Article ; Online: Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9.
Science translational medicine
2024 Volume 16, Issue 736, Page(s) eabq4581
Abstract: Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to what extent endothelial cells also might contribute. We detected increased expression of the transcription ... ...
| Abstract | Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to what extent endothelial cells also might contribute. We detected increased expression of the transcription factor |
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| MeSH term(s) | Animals ; Humans ; Mice ; Disease Models, Animal ; Endothelial Cells ; Fibrosis ; Heart Failure ; Intercellular Signaling Peptides and Proteins ; Liver Cirrhosis/complications ; SOX9 Transcription Factor/genetics ; Transcription Factors | |||||
| Chemical Substances | Intercellular Signaling Peptides and Proteins ; SOX9 protein, human ; SOX9 Transcription Factor ; Transcription Factors ; Sox9 protein, mouse | |||||
| Language | English | |||||
| Publishing date | 2024-02-28 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2518854-9 | |||||
| ISSN | 1946-6242 ; 1946-6234 | |||||
| ISSN (online) | 1946-6242 | |||||
| ISSN | 1946-6234 | |||||
| DOI | 10.1126/scitranslmed.abq4581 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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