depths. ...

    Abstract Depth Director is an interactive system for converting 2D footage to 3D. It integrates recent computer vision advances with specialized tools that let users accurately recreate or stylistically manipulate 3D depths.
    Language English
    Publishing date 2011-01
    Publishing country United States
    Document type Journal Article
    ISSN 0272-1716
    ISSN 0272-1716
    DOI 10.1109/MCG.2010.103
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  10. Article ; Online: Anomalous systemic artery to the non-sequestrated lung

    Bing Kang / Yan Ma / Kai Li / Xi-Heng Wang / Cong Sun / Xi-Ming Wang / Qiang Shi

    Chinese Medical Journal, Vol 133, Iss 18, Pp 2259-

    multi-slice computed tomography features

    2020  Volume 2260

    Keywords Medicine ; R
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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