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  1. Article ; Online: Progestogen-only pill associates with false-positive aldosterone/renin ratio screening test.

    Birkinshaw, Alexander / Sharma, Pankaj / Han, Thang S

    The British journal of cardiology

    2020  Volume 27, Issue 1, Page(s) 9

    Abstract: Aldosterone/renin ratio (ARR) is commonly used to screen for primary hyperaldosteronism (Conn's disease). A number of drugs can alter ARR measurements, thus requiring omission before testing. However, hormonal agents such as the combined oral ... ...

    Abstract Aldosterone/renin ratio (ARR) is commonly used to screen for primary hyperaldosteronism (Conn's disease). A number of drugs can alter ARR measurements, thus requiring omission before testing. However, hormonal agents such as the combined oral contraceptive (COCP) or progestogen-only pill (POP) are not listed for omission. A 20-year-old woman was referred to the endocrinology team, following investigations for syncope by her cardiologist, when ARR was found to be elevated. She was taking POP (Cerelle
    Language English
    Publishing date 2020-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1354589-9
    ISSN 1753-4313 ; 0969-6113
    ISSN (online) 1753-4313
    ISSN 0969-6113
    DOI 10.5837/bjc.2020.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Left atrial paraganglioma in a patient with sarcoidosis.

    Birkinshaw, Alexander / Kamdar, Ravi / Aylwin, Simon / Wendler, Olaf / Sado, Daniel

    European heart journal. Cardiovascular Imaging

    2020  Volume 22, Issue 3, Page(s) e5

    MeSH term(s) Atrial Appendage ; Heart Atria/diagnostic imaging ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Humans ; Paraganglioma/diagnostic imaging ; Paraganglioma/surgery ; Sarcoidosis/complications ; Sarcoidosis/diagnostic imaging
    Language English
    Publishing date 2020-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeaa211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spontaneous coronary artery dissection after COVID-19 infection presenting with ST segment elevation.

    Cannata, Stefano / Birkinshaw, Alexander / Sado, Daniel / Dworakowski, Rafal / Pareek, Nilesh

    European heart journal

    2020  Volume 41, Issue 48, Page(s) 4602

    MeSH term(s) Antibodies, Viral/blood ; COVID-19/complications ; Coronary Angiography ; Coronary Vessel Anomalies/diagnostic imaging ; Coronary Vessel Anomalies/drug therapy ; Coronary Vessel Anomalies/virology ; Electrocardiography ; Female ; Humans ; Middle Aged ; SARS-CoV-2/immunology ; Troponin T/blood ; Vascular Diseases/congenital ; Vascular Diseases/diagnostic imaging ; Vascular Diseases/drug therapy ; Vascular Diseases/virology ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/drug therapy
    Chemical Substances Antibodies, Viral ; Troponin T
    Language English
    Publishing date 2020-12-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Changing trends in the use of novel oral anticoagulants and warfarin for treating non-valvular atrial fibrillation.

    Birkinshaw, Alexander / Fry, Christopher H / Fluck, David / Sharma, Pankaj / Han, Thang S

    JRSM cardiovascular disease

    2020  Volume 9, Page(s) 2048004020915406

    Abstract: Background: Prevention of thromboembolism by novel oral anticoagulants is increasing, whilst use of vitamin K antagonists is on the decline. We assessed changes in the use of these anticoagulants in treating non-valvular atrial fibrillation between 2014 ...

    Abstract Background: Prevention of thromboembolism by novel oral anticoagulants is increasing, whilst use of vitamin K antagonists is on the decline. We assessed changes in the use of these anticoagulants in treating non-valvular atrial fibrillation between 2014 and 2018.
    Methods: One-hundred and sixty-two consecutive patients (95 men, 67 women) with non-valvular atrial fibrillation, mean age 72.3 years (standard deviation = 11.0), underwent cardiac assessment in a single cardiac unit. Use of anticoagulants at the time of investigation was documented: overall 83 (51.2%) patients were prescribed novel oral anticoagulants and 79 (48.8%) warfarin treatment. Trends in treatment rates with either anticoagulant class over time were characterised by calculating the average annual percentage change using a Joinpoint Regression Program 4.7.0.0.
    Results: There were diverging trends in anticoagulant treatment from 2014 to 2018 without join points: yearly increase in novel oral anticoagulant treatment (41.9, 45.5, 53.7, 53.1 and 72.7%, average annual percentage change = 16.2%, 95% confidence interval = 5.8% to 27.5%,
    Conclusions: Changing trends in treatment with anticoagulants for patients with non-valvular atrial fibrillation observed within less than two years provide important information to healthcare services to estimate future pharmaco-economic costs for such treatments.
    Language English
    Publishing date 2020-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663207-X
    ISSN 2048-0040
    ISSN 2048-0040
    DOI 10.1177/2048004020915406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Sex differences in the agreement between left ventricular ejection fraction measured by myocardial perfusion scintigraphy and by echocardiography.

    Jaker, Sams / Burgan, Amjad / Prakash, Vineet / Birkinshaw, Alexander / Moosai, Kishan / Jacques, Adam / Fluck, David / MacGregor, Mark / Lazariashvili, Otar / Sharma, Pankaj / Fry, Christopher H / Han, Thang S

    JRSM cardiovascular disease

    2020  Volume 9, Page(s) 2048004020915393

    Abstract: Background: Left ventricular ejection fraction (LVEF) is generally measured by echocardiography but is increasingly available with myocardial perfusion scintigraphy. With myocardial perfusion scintigraphy, the threshold of LVEF below which there is a ... ...

    Abstract Background: Left ventricular ejection fraction (LVEF) is generally measured by echocardiography but is increasingly available with myocardial perfusion scintigraphy. With myocardial perfusion scintigraphy, the threshold of LVEF below which there is a risk for myocardial infarct or sudden cardiac death is higher for women (51%) than for men (43%). We tested the hypothesis that such a sex difference may also occur with echocardiography and myocardial perfusion scintigraphy.
    Methods: Four hundred and four men, mean age = 67.7 ± SD = 12.3 yr; 339 women, 67.7 ± 11.7 yr had separate myocardial perfusion scintigraphy and echocardiography examinations within six months. A subset of 327 of these patients (181 men, 68.8 ± 12.1 yr; 146 women, 66.4 ± 12.1 yr) had examinations within one month and were additionally analysed as this sub-group. Myocardial perfusion scintigraphy and echocardiography were used to measure LVEF at rest and their agreement (neither considered as a reference method) was assessed by Bland-Altman plots: LVEF difference (myocardial perfusion scintigraphy minus echocardiography ) against average LVEF (
    Results: Of patients who had myocardial perfusion scintigraphy and echocardiography performed within six months, mean LVEF difference = +1.1% (95% limits of agreement: -19.3 to +21.6) in men but +10.9% (-10.7 to +32.5) in women. LVEF difference diverged from zero marginally in men (mean difference = +1.1, 95%CI  = +0.1 to +2.1,
    Conclusions: Caution should be taken when interpreting LVEF measured by different techniques due to their wide limits of agreement and systematic bias, more markedly in women.
    Language English
    Publishing date 2020-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663207-X
    ISSN 2048-0040
    ISSN 2048-0040
    DOI 10.1177/2048004020915393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prognostic relevance of demographic factors in cardiac magnetic resonance-proven acute myocarditis: A cohort study.

    Cannata, Antonio / Bhatti, Prashan / Roy, Roman / Al-Agil, Mohammad / Daniel, Allen / Ferone, Emma / Jordan, Antonio / Cassimon, Barbara / Bradwell, Susie / Khawaja, Abdullah / Sadler, Matthew / Shamsi, Aamir / Huntington, Josef / Birkinshaw, Alexander / Rind, Irfan / Rosmini, Stefania / Piper, Susan / Sado, Daniel / Giacca, Mauro /
    Shah, Ajay M / McDonagh, Theresa / Scott, Paul A / Bromage, Daniel I

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 1037837

    Abstract: Aim: Acute myocarditis (AM) is a heterogeneous condition with variable estimates of survival. Contemporary criteria for the diagnosis of clinically suspected AM enable non-invasive assessment, resulting in greater sensitivity and more representative ... ...

    Abstract Aim: Acute myocarditis (AM) is a heterogeneous condition with variable estimates of survival. Contemporary criteria for the diagnosis of clinically suspected AM enable non-invasive assessment, resulting in greater sensitivity and more representative cohorts. We aimed to describe the demographic characteristics and long-term outcomes of patients with AM diagnosed using non-invasive criteria.
    Methods and results: A total of 199 patients with cardiac magnetic resonance (CMR)-confirmed AM were included. The majority (
    Conclusion: AM is highly heterogeneous with an overall favourable prognosis. Three-quarters of patients with AM present with chest pain, which is associated with a benign prognosis. AM presenting with life-threatening arrhythmias is associated with a higher risk of adverse events.
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1037837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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