Article ; Online: Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes.
Free radical biology & medicine
2020 Volume 161, Page(s) 115–124
Abstract: Lanthionine synthase C-like protein-1 (LanCL1) is a glutathione (GSH)-binding protein of uncertain function, widely expressed in mammalian cells. Recent data suggests that LanCL1 has glutathione S-transferase (GST)-like activity, while other reports ... ...
| Abstract | Lanthionine synthase C-like protein-1 (LanCL1) is a glutathione (GSH)-binding protein of uncertain function, widely expressed in mammalian cells. Recent data suggests that LanCL1 has glutathione S-transferase (GST)-like activity, while other reports claim that LanCL1 suppresses mitogen-activated kinase (MAPK) phosphorylation. In the present study, recombinant human LanCL1 had less than 10% the specific activity of GST. When CRISPR-Cas9 was used to stably ablate LanCL1 from HeLa cells, the resulting line was sensitized to H |
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| MeSH term(s) | Deubiquitinating Enzymes ; HeLa Cells ; Humans ; Hydro-Lyases ; Hydrogen Peroxide ; Multienzyme Complexes ; Oxidation-Reduction ; Receptors, G-Protein-Coupled/metabolism ; Ubiquitin Thiolesterase | |||||
| Chemical Substances | LANCL1 protein, human ; Multienzyme Complexes ; Receptors, G-Protein-Coupled ; USP10 protein, human ; USP9X protein, human ; Hydrogen Peroxide (BBX060AN9V) ; Deubiquitinating Enzymes (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; Hydro-Lyases (EC 4.2.1.-) ; lanthionine synthase (EC 4.2.1.-) | |||||
| Language | English | |||||
| Publishing date | 2020-10-10 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 807032-5 | |||||
| ISSN | 1873-4596 ; 0891-5849 | |||||
| ISSN (online) | 1873-4596 | |||||
| ISSN | 0891-5849 | |||||
| DOI | 10.1016/j.freeradbiomed.2020.10.006 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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