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Article: The Role of Potassium and Calcium Currents in the Bistable Firing Transition.

Borges, Fernando S / Protachevicz, Paulo R / Souza, Diogo L M / Bittencourt, Conrado F / Gabrick, Enrique C / Bentivoglio, Lucas E / Szezech, José D / Batista, Antonio M / Caldas, Iberê L / Dura-Bernal, Salvador / Pena, Rodrigo F O

bioRxiv : the preprint server for biology

2023

Abstract: Healthy brains display a wide range of firing patterns, from synchronized oscillations during slowwave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic ... ...

Abstract	Healthy brains display a wide range of firing patterns, from synchronized oscillations during slowwave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic brain, where neurons can fire in synchronized bursts. Most cortical neurons are pyramidal regular spiking cells (RS) with frequency adaptation and do not exhibit bursts in current-clamp experiments (
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.16.553625
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Roles of Potassium and Calcium Currents in the Bistable Firing Transition.

Brain sciences

2023 Volume 13, Issue 9

Abstract: Healthy brains display a wide range of firing patterns, from synchronized oscillations during slow-wave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic ... ...

Abstract	Healthy brains display a wide range of firing patterns, from synchronized oscillations during slow-wave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic brain, where neurons can fire in synchronized bursts. Most cortical neurons are pyramidal regular spiking (RS) cells with frequency adaptation and do not exhibit bursts in current-clamp experiments (in vitro). In this work, we investigate the transition mechanism of spike-to-burst patterns due to slow potassium and calcium currents, considering a conductance-based model of a cortical RS cell. The joint influence of potassium and calcium ion channels on high synchronous patterns is investigated for different synaptic couplings (gsyn) and external current inputs (
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13091347
Database	MEDical Literature Analysis and Retrieval System OnLINE

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