LIVIVO - Search results -

Search results

Result 1 - 10 of total 252

Search options

Article ; Online: THE EVOLVING FIELD OF HEPATOLOGY IN BRAZIL.

Bittencourt, Paulo Lisboa

2022 Volume 59, Issue 3, Page(s) 325–326

MeSH term(s)	Brazil ; Gastroenterology ; Humans
Language	English
Publishing date	2022-09-14
Publishing country	Brazil
Document type	Editorial
ZDB-ID	137743-7
ISSN	1678-4219 ; 0004-2803
ISSN (online)	1678-4219
ISSN	0004-2803
DOI	10.1590/S0004-2803.202203000-59
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 450: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Biodegradable starch / polyvinyl alcohol composites produced by thermoplastic injection containing cellulose extracted from soybean hulls (Glycine max L.)

Bortolatto, Rubiane / Bittencourt, Paulo Rodrigo Stival / Yamashita, Fabio

Industrial crops and products. 2022 Feb., v. 176

2022

Abstract: Soybean hull is an agro-industrial residue of extensive generation in the soybean oil-producing industry, where approximately 5% of the processed volume of soy beans is converted into hulls. The main use for soy hulls is animal feed, being of great ... ...

Abstract	Soybean hull is an agro-industrial residue of extensive generation in the soybean oil-producing industry, where approximately 5% of the processed volume of soy beans is converted into hulls. The main use for soy hulls is animal feed, being of great importance to find more ways of consumption for the hulls. This research proposed a noble application for soy hulls: using the hulls as a source for extracting cellulose fibers. Cellulose fibers were extracted from the hulls by alkaline treatment, ground (< 600 µm) and added to thermoplastic starch (TPS). Polyvinyl alcohol (PVA) was also added to the materials produced in order to promote better compatibility between the components. Ten formulations were produced, containing between 4 and 19 wt% of cellulose, and 2 controls. Half of the formulations contained 6 wt% PVA. Cellulose fibers and soybean hulls were characterized by FTIR-ATR and SEM, and the analyzes showed partial purification of the cellulose fibers, with a purity of 92 wt%. The composites were produced by extrusion followed by injection, and characterized by stress-strain, FTIR-ATR and dimensional stability after injection (shrinkage and warpage) tests. Cellulose fibers did not increase the tensile strength (TS) of the composites, but reduced the deformation capacity by 62% (to 19% of fibers) compared to the control. Cellulose fibers together with PVA increased the TS by up to 22% (to 19% fibers and 6% PVA in the composition), making the material more mechanically resistant. For this same formulation, the deformation capacity was reduced by a maximum of 75%, and the modulus of elasticity was increased by a maximum of 230% (the composite became more resistant and rigid). Cellulose fibers reduced the shrinkage value of the specimens, reducing the shrinkage value to less than 1% for the formulations containing 19% cellulose fibers. The cellulose fibers associated with 6% PVA had a synergistic action in the shrinkage of the specimens, further reducing the shrinkage in length (0.4% length shrinkage for 15% cellulose fibers; 0.1% length shrinkage for 19% cellulose fibers). The addition of cellulose fibers and 6% PVA to TPS made the composites more rigid and mechanically reinforced, and also with greater dimensional stability after injection.
Keywords	Glycine max ; alkali treatment ; biodegradability ; cellulose ; deformation ; dimensional stability ; extrusion ; feeds ; industry ; modulus of elasticity ; polyvinyl alcohol ; shrinkage ; soybean hulls ; soybeans ; starch ; synergism ; tensile strength ; thermoplastics
Language	English
Dates of publication	2022-02
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2021.114383
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 5577: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Acute-on-Chronic Liver Failure: Which Definition Is Appropriate in Latin America?

Farias, Alberto Queiroz / Bittencourt, Paulo Lisboa

Clinical liver disease

2020 Volume 16, Issue 3, Page(s) 114–116

Abstract: Watch a video presentation of this article. ...

Abstract	Watch a video presentation of this article.
Language	English
Publishing date	2020-09-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2657644-2
ISSN	2046-2484
ISSN	2046-2484
DOI	10.1002/cld.945
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Internet search engines and social media are improving awareness on non-alcoholic fatty liver disease in Brazil.

Bittencourt, Paulo Lisboa / Oliveira, Claudia P / Codes, Liana / Ferraz, Maria Lucia Gomes

Journal of hepatology

2022 Volume 77, Issue 4, Page(s) 1217–1219

MeSH term(s)	Brazil/epidemiology ; Humans ; Internet ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Search Engine ; Social Media
Language	English
Publishing date	2022-07-08
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2022.06.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2027: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR).

Schroeder, Helena Trevisan / De Lemos Muller, Carlos Henrique / Heck, Thiago Gomes / Krause, Mauricio / Homem de Bittencourt, Paulo Ivo

Cell stress & chaperones

2024 Volume 29, Issue 1, Page(s) 66–87

Abstract: Effective resolution of inflammation via the heat shock response (HSR) is pivotal in averting the transition to chronic inflammatory states. This transition characterizes a spectrum of debilitating conditions, including insulin resistance, obesity, type ... ...

Abstract	Effective resolution of inflammation via the heat shock response (HSR) is pivotal in averting the transition to chronic inflammatory states. This transition characterizes a spectrum of debilitating conditions, including insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments. This manuscript explores a range of physiological, pharmacological, and nutraceutical interventions aimed at reinstating the HSR in the context of chronic low-grade inflammation, as well as protocols to assess the HSR. Monitoring the progression or suppression of the HSR in patients and laboratory animals offers predictive insights into the organism's capacity to combat chronic inflammation, as well as the impact of exercise and hyperthermic treatments (e.g., sauna or hot tub baths) on the HSR. Interestingly, a reciprocal correlation exists between the expression of HSR components in peripheral blood leukocytes (PBL) and the extent of local tissue proinflammatory activity in individuals afflicted by chronic inflammatory disorders. Therefore, the Heck index, contrasting extracellular 70 kDa family of heat shock proteins (HSP70) (proinflammatory) and intracellular HSP70 (anti-inflammatory) in PBL, serves as a valuable metric for HSR assessment. Our laboratory has also developed straightforward protocols for evaluating HSR by subjecting whole blood samples from both rodents and human volunteers to ex vivo heat challenges. Collectively, this discussion underscores the critical role of HSR disruption in the pathogenesis of chronic inflammatory states and emphasizes the significance of simple, cost-effective tools for clinical HSR assessment. This understanding is instrumental in the development of innovative strategies for preventing and managing chronic inflammatory diseases, which continue to exert a substantial global burden on morbidity and mortality.
MeSH term(s)	Animals ; Humans ; Diabetes Mellitus, Type 2 ; Heat-Shock Response ; Heat-Shock Proteins/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; Inflammation ; Chronic Disease
Chemical Substances	Heat-Shock Proteins ; HSP70 Heat-Shock Proteins
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1362749-1
ISSN	1466-1268 ; 1355-8145
ISSN (online)	1466-1268
ISSN	1355-8145
DOI	10.1016/j.cstres.2024.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4797: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The dance of proteostasis and metabolism: Unveiling the caloristatic controlling switch.

Schroeder, Helena Trevisan / De Lemos Muller, Carlos Henrique / Heck, Thiago Gomes / Krause, Mauricio / Homem de Bittencourt, Paulo Ivo

Cell stress & chaperones

2024 Volume 29, Issue 1, Page(s) 175–200

Abstract: The heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger ... ...

Abstract	The heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis and energy regulation is rooted in the fundamental need for ATP to fuel protein synthesis and repair, making the HSR an essential component of cellular energy management. Recent findings suggest that the origins of proteostasis-defending systems can be traced back over 3.6 billion years, aligning with the emergence of sugar kinases that optimized glycolysis around 3.594 billion years ago. This evolutionary connection is underscored by the spatial similarities between the nucleotide-binding domain of HSP70, the key player in protein chaperone machinery, and hexokinases. The HSR serves as a hub that integrates energy metabolism and resolution of inflammation, further highlighting its role in maintaining cellular homeostasis. Notably, 5'-adenosine monophosphate-activated protein kinase emerges as a central regulator, promoting the HSR during predominantly proteotoxic stress while suppressing it in response to predominantly metabolic stress. The complex relationship between 5'-adenosine monophosphate-activated protein kinase and the HSR is finely tuned, with paradoxical effects observed under different stress conditions. This delicate equilibrium, known as caloristasis, ensures that cellular homeostasis is maintained despite shifting environmental and intracellular conditions. Understanding the caloristatic controlling switch at the heart of this interplay is crucial. It offers insights into a wide range of conditions, including glycemic control, obesity, type 2 diabetes, cardiovascular and neurodegenerative diseases, reproductive abnormalities, and the optimization of exercise routines. These findings highlight the profound interconnectedness of proteostasis and energy metabolism in cellular function and adaptation.
MeSH term(s)	Humans ; Proteostasis ; Diabetes Mellitus, Type 2 ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Response ; Adenosine Monophosphate/metabolism ; Protein Kinases/metabolism
Chemical Substances	HSP70 Heat-Shock Proteins ; Adenosine Monophosphate (415SHH325A) ; Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2024-02-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1362749-1
ISSN	1466-1268 ; 1355-8145
ISSN (online)	1466-1268
ISSN	1355-8145
DOI	10.1016/j.cstres.2024.02.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4797: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases.

Schroeder, Helena Trevisan / De Lemos Muller, Carlos Henrique / Heck, Thiago Gomes / Krause, Mauricio / Homem de Bittencourt, Paulo Ivo

Cell stress & chaperones

2024 Volume 29, Issue 1, Page(s) 116–142

Abstract: The heat shock response (HSR) is a crucial biochemical pathway that orchestrates the resolution of inflammation, primarily under proteotoxic stress conditions. This process hinges on the upregulation of heat shock proteins (HSPs) and other chaperones, ... ...

Abstract	The heat shock response (HSR) is a crucial biochemical pathway that orchestrates the resolution of inflammation, primarily under proteotoxic stress conditions. This process hinges on the upregulation of heat shock proteins (HSPs) and other chaperones, notably the 70 kDa family of heat shock proteins, under the command of the heat shock transcription factor-1. However, in the context of chronic degenerative disorders characterized by persistent low-grade inflammation (such as insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases) a gradual suppression of the HSR does occur. This work delves into the mechanisms behind this phenomenon. It explores how the Western diet and sedentary lifestyle, culminating in the endoplasmic reticulum stress within adipose tissue cells, trigger a cascade of events. This cascade includes the unfolded protein response and activation of the NOD-like receptor pyrin domain-containing protein-3 inflammasome, leading to the emergence of the senescence-associated secretory phenotype and the propagation of inflammation throughout the body. Notably, the activation of the NOD-like receptor pyrin domain-containing protein-3 inflammasome not only fuels inflammation but also sabotages the HSR by degrading human antigen R, a crucial mRNA-binding protein responsible for maintaining heat shock transcription factor-1 mRNA expression and stability on heat shock gene promoters. This paper underscores the imperative need to comprehend how chronic inflammation stifles the HSR and the clinical significance of evaluating the HSR using cost-effective and accessible tools. Such understanding is pivotal in the development of innovative strategies aimed at the prevention and treatment of these chronic inflammatory ailments, which continue to take a heavy toll on global health and well-being.
MeSH term(s)	Humans ; Heat Shock Transcription Factors ; Diabetes Mellitus, Type 2 ; Inflammasomes/metabolism ; Inflammasomes/pharmacology ; Heat-Shock Response ; Heat-Shock Proteins/metabolism ; Inflammation ; RNA, Messenger ; NLR Proteins/metabolism ; HSP70 Heat-Shock Proteins/metabolism
Chemical Substances	Heat Shock Transcription Factors ; Inflammasomes ; Heat-Shock Proteins ; RNA, Messenger ; NLR Proteins ; HSP70 Heat-Shock Proteins
Language	English
Publishing date	2024-01-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1362749-1
ISSN	1466-1268 ; 1355-8145
ISSN (online)	1466-1268
ISSN	1355-8145
DOI	10.1016/j.cstres.2024.01.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4797: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Influence of Tacrolimus Intrapatient Variability on Allograft Rejection Frequency and Survival Following Liver Transplantation.

Soares, Maria Eduarda / Costa, Gabriela / Guerra, Laura / Morais, Maria Clara / Vaz, Nayana / Codes, Liana / Bittencourt, Paulo Lisboa

Therapeutic drug monitoring

2024

Abstract: Background: Tacrolimus is the primary calcineurin inhibitor used in immunosuppressive regimens to prevent allograft rejection (AR) after organ transplantation. Recent studies have linked intrapatient variability (IPV) of tacrolimus with AR occurrence ... ...

Abstract	Background: Tacrolimus is the primary calcineurin inhibitor used in immunosuppressive regimens to prevent allograft rejection (AR) after organ transplantation. Recent studies have linked intrapatient variability (IPV) of tacrolimus with AR occurrence and reduced survival, especially in kidney transplant recipients. However, limited data are available on the impact of tacrolimus IPV on adverse outcomes after liver transplantation (LT). Aims: The aim of this study was to assess the association between tacrolimus IPV using various methodologies with acute AR and long-term patient survival after LT. Methods: All patients who underwent LT from January 2010 to July 2021 were retrospectively evaluated. Tacrolimus IPV was calculated for each patient using the mean and SD, mean absolute deviation (MAD), coefficient of variation (CV), and time in therapeutic range (TTR). These measures were then compared with AR within the first 24 months after LT and to long-term survival. Results: Out of 234 patients, 32 (13.7%) developed AR and 183 (78.2%) survived, with a mean follow-up of 101 ± 43 months. Tacrolimus IPV, assessed by mean, SD, MAD, and CV, was 8.3 ± 2.1, 2.7 ± 1.3, 32.0% ± 11.7%, and 39.4% ± 15.4%, respectively. There was no statistically significant correlation between Tacrolimus IPV and AR or survival post-LT. Conclusions: In a large cohort of patients from diverse racial backgrounds, tacrolimus IPV was not associated with clinically relevant outcomes such as AR and survival after LT.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	424443-6
ISSN	1536-3694 ; 0163-4356
ISSN (online)	1536-3694
ISSN	0163-4356
DOI	10.1097/FTD.0000000000001192
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1503: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Public knowledge and attitudes toward liver diseases and liver cancer in the Brazilian population: a cross sectional study.

Bittencourt, Paulo Lisboa / Codes, Liana / Cesar, Heloisa Furia / Gomes Ferraz, Maria Lucia

Lancet regional health. Americas

2023 Volume 23, Page(s) 100531

Abstract: Background: Little is known about the knowledge of the Brazilian population regarding prevention/screening/diagnosis of cirrhosis and hepatocellular carcinoma (HCC). We aimed to investigate the public knowledge/attitudes toward liver diseases in Brazil.! ...

Abstract	Background: Little is known about the knowledge of the Brazilian population regarding prevention/screening/diagnosis of cirrhosis and hepatocellular carcinoma (HCC). We aimed to investigate the public knowledge/attitudes toward liver diseases in Brazil. Methods: A cross-sectional survey was conducted in which 1.995 adults were prospectively interviewed regarding knowledge about cirrhosis/HCC and attitudes toward vaccination and viral hepatitis (VH) testing. Findings: Most of the Brazilian subjects believe that alcohol abuse (63%-87%), NAFLD (29%-53%) and smoking (31%-47%) are the leading causes of cirrhosis/HCC. VH were less often linked to both diseases. Brazilians agreed that NAFLD is a risk factor for cirrhosis, cancer and cardiovascular diseases; 66%, 48% and 40% were submitted to hepatitis B vaccination and hepatitis B and C testing, particularly those with older age, higher level of education and income. Interpretation: VH was not considered by the majority of the Brazilians as an important cause liver disease, leading a large proportion of those subjects to neglect hepatitis B vaccination and hepatitis B and C testing. Funding: This work was supported by Brazilian Liver Institute.
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2023.100531
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Telemonitoring of the Continuum of Care of Hepatitis C During the COVID-19 Pandemic in Brazil.

Bittencourt, Paulo Lisboa / Codes, Liana / César, Alessandra Maria Dias Guimarães / Mussi, Fernanda Carneiro / Ferraz, Maria Lúcia Gomes

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2023 Volume 29, Issue 11, Page(s) 1673–1678

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Hepacivirus ; Brazil/epidemiology ; Pandemics ; Antiviral Agents/therapeutic use ; COVID-19/epidemiology ; SARS-CoV-2 ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Continuity of Patient Care
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2022.0306
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4576: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito