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  1. Article ; Online: The Ciji-Hua’ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma

    Shengyan Xi / Xiangyang Zhai / Yanan Wang / Yuewen Gong / Biqian Fu / Chunling Gao / Xuehui Guo / Yunhong Li / Zheng Wang / Shuqiong Huang / Dawei Lu / Yufang Zhao / Linchao Qian / Yanhui Wang

    Frontiers in Pharmacology, Vol

    2021  Volume 12

    Abstract: Background: Ciji-Hua’ai-Baosheng II Formula (CHB-II-F) is a traditional Chinese medicine formula, which specifically targets different aspects of chemotherapy-induced adverse effects in patients with cancer. In our clinical application, CHB-II-F ... ...

    Abstract Background: Ciji-Hua’ai-Baosheng II Formula (CHB-II-F) is a traditional Chinese medicine formula, which specifically targets different aspects of chemotherapy-induced adverse effects in patients with cancer. In our clinical application, CHB-II-F significantly alleviated chemotherapy-induced anorexia (loss of appetite) and improved the quality of life for patients with tumor during and after chemotherapy. However, the mechanism of CHB-II-F in alleviation of chemotherapy-induced anorexia remains to be further investigated.Aim of Study: To explore the therapeutic effect and mechanism of CHB-II-F on chemotherapy-induced anorexia in the mice model of H22 hepatoma.Materials and Methods: A total of 72 Kunming mice of SPF grade were inoculated subcutaneously with H22 hepatoma cells into the right anterior armpit of the mice. After 1 week of seeding, mice were injected intraperitoneally with a high dose of 5-fluorouracil (200 mg/kg 5-FU) to establish the model of chemotherapy. The mice were randomly divided into six groups: untreated group, 5-FU group, 5-FU plus Yangzheng Xiaoji capsule (YZXJC) group, and three groups of 5-FU plus different concentrations of CHB-II-F. All the mice in each group were treated for 14 days. The body weight, food intake, tumor volume, and tumor weight of mice were measured, and pathological examinations of tumor tissue, stomach, and duodenum were carried out. Expressions of serum Leptin, Neuropeptide Y (NPY), epidermal cell growth factor (EGF), Motilin (MTL), Orexin A (OXA), Gastrin (GAS), Ghrelin, Prostaglandin E2 (PGE2), and jejunum superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were examined. The protein and mRNA levels of proopiomelanocortin (POMC), Orexin receptor 1 (OX1R), neuropeptide Y (NPY), cocaine and amphetamine regulated transcript peptide (CART), Agouti gene-related protein (AgRP), Leptin receptor (Ob-R), and Ghrelin receptor (GHSR) were examined in hypothalamus, and the protein levels of substance P (SP) and 5-hydroxytryptamine (5-HT) in duodenum were ...
    Keywords Ciji-Hua’ai-Baosheng II formula ; traditional Chinese medicine ; hepatocellular carcinoma ; chemotherapy ; anorexia ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610 ; 630
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Composition and spatial distribution pattern of ground-dwelling beetle communities in Yeyahu Wetland, Beijing

    Yu Wang / Guangcai Gao / Biqian Fu / Zhuan Wu

    Biodiversity Science, Vol 17, Iss 1, Pp 30-

    2009  Volume 42

    Abstract: In this paper, ground-dwelling beetle communities (GDBCs) from 32 sampling sites with five main vegetation types, two well-conserved ones and three degradated ones, were investigated in Yeyahu Wetland of Beijing by pitfall traps from April to December, ... ...

    Abstract In this paper, ground-dwelling beetle communities (GDBCs) from 32 sampling sites with five main vegetation types, two well-conserved ones and three degradated ones, were investigated in Yeyahu Wetland of Beijing by pitfall traps from April to December, 2007, and the influence of wetland degradation and vegetation variation on the composition of GDBCs was studied at the family level. A total of 42 families were collected in the whole sampling period. Among these, Carabidae and Staphylinidae were dominant, while Anthicidae, Eumolpidae and Lathridiidae were subdominant. In the five types of vegetation investigated, the activity density, family level richness and the Shannon-Wiener diversity index (H') of GDBCs were not significantly different between the well-conserved Phragmites communis and Cyperus glomeratus ones. However, the beetle activity density in these two well-conserved vegetations, and the family richness in the Cyperus glomeratus one were significantly higher than those of the three degradated ones. It was showed by canonical correspondence analysis (CCA) to the relationship between the composition of GDBCs and nine environmental factors, that there was an obviously correspondance between the distribution of the 32 sampling sites in CCA ordination diagram and the vegetation types, and soil water content, plant coverage, plant biomass, and litter coverage were the major factors affecting on the composition and spatial distribution of GDBCs in the wetland. According to the correlation analysis, we also found that the correlation among beetleactivity density and the soil water content, plant biomass and coverage was all significantly positive (P<0.05 or P<0.01), and it was between beetle family richness and plant biomass (P<0.05); while that between the beetle diversity index (H') and plant coverage was significantly negative (P<0.01). Moreover, in a nonlinear regression analysis, the change of soil water content could explain about 57% of the variation in beetle activity density. A synthetic environmental variable, WBC (Water-Biomass-Coverage), which reflects the situation of soil water content, plant biomass and coverage, was obtained by principal component analysis (PCA) of the nine environmental factors. On the basis of relationship between beetle activity density and WBC, the five vegetation types could be divided into three extremely different groups. Our results showed that maintaining appropriate wetland landscapes is vital for beetle protection.
    Keywords vegetation type ; wetland ; canonical correspondence analysis ; principal component analysis ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Subject code 580
    Language Chinese
    Publishing date 2009-01-01T00:00:00Z
    Publisher Science Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

    Biqian Fu / Xiangyang Zhai / Shengyan Xi / Lifeng Yue / Yanan Wang / Yingkun Qiu / Yuewen Gong / Yangxinzi Xu / Linchao Qian / Jingru Huang / Dawei Lu / Shuqiong Huang / Jing Wang / Jing Zhou / Di Wu / Yanhui Wang

    Evidence-Based Complementary and Alternative Medicine, Vol

    2019  Volume 2019

    Abstract: Background. Ciji-Hua’ai-Baosheng II Formula (CHB-II-F) is a new traditional Chinese medical formula that has been shown to reduce toxicity and side effects of chemotherapy and increase the probability of cancer patient survival. Whether CHB-II-F is safe ... ...

    Abstract Background. Ciji-Hua’ai-Baosheng II Formula (CHB-II-F) is a new traditional Chinese medical formula that has been shown to reduce toxicity and side effects of chemotherapy and increase the probability of cancer patient survival. Whether CHB-II-F is safe as an adjunctive therapy for cancer patients receiving chemotherapy has yet to be determined. Purpose. To evaluate the acute and subchronic toxic effects of CHB-II-F in rodent models. Methods. In acute toxicity test, 24 Kunming mice were divided into 2 groups: untreated control and CHB-II-F 1.05 g/mL (31.44 g/kg) treated group. Treatment was administered to the treated group 3 times a day for 14 days. The overall health, adverse reactions, and mortality rate were documented. In subchronic toxicity test, 96 Sprague-Dawley rats were divided into 4 groups: untreated control, high dose CHB-II-F (H) (26.20 g/kg), medium dose CHB-II-F (M) (13. 10 g/kg), and low dose CHB-II-F (L) (6.55 g/kg) [equal to 24.375 g (dried medicinal herb)/kg] treated groups. Treated groups were given the treatments once a day for 4 weeks. The overall health and mortality rate were recorded every day. Body weight and food consumption were measured once a week. Hematologic and biochemical parameters, organ weights, and histopathologic markers were analyzed after 4 weeks. An additional 2 weeks were given as the treatment recovery period before end-point euthanization, and biochemical analyses were performed. Results. The maximum tolerated dose (MTD) of CHB-II-F on mice was found to be 94.31 g/kg [equal to 351 g (dried medicinal herb)/kg], which is 108 times the human adult dose. In the acute toxicity test, administration of CHB-II-F 31.44 g/kg showed no adverse effect and did not cause mortality. In the subchronic toxicity test, after 4 weeks of treatment, compared to the controls, total cholesterol (TCHO) level, cardiac and splenic indexes, body weights of female rats, and mean corpuscular hemoglobin concentration (MCHC) in the CHB-II-F (H) group were significantly increased; triglyceride (TG) ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 630
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22 hepatocellular carcinoma in mice receiving chemotherapy

    Xi, Shengyan / Biqian Fu / Gerald Y. Minuk / Jiaqi Yang / Jinhua Guo / Lifeng Yue / Lili Li / Mengmeng Shi / Qian Li / Yang Peng / Yanhui Wang / Ying Peng / Yuewen Gong

    Journal of ethnopharmacology. 2016 Aug. 22, v. 190

    2016  

    Abstract: Shen-Ling-Bai-Zhu Powder (SLBZP) is a classic traditional Chinese medical formula that has been used for several decades in the treatment of patients with gastrointestinal malignancies. Whether SLBZP is best employed as single agent or adjunctive therapy ...

    Abstract Shen-Ling-Bai-Zhu Powder (SLBZP) is a classic traditional Chinese medical formula that has been used for several decades in the treatment of patients with gastrointestinal malignancies. Whether SLBZP is best employed as single agent or adjunctive therapy has yet to be determined as does the mechanism whereby SLBZP exerts its anti-tumor effects.To investigate the effects of SLBZP alone and in combination with Cytoxan (CTX) on tumor growth, malignant cell apoptosis and Akt/Nuclear Factor kappa B (NF-КB) signaling in a murine model of hepatocellular carcinoma (HCC) receiving chemotherapy.Sixty-four adult mice developed HCC following subcutaneous inoculation with H22 hepatocellular carcinoma cells. Seven days later, all received chemotherapy with CTX (200mg/kg) once. Mice were then randomized into eight study groups (N=8/group). Three groups were treated with different concentrations of SLBZP alone (6.00, 3.00, 1.5g/kg), three with SLBZP (6.00, 3.00, 1.5g/kg) plus CTX (20mg/kg), one with CTX (20mg/kg) alone (positive control), and one with physiologic saline (untreated, negative control). All groups were treated for 14 days. Tumor size, histology and serum or tissue levels and/or mRNA expression of PDGF-BB, VEGF, Ang-1, Ang-2, NF-КB, B-cell lymphoma-2 (Bcl-2); B-cell lymphoma-extra large (Bcl-xL); X-linked inhibitor of apoptosis (XIAP), Survivin, Caspase-3, Caspase-9, Caspase-7, Akt and phosphorylated Akt expression were documented at the end of treatment.Compared to untreated negative controls, tumor sizes were decreased in the CTX alone, SLBZP (M)+CTX and SLBZP (H)+CTX groups (−52%,−53% and −58% respectively). Tumor cell density was decreased in all treated groups but most apparent in the SLBZP (H)+CTX group. Electron microscopic evidence of apoptosis was also most apparent in this group. Serum and/or tissue levels and expression of PDGF-BB, VEGF, Ang-1, Ang-2, their downstream signaling proteins and anti-apoptotic markers were lowest and pro-apoptotic markers highest in SLBZP (H)+CTX treated mice.In this chemotherapy-induced animal model of HCC, SLBZP was most efficacious as adjunctive therapy and appears to act by inhibiting tumor growth promoters and anti-apoptotic proteins while enhancing pro-apoptotic proteins.
    Keywords adults ; animal models ; apoptosis ; blood serum ; B-lymphocytes ; caspase-3 ; caspase-7 ; caspase-9 ; drug therapy ; electron microscopy ; gastrointestinal system ; gene expression ; growth promotion ; hepatoma ; histology ; messenger RNA ; mice ; neoplasm cells ; patients ; platelet-derived growth factor ; pro-apoptotic proteins ; traditional medicine ; transcription factor NF-kappa B ; vascular endothelial growth factors
    Language English
    Dates of publication 2016-0822
    Size p. 1-12.
    Publishing place Elsevier Ireland Ltd
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2016.05.055
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Composition and spatial distribution pattern of ground-dwelling beetle communities in Yeyahu Wetland, Beijing

    Yu Wang / Guangcai Gao / Biqian Fu / Zhuan Wu

    Abstract: In this paper, ground-dwelling beetle communities (GDBCs) from 32 sampling sites with five main vegetation types, two well-conserved ones and three degradated ones, were investigated in Yeyahu Wetland of Beijing by pitfall traps from April to December, ... ...

    Abstract In this paper, ground-dwelling beetle communities (GDBCs) from 32 sampling sites with five main vegetation types, two well-conserved ones and three degradated ones, were investigated in Yeyahu Wetland of Beijing by pitfall traps from April to December, 2007, and the influence of wetland degradation and vegetation variation on the composition of GDBCs was studied at the family level. A total of 42 families were collected in the whole sampling period. Among these, Carabidae and Staphylinidae were dominant, while Anthicidae, Eumolpidae and Lathridiidae were subdominant. In the five types of vegetation investigated, the activity density, family level richness and the Shannon-Wiener diversity index (H') of GDBCs were not significantly different between the well-conserved Phragmites communis and Cyperus glomeratus ones. However, the beetle activity density in these two well-conserved vegetations, and the family richness in the Cyperus glomeratus one were significantly higher than those of the three degradated ones. It was showed by canonical correspondence analysis (CCA) to the relationship between the composition of GDBCs and nine environmental factors, that there was an obviously correspondance between the distribution of the 32 sampling sites in CCA ordination diagram and the vegetation types, and soil water content, plant coverage, plant biomass, and litter coverage were the major factors affecting on the composition and spatial distribution of GDBCs in the wetland. According to the correlation analysis, we also found that the correlation among beetleactivity density and the soil water content, plant biomass and coverage was all significantly positive (P<0.05 or P<0.01), and it was between beetle family richness and plant biomass (P<0.05); while that between the beetle diversity index (H') and plant coverage was significantly negative (P<0.01). Moreover, in a nonlinear regression analysis, the change of soil water content could explain about 57% of the variation in beetle activity density. A synthetic environmental variable, WBC (Water-Biomass-Coverage), which reflects the situation of soil water content, plant biomass and coverage, was obtained by principal component analysis (PCA) of the nine environmental factors. On the basis of relationship between beetle activity density and WBC, the five vegetation types could be divided into three extremely different groups. Our results showed that maintaining appropriate wetland landscapes is vital for beetle protection.
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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