Article ; Online: Optimal control with a strong harmonic trap.
2022 Volume 106, Issue 2, Page(s) L022103
Abstract: Quadratic trapping potentials are widely used to experimentally probe biopolymers and molecular machines and drive transitions in steered molecular-dynamics simulations. Approximating energy landscapes as locally quadratic, we design multidimensional ... ...
Abstract | Quadratic trapping potentials are widely used to experimentally probe biopolymers and molecular machines and drive transitions in steered molecular-dynamics simulations. Approximating energy landscapes as locally quadratic, we design multidimensional trapping protocols that minimize dissipation. The designed protocols are easily solvable and applicable to a wide range of systems. The approximation does not rely on either fast or slow limits and is valid for any duration provided the trapping potential is sufficiently strong. We demonstrate the utility of the designed protocols with a simple model of a periodically driven rotary motor. Our results elucidate principles of effective single-molecule manipulation and efficient nonequilibrium free-energy estimation. |
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Language | English |
Publishing date | 2022-09-15 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2844562-4 |
ISSN | 2470-0053 ; 2470-0045 |
ISSN (online) | 2470-0053 |
ISSN | 2470-0045 |
DOI | 10.1103/PhysRevE.106.L022103 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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