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  1. Article ; Online: The effectiveness of telemedicine interventions, delivered exclusively during the postnatal period, on postpartum depression in mothers without history or existing mental disorders: A systematic review and meta-analysis.

    Hanach, Nivine / de Vries, Nanne / Radwan, Hadia / Bissani, Nour

    Midwifery

    2020  Volume 94, Page(s) 102906

    Abstract: Background: Postpartum depression, one of the most common forms of depression, is highly prevalent worldwide among women during childbirth. Despite available treatments for postpartum depression, numerous barriers hinder women to access care including ... ...

    Abstract Background: Postpartum depression, one of the most common forms of depression, is highly prevalent worldwide among women during childbirth. Despite available treatments for postpartum depression, numerous barriers hinder women to access care including time, financial constraints, and childcare concerns. Telemedicine interventions are suggested to be feasible to prevent and improve postpartum depression.
    Objective: To examine the effectiveness of telemedicine interventions - delivered exclusively during the postnatal period, on postpartum depression symptomatology in women with no history of mental disorders.
    Design: A systematic review and meta-analysis of randomized controlled trials.
    Methods: PubMed, Web of Science, Cochrane Library, and ProQuest Dissertations & Theses databases were used to identify relevant randomized controlled trials, until 7 January 2020. Studies were quality assessed using the Cochrane Library Risk of Bias Tool. The results of postpartum depression scores were pooled using a random-effects model. Intervention completion rate and participants' satisfaction were reported in a narrative form, as secondary outcomes.
    Results: Ten trials including a total of 2366 participants, contributed data to the review. Seven studies were included in the quantitative synthesis. Women who received technology-based interventions, regardless of the type (web-based versus telephone-based), had a statistically significant improvement in postpartum depression (mean difference: -1.81, 95% CI: -2.68 to -0.93; P<.0001). The completion rate was 80% in the intervention groups compared to 76% in the control groups. Three studies reporting participants' satisfaction revealed that the participants were highly satisfied with the technology-based interventions.
    Conclusion: Overall, telemedicine interventions appear to be promising in preventing and improving postpartum depression. Further larger-scale high-quality research is required to establish an evidence-based telemedicine approach, in terms of structure, content, and providers. Future economic evaluation is also vital to evaluate the long-term use of telemedicine in improving postpartum depression.
    MeSH term(s) Depression, Postpartum/therapy ; Female ; Humans ; Mothers ; Parturition ; Pregnancy ; Telemedicine ; Telephone
    Language English
    Publishing date 2020-12-19
    Publishing country Scotland
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1036567-9
    ISSN 1532-3099 ; 0266-6138
    ISSN (online) 1532-3099
    ISSN 0266-6138
    DOI 10.1016/j.midw.2020.102906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2662: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A test to measure oral iron absorption and glucose tolerance simultaneously in 18 to 55 year old premenopausal women.

    El-Helou, Nehmat / El-Mallah, Carla / Wehbe, Nour / Bissani, Nour / Stoffel, Nicole / Herter-Aeberli, Isabelle / Zimmermann, Michael / Obeid, Omar

    Clinical nutrition ESPEN

    2021  Volume 46, Page(s) 325–329

    Abstract: Background & aims: Several methods are available to measure iron absorption (IA). The oral iron absorption test (OIAT) measures IA based on a change in serum iron (ΔSeFe) concentration after an oral iron dose. The objective of this study was to validate ...

    Abstract Background & aims: Several methods are available to measure iron absorption (IA). The oral iron absorption test (OIAT) measures IA based on a change in serum iron (ΔSeFe) concentration after an oral iron dose. The objective of this study was to validate the OIAT by comparing it to the reference method of fractional iron absorption (FIA) using red blood cell incorporation of stable iron isotopes from a labeled iron dose. A second objective was to assess whether the OIAT could be done simultaneously with an oral glucose tolerance test (OGTT), since iron deficiency and glucose intolerance may coexist, especially among overweight individuals with low-grade inflammation.
    Methods: In this prospective experimental study, 116 women were enrolled and IA was measured using two different approaches 1) FIA from a labeled test meal containing 6 mg of
    Results: Prevalence of anemia and iron deficiency (defined as low serum ferritin) were 21% and 14%, respectively. ΔSeFe during the OIAT-OGTT was positively associated with FIA (r = 0.578, p < 0.001). ΔSeFe was not significantly correlated with markers of glucose and insulin metabolism during the OIAT-OGTT.
    Conclusions: The combined OIAT and OGTT method described here correlates well with FIA measured by stable iron isotopes, and could provide information on both IA and glucose tolerance in a single 2-h test, decreasing the burden on patients. clinicaltrials.gov (NCT03642223).
    MeSH term(s) Adolescent ; Adult ; Anemia, Iron-Deficiency/diagnosis ; Female ; Glucose ; Humans ; Iron ; Iron Isotopes ; Middle Aged ; Prospective Studies ; Young Adult
    Chemical Substances Iron Isotopes ; Iron (E1UOL152H7) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2021.09.737
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  3. Article: A test to measure oral iron absorption and glucose tolerance simultaneously in 18 to 55 year old premenopausal women

    El-Helou, Nehmat / El-Mallah, Carla / Wehbe, Nour / Bissani, Nour / Stoffel, Nicole / Herter-Aeberli, Isabelle / Zimmermann, Michael / Obeid, Omar

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2021 Dec., v. 46

    2021  

    Abstract: Several methods are available to measure iron absorption (IA). The oral iron absorption test (OIAT) measures IA based on a change in serum iron (ΔSeFe) concentration after an oral iron dose. The objective of this study was to validate the OIAT by ... ...

    Abstract Several methods are available to measure iron absorption (IA). The oral iron absorption test (OIAT) measures IA based on a change in serum iron (ΔSeFe) concentration after an oral iron dose. The objective of this study was to validate the OIAT by comparing it to the reference method of fractional iron absorption (FIA) using red blood cell incorporation of stable iron isotopes from a labeled iron dose. A second objective was to assess whether the OIAT could be done simultaneously with an oral glucose tolerance test (OGTT), since iron deficiency and glucose intolerance may coexist, especially among overweight individuals with low-grade inflammation. In this prospective experimental study, 116 women were enrolled and IA was measured using two different approaches 1) FIA from a labeled test meal containing 6 mg of ⁵⁷Fe and 2) the OIAT assessing ΔSeFe at 2 h after the intake of 100 mg oral iron, done simultaneously with an OGTT. Markers of iron status, glycaemia and inflammation, and serum hepcidin, were measured. Prevalence of anemia and iron deficiency (defined as low serum ferritin) were 21% and 14%, respectively. ΔSeFe during the OIAT-OGTT was positively associated with FIA (r = 0.578, p < 0.001). ΔSeFe was not significantly correlated with markers of glucose and insulin metabolism during the OIAT-OGTT. The combined OIAT and OGTT method described here correlates well with FIA measured by stable iron isotopes, and could provide information on both IA and glucose tolerance in a single 2-h test, decreasing the burden on patients. clinicaltrials.gov (NCT 03642223).
    Keywords anemia ; blood glucose ; blood serum ; clinical nutrition ; erythrocytes ; ferritin ; glucose ; glucose tolerance ; glucose tolerance tests ; hepcidin ; inflammation ; insulin ; iron ; iron absorption ; overweight ; premenopause ; test meals
    Language English
    Dates of publication 2021-12
    Size p. 325-329.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2021.09.737
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: The effect of central obesity on inflammation, hepcidin, and iron metabolism in young women.

    Stoffel, Nicole U / El-Mallah, Carla / Herter-Aeberli, Isabelle / Bissani, Nour / Wehbe, Nour / Obeid, Omar / Zimmermann, Michael B

    International journal of obesity (2005)

    2020  Volume 44, Issue 6, Page(s) 1291–1300

    Abstract: Background/objectives: In overweight and obesity (OW/OB), greater total body fat predicts higher serum hepcidin (SHep) which can impair iron homeostasis and increase risk for iron deficiency (ID). However, the effect of body fat distribution on SHep and ...

    Abstract Background/objectives: In overweight and obesity (OW/OB), greater total body fat predicts higher serum hepcidin (SHep) which can impair iron homeostasis and increase risk for iron deficiency (ID). However, the effect of body fat distribution on SHep and iron homeostasis is unclear. In central obesity, interleukin (IL)-6 released from visceral adipose tissue into portal blood could strongly stimulate hepatic hepcidin synthesis. Thus, our hypothesis was that higher amounts of android fat, rather than gynoid fat, would predict impaired iron metabolism in OW/OB.
    Subjects/methods: In this cross-sectional study, we enrolled 117 otherwise-healthy women into two groups: normal weight; BMI < 25 (n = 36) and OW/OB; BMI ≥ 25 (n = 81); we then subdivided the OW/OB using DEXA into tertiles based on the ratio of android fat/total body fat (AF/TBF). We measured inflammation and iron status, and assessed iron absorption in two ways: by measuring erythrocyte isotope incorporation from a labeled test meal containing 6 mg
    Results: Greater AF/TBF correlated with higher CRP, AGP, SHep, and TIBC, and lower transferrin saturation and SeFe/SHep ratio (for all, p < 0.05). Greater AF/TBF correlated with lower supplemental iron absorption (ΔSeFe) (p = 0.08) but not lower dietary iron absorption. In multiple regressions, AF/TBF positively predicted CRP (p < 0.001) and SHep (p < 0.05); a model including AF/TBF and serum ferritin as covariates explained 65% of the variance in SHep. AF/TBF negatively predicted TSAT (p < 0.05) and iron absorption (ΔSeFe) (p = 0.07). In contrast, the ratio of gynoid fat/total body fat was not significantly associated with these variables.
    Conclusion: Body fat distribution affects iron metabolism: women with greater central adiposity have higher SHep, greater impairments in iron homeostasis, and reduced iron absorption from a supplemental iron dose.
    MeSH term(s) Adult ; C-Reactive Protein/analysis ; Cross-Sectional Studies ; Female ; Hepcidins/blood ; Humans ; Inflammation/metabolism ; Iron/metabolism ; Obesity, Abdominal/physiopathology ; Transferrin/metabolism ; Young Adult
    Chemical Substances Hepcidins ; Transferrin ; C-Reactive Protein (9007-41-4) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-020-0522-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1325: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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