Article ; Online: Air pollution and out-of-hospital cardiac arrest risk: a 7-year study from a highly polluted area.
European heart journal. Acute cardiovascular care
2023 Volume 12, Issue 12, Page(s) 810–817
Abstract: Aims: Globally, nearly 20% of cardiovascular disease deaths were attributable to air pollution. Out-of-hospital cardiac arrest (OHCA) represents a major public health problem; therefore, the identification of novel OHCA triggers is of crucial relevance. ...
| Abstract | Aims: Globally, nearly 20% of cardiovascular disease deaths were attributable to air pollution. Out-of-hospital cardiac arrest (OHCA) represents a major public health problem; therefore, the identification of novel OHCA triggers is of crucial relevance. The aim of the study was to evaluate the association between air pollution (short-, mid-, and long-term exposures) and OHCA risk, during a 7-year period in a highly polluted urban area in northern Italy, with a high density of automated external defibrillators (AEDs). Methods and results: Out-of-hospital cardiac arrests were prospectively collected from the 'Progetto Vita Database' between 1 January 2010 and 31 December 2017; day-by-day air pollution levels were extracted from the Environmental Protection Agency stations. Electrocardiograms of OHCA interventions were collected from the AED data cards. Day-by-day particulate matter (PM) 2.5 and 10, ozone (O3), carbon monoxide (CO), and nitrogen dioxide (NO2) levels were measured. A total of 880 OHCAs occurred in 748 days. A significant increase in OHCA risk with a progressive increase in PM2.5, PM10, CO, and NO2 levels was found. After adjustment for temperature and seasons, a 9% and 12% increase in OHCA risk for each 10 μg/m3 increase in PM10 (P < 0.0001) and PM2.5 (P < 0.0001) levels was found. Air pollutant levels were associated with both asystole and shockable rhythm risk, while no correlation was found with pulseless electrical activity. Conclusion: Short- and mid-term exposures to PM2.5 and PM10 are independently associated with the risk of OHCA due to asystole or shockable rhythm. |
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| MeSH term(s) | United States ; Humans ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/etiology ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Nitrogen Dioxide/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Air Pollutants/adverse effects ; Air Pollutants/analysis |
| Chemical Substances | Particulate Matter ; Nitrogen Dioxide (S7G510RUBH) ; Air Pollutants |
| Language | English |
| Publishing date | 2023-09-14 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2663340-1 |
| ISSN | 2048-8734 ; 2048-8726 |
| ISSN (online) | 2048-8734 |
| ISSN | 2048-8726 |
| DOI | 10.1093/ehjacc/zuad105 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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