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Article: Significant effects of exposure to relatively low level ozone on daily mortality in 17 cities from three Eastern Asian Countries

Huang, Wei-Heng / Bing-Yu Chen / Ho Kim / Yasushi Honda / Yue Leon Guo

Environmental research. 2019 Jan., v. 168

2019

Abstract: Studies have examined the variation in mortality risk associated with ambient ozone. We conducted an international cooperation study for investigating the non-linear ozone–mortality association accounting for lag effect and for examining the ozone level ... ...

Abstract	Studies have examined the variation in mortality risk associated with ambient ozone. We conducted an international cooperation study for investigating the non-linear ozone–mortality association accounting for lag effect and for examining the ozone level with significant health effect.Daily counts of total non-accidental death and ambient air pollutant concentration were obtained in 17 cities from 3 Eastern Asian countries or regions (Taiwan, Korea, and Japan). The total study period was from 1979 to 2010 and differed by city based on data availability. The ozone–mortality association in each city was estimated by running a time-series quasi-Poisson regression model, allowing for overdispersion. The city-specific estimates were then pooled by country by using multivariate random effects meta-analysis.The non-linear ozone exposure–mortality response curves were generated in 17 cities from Taiwan, Korea, and Japan. The association curves in the three countries all showed increased mortality with elevated ozone, and the significant mortality effects of ozone exposure were observed at level higher than 40, 50, and 40 ppb for Taiwan, Korea, and Japan, respectively. These associations are unaffected by co-pollutant of particulate matter in Taiwan and Japan. But the potential confounding effect of co-pollutant could not be ignorable in Korea.Our study provides evidence that exposure to a relative low level of ambient ozone is associated with an increased risk of mortality. Our results emphasize the continual need to examine the existing standard by documenting potential human adverse effects.
Keywords	adverse effects ; air pollutants ; air pollution ; cities ; death ; humans ; international cooperation ; mortality ; ozone ; particulates ; regression analysis ; risk ; time series analysis ; Japan ; Korean Peninsula ; Taiwan
Language	English
Dates of publication	2019-01
Size	p. 80-84.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2018.09.017
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: An optimized industry processing technology of peanut tofu and the novel prediction model for suitable peanut varieties

Bing-yu CHEN / Qi-zhai LI / Hui HU / Shi MENG / Faisal SHAH / Qiang WANG / Hong-zhi LIU

Journal of Integrative Agriculture, Vol 19, Iss 9, Pp 2340-

2020 Volume 2351

Abstract: Peanut protein is easily digested and absorbed by the human body, and peanut tofu does not contain flatulence factors and beany flour. However, at present, there is no industrial preparation process of peanut tofu, whereas the quality of tofu prepared by ...

Abstract	Peanut protein is easily digested and absorbed by the human body, and peanut tofu does not contain flatulence factors and beany flour. However, at present, there is no industrial preparation process of peanut tofu, whereas the quality of tofu prepared by different peanut varieties is quite different. This study established an industrial feasible production process of peanut tofu and optimized the key process that regulates its quality. Compared with the existing method, the production time is reduced by 53.80%, therefore the daily production output is increased by 183.33%. The chemical properties of 26 peanut varieties and the quality characteristics of tofu prepared from these 26 varieties were determined. The peanut varieties were classified based on the quality characteristics of tofu using the hierarchical cluster analysis (HCA) method, out of which 7 varieties were screened out which were suitable for preparing peanut tofu. An evaluation standard was founded based on peanut tofu qualities. Six chemical trait indexes were correlated with peanut tofu qualities (P<0.05). A logistic regressive model was developed to predict suitable peanut varieties and this prediction model was verified. This study may help broaden the peanut protein utilization, and provide guidance for breeding experts to select certain varieties for product specific cultivation of peanut.
Keywords	peanut tofu ; process ; quality ; peanut variety selection ; evaluation standard ; prediction model ; Agriculture (General) ; S1-972
Subject code	670
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of age-related macular degeneration on fracture risks among osteoporosis population

Bing-Yu Chen / Chi Chin Sun / Ting-Shuo Huang / Tsai-Sheng Fu / Chia-Yi Lee / Fang-Ping Chen

BMJ Open, Vol 10, Iss

a nationwide population-based cohort study

2020 Volume 9

Abstract: Objectives Visual impairment is an important risk factor for fracture in the elderly population. Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment in elderly people. This study was conducted to explore the ... ...

Abstract	Objectives Visual impairment is an important risk factor for fracture in the elderly population. Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment in elderly people. This study was conducted to explore the relationship between AMD and incident fractures in patients with osteoporosis (OS).Design Retrospective analysis of Taiwan’s National Health Insurance Research Database (NHIRD).Setting A multicenter study conducted in Taiwan.Participants and controls The current study used the NHIRD in Taiwan between 1996 and 2011. A total of 13 584 and 54 336 patients with OS were enrolled in the AMD group and the non-AMD group, respectively.Intervention Patients with OS were included from the Taiwan’s NHIRD after exclusion, and each patient with AMD was matched for age, sex and comorbidities to four patients with non-AMD OS, who served as the control group. A Cox proportional hazard model was used for the multivariable analysis.Primary outcome measures Transitions for OS to spine fracture, OS to hip fracture, OS to humero-radio-ulnar fracture and OS to death.Results The risks of spine and hip fractures were significantly higher in the AMD group (HR=1.09, 95% CI=1.04 to 1.15, p<0.001; HR=1.18; 95% CI=1.08 to 1.30, p=0.001, respectively) than in the non-AMD group. The incidence of humero-radio-ulnar fracture between AMD and non-AMD individuals was similar (HR=0.98; 95% CI=0.90 to 1.06; p=0.599). However, the risk of death was higher in patients with OS with older age, male sex and all types of comorbidity (p<0.05), except for hyperthyroidism (p=0.200).Conclusion Patients with OS with AMD had a greater risk of spine and hip fractures than did patients without AMD.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Atrial fibrillation hospitalization is associated with exposure to fine particulate air pollutants

Hsiu Hao Lee / Shih Chun Pan / Bing Yu Chen / Shih Hsiang Lo / Yue Leon Guo

Environmental Health, Vol 18, Iss 1, Pp 1-

2019 Volume 8

Abstract: Abstract Background Although air pollutants have been associated with cardiopulmonary mortality, their effects on the occurrence of atrial fibrillation (Afib) remain unclear. This study examined the association between ambient air pollutants and Afib ... ...

Abstract	Abstract Background Although air pollutants have been associated with cardiopulmonary mortality, their effects on the occurrence of atrial fibrillation (Afib) remain unclear. This study examined the association between ambient air pollutants and Afib occurrence. Methods Using a representative sample from the National Health Insurance Database of Taiwan, we applied a case–crossover study design to explore the associations between air pollutants and patients hospitalized with Afib from 2006 to 2011. The event day was when a patient was hospitalized with Afib, and the control days were the same days of the following weeks of the same month. The association between Afib occurrence and levels of ambient air pollutants (including particulate matter [PM] 2.5 PM10, NO2, SO2, and O3) was examined after adjusting for temperature and relative humidity. A two-pollutant model was used to examine the effect of the second pollutant when the first pollutant was determined to be significantly related to Afib. Results During 2006–2011, 670 patients hospitalized with the first onset of Afib were identified. The occurrence of Afib was associated with PM2.5, in which a 22% (95% confidence interval = 3–44%) increase was related to an interquartile range increase (26.2 μg/m3) on the same day and a 19% (95% confidence interval = 0–40%) increase on the second day. A two-pollutant model was applied, and the results indicated that the effect of PM2.5 was significantly associated with the occurrence of Afib. Patients aged over 65 years with DM and with hyperlipidemia were more susceptible to the effect of PM2.5. Conclusions In conclusion, the occurrence of Afib was associated with short-term exposure to fine particulate air pollutants in the general population.
Keywords	Air pollution ; Atrial fibrillation ; Particulate matter ; Case–crossover ; Industrial medicine. Industrial hygiene ; RC963-969 ; Public aspects of medicine ; RA1-1270
Subject code	333
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prenatal exposure to PM2.5 and Congenital Heart Diseases in Taiwan

Huang, Ching-chun / Bing-yu Chen / Shih-chun Pan / Yi-lwun Ho / Yue Leon Guo

Science of the total environment. 2019 Mar. 10, v. 655

2019

Abstract: Gestational exposure to ambient air pollution has been associated with Congenital Heart Diseases (CHDs). However, only a few studies, with inconsistent results, have investigated the effects of PM2.5 exposure during early pregnancy. This study aims to ... ...

Abstract	Gestational exposure to ambient air pollution has been associated with Congenital Heart Diseases (CHDs). However, only a few studies, with inconsistent results, have investigated the effects of PM2.5 exposure during early pregnancy. This study aims to evaluate the association between prenatal exposure to PM2.5 and CHDs occurrence. We selected 782 births reported to have CHDs between 2007 and 2014 from the Taiwanese Birth Registry and randomly selected 4692 controls without any birth defects using a population-based case-control design. Data of exposure to ambient air pollutants, mainly PM2.5, PM10, CO, SO2, NO2, and O3 during weeks 3–8 of pregnancy were retrieved from air quality monitoring stations and interpolated to every township using ordinary kriging. We applied unconditional logistic regression models adjusted for potential confounders to evaluate the associations. The results revealed a positive correlation between increased PM2.5 exposure (adjusted odds ratio [aOR] = 1.21, 95% confidence interval [CI] = 1.03–1.42, per interquartile range change = 13.4 μg/m3) during early pregnancy and overall CHDs occurrence. Furthermore, we found that atrial septal defect (aOR = 1.43, 95% CI = 1.01–2.02), endocardial cushion defect (aOR = 2.37, 95% CI = 1.01–5.58), and pulmonary artery and valve stenosis (aOR = 1.71, 95% CI = 1.06–2.78) were significantly associated with PM2.5 exposures. No similar effects were observed for the other air pollutants. This study has demonstrated some positive associations between increased PM2.5 exposure during the critical period of cardiac embryogenesis and certain CHDs occurrence.
Keywords	air pollutants ; air pollution ; air quality ; carbon monoxide ; confidence interval ; congenital abnormalities ; embryogenesis ; heart diseases ; kriging ; maternal exposure ; monitoring ; nitrogen dioxide ; odds ratio ; ozone ; particulates ; pregnancy ; pulmonary artery ; regression analysis ; sulfur dioxide ; Taiwan
Language	English
Dates of publication	2019-0310
Size	p. 880-886.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2018.11.284
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 949: Show issues

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Article: Lifetime exposure to particulate air pollutants is negatively associated with lung function in non-asthmatic children

Tsui, Hung-Chang / Chi-Hsien Chen / Ying-Hsuan Wu / Hung-Che Chiang / Bing-Yu Chen / Yue Leon Guo

Environmental pollution. 2018 May, v. 236

2018

Abstract: Pulmonary function is known to be affected by acute and subacute exposure to ambient air pollution. However, the impacts of lifetime exposure to air pollution on the pulmonary function of children have been inconsistent. The present study investigated ... ...

Abstract	Pulmonary function is known to be affected by acute and subacute exposure to ambient air pollution. However, the impacts of lifetime exposure to air pollution on the pulmonary function of children have been inconsistent. The present study investigated the impact of lifetime residential exposure to intermediate levels of air pollution on the pulmonary function of schoolchildren.In 2011, a survey of children aged 6–15 years was conducted in 44 schools in Taiwan. Atopic history, residential history, and environmental factors were recorded. Spirograms were obtained from a random sample of children without asthma. A total of 535 girls and 481 boys without a history of asthma were enrolled. Lifetime residential exposure to air pollutants, including particulate matter with an aerodynamic diameter less than 10 μm (PM10), ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2), and carbon monoxide (CO), was estimated using the kriging method, based on monitored data from the Taiwan Environmental Protection Administration. Multiple linear regression was used to analyze the association between lifetime air pollution exposure and pulmonary function, after adjustment for potential confounders and recent exposure.After adjustment for 7-day average air pollutant levels, a 10 μg/m3 increase in PM10 was related to reductions in the forced expiratory volume in 1 s (−2.00%; 95% confidence interval [CI] −3.09% to −0.90%), forced vital capacity (−1.86%; CI: −2.96% to −0.75%), and maximal midexpiratory flow (−2.28%; CI: −4.04% to −0.51%). These associations were independent of the other pollutants.Lifetime exposure to 25–85 μg/m3 of PM10 has negative impacts on the pulmonary function of children.
Keywords	air pollutants ; air pollution ; asthma ; boys ; carbon monoxide ; children ; chronic exposure ; confidence interval ; environmental factors ; environmental protection ; girls ; kriging ; lung function ; nitrogen dioxide ; ozone ; particulates ; regression analysis ; schools ; sulfur dioxide ; surveys ; Taiwan
Language	English
Dates of publication	2018-05
Size	p. 953-961.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2017.10.092
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

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Article ; Online: Second-line Hormonal Therapy for the Management of Metastatic Castration-resistant Prostate Cancer

Jui-Ming Liu / Cheng-Chia Lin / Kuan-Lin Liu / Cheng-Feng Lin / Bing-Yu Chen / Tien-Hsing Chen / Chi-Chin Sun / Chun-Te Wu

Scientific Reports, Vol 10, Iss 1, Pp 1-

a Real-World Data Study Using a Claims Database

2020 Volume 7

Abstract: Abstract We evaluated the efficacy of second-line hormonal therapy for treatment of metastatic castration-resistant prostate cancer (mCRPC) in a real-world retrospective study. We conducted a population-based real-world cohort study of 258 mCRPC patients ...

Abstract	Abstract We evaluated the efficacy of second-line hormonal therapy for treatment of metastatic castration-resistant prostate cancer (mCRPC) in a real-world retrospective study. We conducted a population-based real-world cohort study of 258 mCRPC patients between 2014 and 2018 using the Chang Gung Research Database (CGRD) of Taiwan. The second-line hormonal therapy included abiraterone acetate and enzalutamide. The clinical efficacy outcomes were overall survival (OS) and prostate-specific antigen (PSA) doubling time. The median PSA level was also assessed. In total, 223 mCRPC patients who underwent second-line hormonal therapy met all of the inclusion and exclusion criteria for this study. Among them, 65 (29.1%) patients were in the PSA response group and 158 (70.9%) were in the non-response group. The median age was 72.9 years. The median OS was 12.3 months (range: 9.9–19.9 months) and 9.6 months (range: 5.3–15.9 months) in the response and non-response groups, respectively, and the respective PSA doubling times were 9.0 months (range: 4.4–11.6 months) and 3.9 months (range: 2.2–9.1 months), with a median follow-up period of 10.5 months. A significantly longer median OS was seen in the PSA response group. This real-world database study demonstrated that clinical outcomes of second-line hormonal therapy were better in patients with a PSA response. Further studies are warranted to achieve a better understanding of second-line hormonal therapy for mCRPC in Asian populations.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of PM2.5 on Skeletal Muscle Mass and Body Fat Mass of the Elderly in Taipei, Taiwan

Chi-Hsien Chen / Li-Ying Huang / Kang-Yun Lee / Chih-Da Wu / Hung-Che Chiang / Bing-Yu Chen / Wei-Shan Chin / Shih-Chun Pan / Yue Leon Guo

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 8

Abstract: Abstract Loss of skeletal muscle mass is common with aging and can cause morbidity and mortality in the elderly. The effects of particulate air pollution on skeletal muscle mass is not known. The study aims to assess the chronic effects of ambient fine ... ...

Abstract	Abstract Loss of skeletal muscle mass is common with aging and can cause morbidity and mortality in the elderly. The effects of particulate air pollution on skeletal muscle mass is not known. The study aims to assess the chronic effects of ambient fine particulates (PM2.5) on the body composition of the elderly. From October 2015 to November 2016, a cross-sectional survey on 530 elderly (age > = 65 years) was conducted in the Taipei Basin, Taiwan. The body composition was measured by bioelectrical impedance analysis (InBody 120). One year exposure to air pollution was estimated using the Kriging method at the participant’s residence. Multiple linear regression analysis, after adjustments for demographics and co-pollutants, was used to examine the effects of PM2.5 on body composition indices and force of handgrip. Changes in body composition for an interquartile (1.4 μm/m3) increase in PM2.5 concentration included a 0.4 kg (95% confidence interval (CI): −0.31, −0.58; p < 0.0001) decrease in skeletal muscle mass (2.0%) and a 0.7 kg (95% CI: 0.47, 0.91; p < 0.0001) increase in body fat mass (3.6%). While PM2.5 reduced fat free mass in the upper extremities and trunk, but not in the lower extremities, it increased body fat mass in the three parts. There was no significant effect of PM2.5 on handgrip force. Higher physical activity (versus lower than median) was associated with less detrimental effect of PM2.5 on skeletal muscle mass and body fat mass (p values for interaction term: 0.009 and 0.013, respectively). Long-term PM2.5 exposure is associated with decreased skeletal muscle mass and increased body fat mass in the elderly, which can be ameliorated by physical activity.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: swDMR

Zhen Wang / Xianfeng Li / Yi Jiang / Qianzhi Shao / Qi Liu / BingYu Chen / Dongsheng Huang

PLoS ONE, Vol 10, Iss 7, p e

A Sliding Window Approach to Identify Differentially Methylated Regions Based on Whole Genome Bisulfite Sequencing.

2015 Volume 0132866

Abstract: DNA methylation is a widespread epigenetic modification that plays an essential role in gene expression through transcriptional regulation and chromatin remodeling. The emergence of whole genome bisulfite sequencing (WGBS) represents an important ... ...

Abstract	DNA methylation is a widespread epigenetic modification that plays an essential role in gene expression through transcriptional regulation and chromatin remodeling. The emergence of whole genome bisulfite sequencing (WGBS) represents an important milestone in the detection of DNA methylation. Characterization of differential methylated regions (DMRs) is fundamental as well for further functional analysis. In this study, we present swDMR (http://sourceforge.net/projects/swDMR/) for the comprehensive analysis of DMRs from whole genome methylation profiles by a sliding window approach. It is an integrated tool designed for WGBS data, which not only implements accessible statistical methods to perform hypothesis test adapted to two or more samples without replicates, but false discovery rate was also controlled by multiple test correction. Downstream analysis tools were also provided, including cluster, annotation and visualization modules. In summary, based on WGBS data, swDMR can produce abundant information of differential methylated regions. As a convenient and flexible tool, we believe swDMR will bring us closer to unveil the potential functional regions involved in epigenetic regulation.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of particulate air pollution and ozone on lung function in non-asthmatic children

Chen, Chi-Hsien / Bing-Yu Chen / Chang-Chuan Chan / Tsun-Jen Cheng / Yue Leon Guo

Environmental Research. 2015 Feb., v. 137

2015

Abstract: Information on the long-term effects of different air pollutant levels on lung function is relatively lacking in Asia and still inconclusive in the world. Age differential effects of air pollution are not known.To assess the acute and subchronic effects ... ...

Abstract	Information on the long-term effects of different air pollutant levels on lung function is relatively lacking in Asia and still inconclusive in the world. Age differential effects of air pollution are not known.To assess the acute and subchronic effects of ambient air pollution on lung function and compared among children of different ages.From April to May 2011, a nationwide study was conducted on schoolchildren aged 6â15 years in 44 schools of 24 districts in Taiwan. Spirograms were obtained from 1494 non-asthmatic children. Air pollution data were retrieved from air monitoring stations within one kilometre of the schools. Using three-level hierarchical linear models, individual lung function was fitted to air pollution, with adjustments for demographics, indoor exposures, outdoor activity, and districts.Lung function changes per inter-quartile increase of the past two-months average levels of particulate matter <2.5Î¼m (PM2.5) and ozone (12Î¼g/m3, 32â44 and 6.7ppb, 32â38, respectively) were â103 and â142ml on FVC, â86 and â131 on FEV1, and â102 and â188ml/s on MMEF, respectively. Lag-1-day ozone exposure was associated with decreased MMEF. In children aged 6â10, PM2.5 was associated with decreased FEV1/FVC and MMEF/FVC ratios.In children aged 6â15 years, sub-chronic exposure to ambient PM2.5 and ozone leads to reduced lung capacity, whereas acute exposure to ozone decreases mid-expiratory flow. In children aged 6â10 years, additional airway obstructive patterns in lung function may be associated with PM2.5 exposure.
Keywords	acute exposure ; air ; air pollution ; demographic statistics ; linear models ; long term effects ; lung function ; monitoring ; ozone ; particulates ; pollutants ; school children ; schools ; subchronic exposure ; Taiwan
Language	English
Dates of publication	2015-02
Size	p. 40-48.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2014.11.021
Database	NAL-Catalogue (AGRICOLA)

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