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Article ; Online: Impact of the SARS-CoV-2 pandemic on the diagnostic delay of oral carcinoma: a retrospective analysis.

Lemma, Francesco / Parrino, Daniela / Bissolotti, Guido / Emanuelli, Enzo / DI Carlo, Roberto / Fusetti, Stefano

2023 Volume 71, Issue 6, Page(s) 308–317

Abstract: Background: The aim of the present study was to investigate how the organisation of healthcare activity during the first wave of the SARS-CoV-2 pandemic affected the timing of diagnosis of oral carcinoma in the Functional Head and Neck Department of ... ...

Abstract	Background: The aim of the present study was to investigate how the organisation of healthcare activity during the first wave of the SARS-CoV-2 pandemic affected the timing of diagnosis of oral carcinoma in the Functional Head and Neck Department of Padua (Italy). This study gives an effective temporal dimension of the diagnostic delay that occurred during the pandemic, compared with data from the literature. Methods: A retrospective analysis of the diagnostic path of a patient affected by oral cancer during COVID-19 pandemic was performed. The time elapsed from the patient's awareness of the problem to the first curative surgical intervention was considered both during the blockage of elective care activities and in the period immediately following. The results were compared to a group of patients treated in the same period of the year 2019. Results: The territorial time was 53.9% longer in the post-lockdown period than in the lockdown period (39.6 days) while the hospital time was 56.6% shorter than in the post-lockdown period (56 days). Conclusions: The response time of territorial medicine has been longer during the pandemic peak. The unintentional creation of exclusive pathways for oncological patients speeded up the diagnostic process. The organization and accessibility of operating theatres can become particularly problematic during the acute phases of a pandemic.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; COVID-19/epidemiology ; Pandemics ; Delayed Diagnosis ; Retrospective Studies ; Communicable Disease Control ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/epidemiology ; Carcinoma ; COVID-19 Testing
Language	English
Publishing date	2023-02-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062693-6
ISSN	2724-6337
ISSN (online)	2724-6337
DOI	10.23736/S2724-6329.22.04645-9
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Article: Odontogenic Chronic Rhinosinusitis: Structured Histopathology Evidence in Different Patho-Physiological Mechanisms.

Brescia, Giuseppe / Alessandrini, Lara / Bacci, Christian / Bissolotti, Guido / Fedrigo, Marny / Contro, Giacomo / Frasconi, Samuele / Boccuto, Maria Grazia / Calcavecchia, Arianna / Frigo, Anna Chiara / Barion, Umberto / Fusetti, Stefano / Angelini, Annalisa / Marioni, Gino

Biomedicines

2022 Volume 10, Issue 11

Abstract: An increased odontogenic chronic rhinosinusitis (oCRS) occurrence rate has quite recently been reported, likely due to an intensification of conservative dental surgery and implantology. The main aim of the study was to report for the first time the ... ...

Abstract	An increased odontogenic chronic rhinosinusitis (oCRS) occurrence rate has quite recently been reported, likely due to an intensification of conservative dental surgery and implantology. The main aim of the study was to report for the first time the structured histopathological characteristics of the surgical specimens of oCRS. Possible associations between histopathological features and oCRS patho-physiological mechanisms were also evaluated. Structured histopathology features were investigated in the sinonasal mucosa tissue of 42 consecutive oCRS patients.Mean tissue eosinophil counts were significantly different between oCRS with radicular cysts, dental implants, or other dental diseases (
Language	English
Publishing date	2022-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10112768
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Article ; Online: Keratocyst, conservative treatment: case report.

Terranova, F / Trevisiol, L / Nocini, P F / Bissolotti, G / Bondì, V / De Santis, D / Bertossi, D / D'agostino, A

Minerva stomatologica

2013

Abstract: The odontogenic keratocyst is now designated as a keratocystic odontogenic tumor and is defined as a benign uni- or multicystic, intraosseus tumor of odontogenic origin, with a characteristic lining of parakeratiniezed tumour as a better reflects is ... ...

Abstract	The odontogenic keratocyst is now designated as a keratocystic odontogenic tumor and is defined as a benign uni- or multicystic, intraosseus tumor of odontogenic origin, with a characteristic lining of parakeratiniezed tumour as a better reflects is neoplastic nature. This case report presents the marsupialization procedure for the treatment of a keratocystic lesion.
Language	English
Publishing date	2013-08-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	416059-9
ISSN	1827-174X ; 0026-4970
ISSN (online)	1827-174X
ISSN	0026-4970
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Article ; Online: Evaluation of quality of life in patients with total or partial edentulism treated with computer-assisted implantology.

Bertossi, D / Rossetto, A / Piubelli, C / Rossini, N / Zanotti, G / Rodella, L F / Bissolotti, G / Colletti, G / Chiarini, L / Nocini, P F

Minerva stomatologica

2013

Abstract: Aim: The study deals with a preliminary analysis that compares quality of life of a randomized sample of patients with total or partial edentulism rehabilitated through conventional implantology or computer-assisted implantology. Methods: The first group ...

Abstract	Aim: The study deals with a preliminary analysis that compares quality of life of a randomized sample of patients with total or partial edentulism rehabilitated through conventional implantology or computer-assisted implantology. Methods: The first group was treated with conventional implantology, while the second group was treated with NobelGuide™ computer-assisted implantology. every patient has filled up a questionnaire about quality of life in presurgical period (sf-361), in postsurgical period (sf-361; tiq2) and about the gratification after prosthetic treatment. the questionnaire has evaluated physical, general and psycho-emotive health parameter. Results: sf-36 has demonstrated an improvement in quality of life after computer-assisted surgery. tiq has revealed that patients symptoms in post-surgical week were inferior in quality and in quantity in NobelGuide™ technique. gratification questionnaire has demonstrated that quality of life improvement matches patient full satisfaction after the treatment. Conclusion: NobelGuide™ protocol improves physical health after implantology with positive reflections on psycho-emotive health. furthermore prefabricated temporary prostheses reduces treatment time and patient discomfort.
Language	English
Publishing date	2013-08-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	416059-9
ISSN	1827-174X ; 0026-4970
ISSN (online)	1827-174X
ISSN	0026-4970
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Article ; Online: Aneurysmal bone cyst of the nasal bone: case report.

Galzignato, P / Trevisiol, L / D'itri, L / Bissolotti, G / Mocella, S / De Santis, D / Chiarini, L / Nocini, P F / Bertossi, D

Minerva stomatologica

2013

Abstract: The aneurysmal bone cyst (ABC) is a solitary, expansile, non-neoplastic bone lesion, described as a distinct clinicopathological entity by Jaffe and Lichtenstein. We report a case of an ABC arising from the nasal bone in a adult male patient treated with ...

Abstract	The aneurysmal bone cyst (ABC) is a solitary, expansile, non-neoplastic bone lesion, described as a distinct clinicopathological entity by Jaffe and Lichtenstein. We report a case of an ABC arising from the nasal bone in a adult male patient treated with complete surgical excision.
Language	English
Publishing date	2013-08-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	416059-9
ISSN	1827-174X ; 0026-4970
ISSN (online)	1827-174X
ISSN	0026-4970
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Article ; Online: Lingual frenectomy: a comparison between the conventional surgical and laser procedure.

De Santis, D / Gerosa, R / Graziani, P F / Zanotti, G / Rossini, N / Castellani, R / Bissolotti, G / Chiarini, L / Nocini, P F / Bertossi, D

Minerva stomatologica

2013

Abstract: Aim: Ankyloglossia, commonly known as tongue-tie, is a congenital oral anomaly characterized by a short lingual frenulum that may contribute to feeding, speech and mechanical problems. The purpose of this study is to compare the advantages of laser vis-à- ...

Abstract	Aim: Ankyloglossia, commonly known as tongue-tie, is a congenital oral anomaly characterized by a short lingual frenulum that may contribute to feeding, speech and mechanical problems. The purpose of this study is to compare the advantages of laser vis-à-vis conventional frenectomy in both intra- and post-surgical phases. Methods: This study took into consideration two patients, who were respectively 9 and 10-year-old. The first one underwent a common surgical procedure. A Nd:Yap laser device with a micropulsed wavelength of 1340 nm and power of 8 watts was used for the second. The postsurgical discomfort and healing characteristics were evaluated. Results: The results indicated that the Nd:Yap laser has the following advantages when compared to the conventional frenectomy: 1) soft tissue cutting was efficient, with no bleeding, giving a clear operative field; 2) there was no need to use sutures; 3) the surgery was less time-consuming; 4) there was no postsurgical infection and no need for analgesics or antibiotics; 5) wound contraction and scarring were decreased or eliminated; 6) despite the initial slowness of the healing process, the complete and final recovery was faster. Conclusion: Considering the above elements, it is possible to assert that the laser frenectomy has a series of unquestionable advantages if compared to the conventional surgical technique.
Language	English
Publishing date	2013-08-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	416059-9
ISSN	1827-174X ; 0026-4970
ISSN (online)	1827-174X
ISSN	0026-4970
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Article: Approccio multimodale al carcinoma del retto con metastasi epatica.

Orsenigo, E / Aldrighetti, L / Pulitanò, C / Bissolotti, G / Bisagni, P / Staudacher, C

I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.

2005 Volume 4, Issue 3, Page(s) S15

Abstract: Background: The role of surgery in the treatment of rectal cancer has been demonstrated worldwide. Moreover, curative liver resection of colorectal liver metastases is the only treatment offering a chance of long-term survival. Unfortunately, the liver ... ...

Title translation	Multimodal approach to rectal carcinoma with hepatic metastasis.
Abstract	Background: The role of surgery in the treatment of rectal cancer has been demonstrated worldwide. Moreover, curative liver resection of colorectal liver metastases is the only treatment offering a chance of long-term survival. Unfortunately, the liver resection can be performed in only 10% of the patients. Aim: In order to extend the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer, we describe, in the video, a multimodal approach to rectal cancer with liver metastasis in the right lobe. Patient and methods. A 51 years old woman was admitted to our Department for adenocarcinoma of the distal rectum and a resectable solitary synchronous liver metastasis located across the right and the middle hepatic vein. Unfortunately, the future remnant liver was too small, risking severe post-operative liver failure. For this reason, a portal vein embolization or occlusion has been proposed. First of all, the patient has been submitted to laparoscopic low anterior resection with simultaneous right portal vein ligature. Two months later, after a CT estimation of liver volume in vivo, she was submitted to right hepatectomy (open surgery). Results: Both postoperative courses were uneventful. Conclusions: As a preparation for large hepatic resection for liver rectal metastasis the laparoscopic ligature of the right portal vein performed simultaneously to the laparoscopic low anterior resection is feasible and safe.
MeSH term(s)	Combined Modality Therapy ; Female ; Humans ; Ligation ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Middle Aged ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy
Language	Italian
Publishing date	2005-05
Publishing country	Italy
Document type	Case Reports ; English Abstract ; Journal Article
ISSN	2283-5423
ISSN	2283-5423
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Article: Laparoscopic central pancreatectomy.

Orsenigo, Elena / Baccari, Paolo / Bissolotti, Guido / Staudacher, Carlo

American journal of surgery

2006 Volume 191, Issue 4, Page(s) 549–552

Abstract: Background: The role of mini-invasive surgery in pancreatic surgery is still being debated. Indications and results are still controversial. Only a few centers in the world report on laparoscopic pancreatic resections. With the aim of improving the use ... ...

Abstract	Background: The role of mini-invasive surgery in pancreatic surgery is still being debated. Indications and results are still controversial. Only a few centers in the world report on laparoscopic pancreatic resections. With the aim of improving the use of minimally invasive surgery, we have devised a novel laparoscopic procedure for surgical treatment of neuroendocrine tumor of the neck of the pancreas. Methods: A central laparoscopic pancreatic resection was successfully performed. The pancreatic resection was performed using the harmonic scalpel. The duct was isolated and transected. The proximal duct stump was closed by an endoscopic stitch. The pancreaticojejunostomy was intracorporeally performed using a Roux-en-Y loop. Results: Histologic findings showed a well differentiated neuroendocrine tumor. Operating time was 330 minutes and blood loss 300 mL. The postoperative course was uneventful. Conclusions: Laparoscopic central pancreatectomy is a feasible and safe procedure. The minimally invasive approach ensures an adequate treatment despite requiring the expertise of highly skilled laparoscopic surgeons.
MeSH term(s)	Aged ; Anastomosis, Roux-en-Y ; Female ; Humans ; Laparoscopy/methods ; Neuroendocrine Tumors/surgery ; Pancreatectomy/methods ; Pancreatic Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2006-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2006.01.010
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Article ; Online: Acute particulate matter affects cardiovascular autonomic modulation and IFN-γ methylation in healthy volunteers.

Tobaldini, Eleonora / Bollati, Valentina / Prado, Marta / Fiorelli, Elisa M / Pecis, Marica / Bissolotti, Giorgio / Albetti, Benedetta / Cantone, Laura / Favero, Chiara / Cogliati, Chiara / Carrer, Paolo / Baccarelli, Andrea / Bertazzi, Pier Alberto / Montano, Nicola

Environmental research

2017 Volume 161, Page(s) 97–103

Abstract: Aims: Air particulate matter (PM) is associated with increased cardiovascular morbidity and mortality. Altered autonomic functions play a key role in PM-induced cardiovascular disease. However, previous studies have not address the impact of PM on ... ...

Abstract	Aims: Air particulate matter (PM) is associated with increased cardiovascular morbidity and mortality. Altered autonomic functions play a key role in PM-induced cardiovascular disease. However, previous studies have not address the impact of PM on sympathetic and parasympathetic control of heart function, independently, and using controlled conditions, i.e., increasing titration of PM of known composition, in absence of other potential confounding factors. To fill this gap, here we used symbolic analysis that is capable of detecting non-mutual changes of the two autonomic branches, thus considering them as independent, and concentrations of PM as they could be measured at peak levels in Milan during a polluted winter day. Methods and results: In this randomized, cross-over study, we enrolled 12 healthy subjects who underwent two random sessions: inhalation of filtered air mixture or inhalation of filtered air containing particulate mixture (PM 10, PM 2.5, PM 1.0 and PM 0.5µm). ECG and respiration for autonomic analysis and blood sample for DNA Methylation were collected at baseline (T1), after air exposure (T2) and after 2h (T3). Spectral and symbolic analysis of heart rate variability (HRV) were performed for autonomic control of cardiac function, while alterations in DNA methylation of candidate genes were used to index pro-inflammatory modifications. In the PM expose group, autonomic analysis revealed a significant decrease of 2UV%, index of parasympathetic modulation (14% vs 9%, p = 0.0309), while DNA analysis showed a significant increase of interferon γ (IFN- γ) methylation, from T1 to T3. In a mixed model using T1, T2 and T3, fine and ultrafine PM fractions showed significant associations with IFN- γ methylation and parasympathetic modulation. Conclusions: Our study shows, for the first time, that in healthy subjects, acute exposure to PM affects parasympathetic control of heart function and it increases methylation of a pro-inflammatory gene (i.e. methylation of interferon γ). Thus, our study suggests that, even in absence of other co-factors and in otherwise healthy individuals, PM per se is sufficient to trigger parasympathetic dysautonomia, independently from changes in sympathetic control, and inflammation, in a dose-dependent manner.
MeSH term(s)	Air Pollutants/adverse effects ; Cardiovascular System/drug effects ; Cross-Over Studies ; Healthy Volunteers ; Heart Rate ; Humans ; Inhalation Exposure ; Interferon-gamma/drug effects ; Interferon-gamma/metabolism ; Methylation ; Particle Size ; Particulate Matter/adverse effects
Chemical Substances	Air Pollutants ; Particulate Matter ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2017-11-05
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2017.10.036
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Article: Long-term results of immediately loaded fast bone regeneration-coated implants placed in fresh extraction sites in the upper jaw.

Malchiodi, Luciano / Corrocher, Giovanni / Cucchi, Alessandro / Ghensi, Paolo / Bissolotti, Guido / Nocini, Pier Francesco

The Journal of oral implantology

2010 Volume 36, Issue 4, Page(s) 251–261

Abstract: Recently, many authors have investigated the results of immediately loaded implants in fresh extraction sites, reporting favorable success rates, but only a few studies have included a long-term follow-up in the maxilla with analysis of clinical and ... ...

Abstract	Recently, many authors have investigated the results of immediately loaded implants in fresh extraction sites, reporting favorable success rates, but only a few studies have included a long-term follow-up in the maxilla with analysis of clinical and radiographic data. The aim of this study was to evaluate the predictability of the immediate loading protocol with fast bone regeneration (FBR)-coated implants placed in postextractive sites in the maxilla, considering the success rate after at least 5 years of follow-up. Moreover, the clinical and radiographic results are evaluated in terms of soft tissue conditions and crestal bone loss values. One hundred fifty-eight implants were inserted following dental extraction in 70 consecutively operated patients. Each implant was immediately prosthesized. The data were collected before surgical planning, at the time of insertion, and after 3 and 5 years of occlusal loading. Specific success criteria were used to assess the success rate of immediately loaded postextraction implants. Clinical and radiographic examinations were used to determine long-term results. After a 5-year follow-up, 2 implants were lost, with a cumulative success rate of 98.7%. The radiographic and clinical data revealed well-maintained hard and soft tissues, with acceptable long-term results. The use of immediately loaded FBR-coated implants in fresh extraction sockets is shown to be a predictable technique if implants are inserted in selected cases and positioned with great care, following thorough preoperative analysis.
MeSH term(s)	Alveolar Bone Loss/etiology ; Bone Regeneration ; Coated Materials, Biocompatible ; Dental Implantation, Endosseous/adverse effects ; Dental Implantation, Endosseous/methods ; Dental Implants ; Dental Prosthesis Design ; Dental Prosthesis, Implant-Supported ; Dental Restoration Failure ; Dental Stress Analysis ; Humans ; Maxilla ; Time Factors ; Tooth Socket/surgery ; Treatment Outcome ; Weight-Bearing
Chemical Substances	Coated Materials, Biocompatible ; Dental Implants
Language	English
Publishing date	2010
Publishing country	United States
Document type	Journal Article
ZDB-ID	448462-9
ISSN	1548-1336 ; 0160-6972
ISSN (online)	1548-1336
ISSN	0160-6972
DOI	10.1563/AAID-JOI-D-09-00016
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