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Artikel ; Online: Factores de riesgo de artrosis de rodilla, cadera o ambas en mujeres chilenas de mediana edad: un estudio de cohorte de tres décadas.

Blümel, Juan E / Aedo, Sócrates / Arteaga, Eugenio / Vallejo, María S / Chedraui, Peter

2022 Band 150, Heft 1, Seite(n) 46–53

Abstract: Background: Osteoarthritis (OA) is a health problem affecting millions of individuals worldwide.: Aim: To evaluate risk factors for hip and knee osteoarthritis (OA) in women aged 40 to 59 years.: Material and methods: Analysis of a prospective ... ...

Titelübersetzung	Risk factors for the development of osteoarthritis in middle-aged women.
Abstract	Background: Osteoarthritis (OA) is a health problem affecting millions of individuals worldwide. Aim: To evaluate risk factors for hip and knee osteoarthritis (OA) in women aged 40 to 59 years. Material and methods: Analysis of a prospective cohort of 1159 women attending preventive health care programs and followed during 28 years. They underwent a clinical and laboratory evaluation from 1990 to 1993. The diagnosis of OA was retrieved from registries of a special program for osteoarthritis in 2020. Results: Twenty four percent of participants developed osteoarthritis during the follow-up. At the beginning of the study and compared with women without OA, they were older (median [interquartile range or IQR]: 49.6 [8.5] and 47.2 [8.2] years respectively), had a higher body mass index (26.3 [5.3] and 25.1 [5.3] respectively), and a higher frequency of jobs with low qualification (76 and 62% respectively). The presence of type 2 diabetes mellitus, chronic hypertension, a previous history of alcohol or cigarette consumption, postmenopausal status and lipid and glucose blood levels did not differ between women with or without OA. Cox regression showed a final model that incorporates body mass index (hazard ratio (HR): 1.04; 95% confidence intervals (CI): 1.01-1.07), age (HR: 1.05; 95% CI: 1.03-1.08) and having an unqualified job (HR: 1.88; 95% CI: 1.43-2.47) as risk factors for OA. Conclusions: Obesity and the type of job are the most relevant risk factors found for OD: both may be modified with proper care.
Mesh-Begriff(e)	Diabetes Mellitus, Type 2/complications ; Female ; Humans ; Middle Aged ; Osteoarthritis, Hip/diagnosis ; Osteoarthritis, Hip/epidemiology ; Osteoarthritis, Hip/etiology ; Osteoarthritis, Knee/epidemiology ; Osteoarthritis, Knee/etiology ; Prospective Studies ; Risk Factors
Sprache	Spanisch
Erscheinungsdatum	2022-07-20
Erscheinungsland	Chile
Dokumenttyp	Journal Article
ZDB-ID	732136-3
ISSN	0717-6163 ; 0034-9887
ISSN (online)	0717-6163
ISSN	0034-9887
DOI	10.4067/S0034-98872022000100046
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Health screening of middle-aged women: what factors impact longevity?

Blümel, Juan E / Aedo, Sócrates / Murray, Nigel / Vallejo, María S / Chedraui, Peter

Menopause (New York, N.Y.)

2022 Band 29, Heft 9, Seite(n) 1008–1013

Abstract: Objective: The aim of this study was to measure the impact of different risk factors in middle-aged women on longevity evaluated after three decades of an initial health screening.: Methods: Women who received an annual check-up between 1990 and 1993 ...

Abstract	Objective: The aim of this study was to measure the impact of different risk factors in middle-aged women on longevity evaluated after three decades of an initial health screening. Methods: Women who received an annual check-up between 1990 and 1993 were recruited. Anamnesis and physical examination were recorded. Blood samples for the measurement of glycemia and lipids were taken. Data are reported as of December 2021. Results: A total of 1,158 women aged 40 to 60 were studied. At 30.9 years of follow-up, the Kaplan-Meier overall survival was 75.6% (95% confidence interval, 72.6-78.3). The main causes of the 260 deaths observed were the following: cancer ( n = 88; 33.8%), cardiovascular disease ( n = 55; 21.2%), and infectious disease ( n = 41; 15.8%). The following hazard ratios were found with the flexible parametric survival model: personal history of fracture (hazard ratio, 2.55; 95% confidence interval, 1.29-5.02; P = 0.007), type 2 diabetes mellitus (2.14; 1.18-3.88; P = 0.012), personal history of heart disease (1.85; 1.09-3.13; P = 0.022), chronic arterial hypertension (1.65; 1.25-2.17; P < 0.001), postmenopausal status (1.60; 1.13-2.26; P = 0.008), unskilled jobs (1.56; 1.17-2.07; P = 0.002), cigarette smoking (1.51; 1.17-1.94; P = 0.002), age (1.06; 1.03-1.09; P < 0.001), body mass index (1.04; 1.01-1.07; P = 0.004), multiparous (0.72; 0.56-0.93; P = 0.012), and active sexual intercourse (0.68; 0.52-0.87; P = 0.003). Lipid disorders did not reach statistical significance as a risk factor. Conclusions: In this cohort, it was observed that most of the classic risk factors for mortality were present. However, a history of fracture appears in middle-aged women as a strong predictor of mortality, surpassing diabetes and arterial hypertension. Multiparity, on the other hand, was a protective factor.
Mesh-Begriff(e)	Adult ; Body Mass Index ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2 ; Female ; Humans ; Hypertension/epidemiology ; Longevity ; Middle Aged ; Risk Factors
Sprache	Englisch
Erscheinungsdatum	2022-08-16
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000002025
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Efficacy and safety of visnadine in the treatment of symptoms of sexual dysfunction in heterosexual women: a systematic review of randomized clinical trials.

Caira-Chuquineyra, Brenda / Fernandez-Guzmán, Daniel / Garayar-Peceros, Humberto / Benites-Zapata, Vicente A / Pérez-López, Faustino R / Blümel, Juan E / Mezones-Holguín, Edward

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

2024 Band 40, Heft 1, Seite(n) 2328619

Abstract: Objective: To synthesize the primary evidence on the efficacy and safety of visnadine on symptoms of sexual dysfunction (SD) in heterosexual women.: Methods: We conducted a systematic review of randomized clinical trials (RCTs) with a primary search ... ...

Abstract	Objective: To synthesize the primary evidence on the efficacy and safety of visnadine on symptoms of sexual dysfunction (SD) in heterosexual women. Methods: We conducted a systematic review of randomized clinical trials (RCTs) with a primary search without language restriction in PubMed/Medline, Scopus, Embase, Web of Science, Cochrane Library, and international clinical trial registries. Trials reporting the use of visnadine by any route in women with SD were eligible. We performed screening, data extraction, and risk of bias assessment in a double-blind approach. The primary outcomes were the Female Sexual Function Index (FSFI) and its domains. Secondary outcomes were safety, arousal, lubrication, pleasure, orgasm, negative sensations, duration, and overall satisfaction. Results: Initially, 242 records were retrieved. We selected nine papers for full-text reading and finally included two RCTs: one with a parallel design and one with a crossover design with a total of 96 patients. One study compared visnadine aerosol with a placebo, while the other compared different frequencies of visnadine aerosol use. Visnadine use showed a statistically significant improvement ( Conclusion: RCTs regarding the use of visnadine for the Female SD are scarce and methodologically limited. This preliminary evidence shows visnadine as a potentially effective and safe option to alleviate some of the clinical symptoms of SD in heterosexual women. However, future better-designed randomized studies with larger sample numbers are required.
Mesh-Begriff(e)	Female ; Humans ; Heterosexuality ; Randomized Controlled Trials as Topic ; Sexual Dysfunction, Physiological/drug therapy ; Aerosols/therapeutic use ; Chromans
Chemische Substanzen	visnadin (0RL4V0K263) ; Aerosols ; Chromans
Sprache	Englisch
Erscheinungsdatum	2024-03-25
Erscheinungsland	England
Dokumenttyp	Systematic Review ; Journal Article
ZDB-ID	639237-4
ISSN	1473-0766 ; 0951-3590
ISSN (online)	1473-0766
ISSN	0951-3590
DOI	10.1080/09513590.2024.2328619
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Is premature ovarian insufficiency associated with mortality? A three-decade follow-up cohort.

Blümel, Juan E / Mezones-Holguín, Edward / Chedraui, Peter / Soto-Becerra, Percy / Arteaga, Eugenio / Vallejo, María S

Maturitas

2022 Band 163, Seite(n) 82–87

Abstract: Objective: To evaluate the association between premature ovarian insufficiency (POI) and mortality.: Materials and methods: This was a secondary analysis of a long-term cohort of Chilean women who received preventive health care between 1990 and 1993. ...

Abstract	Objective: To evaluate the association between premature ovarian insufficiency (POI) and mortality. Materials and methods: This was a secondary analysis of a long-term cohort of Chilean women who received preventive health care between 1990 and 1993. The exposure variable was POI and the outcome was death, and follow-up time was 30 years. Patient data were extracted from medical records. Data related to deaths were obtained from the records of the official government registry as of January 2021. Cox regression proportional hazard models were used to estimate crude and adjusted hazard ratios (HR) and 95 % confidence intervals (CI). Results: Data for a total of 1119 women were included in the analysis. Median age was 47 years (interquartile range: 44-52). The baseline prevalence of POI was 6.7 %. At the end of the follow-up, 34.7 % of women with POI had died, compared with 19.3 % of women without the condition (p < 0.001). A larger proportion of women with POI died from cardiovascular disease (12.0 % vs. 5.1 %; OR: 2.55, 95 % CI: 1.21-5.39) whereas there was no significant difference in cancer mortality (6.7 % vs. 7.7 %; OR: 0.86, 95 % CI: 0.34-2.19). In the adjusted Cox model, POI was among the main factors associated with mortality (hazard ratio [HR] 1.60, 95 % CI: 1.03-2.47), after diabetes (HR 2.51, 95 % CI: 1.40-4.51) and arterial hypertension (HR 1.75, 95 % CI: 1.29-2.37). Conclusion: Although POI affects a small group of women, its association with mortality seems to be relevant; hence it is necessary to implement measures that reduce this risk.
Mesh-Begriff(e)	Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Menopause, Premature ; Primary Ovarian Insufficiency/complications ; Primary Ovarian Insufficiency/epidemiology ; Risk Factors
Sprache	Englisch
Erscheinungsdatum	2022-06-13
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2022.06.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association of muscle disorders in late postmenopausal women according to the type of experienced menopause.

Vallejo, María S / Blümel, Juan E / Chedraui, Peter / Tserotas, Konstantinos / Salinas, Carlos / Rodrigues, Marcio A / Rodríguez, Doris A / Rey, Claudia / Ojeda, Eliana / Ñañez, Mónica / Monterrosa-Castro, Álvaro / Gómez-Tabares, Gustavo / Espinoza, María T / Escalante, Carlos / Elizalde, Alejandra / Dextre, Maribel / Calle, Andrés / Aedo, Sócrates

Menopause (New York, N.Y.)

2024

Abstract: Objective: Musculoskeletal disorders frequently affect postmenopausal women. This study aims to compare muscle disorders between women according to the type of experienced menopause: premature (PM) or normal age of menopause (NAM).: Methods: This was ...

Abstract	Objective: Musculoskeletal disorders frequently affect postmenopausal women. This study aims to compare muscle disorders between women according to the type of experienced menopause: premature (PM) or normal age of menopause (NAM). Methods: This was a cross-sectional study conducted in nine Latin American countries in which late postmenopausal women (55 to 70 years) were surveyed with a general questionnaire, the Menopause Rating Scale (MRS: item #4 exploring musculoskeletal discomfort), and the trength, assistance with walking, rising from a chair, climbing stairs, and falling questionnaire (risk of sarcopenia). Results: A total of 644 women were included: 468 who had NAM, and 176 who had PM (116 spontaneous and 60 surgical). The overall mean age of the participants was 60.9 ± 4.2 years. Women who had PM experienced more musculoskeletal discomfort (33.5% vs 20.9%, P < 0.001) and a higher likelihood of sarcopenia (35.2% vs 19.9%, P < 0.001) than women who had a NAM. Women who had surgical PM exhibited a higher prevalence of severe musculoskeletal discomfort (46.7% vs 29.3%, P < 0.02) and a higher likelihood of sarcopenia (45.0% vs 27.6%, P < 0.02) than women who had a NAM. After adjusting for covariates (age, body mass index, menopausal hormone therapy use, physical activity, education, cigarette consumption, use of antidepressants, sexual activity, comorbidities, and having a partner), our logistic regression model determined that spontaneous PM was not associated with higher odds of musculoskeletal discomfort and higher odds of sarcopenia. On the other hand, women who had surgical PM were more likely to experience musculoskeletal discomforts (odds ratio: 2.26; 95% confidence interval: 1.22-4.17) and higher odds for sarcopenia (odds ratio: 2.05; 95% confidence interval: 1.16-3.65) as compared to women who experienced a NAM. Conclusions: Women experiencing surgical PM have a higher likelihood of developing muscle disorders. This underscores the potential significance of hormonal levels in influencing musculoskeletal health during postmenopause.
Sprache	Englisch
Erscheinungsdatum	2024-04-30
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000002367
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Multimorbidity in a cohort of middle-aged women: Risk factors and disease clustering.

Blümel, Juan E / Carrillo-Larco, Rodrigo M / Vallejo, María S / Chedraui, Peter

Maturitas

2020 Band 137, Seite(n) 45–49

Abstract: Objective: We aimed to evaluate which risk factors in middle-aged women are associated with higher risk of multimorbidity in older age.: Study design: We conducted a prospective cohort study from 1990 to 1993 in Santiago de Chile, Chile among women ... ...

Abstract	Objective: We aimed to evaluate which risk factors in middle-aged women are associated with higher risk of multimorbidity in older age. Study design: We conducted a prospective cohort study from 1990 to 1993 in Santiago de Chile, Chile among women aged 40-59 (at baseline). Diagnosed illnesses were retrieved from national health records in 2020. Main outcome measures: Clinical and laboratory evaluation was conducted. Results: 1066 women were followed-up for a mean of 27.8 years, after which 49.7% presented multimorbidity. These women, as compared with those without multimorbidity, were more likely at baseline to have had obesity (20.4% vs. 8.6%, p < 0.001); be post-menopause (47.2% vs. 40.5%; p < 0.03); have jobs that did not require a qualification (74.2% vs. 56.0%, p < 0.001); arterial hypertension (19.8% vs 14.4%, p < 0.018); lower HDL-cholesterol (51.3 ± 12.9 vs. 53.6±12.7 mg/dL, p < 0.005); and higher triglyceride levels (136.0 ± 65.0 vs. 127.0 ± 74.0 mg/dL, p = 0.028). Hypertension was associated in 22.0% of women with diabetes, in 20.9% with osteoarthritis and 14.0% with depression. Osteoarthritis was also associated with diabetes mellitus (8.3%) and depression (7.8%). Diabetes mellitus, in addition to hypertension and osteoarthritis, was associated with depression (6.4%). In a logistic regression model, we observed that obesity in middle-aged women was the strongest risk factor for multimorbidity in the elderly (OR: 2.48; 95% CI, 1.71-3.61), followed by having a job that did not require a qualification (OR: 2.18; 95% CI, 1.67-2.83) and having a low HDL-cholesterol level (OR: 1.31; 95% CI, 1.02-1.68). Conclusions: Multimorbidity was highly prevalent in this older female population. Obesity in middle-aged women was the strongest risk factor for multimorbidity at older age. These results are relevant for Chile and other countries with similar population profiles.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Chile/epidemiology ; Cholesterol, HDL/blood ; Cluster Analysis ; Depression/epidemiology ; Diabetes Mellitus/epidemiology ; Employment/statistics & numerical data ; Female ; Humans ; Hypertension/epidemiology ; Middle Aged ; Multimorbidity ; Obesity/epidemiology ; Osteoarthritis/epidemiology ; Postmenopause ; Prospective Studies ; Risk Factors ; Triglycerides/blood
Chemische Substanzen	Cholesterol, HDL ; Triglycerides
Sprache	Englisch
Erscheinungsdatum	2020-05-04
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2020.04.016
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Low sexual function is associated with menopausal status in mid-aged women with human immunodeficiency virus infection.

Mezones-Holguín, Edward / Arriola-Montenegro, José / Cutimanco-Pacheco, Víctor / Al-Kassab-Córdova, Ali / Niño-García, Roberto / Zeta, Ludwing A / Urrunaga-Pastor, Diego / Blümel, Juan E / Chedraui, Peter / Pérez-López, Faustino R

Menopause (New York, N.Y.)

2022 Band 29, Heft 3, Seite(n) 317–326

Abstract: Objective: To assess the association between menopausal status and female sexual function among mid-aged women with human immunodeficiency virus (HIV) infection.: Methods: We carried out a cross-sectional study of 221 sexually active HIV-infected ... ...

Abstract	Objective: To assess the association between menopausal status and female sexual function among mid-aged women with human immunodeficiency virus (HIV) infection. Methods: We carried out a cross-sectional study of 221 sexually active HIV-infected women ages 40 to 59 years, based on a secondary analysis of a three-hospital survey in Lima, Perú. We classified menopausal status according to Stages of Reproductive Aging Workshop criteria (STRAW+10); this exposure variable was categorized as binary (non-postmenopausal and postmenopausal) and-for exploratory analysis-as multinomial (pre-, peri-, and postmenopausal). We defined low sexual function (LSF) using the 6-item Female Sexual Function Index (total score ≤19). Socio-demographic and clinical variables were assessed, including age, used highly active antiretroviral therapy scheme, disease duration, depressive symptoms, and co-morbidities. We performed Poisson generalized linear models with a robust variance to estimate 95% confidence interval (CI), crude prevalence ratios (cPRs), and adjusted prevalence ratios (aPRs) by epidemiological and statistical approaches using nonparametric method of bias-corrected and accelerated bootstrap resampling with 1,000 repetitions. Results: Studied women had a median age of 47.0 years (interquartile range: 7.5); 25.3% were premenopausal, 25.8% were perimenopausal, and 48.9% were postmenopausal. Also, 64.3% had LSF. The frequency of LSF was 53.6% in non-postmenopausal and 75.0% in postmenopausal women. Postmenopausal status was associated with LSF in both the crude (cPR = 1.39; 95% CI: 1.13-1.71) and the adjusted regression models (aPR = 1.38; 95% CI: 1.12-1.71). Conclusions: HIV-infected postmenopausal women have a higher prevalence of LSF than those non-postmenopausal ones, even when adjusting for multiple potential confounders.
Mesh-Begriff(e)	Adult ; Antiretroviral Therapy, Highly Active ; Cross-Sectional Studies ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Menopause ; Middle Aged ; Premenopause ; Surveys and Questionnaires
Sprache	Englisch
Erscheinungsdatum	2022-01-14
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000001914
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Older women do not have seasonal variations of vitamin D levels: a study from a southern country.

Vallejo, María S / Blümel, Juan E / Lavín, Pablo / Torres, Claudio / Araos, Alejandro / Sciaraffia, Carlos

Menopause (New York, N.Y.)

2018 Band 25, Heft 8, Seite(n) 912–917

Abstract: Objective: The aim was to study whether the seasonal variation of vitamin D [25(OH)-D or calcidiol] is similar or different in younger and older women living in a southern country.: Methods: Measurement of serum 25(OH)-D concentration in 739 Chilean ... ...

Abstract	Objective: The aim was to study whether the seasonal variation of vitamin D [25(OH)-D or calcidiol] is similar or different in younger and older women living in a southern country. Methods: Measurement of serum 25(OH)-D concentration in 739 Chilean women aged 20 to 87 years, residents of Santiago (latitude: 33.4° South) who, during a routine gynaecological checkup, agreed to be evaluated. Results: The mean serum concentration of 25(OH)-D for the group was 24.1 ± 10.5 ng/mL. In women 20 to 39 years, the mean was significantly different from the mean of the ≥60 years old group (25.8 ± 10.6 ng/mL vs 23.9 ± 11.1 ng/mL; P < 0.02). Globally, 38.4% of participants had vitamin D deficiency and 36.1% insufficiency. A deficiency was present in 28.4% of the 20 to 39 years old, and in 43.9% in the ≥60 years old group (P < 0.004). In the whole group, a lower proportion (P < 0.0001) of vitamin D deficiency cases in the youngest women occurred during the summer (23.7%) in comparison to the winter (47.7%). It was observed that the proportion of participants in the 20 to 39 years old group with vitamin D deficiency fell from 48.9% in winter to 4.9% in summer (P = 0.0001). In the older groups, this change (less deficiency) is progressively smaller, 51.2% to 27.6% (P = 0.0020) in women 40 to 59 years old, and it does not happen in women ≥60 years (40% with vitamin D deficiency). Conclusions: Serum vitamin D deficiency [25(OH)-D or calcidiol] is highly prevalent in Santiago, especially in older women (≥60 y) throughout the year. In contrast, in younger women (<40 y), the vitamin D deficiency tends to disappear during summer. More epidemiological studies and targeted prevention actions on vitamin D deficiency are warranted.
Mesh-Begriff(e)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Chile/epidemiology ; Female ; Humans ; Middle Aged ; Prevalence ; Risk Factors ; Seasons ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/etiology ; Young Adult
Chemische Substanzen	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Sprache	Englisch
Erscheinungsdatum	2018-04-10
Erscheinungsland	United States
Dokumenttyp	Evaluation Studies ; Journal Article
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000001103
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Factors affecting climacteric women with SARS-CoV-2 infection: A multinational Latin America study (REDLINC XI).

Vallejo, María S / Blümel, Juan E / Bencosme, Ascanio / Calle, Andrés / Dextre, Maribel / Díaz, Karen / López, Marcela / Miranda, Carlos / Ñañez, Mónica / Ojeda, Eliana / Rey, Claudia / Rodrigues, Marcio A / Salinas, Carlos / Tserotas, Konstantinos / Pérez-López, Faustino R

Maturitas

2022 Band 165, Seite(n) 33–37

Abstract: Objective: To evaluate the association between factors, especially those linked to the climacteric, and a history of COVID-19 infection.: Methods: This was an observational, cross-sectional, and analytical study in which women from ten Latin American ...

Abstract	Objective: To evaluate the association between factors, especially those linked to the climacteric, and a history of COVID-19 infection. Methods: This was an observational, cross-sectional, and analytical study in which women from ten Latin American countries, aged 40-64, who attended a routine health check-up were invited to participate. A positive history for COVID-19 was based on reverse transcription-polymerase chain reaction reports. We evaluated sociodemographic, clinical, lifestyle, anthropometric variables, and menopausal symptoms using the Menopause Rating Scale (MRS). Results: A total of 1238 women were included for analysis, of whom 304 (24.6 %) had a positive history for COVID-19. The median [interquartile range: IQR] age of participants was 53 [IQR 12] years, duration of formal education was 16 [6] years, body mass index 25.6 [5.1] kg/m Conclusion: Postmenopausal status and a family history of dementia were more frequent among women who had had COVID-19, and the infection was less frequent among current or past menopause hormone therapy users and in those with less physical contact.
Mesh-Begriff(e)	COVID-19/epidemiology ; Climacteric ; Cross-Sectional Studies ; Dementia ; Female ; Humans ; Hypnotics and Sedatives ; Latin America/epidemiology ; Menopause ; Quality of Life ; SARS-CoV-2
Chemische Substanzen	Hypnotics and Sedatives
Sprache	Englisch
Erscheinungsdatum	2022-07-22
Erscheinungsland	Ireland
Dokumenttyp	Journal Article ; Observational Study
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2022.07.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Low bone mineral density in middle-aged women: a red flag for sarcopenia.

Campodónico, Italo / Blümel, Juan E / Arteaga, Eugenio / Vallejo, María S / Valdivia, María I

Menopause (New York, N.Y.)

2017 Band 25, Heft 3, Seite(n) 324–328

Abstract: Objective: This study evaluated whether low bone density, a condition related to aging, is associated with low muscle mass, a surrogate for sarcopenia, and whether it could be used as a marker of the condition.: Methods: We studied 483 women aged 35 ... ...

Abstract	Objective: This study evaluated whether low bone density, a condition related to aging, is associated with low muscle mass, a surrogate for sarcopenia, and whether it could be used as a marker of the condition. Methods: We studied 483 women aged 35 to 69 years old who appeared healthy and attended a preventive gynecological examination. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) and regional body composition. BMD was assessed using the T-score. Low appendicular lean mass (aLM) adjusted by height (aLM index) was defined according to Baumgartner et al (<5.45 kg/m). The association of low aLM index with bone mass was evaluated with a binary logistic regression using a cutoff point on the receiver operating characteristic curves for the T-score of -1.5. Results: The participants had a mean age of 54.7 ± 9.1 years, body mass index of 24.6 ± 3.6 kg/m, aLM index of 5.9 ± 0.6 kg/m (22.6% showed sarcopenia), abdominal fat percentage of 44.0 ± 9.1%, and T-score of -0.48 ± 0.97. In the logistic regression model, we found that low BMD implied a significant risk for sarcopenia (odds ratio [OR] 1.77; 95% CI, 1.02-3.06). In contrast, excess body weight was a protective factor (OR 0.12; 95% CI, 0.06-0.25). Neither age nor abdominal fat percentage, however, influenced the likelihood of sarcopenia in these women. Conclusions: A BMD T-score below -1.5 suggests low muscle mass in middle-aged women, which is a central element in the diagnosis of sarcopenia. Early diagnosis provides the opportunity to introduce preventive and therapeutic options.
Mesh-Begriff(e)	Absorptiometry, Photon ; Body Mass Index ; Bone Density/physiology ; Chile ; Female ; Femur Neck/diagnostic imaging ; Femur Neck/pathology ; Humans ; Logistic Models ; Middle Aged ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/pathology ; ROC Curve ; Risk Factors ; Sarcopenia/diagnosis
Sprache	Englisch
Erscheinungsdatum	2017-11-07
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000000995
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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