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  1. Article ; Online: Evaluation of the utility of prognostic models for patients with resected hilar cholangiocarcinoma.

    Bird, Nicholas T E / Manu, Nichola / Quinn, Leonard / Needham, Alex / Jones, Robert / Fenwick, Stephen / Poston, Graeme / Palmer, Daniel / Malik, Hassan

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2019  Volume 21, Issue 10, Page(s) 1376–1384

    Abstract: Background: Several prognostic systems have been proposed to guide management strategies post-resection for patients with hilar cholangiocarcinoma. The objective of this study was to evaluate the efficacy of these conventional prognostic models, with ... ...

    Abstract Background: Several prognostic systems have been proposed to guide management strategies post-resection for patients with hilar cholangiocarcinoma. The objective of this study was to evaluate the efficacy of these conventional prognostic models, with respect to Overall Survival (OS), on patients in a modern single-centre resectional cohort.
    Method: Patients diagnosed with hilar cholangiocarcinoma, referred to a supra-regional tertiary referral centre between February 2009 and February 2016, were retrospectively analysed from a prospectively held database linked to Hospital Episode Statistics and Somerset Cancer Registry data.
    Results: Two-hundred and one patients were assessed for suitability for surgery. Eighty-three (41%) patients considered to have potentially resectable disease underwent surgical assessment of resectability. Fifty-six (68%) patients proceeded to resection. Multivariate analysis demonstrated that pre-operative Serum CA 19-9 (p = 0.007), Radiological Arterial Involvement (p = 0.005) and Amsterdam Medical Centre (AMC) prognostic model score (p = 0.032) retained significance in association with OS. Multivariate models developed from this cohort out-performed the conventional prognostic systems for OS.
    Conclusion: The cohort-derived multivariate models demonstrated significantly improved prognostic capability compared to conventional systems in explaining OS.
    MeSH term(s) Adult ; Aged ; Biopsy ; Female ; Follow-Up Studies ; Humans ; Klatskin Tumor/diagnosis ; Klatskin Tumor/mortality ; Klatskin Tumor/surgery ; Male ; Middle Aged ; Postoperative Period ; Prognosis ; Retrospective Studies ; Survival Rate/trends ; Tomography, X-Ray Computed/methods ; United Kingdom/epidemiology
    Language English
    Publishing date 2019-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2019.02.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6326: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Should pre-hospital resuscitative thoracotomy be reserved only for penetrating chest trauma?

    Nevins, Edward J / Moori, Parisa L / Smith-Williams, Jonathan / Bird, Nicholas T E / Taylor, John V / Misra, Nikhil

    European journal of trauma and emergency surgery : official publication of the European Trauma Society

    2018  Volume 44, Issue 6, Page(s) 811–818

    Abstract: Purpose: The indications for pre-hospital resuscitative thoracotomy (PHRT) remain undefined. The aim of this paper is to explore the variation in practice for PHRT in the UK, and review the published literature.: Methods: MEDLINE and PUBMED search ... ...

    Abstract Purpose: The indications for pre-hospital resuscitative thoracotomy (PHRT) remain undefined. The aim of this paper is to explore the variation in practice for PHRT in the UK, and review the published literature.
    Methods: MEDLINE and PUBMED search engines were used to identify all relevant articles and 22 UK Air Ambulance Services were sent an electronic questionnaire to assess their PHRT practice.
    Results: Four European publications report PHRT survival rates of 9.7, 18.3, 10.3 and 3.0% in 31, 71, 39 and 33 patients, respectively. All patients sustained penetrating chest injury. Six case reports also detail survivors of PHRT, again all had sustained penetrating thoracic injury. One Japanese paper presents 34 cases of PHRT following blunt trauma, of which 26.4% survived to the intensive therapy unit but none survived to discharge. A UK population reports a single survivor of PHRT following blunt trauma but the case details remain unpublished. Ten (45%) air ambulance services responded, each service reported different indications for PHRT. All perform PHRT for penetrating chest trauma, however, length of allowed pre-procedure down time varied, ranging from 10 to 20 min. Seventy percent perform PHRT for blunt traumatic cardiac arrest, a procedure which is likely to require aggressive concurrent circulatory support, despite this only 5/10 services carry pre-hospital blood products.
    Conclusions: Current indications for PHRT vary amongst different geographical locations, across the UK, and worldwide. Survivors are likely to have sustained penetrating chest injury with short down time. There is only one published survivor of PHRT following blunt trauma, despite this, PHRT is still being performed in the UK for this indication.
    MeSH term(s) Emergency Medical Services ; Humans ; Resuscitation ; Survival Rate ; Thoracic Injuries/mortality ; Thoracic Injuries/therapy ; Thoracotomy/methods ; Wounds, Penetrating/mortality ; Wounds, Penetrating/therapy
    Language English
    Publishing date 2018-03-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2275480-5
    ISSN 1863-9941 ; 1863-9933
    ISSN (online) 1863-9941
    ISSN 1863-9933
    DOI 10.1007/s00068-018-0937-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1221: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 607: Show issues

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  3. Article ; Online: Prognostic molecular markers in resected extrahepatic biliary tract cancers; a systematic review and meta-analysis of immunohistochemically detected biomarkers.

    Jones, Robert P / Bird, Nicholas T E / Smith, Richard A / Palmer, Daniel H / Fenwick, Steven W / Poston, Graeme J / Malik, Hassan Z

    Biomarkers in medicine

    2015  Volume 9, Issue 8, Page(s) 763–775

    Abstract: Unlabelled: Better prognostic information for resected extrahepatic cholangiocarcinoma could guide treatment strategies and potentially improve outcome. This study performed a systematic review and meta-analysis to identify prognostic biomarkers for ... ...

    Abstract Unlabelled: Better prognostic information for resected extrahepatic cholangiocarcinoma could guide treatment strategies and potentially improve outcome. This study performed a systematic review and meta-analysis to identify prognostic biomarkers for further investigation.
    Methods: Relevant literature was identified using Medline, EMBASE and Web of Science. Primary end point was overall survival assessed on univariate analysis. Log hazard ratio and variance were calculated and pooled using a random effects inverse variance approach. Hazard ratio and 95% confidence intervals were calculated.
    Results: Thirty-seven studies, including 2371 patients, met the inclusion criteria. Subsequently nine biomarkers predictive of OS were identified (HR, 95% CI): VEGF (2.32, 1.57-3.44), COX-2 (1.94, 1.01-3.71), GLUT-1 (2.09, 1.52-2.89), Cyclin D1 (1.96, 1.02-3.76), p16 (0.68, 0.47-0.98), p27 (0.48, 0.3-0.78), E-Cadherin (0.47, 0.35-0.63), Fascin (2.19, 1.35-3.55), and Ki-67 (1.69, 1.02-2.79).
    Conclusion: Meta-analysis has identified a number of prognostic biomarkers for resected extrahepatic cholangiocarcinoma. These markers warrant further investigation as potential therapeutic targets and validation in a prospective setting.
    MeSH term(s) Bile Ducts, Extrahepatic/metabolism ; Bile Ducts, Extrahepatic/pathology ; Biliary Tract Neoplasms/diagnosis ; Biliary Tract Neoplasms/metabolism ; Biomarkers, Tumor/analysis ; Humans ; Immunohistochemistry/methods ; Immunohistochemistry/statistics & numerical data ; Prognosis ; Proportional Hazards Models ; Reproducibility of Results ; Sensitivity and Specificity ; Survival Analysis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/BMM.15.48
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6985: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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