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  1. Article ; Online: Daily spirometry in an acute exacerbation of adult cystic fibrosis patients.

    Stephen, Michael J / Long, Alex / Bonsall, Chad / Hoag, Jeffrey B / Shah, Smita / Bisberg, Dorothy / Holsclaw, Douglas / Varlotta, Laurie / Fiel, Stan / Du, Doantrang / Zanni, Robert / Hadjiliadis, Denis

    Chronic respiratory disease

    2017  Volume 15, Issue 3, Page(s) 258–264

    Abstract: To help answer the question of length of intravenous antibiotics during an acute exacerbation of cystic fibrosis (CF), we had subjects to follow daily home spirometry while on intravenous antibiotics. CF patients, 18 and older, with an acute exacerbation ...

    Abstract To help answer the question of length of intravenous antibiotics during an acute exacerbation of cystic fibrosis (CF), we had subjects to follow daily home spirometry while on intravenous antibiotics. CF patients, 18 and older, with an acute exacerbation requiring intravenous antibiotics had a daily FEV1. The average time to a 10% increase over their initial sick FEV1 was calculated, as well as the time to a new baseline. A total of 25 subjects completed the study. Ten of the 25 subjects did not have a sustainable 10% increase in FEV1. Of the 15 subjects with a sustainable 10% increase in FEV1, it took 5.2 days (±4.5) after day 1, while a new baseline was achieved on average at 6.6 days (±4.8) after day 1. Given the wide range of time to a 10% improvement and new baseline, it is recommended there should be flexibility in length of intravenous antibiotics in CF, not by a preset number.
    MeSH term(s) Administration, Intravenous ; Adult ; Anti-Bacterial Agents/administration & dosage ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Female ; Forced Expiratory Volume ; Humans ; Male ; Prospective Studies ; Spirometry ; Surveys and Questionnaires ; Symptom Flare Up ; Time Factors ; Young Adult
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2017-11-28
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2211488-9
    ISSN 1479-9731 ; 1479-9723
    ISSN (online) 1479-9731
    ISSN 1479-9723
    DOI 10.1177/1479972317743756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis.

    Sexauer, William P / Hadeh, Anas / Ohman-Strickland, Pamela A / Zanni, Robert L / Varlotta, Laurie / Holsclaw, Douglas / Fiel, Stanley / Graff, Gavin R / Atlas, Arthur / Bisberg, Dorothy / Hadjiliadis, Denis / Michel, Suzanne H / Mintz, Daria / Chakraborty, Rebanta / Marra, Bridget / Lomas, Paula / Ward, Tara / Sassman, Meagen / Imbesi, Giovanna C /
    Kitch, Diane M / Mallowe, Allison M

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2015  Volume 14, Issue 4, Page(s) 497–506

    Abstract: Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown.: Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH) ...

    Abstract Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown.
    Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF.
    Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function.
    Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.
    MeSH term(s) Adolescent ; Adult ; Child ; Cystic Fibrosis/blood ; Cystic Fibrosis/complications ; Cystic Fibrosis/physiopathology ; Female ; Forced Expiratory Volume/physiology ; Humans ; Male ; Retrospective Studies ; Vital Capacity/physiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/physiopathology ; Young Adult
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2015-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2091075-7
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2014.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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