Article ; Online: In vitro antifungal susceptibility of clinical and environmental isolates of Aspergillus fumigatus and Aspergillus flavus in Brazil.
2017 Volume 22, Issue 1, Page(s) 30–36
Abstract: The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the ... ...
| Abstract | The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC>2.0mg/L). Voriconazole showed good activity against A. fumigatus and A. flavus strains, except for one clinical strain of A. fumigatus whose MIC was 4.0mg/L. Posaconazole (≤0.25mg/L) also showed appreciable activity against both species of Aspergillus, except for six A. fumigatus strains with relatively higher MICs (0.5mg/L). The MICs for Amphotericin B ranged from 0.06 to 1.0mg/L for A. fumigatus, but were much higher (0.5-8.0mg/L) for A. flavus. Among the echinocandins, caspofungin showed a geometric mean of 0.078 and 0.113 against the clinical and environmental strains of A. flavus, respectively, but had elevated minimal effective concentrations (MECs) for seven of the A. fumigatus strains. Anidulafungin and micafungin exhibited considerable activity against both A. fumigatus and A. flavus isolates, except for one environmental isolate of A. fumigatus that showed an MEC of 1mg/L to micafungin. Our study proposes that a detailed investigation of the antifungal susceptibility of the genus Aspergillus from different regions of Brazil is necessary for establishing a response profile against the different classes of antifungal agents used in the treatment of aspergillosis. |
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| MeSH term(s) | Antifungal Agents/pharmacology ; Aspergillus flavus/drug effects ; Aspergillus flavus/isolation & purification ; Aspergillus fumigatus/drug effects ; Aspergillus fumigatus/isolation & purification ; Brazil ; Drug Resistance, Multiple, Fungal ; Humans ; Microbial Sensitivity Tests ; Polymerase Chain Reaction ; Reference Values |
| Chemical Substances | Antifungal Agents |
| Language | English |
| Publishing date | 2017-11-22 |
| Publishing country | Brazil |
| Document type | Journal Article |
| ZDB-ID | 2041400-6 |
| ISSN | 1678-4391 ; 1413-8670 |
| ISSN (online) | 1678-4391 |
| ISSN | 1413-8670 |
| DOI | 10.1016/j.bjid.2017.10.005 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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