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Article ; Online: Implantable cardioverter-defibrillator therapy to reduce sudden cardiac death in adults with congenital heart disease: A registry study.

Slater, Thomas A / Cupido, Blanche / Parry, Helen / Drozd, Michael / Blackburn, Michael E / Hares, Dominic / Pepper, Christopher B / Birkitt, Linda / Cullington, Damien / Witte, Klaus K / Oliver, James / English, Kate M / Sengupta, Anshuman

Journal of cardiovascular electrophysiology

2020  Volume 31, Issue 8, Page(s) 2086–2092

Abstract: Introduction: The adult congenital heart disease (ACHD) population is rapidly expanding. However, a significant proportion of these patients suffer sudden cardiac death. Recommending implantable cardioverter-defibrillator (ICD) insertion requires ... ...

Abstract Introduction: The adult congenital heart disease (ACHD) population is rapidly expanding. However, a significant proportion of these patients suffer sudden cardiac death. Recommending implantable cardioverter-defibrillator (ICD) insertion requires balancing the need for appropriate therapy in malignant arrhythmia against the consequences of inappropriate therapy and procedural complications. Here we present long-term follow-up data for ICD insertion in patients with ACHD from a large Level 1 congenital cardiac center.
Methods and results: All patients with ACHD undergoing ICD insertion over an 18-year period were identified. Data were extracted for baseline characteristics including demographics, initial diagnosis, ventricular function, relevant medication, and indication for ICD insertion. Details regarding device insertion were gathered along with follow-up data including appropriate and inappropriate therapy and complications. A total of 136 ICDs were implanted during this period: 79 for primary and 57 for secondary prevention. The most common congenital cardiac conditions in both groups were tetralogy of Fallot and transposition of the great arteries. Twenty-two individuals in the primary prevention group received appropriate antitachycardia pacing (ATP), 14 underwent appropriate cardioversion, 17 received inappropriate ATP, and 15 received inappropriate cardioversion. In the secondary prevention group, 18 individuals received appropriate ATP, 8 underwent appropriate cardioversion, 8 received inappropriate ATP, and 7 were inappropriately cardioverted. Our data demonstrate low complication rates, particularly with leads without advisories.
Conclusion: ICD insertion in the ACHD population involves a careful balance of the risks and benefits. Our data show a significant proportion of patients receiving appropriate therapy indicating that ICDs were inserted appropriately.
MeSH term(s) Adult ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/therapy ; Humans ; Registries ; Transposition of Great Vessels
Language English
Publishing date 2020-07-07
Publishing country United States
Document type Journal Article
ZDB-ID 1025989-2
ISSN 1540-8167 ; 1045-3873
ISSN (online) 1540-8167
ISSN 1045-3873
DOI 10.1111/jce.14633
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