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  1. Article ; Online: Fundamentals of chirality, resolution, and enantiopure molecule synthesis methods.

    Kaya, Cem / Birgül, Kaan / Bülbül, Bahadır

    Chirality

    2022  Volume 35, Issue 1, Page(s) 4–28

    Abstract: The chirality of molecules is a concept that explains the interactions in nature. We may observe the same formula but different organizations revolving around the chiral center. Since Pasteur's meticulous observation of sodium ammonium tartrate crystals' ...

    Abstract The chirality of molecules is a concept that explains the interactions in nature. We may observe the same formula but different organizations revolving around the chiral center. Since Pasteur's meticulous observation of sodium ammonium tartrate crystals' structure, scientists have discovered many features of chiral molecules. The number of newly approved single enantiomeric drugs increases every year and takes place in the market. Thus, separation or resolution methods of racemic mixtures are of continued importance in the efficacy of drugs, installation of affordable production processes, and convenient synthetic chemistry practice. This article presents the asymmetric synthesis approaches and the classification of direct resolution methods of chiral molecules.
    MeSH term(s) Stereoisomerism
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1011639-4
    ISSN 1520-636X ; 0899-0042
    ISSN (online) 1520-636X
    ISSN 0899-0042
    DOI 10.1002/chir.23512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: A Novel PEtOx-Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery.

    Gülyüz, Sevgi / Sessevmez, Melike / Ukuser, Gokcen / Khalily, Melek Parlak / Tiryaki, Selen / Sipahioglu, Tarik / Birgül, Kaan / Ömeroğlu, İpek / Özçubukçu, Salih / Telci, Dilek / Küçükgüzel, Ş Güniz / Durmuş, Mahmut / Cevher, Erdal / Yılmaz, Özgür

    Macromolecular bioscience

    2023  Volume 24, Issue 3, Page(s) e2300324

    Abstract: This study focuses on creating a specialized nanogel for targeted drug delivery in cancer treatment, specifically targeting prostate cancer. This nanogel (referred to as SGK 636/Peptide 563/PEtOx nanogel) is created using hydrophilic poly(2-ethyl-2- ... ...

    Abstract This study focuses on creating a specialized nanogel for targeted drug delivery in cancer treatment, specifically targeting prostate cancer. This nanogel (referred to as SGK 636/Peptide 563/PEtOx nanogel) is created using hydrophilic poly(2-ethyl-2-oxazoline) (PEtOx) through a combination of living/cationic ring-opening polymerization (CROP) and alkyne-azide cycloaddition (CuAAC) "click" chemical reactions. A fluorescent probe (BODIPY) is also conjugated with the nanogel to monitor drug delivery. The characterizations through
    MeSH term(s) Humans ; Male ; Nanogels ; Spectroscopy, Fourier Transform Infrared ; Drug Delivery Systems ; Polyethylene Glycols/chemistry ; Prostatic Neoplasms/drug therapy ; Peptides/pharmacology ; Drug Carriers/chemistry ; Polyethyleneimine
    Chemical Substances polyethylene glycol polyethyleneimine nanogel ; Nanogels ; Polyethylene Glycols (3WJQ0SDW1A) ; Peptides ; Drug Carriers ; Polyethyleneimine (9002-98-6)
    Language English
    Publishing date 2023-10-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2039130-4
    ISSN 1616-5195 ; 1616-5187
    ISSN (online) 1616-5195
    ISSN 1616-5187
    DOI 10.1002/mabi.202300324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Design, synthesis and molecular modeling studies on novel moxifloxacin derivatives as potential antibacterial and antituberculosis agents.

    Türe, Aslı / Kulabaş, Necla / Dingiş, Serap İpek / Birgül, Kaan / Bozdeveci, Arif / Alpay Karaoğlu, Şengül / Krishna, Vagolu Siva / Sriram, Dharmarajan / Küçükgüzel, İlkay

    Bioorganic chemistry

    2019  Volume 88, Page(s) 102965

    Abstract: Twenty-one novel alkyl/acyl/sulfonyl substituted fluoroquinolone derivatives were designed, synthesized and evaluated for their anti-tuberculosis and antibacterial activity. The targeted compounds were synthesized by the introduction of alkyl, acyl or ... ...

    Abstract Twenty-one novel alkyl/acyl/sulfonyl substituted fluoroquinolone derivatives were designed, synthesized and evaluated for their anti-tuberculosis and antibacterial activity. The targeted compounds were synthesized by the introduction of alkyl, acyl or sulfonyl moieties to the basic secondary amine moiety of moxifloxacin. Structures of the compounds were enlightened by FT-IR,
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Cell Survival/drug effects ; Cells, Cultured ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Drug Design ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Mice ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Moxifloxacin/chemical synthesis ; Moxifloxacin/chemistry ; Moxifloxacin/pharmacology ; RAW 264.7 Cells ; Saccharomyces cerevisiae/drug effects ; Structure-Activity Relationship
    Chemical Substances Anti-Bacterial Agents ; Antifungal Agents ; Moxifloxacin (U188XYD42P)
    Language English
    Publishing date 2019-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2019.102965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
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  4. Article ; Online: Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives.

    Birgül, Kaan / Yıldırım, Yeliz / Karasulu, H Yeşim / Karasulu, Ercüment / Uba, Abdullah Ibrahim / Yelekçi, Kemal / Bekçi, Hatice / Cumaoğlu, Ahmet / Kabasakal, Levent / Yılmaz, Özgür / Küçükgüzel, Ş Güniz

    European journal of medicinal chemistry

    2020  Volume 208, Page(s) 112841

    Abstract: In this study, (S)-naproxen thiosemicarbazides (3a-d), 1,2,4-triazoles (4a-c), triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d, 4a and 5a-p) were confirmed by FT-IR, ...

    Abstract In this study, (S)-naproxen thiosemicarbazides (3a-d), 1,2,4-triazoles (4a-c), triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d, 4a and 5a-p) were confirmed by FT-IR,
    MeSH term(s) Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/therapeutic use ; Humans ; Male ; Methionyl Aminopeptidases/antagonists & inhibitors ; Methionyl Aminopeptidases/metabolism ; Mice, Nude ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Naproxen/analogs & derivatives ; Naproxen/metabolism ; Naproxen/therapeutic use ; Prostatic Neoplasms/drug therapy ; Protein Binding ; Stereoisomerism ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents ; Enzyme Inhibitors ; Naproxen (57Y76R9ATQ) ; METAP2 protein, human (EC 3.4.11.18) ; Metap2 protein, mouse (EC 3.4.11.18) ; Methionyl Aminopeptidases (EC 3.4.11.18)
    Language English
    Publishing date 2020-09-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2020.112841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 784: Show issues Location:
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