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  1. Article ; Online: The actin cytoskeleton in hair bundle development and hearing loss.

    Park, Jinho / Bird, Jonathan E

    Hearing research

    2023  Volume 436, Page(s) 108817

    Abstract: Inner ear hair cells assemble mechanosensitive hair bundles on their apical surface that transduce sounds and accelerations. Each hair bundle is comprised of ∼ 100 individual stereocilia that are arranged into rows of increasing height and width; their ... ...

    Abstract Inner ear hair cells assemble mechanosensitive hair bundles on their apical surface that transduce sounds and accelerations. Each hair bundle is comprised of ∼ 100 individual stereocilia that are arranged into rows of increasing height and width; their specific and precise architecture being necessary for mechanoelectrical transduction (MET). The actin cytoskeleton is fundamental to establishing this architecture, not only by forming the structural scaffold shaping each stereocilium, but also by composing rootlets and the cuticular plate that together provide a stable foundation supporting each stereocilium. In concert with the actin cytoskeleton, a large assortment of actin-binding proteins (ABPs) function to cross-link actin filaments into specific topologies, as well as control actin filament growth, severing, and capping. These processes are individually critical for sensory transduction and are all disrupted in hereditary forms of human hearing loss. In this review, we provide an overview of actin-based structures in the hair bundle and the molecules contributing to their assembly and functional properties. We also highlight recent advances in mechanisms driving stereocilia elongation and how these processes are tuned by MET.
    MeSH term(s) Humans ; Hair Cells, Auditory/metabolism ; Actin Cytoskeleton/metabolism ; Deafness/metabolism ; Hair Cells, Auditory, Inner/metabolism ; Actins/metabolism ; Stereocilia
    Chemical Substances Actins
    Language English
    Publishing date 2023-05-26
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 282629-x
    ISSN 1878-5891 ; 0378-5955
    ISSN (online) 1878-5891
    ISSN 0378-5955
    DOI 10.1016/j.heares.2023.108817
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1467: Show issues Location:
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  2. Article ; Online: Myosin motors in sensory hair bundle assembly.

    Moreland, Zane G / Bird, Jonathan E

    Current opinion in cell biology

    2022  Volume 79, Page(s) 102132

    Abstract: Mechanosensory hair bundles are assembled from actin-based stereocilia that project from the apical surface of hair cells in the inner ear. Stereocilia architecture is critical for the transduction of sound and accelerations, and structural defects in ... ...

    Abstract Mechanosensory hair bundles are assembled from actin-based stereocilia that project from the apical surface of hair cells in the inner ear. Stereocilia architecture is critical for the transduction of sound and accelerations, and structural defects in these mechano-sensors are a clinical cause of hearing and balance disorders in humans. Unconventional myosin motors are central to the assembly and shaping of stereocilia architecture. A sub-group of myosin motors with MyTH4-FERM domains (MYO7A, MYO15A) are particularly important in these processes, and hypothesized to act as transporters delivering structural and actin-regulatory cargos, in addition to generating force and tension. In this review, we summarize existing evidence for how MYO7A and MYO15A operate and how their dysfunction leads to stereocilia pathology. We further highlight emerging properties of the MyTH4/FERM myosin family and speculate how these new functions might contribute towards the acquisition and maintenance of mechano-sensitivity.
    MeSH term(s) Humans ; Actins ; Myosins
    Chemical Substances Actins ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2022.102132
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
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  3. Article ; Online: An optimized approach to study nanoscale sarcomere structure utilizing super-resolution microscopy with nanobodies.

    Douglas, Collin M / Bird, Jonathan E / Kopinke, Daniel / Esser, Karyn A

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0300348

    Abstract: The sarcomere is the fundamental contractile unit in skeletal muscle, and the regularity of its structure is critical for function. Emerging data demonstrates that nanoscale changes to the regularity of sarcomere structure can affect the overall function ...

    Abstract The sarcomere is the fundamental contractile unit in skeletal muscle, and the regularity of its structure is critical for function. Emerging data demonstrates that nanoscale changes to the regularity of sarcomere structure can affect the overall function of the protein dense ~2μm sarcomere. Further, sarcomere structure is implicated in many clinical conditions of muscle weakness. However, our understanding of how sarcomere structure changes in disease, especially at the nanoscale, has been limited in part due to the inability to robustly detect and measure at sub-sarcomere resolution. We optimized several methodological steps and developed a robust pipeline to analyze sarcomere structure using structured illumination super-resolution microscopy in conjunction with commercially-available and fluorescently-conjugated Variable Heavy-Chain only fragment secondary antibodies (nanobodies), and achieved a significant increase in resolution of z-disc width (353nm vs. 62nm) compared to confocal microscopy. The combination of these methods provides a unique approach to probe sarcomere protein localization at the nanoscale and may prove advantageous for analysis of other cellular structures.
    MeSH term(s) Sarcomeres/metabolism ; Sarcomeres/ultrastructure ; Single-Domain Antibodies/chemistry ; Animals ; Microscopy, Fluorescence/methods ; Mice ; Microscopy, Confocal/methods
    Chemical Substances Single-Domain Antibodies
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300348
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  4. Article ; Online: Dynamic mechanisms of exercise to improve body satisfaction: Perceived or actual fat loss?

    Wang, Yu-Bu / Bird, Jonathan / Guo, Lu

    International journal of psychology : Journal international de psychologie

    2023  Volume 59, Issue 1, Page(s) 121–131

    Abstract: We examined the dynamic mechanisms of aerobic training (AT) and strength training (ST) to improve body satisfaction. Sixty-six participants were randomised to either the AT or ST condition and completed an 8-week intervention. Participants completed 3 ... ...

    Abstract We examined the dynamic mechanisms of aerobic training (AT) and strength training (ST) to improve body satisfaction. Sixty-six participants were randomised to either the AT or ST condition and completed an 8-week intervention. Participants completed 3 weekly, 30-minute sessions of moderate intensity AT (65-75% VO
    MeSH term(s) Humans ; Female ; Male ; Exercise ; Resistance Training ; Body Composition ; Adipose Tissue
    Language English
    Publishing date 2023-10-15
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1480995-3
    ISSN 1464-066X ; 0020-7594
    ISSN (online) 1464-066X
    ISSN 0020-7594
    DOI 10.1002/ijop.12955
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  5. Article: Improving mental wellbeing for survivors of childhood abuse and neglect: psychological healing and education course in prisons.

    Bird, Jonathan

    Perspectives in public health

    2015  Volume 135, Issue 1, Page(s) 21–23

    MeSH term(s) Adaptation, Psychological ; Adult ; Adult Survivors of Child Abuse/psychology ; Female ; Health Promotion ; Humans ; Male ; Mental Disorders/therapy ; Mental Health ; Prisoners/psychology ; Resilience, Psychological ; Social Support ; United Kingdom
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2478358-4
    ISSN 1757-9147 ; 1757-9139
    ISSN (online) 1757-9147
    ISSN 1757-9139
    DOI 10.1177/1757913914561701
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 423: Show issues Location:
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  6. Article ; Online: A Grounded Theory of Music-Video Use in an Exercise Facility.

    Bird, Jonathan M / Karageorghis, Costas I

    Research quarterly for exercise and sport

    2020  Volume 91, Issue 3, Page(s) 445–459

    Abstract: ... ...

    Abstract Purpose
    MeSH term(s) Consumer Behavior ; Exercise/physiology ; Exercise/psychology ; Grounded Theory ; Health Behavior ; Humans ; Interpersonal Relations ; Music ; Qualitative Research ; Social Environment ; Video Recording
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 225654-x
    ISSN 2168-3824 ; 0270-1367
    ISSN (online) 2168-3824
    ISSN 0270-1367
    DOI 10.1080/02701367.2019.1680788
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  7. Article: Relationships among behavioural regulations, physical activity, and mental health pre- and during COVID-19 UK lockdown.

    Bird, Jonathan M / Karageorghis, Costas I / Hamer, Mark

    Psychology of sport and exercise

    2021  Volume 55, Page(s) 101945

    Abstract: A nationwide survey was conducted during the first UK lockdown to further understanding of the degree to which motives for exercise were associated with physical activity (PA) behaviours and, in turn, how PA behaviours were associated with mental health. ...

    Abstract A nationwide survey was conducted during the first UK lockdown to further understanding of the degree to which motives for exercise were associated with physical activity (PA) behaviours and, in turn, how PA behaviours were associated with mental health. A cross-sectional design was employed and data were collected by use of a one-off online survey (
    Language English
    Publishing date 2021-04-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1469-0292
    ISSN 1469-0292
    DOI 10.1016/j.psychsport.2021.101945
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  8. Article ; Online: Caution in the use of TissuePatchDS-P

    Bird, Jonathan / Mirza, Adal Hussain / King, Emma

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2020  Volume 45, Issue 5, Page(s) 837–840

    MeSH term(s) Aged ; Equipment Design ; Female ; Hemostatic Techniques/instrumentation ; Humans ; Male ; Parotid Gland/surgery ; Parotid Neoplasms/surgery ; Pilot Projects ; Postoperative Complications/prevention & control ; Retrospective Studies
    Language English
    Publishing date 2020-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.13594
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    Zs.A 1309: Show issues Location:
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  9. Article ; Online: Correlated insulator collapse due to quantum avalanche via in-gap ladder states.

    Han, Jong E / Aron, Camille / Chen, Xi / Mansaray, Ishiaka / Han, Jae-Ho / Kim, Ki-Seok / Randle, Michael / Bird, Jonathan P

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2936

    Abstract: The significant discrepancy observed between the predicted and experimental switching fields in correlated insulators under a DC electric field far-from-equilibrium necessitates a reevaluation of current microscopic understanding. Here we show that an ... ...

    Abstract The significant discrepancy observed between the predicted and experimental switching fields in correlated insulators under a DC electric field far-from-equilibrium necessitates a reevaluation of current microscopic understanding. Here we show that an electron avalanche can occur in the bulk limit of such insulators at arbitrarily small electric field by introducing a generic model of electrons coupled to an inelastic medium of phonons. The quantum avalanche arises by the generation of a ladder of in-gap states, created by a multi-phonon emission process. Hot-phonons in the avalanche trigger a premature and partial collapse of the correlated gap. The phonon spectrum dictates the existence of two-stage versus single-stage switching events which we associate with charge-density-wave and Mott resistive phase transitions, respectively. The behavior of electron and phonon temperatures, as well as the temperature dependence of the threshold fields, demonstrates how a crossover between the thermal and quantum switching scenarios emerges within a unified framework of the quantum avalanche.
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38557-8
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  10. Article: Probing the Dynamics of Electric Double Layer Formation over Wide Time Scales (10–⁹–10⁺⁵ s) in the Ionic Liquid DEME-TFSI

    Yin, Shenchu / He, Keke / Randle, Michael D. / Barut, Bilal / Dixit, Ripudaman / Lipatov, Alexey / Sinitskii, Alexander / Bird, Jonathan P.

    Journal of physical chemistry. 2022 Jan. 25, v. 126, no. 4

    2022  

    Abstract: We investigate the transient response of N,N-diethyl-N-(2-methoxyethyl)-N-methylammonium bis(trifluoromethylsulfonyl)-imide-based ionic liquid (IL) planar capacitors, studying this response over time scales ranging from as little as a few nanoseconds to ... ...

    Abstract We investigate the transient response of N,N-diethyl-N-(2-methoxyethyl)-N-methylammonium bis(trifluoromethylsulfonyl)-imide-based ionic liquid (IL) planar capacitors, studying this response over time scales ranging from as little as a few nanoseconds to as much as several days. Our measurements point to the existence of three distinct mechanisms for charging/discharging of the IL. The fastest of these is associated with the development of a standard polarization charge in the bulk of the liquid dielectric, which dominates at times less than ∼10–⁶ s. The second process is attributed to electric double layer formation, which is initiated after ∼10–⁶ but which takes as long as ∼10–² s to reach completion. Finally, we also identify the presence of a pseudocapacitance that arises from electrochemical reactions; this process is only activated at voltages above ∼2.5 V and is relatively slow. Indeed, we find evidence that full discharging of this pseudocapacitance can take as long as 10⁵ s (i.e., days). Overall, our findings provide useful insights into the mechanisms for slow ion dynamics in ILs and highlight the constraints that these dynamics place on the potential operational speed of IL-based transistors.
    Keywords electrochemistry ; ionic liquids ; liquids ; physical chemistry
    Language English
    Dates of publication 2022-0125
    Size p. 1958-1965.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1932-7455
    DOI 10.1021/acs.jpcc.1c10067
    Database NAL-Catalogue (AGRICOLA)

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