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  1. Article ; Online: Klotho: A Possible Role in the Pathophysiology of Nephrotic Syndrome.

    Tomo, Sojit / Birdi, Amandeep / Yadav, Dharmveer / Chaturvedi, Manish / Sharma, Praveen

    EJIFCC

    2022  Volume 33, Issue 1, Page(s) 3–10

    Abstract: Klotho, encoded by ... ...

    Abstract Klotho, encoded by the
    Language English
    Publishing date 2022-04-11
    Publishing country Italy
    Document type Journal Article ; Review
    ISSN 1650-3414
    ISSN (online) 1650-3414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Smouldering Myeloma: Chasing a Hyperviscous Sample.

    Birdi, Amandeep / Sinha, Arun / Banerjee, Mithu / SelviN, Maithili Karpaga

    Indian journal of clinical biochemistry : IJCB

    2021  Volume 38, Issue 2, Page(s) 279–283

    Abstract: Serum hyperviscosity is a rare laboratory finding. Amongst several causes of serum hyperviscosity, malignant disorders are quite common. Monoclonal gammopathy is a family of disorders in which monoclonal gammopathy of unknown significance (MGUS) and ... ...

    Abstract Serum hyperviscosity is a rare laboratory finding. Amongst several causes of serum hyperviscosity, malignant disorders are quite common. Monoclonal gammopathy is a family of disorders in which monoclonal gammopathy of unknown significance (MGUS) and smoldering myeloma are the asymptomatic variants whereas multiple myeloma is the malignant variant showing different signs and symptoms related to bone lesions, renal failure and anemia. Initially during sample preparation, pipetting of a serum sample was found to be cumbersome. This sample during routine analysis in the automated analyser flagged repeated alarms for clot detection indicating a possibility of a hyper viscous sample. Serum was subjected to fibrinogen and D- dimer test. The D-Dimer levels were found to be normal and fibrinogen levels were mildly elevated. Routine biochemistry investigations were normal except grossly reversed A/G ratio. Due to gross reversal of A/G ratio, the possibility of Multiple myeloma was entertained. Physician's were alerted on telephone. Serum was sent for electrophoresis which showeda M spike. Bone marrow aspirate showed 13% plasma cells. Considering the above lab results the diagnosis of monoclonal gammopathy of smoldering type was considered. The sample was traced to a 77 years old male, who presented to Medicine OPD with the chief complaints of generalised weakness for two months without any history of fever. On physical examination pallor was evident but there was no icterus, cyanosis, clubbing, lymphadenopathy or edema. On haematological evaluation patient was found to be anemic.
    Language English
    Publishing date 2021-07-14
    Publishing country India
    Document type Case Reports
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-021-00990-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2949: Show issues Location:
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  3. Article ; Online: A Framework Model for a Contextualized and Integrated Warfarin Therapy Case in a Master of Pharmacy Program.

    Fergus, Suzanne / Birdi, Amandeep / Riaz, Farakh

    American journal of pharmaceutical education

    2019  Volume 83, Issue 5, Page(s) 6688

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Clinical Competence ; Curriculum ; Education, Pharmacy/methods ; Feedback ; Focus Groups ; Humans ; Models, Educational ; Program Development/methods ; Program Evaluation ; Students, Pharmacy ; Surveys and Questionnaires ; Warfarin/therapeutic use
    Chemical Substances Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2019-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603807-4
    ISSN 1553-6467 ; 0002-9459
    ISSN (online) 1553-6467
    ISSN 0002-9459
    DOI 10.5688/ajpe6688
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  4. Article: Association of Vitamin D Status with COVID-19 Infection and Mortality in the Asia Pacific region: A Cross-Sectional Study.

    Yadav, Dharmveer / Birdi, Amandeep / Tomo, Sojit / Charan, Jaykaran / Bhardwaj, Pankaj / Sharma, Praveen

    Indian journal of clinical biochemistry : IJCB

    2021  Volume 36, Issue 4, Page(s) 492–497

    Abstract: COVID-19 has been declared a global pandemic by WHO on 11 March 2020. Still, very little is known about the potential protective dietary factors for the prevention of infection and mortality due to COVID-19. Keeping in view the scarcity of literature/ ... ...

    Abstract COVID-19 has been declared a global pandemic by WHO on 11 March 2020. Still, very little is known about the potential protective dietary factors for the prevention of infection and mortality due to COVID-19. Keeping in view the scarcity of literature/studies available, in this regards present study was undertaken to assess if there is any correlation between mean levels of Vitamin D in various Asia Pacific countries with the infection and mortality caused by COVID-19. We collected data for mean levels of Vitamin D for 37 Asia Pacific countries for which we have also got the data regarding the morbidity and mortality of COVID-19. The mean levels of Vitamin D were found to have a significant association with the number of cases/million(r =  - 0.394,
    Language English
    Publishing date 2021-02-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-020-00950-1
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  5. Article: Role of Klotho Protein in Neuropsychiatric Disorders: A Narrative Review.

    Birdi, Amandeep / Tomo, Sojit / Yadav, Dharmveer / Sharma, Praveen / Nebhinani, Naresh / Mitra, Prasenjit / Banerjee, Mithu / Purohit, Purvi

    Indian journal of clinical biochemistry : IJCB

    2022  Volume 38, Issue 1, Page(s) 13–21

    Abstract: Neuropsychiatric disorders are comprised of diseases having both the neurological and psychiatric manifestations. The increasing burden of the disease on the population worldwide makes it necessary to adopt measures to decrease the prevalence. The Klotho ...

    Abstract Neuropsychiatric disorders are comprised of diseases having both the neurological and psychiatric manifestations. The increasing burden of the disease on the population worldwide makes it necessary to adopt measures to decrease the prevalence. The Klotho is a single pass transmembrane protein that decreases with age, has been associated with various pathological diseases, like reduced bone mineral density, cardiac problems and cognitive impairment. However, multiple studies have explored its role in different neuropsychiatric disorders. A comprehensive search was undertaken in the Pubmed database for articles with the keywords "Klotho" and "neuropsychiatric disorders". The available literature, based on the above search strategy, has been compiled in this brief narrative review to describe the emerging role of Klotho in various neuropsychiatric disorders. The Klotho levels were decreased in various neuropsychiatric disorders except for bipolar disorder. A suppressed Klotho protein levels induced oxidative stress and incited pro-inflammatory conditions significantly contributing to the pathophysiology of neuropsychiatric disorder. The increasing evidence of altered Klotho protein levels in cognition-decrement-related disorders warrants its consideration as a biomarker in various neuropsychiatric diseases. However, further evidence is required to understand its role as a therapeutic target.
    Language English
    Publishing date 2022-08-13
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-022-01078-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of circulatory Klotho levels and its expression with miRNA- 339 in patients with schizophrenia.

    Birdi, Amandeep / Kumar, Pvsn Kiran / Nebhinani, Naresh / Gupta, Tanu / Tomo, Sojit / Purohit, Purvi / Banerjee, Mithu / Mitra, Prasenjit / Sharma, Praveen / Yadav, Dharmveer

    Behavioural brain research

    2023  Volume 445, Page(s) 114359

    Abstract: Schizophrenia is one of the major neuropsychiatric disorders affecting 1% of the population worldwide. Neuroinflammation, neurodevelopment, and oxidative stress are some of the crucial factors that can contribute to the pathogenesis of Schizophrenia. ... ...

    Abstract Schizophrenia is one of the major neuropsychiatric disorders affecting 1% of the population worldwide. Neuroinflammation, neurodevelopment, and oxidative stress are some of the crucial factors that can contribute to the pathogenesis of Schizophrenia. Klotho gene is an antiaging gene whose dysregulated expression can lead to Schizophrenia and aging-like symptoms in patients. Klotho gene expression is regulated by miRNA- 339, which might lead to expression changes of the klotho gene in schizophrenia patients. This study aimed to determine the Role of miRNA- 339-5p in the Regulation of Klotho Gene Expression and its Circulatory Levels in Schizophrenia. In this study total of 60 cases, schizophrenia patients and 30 healthy controls were recruited, and written informed consent was obtained from all the study subjects. The klotho gene and miRNA - 339-5p expressions were done using a reverse transcription polymerase chain reaction. And relative fold change expression was calculated by Livaak's method, that is 2^-double delta ct. It was found that the klotho gene is around 2.08 times upregulated as compared to healthy control, and miRNA- 339-5p was downregulated and showed an inverse relationship. The present study is the first to evaluate the klotho gene expression and correlate it with miRNA- 339-5p. Further confirmation of the results study should be planned with a large sample size and with drug naïve patients.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Glucuronidase/genetics ; Glucuronidase/metabolism ; Schizophrenia/genetics ; Aging/genetics ; Oxidative Stress
    Chemical Substances MicroRNAs ; Glucuronidase (EC 3.2.1.31)
    Language English
    Publishing date 2023-02-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2023.114359
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  7. Article: Trace Elements as Immunoregulators in SARS-CoV-2 and Other Viral Infections.

    Dharmalingam, Karthick / Birdi, Amandeep / Tomo, Sojit / Sreenivasulu, Karli / Charan, Jaykaran / Yadav, Dharmveer / Purohit, Purvi / Sharma, Praveen

    Indian journal of clinical biochemistry : IJCB

    2021  Volume 36, Issue 4, Page(s) 416–426

    Abstract: Nutritional deficiency is associated with impaired immunity and increased susceptibility to infections. The complex interactions of trace elements with the macromolecules trigger the effective immune response against the viral diseases. The outcome of ... ...

    Abstract Nutritional deficiency is associated with impaired immunity and increased susceptibility to infections. The complex interactions of trace elements with the macromolecules trigger the effective immune response against the viral diseases. The outcome of various viral infections along with susceptibility is affected by trace elements such as zinc, selenium, iron, copper, etc. due to their immuno-modulatory effects. Available electronic databases have been comprehensively searched for articles published with full text available and with the key words "Trace elements", "COVID-19", "Viral Infections" and "Immune Response" (i.e. separately Zn, Se, Fe, Cu, Mn, Mo, Cr, Li, Ni, Co) appearing in the title and abstract. On the basis of available articles we have explored the role of trace elements in viral infections with special reference to COVID-19 and their interactions with the immune system. Zinc, selenium and other trace elements are vital to triggerT
    Language English
    Publishing date 2021-02-12
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-021-00961-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2949: Show issues Location:
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