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Article ; Online: Neuroinflammation: Fanning the fire of l-dopa-induced dyskinesia.

Bishop, Christopher

Movement disorders : official journal of the Movement Disorder Society

2020 Volume 34, Issue 12, Page(s) 1758–1760

MeSH term(s)	Animals ; Antiparkinson Agents/adverse effects ; Cytokines/metabolism ; Disease Models, Animal ; Dyskinesia, Drug-Induced/physiopathology ; Humans ; Inflammation/chemically induced ; Inflammation/pathology ; Levodopa/adverse effects ; Nervous System Diseases/chemically induced ; Nervous System Diseases/pathology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Antiparkinson Agents ; Cytokines ; Tumor Necrosis Factor-alpha ; Levodopa (46627O600J)
Language	English
Publishing date	2020-01-09
Publishing country	United States
Document type	Editorial
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.27900
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 238: Show issues

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Book ; Online: COVID-19 Assignment Details

Bishop, Christopher

COVID-19 Student Journal Project

2020

Keywords	COVID-19 ; student works ; journals ; HY201 ; HY202 ; Epidemiology ; United States History ; covid19
Publishing date	2020-05-01T07:00:00Z
Publisher	JSU Digital Commons
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Dopamine D3 Receptor Plasticity in Parkinson's Disease and L-DOPA-Induced Dyskinesia.

Lanza, Kathryn / Bishop, Christopher

Biomedicines

2021 Volume 9, Issue 3

Abstract: Parkinson's Disease (PD) is characterized by primary and secondary plasticity that occurs in response to progressive degeneration and long-term L-DOPA treatment. Some of this plasticity contributes to the detrimental side effects associated with chronic ... ...

Abstract	Parkinson's Disease (PD) is characterized by primary and secondary plasticity that occurs in response to progressive degeneration and long-term L-DOPA treatment. Some of this plasticity contributes to the detrimental side effects associated with chronic L-DOPA treatment, namely L-DOPA-induced dyskinesia (LID). The dopamine D3 receptor (D3R) has emerged as a promising target in LID management as it is upregulated in LID. This upregulation occurs primarily in the D1-receptor-bearing (D1R) cells of the striatum, which have been repeatedly implicated in LID manifestation. D3R undergoes dynamic changes both in PD and in LID, making it difficult to delineate D3R's specific contributions, but recent genetic and pharmacologic tools have helped to clarify its role in LID. The following review will discuss these changes, recent advances to better clarify D3R in both PD and LID and potential steps for translating these findings.
Language	English
Publishing date	2021-03-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9030314
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Book ; Online: Conformal mapping in linear time

Bishop, Christopher J.

2020

Abstract: Given any $\epsilon >0$ and any planar region $\Omega$ bounded by a simple n-gon $P$ we construct a ($1 + \epsilon)$-quasiconformal map between $\Omega$ and the unit disk in time $C(\epsilon)n$. One can take $ C(\epsilon) = C + C \log (1/\epsilon) \log \ ... ...

Abstract	Given any $\epsilon >0$ and any planar region $\Omega$ bounded by a simple n-gon $P$ we construct a ($1 + \epsilon)$-quasiconformal map between $\Omega$ and the unit disk in time $C(\epsilon)n$. One can take $ C(\epsilon) = C + C \log (1/\epsilon) \log \log (1/\epsilon)$. Comment: 126 pages, 57 figures
Keywords	Mathematics - Complex Variables ; Computer Science - Computational Geometry ; Primary 30C35 ; Secondary: 30C85 ; 30C62
Publishing date	2020-07-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Optimal angle bounds for quadrilateral meshes

Bishop, Christopher J.

2020

Abstract: We show that any simple planar n-gon can be meshed in linear time by $O(n)$ quadrilaterals with all new angles bounded between $60$ and $120$ degrees. ... Comment: 27 pages, 22 ... ...

Abstract	We show that any simple planar n-gon can be meshed in linear time by $O(n)$ quadrilaterals with all new angles bounded between $60$ and $120$ degrees. Comment: 27 pages, 22 figures
Keywords	Computer Science - Computational Geometry ; Mathematics - Complex Variables ; 30C20 (primary) 30C30 ; 65D17 (secondary)
Publishing date	2020-07-15
Publishing country	us
Document type	Book ; Online
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Article ; Online: Striatal serotonin transporter gain-of-function in L-DOPA-treated, hemi-parkinsonian rats.

Conti Mazza, Melissa M / Centner, Ashley / Werner, David F / Bishop, Christopher

Brain research

2023 Volume 1811, Page(s) 148381

Abstract: L-DOPA is the standard treatment for Parkinson's disease (PD), but chronic treatment typically leads to L-DOPA-induced dyskinesia (LID). LID involves a complex interaction between the remaining dopamine (DA) system and the semi-homologous serotonin (5-HT) ...

Abstract	L-DOPA is the standard treatment for Parkinson's disease (PD), but chronic treatment typically leads to L-DOPA-induced dyskinesia (LID). LID involves a complex interaction between the remaining dopamine (DA) system and the semi-homologous serotonin (5-HT) system. Since serotonin transporters (SERT) have some affinity for DA uptake, they may serve as a functional compensatory mechanism when DA transporters (DAT) are scant. DAT and SERT's functional contributions in the dyskinetic brain have not been well delineated. The current investigation sought to determine how DA depletion and L-DOPA treatment affect DAT and SERT transcriptional processes, translational processes, and functional DA uptake in the 6-hydroxydopamine-lesioned hemi-parkinsonian rat. Rats were counterbalanced for motor impairment into equally lesioned treatment groups then given daily L-DOPA (0 or 6 mg/kg) for 2 weeks. At the end of treatment, the substantia nigra was processed for tyrosine hydroxylase (TH) and DAT gene expression and dorsal raphe was processed for SERT gene expression. The striatum was processed for synaptosomal DAT and SERT protein expression and ex vivo DA uptake. Nigrostriatal DA loss severely reduced DAT mRNA and protein expression in the striatum with minimal changes in SERT. L-DOPA treatment, while not significantly affecting DAT or SERT alone, did increase striatal SERT:DAT protein ratios. Using ex vivo microdialysis, L-DOPA treatment increased DA uptake via SERT when DAT was depleted. Overall, these results suggest that DA loss and L-DOPA treatment uniquely alter DAT and SERT, revealing implications for monoamine transporters as potential biomarkers and therapeutic targets in the hemi-parkinsonian model and dyskinetic PD patients.
MeSH term(s)	Rats ; Animals ; Levodopa/therapeutic use ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Serotonin/metabolism ; Gain of Function Mutation ; Rats, Sprague-Dawley ; Dopamine/metabolism ; Corpus Striatum/metabolism ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Oxidopamine/metabolism
Chemical Substances	Levodopa (46627O600J) ; Serotonin Plasma Membrane Transport Proteins ; Serotonin (333DO1RDJY) ; Dopamine (VTD58H1Z2X) ; Oxidopamine (8HW4YBZ748)
Language	English
Publishing date	2023-04-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2023.148381
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Article ; Online: Effect of Foot Orthoses on Running Economy and Foot Longitudinal Arch Motion in Runners With Flat-Arched Feet.

Crago, Daniel / Arnold, John B / Bishop, Christopher

International journal of sports physiology and performance

2021 Volume 16, Issue 10, Page(s) 1401–1407

Abstract: Purpose: To determine the effect of manipulating foot longitudinal arch motion with different-stiffness foot orthoses on running economy (RE) in runners with flat-arched feet and if changes in arch deformation and recoil were associated with changes in ... ...

Abstract	Purpose: To determine the effect of manipulating foot longitudinal arch motion with different-stiffness foot orthoses on running economy (RE) in runners with flat-arched feet and if changes in arch deformation and recoil were associated with changes in RE. Methods: Twenty-three recreational distance runners performed 5-minute submaximal treadmill runs at 12 km·h-1, in the following 3 conditions in a randomized order: (1) footwear only, (2) flexible orthoses (reduced arch thickness), and (3) standard orthoses. The RE (submaximal steady-state oxygen consumption [VO2submax]) and sagittal arch range of motion were compared among conditions using a repeated-measures analysis of variance and effect sizes (Cohen d). Pearson correlation coefficients were used to determine the association between the change in the sagittal arch range of motion and VO2submax. Results: Compared with standard orthoses, the mean VO2submax was significantly lower in both the flexible orthoses (-0.8 mL·kg-1·min-1, P < .001, d = 0.35) and footwear-only conditions (-1.2 mL·kg-1·min-1, P < .001, d = 0.49). The change in VO2submax between the flexible orthoses and footwear-only conditions was significantly positively correlated with the change in sagittal arch range of motion (r = .591, P = .005). Conclusion: Conventional foot orthoses were associated with poorer RE compared with flexible orthoses and footwear alone. Changes in arch deformation were positively correlated to changes in oxygen consumption, indicating that foot orthoses that limit arch deformation and recoil degrade RE. Foot orthoses that facilitate energy storage and release in the foot longitudinal arch may be advisable for athletes prescribed these devices for clinical purposes to maintain optimal running performance.
MeSH term(s)	Biomechanical Phenomena ; Foot ; Foot Orthoses ; Humans ; Range of Motion, Articular ; Running
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2020-0717
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Article ; Online: The effects of L-DOPA on gait abnormalities in a unilateral 6-OHDA rat model of Parkinson's disease.

Holden, Hannah / Venkatesh, Shruti / Budrow, Carla / Nezaria, Sareen / Coyle, Michael / Centner, Ashley / Lipari, Natalie / McManus, Grace / Bishop, Christopher

Physiology & behavior

2024 Volume 281, Page(s) 114563

Abstract: Parkinson's Disease (PD) is a neurodegenerative movement disorder characterized by dopamine (DA) cell loss in the substantia nigra pars compacta (SNc). As PD progresses, patients display disruptions in gait such as changes in posture, bradykinesia, and ... ...

Abstract	Parkinson's Disease (PD) is a neurodegenerative movement disorder characterized by dopamine (DA) cell loss in the substantia nigra pars compacta (SNc). As PD progresses, patients display disruptions in gait such as changes in posture, bradykinesia, and shortened stride. DA replacement via L-DOPA alleviates many PD symptoms, though its effects on gait are not well demonstrated. This study aimed to assess the relationship between DA lesion, gait, and deficit-induced reversal with L-DOPA. To do so, Sprague-Dawley rats (N = 25, 14 males, 11 females) received unilateral medial forebrain bundle (MFB) DA lesions with 6-hydroxydopamine (6-OHDA). An automated gait analysis system assessed spatiotemporal gait parameters pre- and post-lesion, and after various doses of L-DOPA (0, 3, or 6 mg/kg; s.c.). The forepaw adjusting steps (FAS) test was implemented to evaluate lesion efficacy while the abnormal involuntary movements (AIMs) scale monitored the emergence of L-DOPA-induced dyskinesia (LID). High performance liquid chromatography (HPLC) assessed changes in brain monoamines on account of lesion and treatment. Results revealed lesion-induced impairments in gait, inclusive of max-contact area and step-sequence alterations that were not reversible with L-DOPA. However, the emergence of AIMs were observed at higher doses. Post-mortem, 6-OHDA lesions induced a loss of striatal DA and norepinephrine (NE), while prefrontal cortex (PFC) displayed noticeable reduction in NE but not DA. Our findings indicate that hemiparkinsonian rats display measurable gait disturbances similar to PD patients that are not rescued by DA replacement. Furthermore, non-DA mechanisms such as attention-related NE in PFC may contribute to altered gait and may constitute a novel target for its treatment.
Language	English
Publishing date	2024-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2024.114563
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Article ; Online: Heptadecanoic Acid Is Not a Key Mediator in the Prevention of Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice.

Bishop, Christopher A / Machate, Tina / Henkel, Janin / Schulze, Matthias B / Klaus, Susanne / Piepelow, Karolin

Nutrients

2023 Volume 15, Issue 9

Abstract: Epidemiological studies found that the intake of dairy products is associated with an increased amount of circulating odd-chain fatty acids (OCFA, C15:0 and C17:0) in humans and further indicate that especially C17:0 is associated with a lower incidence ... ...

Abstract	Epidemiological studies found that the intake of dairy products is associated with an increased amount of circulating odd-chain fatty acids (OCFA, C15:0 and C17:0) in humans and further indicate that especially C17:0 is associated with a lower incidence of type 2 diabetes. However, causal relationships are not elucidated. To provide a mechanistic link, mice were fed high-fat (HF) diets supplemented with either milk fat or C17:0 for 20 weeks. Cultured primary mouse hepatocytes were used to distinguish differential effects mediated by C15:0 or C17:0. Despite an induction of OCFA after both dietary interventions, neither long-term milk fat intake nor C17:0 supplementation improved diet-induced hepatic lipid accumulation and insulin resistance in mice. HF feeding with milk fat actually deteriorates liver inflammation. Treatment of primary hepatocytes with C15:0 and C17:0 suppressed JAK2/STAT3 signaling, but only C15:0 enhanced insulin-stimulated phosphorylation of AKT. Overall, the data indicate that the intake of milk fat and C17:0 do not mediate health benefits, whereas C15:0 might be promising in further studies.
MeSH term(s)	Humans ; Animals ; Mice ; Insulin Resistance ; Diabetes Mellitus, Type 2/prevention & control ; Fatty Acids ; Fatty Liver ; Diet, High-Fat/adverse effects
Chemical Substances	margaric acid (V987Y9OZ8L) ; Fatty Acids
Language	English
Publishing date	2023-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15092052
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Article ; Online: Serotonergic targets for the treatment of L-DOPA-induced dyskinesia.

Lanza, Kathryn / Bishop, Christopher

Journal of neural transmission (Vienna, Austria : 1996)

2018 Volume 125, Issue 8, Page(s) 1203–1216

Abstract: Dopamine (DA) replacement therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) continues to be the gold-standard treatment for Parkinson's disease (PD). Despite clear symptomatic benefit, long-term L-DOPA use often results in the development of L-DOPA- ... ...

Abstract	Dopamine (DA) replacement therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) continues to be the gold-standard treatment for Parkinson's disease (PD). Despite clear symptomatic benefit, long-term L-DOPA use often results in the development of L-DOPA-induced dyskinesia (LID), significantly reducing quality of life and increasing costs for PD patients and their caregivers. Accumulated research has demonstrated that several pre- and post-synaptic mechanisms contribute to LID development and expression. In particular, raphe-striatal hyperinnervation and unregulated DA release from 5-HT terminals is postulated to play a central role in LID manifestation. As such, manipulation of the 5-HT system has garnered considerable attention. Both pre-clinical and clinical research has supported the potential of modulating the 5-HT system for LID prevention and treatment. This review discusses the rationale for continued investigation of several potential anti-dyskinetic strategies including 5-HT stimulation of 5-HT1A and 5-HT1B receptors and blockade of 5-HT2A receptors and SERT. We present the latest findings from experimental and clinical investigations evaluating these 5-HT targets with the goal of identifying those with translational promise and the challenges associated with each.
MeSH term(s)	Animals ; Antiparkinson Agents/adverse effects ; Dyskinesia, Drug-Induced ; Humans ; Levodopa/adverse effects ; Receptors, Serotonin/drug effects ; Receptors, Serotonin/metabolism ; Serotonin/metabolism ; Serotonin/pharmacology ; Serotonin Receptor Agonists/pharmacology
Chemical Substances	Antiparkinson Agents ; Receptors, Serotonin ; Serotonin Receptor Agonists ; Serotonin (333DO1RDJY) ; Levodopa (46627O600J)
Language	English
Publishing date	2018-01-05
Publishing country	Austria
Document type	Journal Article ; Review
ZDB-ID	184163-4
ISSN	1435-1463 ; 0300-9564
ISSN (online)	1435-1463
ISSN	0300-9564
DOI	10.1007/s00702-017-1837-1
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