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Article ; Online: Bacterial Communities in Multiple Tissues Across the Body Surface of Three Coastal Shark Species.

Black, Chelsea / Merly, Liza / Hammerschlag, Neil

2021 Volume 60, Page(s) e69

Abstract: Bacteria are known to have explicit roles within the microbiomes of host tissues, therefore examining these communities may prove useful in assessing host health and responses to environmental change. The present study contributes to the emerging, yet ... ...

Abstract	Bacteria are known to have explicit roles within the microbiomes of host tissues, therefore examining these communities may prove useful in assessing host health and responses to environmental change. The present study contributes to the emerging, yet understudied, field of microbiome research in elasmobranchs. We provide a screening of the culturable bacteria communities found on multiple tissue sites on the body surface of blacktip (
Language	English
Publishing date	2021-11-22
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2105348-0
ISSN	1810-522X ; 1810-522X
ISSN (online)	1810-522X
ISSN	1810-522X
DOI	10.6620/ZS.2021.60-69
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Article ; Online: Developmental and behavioral phenotypes of pediatric patients with PTEN hamartoma tumor syndrome.

MacFarland, Suzanne P / Duvall, Melani / Kemajou, Raissa Tchetcho / Baldino, Sarah E / Zelley, Kristin / Black, Chelsea / Thomas, Allison / Thomas, Nina H / Ruffner, Melanie / Li, Yimei / Miller, Judith S / Brodeur, Garrett M / Shabason, Emily

American journal of medical genetics. Part A

2024 , Page(s) e63608

Abstract: Our study characterized the neurodevelopmental spectrum of individuals with PTEN Hamartoma Tumor Syndrome (PHTS), a syndrome that predisposes to both neurodevelopmental phenotypes and cancer risk. We aim to better understand life-impacting ... ...

Abstract	Our study characterized the neurodevelopmental spectrum of individuals with PTEN Hamartoma Tumor Syndrome (PHTS), a syndrome that predisposes to both neurodevelopmental phenotypes and cancer risk. We aim to better understand life-impacting neurodevelopmental features of PHTS. Our study recruited 20 children/adolescents with PHTS, who were then administered assessments for autism spectrum disorder (ASD) and other neurocognitive measures, including assessment of IQ, executive and adaptive functioning, and health-related quality of life. Thirteen individuals (65%) were identified as having ASD, of which five were newly diagnosed during the study. Of those, ASD symptom severity was in the mild-moderate range for 77%. Overall, IQ was in the average range, with a mean of 92.61 (SD 24.45, p = 0.5), though there was a non-statistically significant trend toward individuals without ASD having a higher mean IQ (102.7 vs 82.3; p = 0.1). Subjects had significant impairment in processing speed (mean 75.38, SD 24.75, p < 0.05), decreased adaptive functioning skills across all domains, and a trend toward having more executive functioning problems. Individuals with PHTS are at increased risk of neurodevelopmental disorders, including ASD and impaired executive and adaptive functioning. Although clear guidelines exist for cancer surveillance for individuals with PHTS, additional guidelines and screening for neurodevelopmental disorders are warranted.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2108614-X
ISSN	1552-4833 ; 0148-7299 ; 1552-4825
ISSN (online)	1552-4833
ISSN	0148-7299 ; 1552-4825
DOI	10.1002/ajmg.a.63608
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Article ; Online: The interactive association of proximal life stress and cumulative HPA axis functioning with depressive symptoms.

Shapero, Benjamin G / Curley, Erin E / Black, Chelsea L / Alloy, Lauren B

Depression and anxiety

2019 Volume 36, Issue 11, Page(s) 1089–1101

Abstract: Background: Stress is consistently implicated in depression. Using a vulnerability-stress framework, the hypothalamic-pituitary-adrenal (HPA) axis may be one factor affecting the stress-depression association. However, the interactive influence of ... ...

Abstract	Background: Stress is consistently implicated in depression. Using a vulnerability-stress framework, the hypothalamic-pituitary-adrenal (HPA) axis may be one factor affecting the stress-depression association. However, the interactive influence of recent life stress and HPA axis functioning on depressive symptoms remains unclear. It is particularly important to understand the synergistic association during adolescence, as this is a developmental period associated with a high risk for depression. Methods: A community sample of 58 adolescents (67% female, 59% Caucasian; mean age, 15.07 years) participated. Adolescents completed a well-validated measure of depressive symptoms and a structured life events interview to assess recent life stress. Hair cortisol concentration was obtained to measure cumulative exposure to HPA axis functioning. Results: Recent life stress and cumulative HPA axis exposure measured through hair cortisol were directly associated with higher depressive symptoms. Further, cumulative HPA axis exposure moderated the relationship between recent life stress and depressive symptoms. The recent life stress-depression association occurred for adolescents who experienced average and high, but not low, levels of cumulative HPA axis exposure. Conclusions: The current study builds on prior work and finds both a direct and interactive association of recent life stress and cumulative HPA axis functioning with depressive symptoms during adolescence. Identifying youth who experience high levels of HPA axis exposure is important to prevent the onset of depression.
MeSH term(s)	Adolescent ; Depression/physiopathology ; Depression/psychology ; Depressive Disorder/physiopathology ; Depressive Disorder/psychology ; Female ; Humans ; Hydrocortisone/analysis ; Hypothalamo-Hypophyseal System/physiopathology ; Male ; Pituitary-Adrenal System/physiopathology ; Stress, Psychological/physiopathology ; Stress, Psychological/psychology
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2019-10-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1378635-0
ISSN	1520-6394 ; 1091-4269
ISSN (online)	1520-6394
ISSN	1091-4269
DOI	10.1002/da.22957
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Zs.A 3823: Show issues

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Article ; Online: Apoptosis-regulated low-avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER2/neu-expressing tumors by costimulatory agonists in tolerized mice.

Black, Chelsea M / Armstrong, Todd D / Jaffee, Elizabeth M

Cancer immunology research

2014 Volume 2, Issue 4, Page(s) 307–319

Abstract: A major barrier to vaccines in cancer treatment is their failure to activate and maintain a complete cancer-specific CD8(+) effector T-cell repertoire. Low-avidity T cells are more likely to escape clonal deletion in the thymus when compared with high- ... ...

Abstract	A major barrier to vaccines in cancer treatment is their failure to activate and maintain a complete cancer-specific CD8(+) effector T-cell repertoire. Low-avidity T cells are more likely to escape clonal deletion in the thymus when compared with high-avidity T cells, and therefore comprise the major population of effector T cells available for activation in patients with cancer. However, low-avidity T cells fail to traffic into the tumor microenvironment and function in eradicating tumor under optimal vaccination conditions as opposed to high-avidity T cells that escape clonal deletion and function in tumor killing. We used high- and low-avidity T-cell receptor transgenic CD8(+) T cells specific for the immunodominant epitope HER2/neu (RNEU420-429) to identify signaling pathways responsible for the inferior activity of the low-avidity T cells. Adoptive transfer of these cells into tumor-bearing vaccinated mice identified the members of apoptosis pathways that are upregulated in low-avidity T cells. The increased expression of proapoptotic proteins by low-avidity T cells promoted their own cell death and also that of other tumor-specific CD8(+) T cells within their local environment. Importantly, we show that this proapoptotic effect can be overcome by using a strong costimulatory signal that prevents the activation-induced cell death and enables the low-avidity T cells to traffic into the tumor and assist in tumor clearance. These findings identify new therapeutic opportunities for activating the most potent anticancer T-cell responses.
MeSH term(s)	Animals ; Antigens, Differentiation/pharmacology ; Antigens, Neoplasm/immunology ; Apoptosis/immunology ; CD24 Antigen/genetics ; CD24 Antigen/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; Fas Ligand Protein/genetics ; Fas Ligand Protein/metabolism ; Female ; Humans ; Immunodominant Epitopes/immunology ; Interferon-gamma/biosynthesis ; Mice ; Mice, Transgenic ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Receptor, ErbB-2/chemistry ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/immunology ; Receptor, ErbB-2/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; T-Cell Antigen Receptor Specificity/immunology ; Tumor Escape/immunology
Chemical Substances	Antigens, Differentiation ; Antigens, Neoplasm ; CD24 Antigen ; Fas Ligand Protein ; Immunodominant Epitopes ; OX40Ig ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Interferon-gamma (82115-62-6) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2014-01-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2732489-8
ISSN	2326-6074 ; 2326-6066
ISSN (online)	2326-6074
ISSN	2326-6066
DOI	10.1158/2326-6066.CIR-13-0145
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Zs.A 7022: Show issues

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Article ; Online: Impact of gene molecular evolution on phylogenetic reconstruction: a case study in the rosids (Superorder Rosanae, Angiosperms).

Hilu, Khidir W / Black, Chelsea M / Oza, Dipan

PloS one

2014 Volume 9, Issue 6, Page(s) e99725

Abstract: Rate of substitution of genomic regions is among the most debated intrinsic features that impact phylogenetic informativeness. However, this variable is also coupled with rates of nonsynonymous substitutions that underscore the nature and degree of ... ...

Abstract	Rate of substitution of genomic regions is among the most debated intrinsic features that impact phylogenetic informativeness. However, this variable is also coupled with rates of nonsynonymous substitutions that underscore the nature and degree of selection on the selected genes. To empirically address these variables, we constructed four completely overlapping data sets of plastid matK, atpB, rbcL, and mitochondrial matR genes and used the rosid lineage (angiosperms) as a working platform. The genes differ in combinations of overall rates of nucleotide and amino acid substitutions. Tree robustness, homoplasy, accuracy in contrast to a reference tree, and phylogenetic informativeness are evaluated. The rapidly evolving/unconstrained matK faired best, whereas remaining genes varied in degrees of contribution to rosid phylogenetics across the lineage's 108 million years evolutionary history. Phylogenetic accuracy was low with the slowly evolving/unconstrained matR despite least amount of homoplasy. Third codon positions contributed the highest amount of parsimony informative sites, resolution and informativeness, but magnitude varied with gene mode of evolution. These findings are in clear contrast with the views that rapidly evolving regions and the 3rd codon position have inevitable negative impact on phylogenetic reconstruction at deep historic level due to accumulation of multiple hits and subsequent elevation in homoplasy and saturation. Relaxed evolutionary constraint in rapidly evolving genes distributes substitutions across codon positions, an evolutionary mode expected to reduce the frequency of multiple hits. These findings should be tested at deeper evolutionary histories.
MeSH term(s)	Codon/genetics ; Databases, Genetic ; Evolution, Molecular ; Genes, Plant ; Magnoliopsida/genetics ; Phylogeny
Chemical Substances	Codon
Language	English
Publishing date	2014-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0099725
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Article ; Online: Everyday executive function in focal onset pediatric epilepsy on the parent-report BRIEF2.

Black, Chelsea L / Shih, Sharon W / Sepeta, Leigh N / Facella-Ervolini, Joy M / Isquith, Peter K / Berl, Madison M

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

2018 Volume 25, Issue 1, Page(s) 22–43

Abstract: Executive function (EF) difficulties are a core neuropsychological feature of pediatric epilepsy, and parent-report measures of EF concerns are an important complement to task-based EF measures. The Behavior Rating Inventory of Executive Function (BRIEF) ...

Abstract	Executive function (EF) difficulties are a core neuropsychological feature of pediatric epilepsy, and parent-report measures of EF concerns are an important complement to task-based EF measures. The Behavior Rating Inventory of Executive Function (BRIEF) has shown sensitivity to parent-reported EF concerns in epilepsy and other pediatric populations. We compared profiles of parent-reported EF concerns using the BRIEF and its revision, the BRIEF2, in 117 pediatric patients with focal onset epilepsy to examine the clinical utility of the revised scale. We then compared BRIEF2 profiles between patients and age- and gender-matched healthy controls. Among patients, profiles on the BRIEF did not globally differ from the BRIEF2, and agreement was very good across scales. Patients and controls differed significantly on the BRIEF2, with patients showing higher EF difficulties reported by parents across most scales. High rates of clinical elevation among patients emerged on the Task Monitor, Plan/Organize, Working Memory, and Shift scales. Younger age of epilepsy onset, chronic epilepsy, and right hemisphere seizure focus were associated with higher parent-reported EF concerns. Findings suggest that the BRIEF2 demonstrates similar performance to the BRIEF among pediatric patients with focal onset epilepsy who are most at risk in the areas of task monitoring, working memory, planning and organization, and flexibility. These findings are informative when comparing literature across versions and provide additional insight into the nature of parent-reported EF difficulties among children with focal onset epilepsy.
MeSH term(s)	Adolescent ; Case-Control Studies ; Child ; Epilepsies, Partial/complications ; Executive Function/physiology ; Female ; Humans ; Male ; Memory, Short-Term/physiology ; Neuropsychological Tests ; Parents/psychology
Language	English
Publishing date	2018-01-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1483041-3
ISSN	1744-4136 ; 0929-7049
ISSN (online)	1744-4136
ISSN	0929-7049
DOI	10.1080/09297049.2018.1424326
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Article ; Online: Amygdala subnuclei volume in bipolar spectrum disorders: Insights from diffusion-based subsegmentation and a high-risk design.

Damme, Katherine S F / Alloy, Lauren B / Young, Christina B / Kelley, Nicholas J / Chein, Jason / Ng, Tommy H / Titone, Madison K / Black, Chelsea L / Nusslock, Robin

Human brain mapping

2020 Volume 41, Issue 12, Page(s) 3358–3369

Abstract: Amygdala abnormalities are widely documented in bipolar spectrum disorders (BSD). Amygdala volume typically is measured after BSD onset; thus, it is not known whether amygdala abnormalities predict BSD risk or relate to the disorder. Additionally, past ... ...

Abstract	Amygdala abnormalities are widely documented in bipolar spectrum disorders (BSD). Amygdala volume typically is measured after BSD onset; thus, it is not known whether amygdala abnormalities predict BSD risk or relate to the disorder. Additionally, past literature often treated the amygdala as a homogeneous structure, and did not consider its distinct subnuclei and their differential connectivity to other brain regions. To address these issues, we used a behavioral high-risk design and diffusion-based subsegmentation to examine amygdala subnuclei among medication-free individuals with, and at risk for, BSD. The behavioral high-risk design (N = 114) included low-risk (N = 37), high-risk (N = 47), and BSD groups (N = 30). Diffusion-based subsegmentation of the amygdala was conducted to determine whether amygdala volume differences related to particular subnuclei. Individuals with a BSD diagnosis showed greater whole, bilateral amygdala volume compared to Low-Risk individuals. Examination of subnuclei revealed that the BSD group had larger volumes compared to the High-Risk group in both the left medial and central subnuclei, and showed larger volume in the right lateral subnucleus compared to the Low-Risk group. Within the BSD group, specific amygdala subnuclei volumes related to time since first episode onset and number of lifetime episodes. Taken together, whole amygdala volume analyses replicated past findings of enlargement in BSD, but did not detect abnormalities in the high-risk group. Examination of subnuclei volumes detected differences in volume between the high-risk and BSD groups that were missed in the whole amygdala volume. Results have implications for understanding amygdala abnormalities among individuals with, and at risk for, a BSD.
MeSH term(s)	Adult ; Amygdala/diagnostic imaging ; Amygdala/pathology ; Bipolar Disorder/diagnostic imaging ; Bipolar Disorder/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neuroimaging/methods ; Risk ; Young Adult
Language	English
Publishing date	2020-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.25021
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Zs.A 4028: Show issues

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Article ; Online: Impulsive personality dimensions are associated with altered behavioral performance and neural responses in the monetary incentive delay task.

Gu, Ruolei / Jiang, Yang / Kiser, Seth / Black, Chelsea L / Broster, Lucas S / Luo, Yue-Jia / Kelly, Thomas H

Neuropsychologia

2017 Volume 103, Page(s) 59–68

Abstract: Individual differences in dimensions of impulsivity personality including disinhibition and sensation seeking modulate approach responses to reinforcing stimuli, such as drugs and money. The current study examined the effects of monetary incentive on ... ...

Abstract	Individual differences in dimensions of impulsivity personality including disinhibition and sensation seeking modulate approach responses to reinforcing stimuli, such as drugs and money. The current study examined the effects of monetary incentive on both behavioral performance and electrophysiological activity among individuals varying in disinhibition and sensation seeking. The monetary incentive delay (MID) task was completed under electroencephalogram (EEG) recording. Behavioral data showed that higher disinhibition and sensation-seeking were associated with lower performance accuracy. Event-related potential (ERP) data showed that high reinforcement cues elicited a larger late positive component (LPC) than other conditions among high disinhibition participants, indicating its strong emotional influence. Additionally, in the neutral incentive condition, the feedback-related negativity (FRN) elicited by correct outcomes was larger than that elicited by incorrect outcomes in the high disinhibition group only. This novel finding indicates that high disinhibition participants were less likely to expect correct outcomes compared to incorrect outcomes in the neutral incentive condition. Finally, the P3 component elicited by outcome presentation showed an interaction between two impulsivity dimensions; when disinhibition level was low, the P3 was larger among high than low sensation seeking participants.
MeSH term(s)	Analysis of Variance ; Brain/physiology ; Electroencephalography ; Evoked Potentials ; Female ; Humans ; Impulsive Behavior/physiology ; Inhibition (Psychology) ; Male ; Neuropsychological Tests ; Personality/physiology ; Reaction Time ; Young Adult
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	207151-4
ISSN	1873-3514 ; 0028-3932
ISSN (online)	1873-3514
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2017.07.013
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Zs.A 524: Show issues

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Article ; Online: A multi-disciplinary clinic for SCN8A-related epilepsy.

Schreiber, John M / Tochen, Laura / Brown, Mackenzie / Evans, Sarah / Ball, Laura J / Bumbut, Adrian / Thewamit, Rapeepat / Whitehead, Matthew T / Black, Chelsea / Boutzoukas, Emanuel / Fanto, Eleanor / Suslovic, William / Berl, Madison / Hammer, Michael / Gaillard, William D

Epilepsy research

2019 Volume 159, Page(s) 106261

Abstract: Objective: We endeavored to evaluate a cohort of patients diagnosed with SCN8A-related epilepsy in a multi-disciplinary clinic and to create a bio-repository.: Methods: We recruited patients with epilepsy due to SCN8A variants at Children's National ... ...

Abstract	Objective: We endeavored to evaluate a cohort of patients diagnosed with SCN8A-related epilepsy in a multi-disciplinary clinic and to create a bio-repository. Methods: We recruited patients with epilepsy due to SCN8A variants at Children's National Medical Center, through family organizations, or SCN8A.net. Study procedures included medical record review, review of EEG and MRI data, clinical evaluation, the Vineland Adaptive Behavior Scales, Third Edition (VABS-3), DNA extraction, and preparation of peripheral blood mononuclear cells. Results: Seventeen patients (9 months - 19 years) completed the study. Age at seizure onset was 1 day to 4 years old (median age 4 months). Epilepsy phenotype ranged from mild epilepsy to severe developmental and epileptic encephalopathy. Medications targeting the voltage-gated sodium channel were most often effective, while levetiracetam resulted in worsening seizures and/or developmental regression in 7/16 (p < 0.05). VABS-3 scores were below age expectations for most children; older children had lower scores. Neurological examination revealed hypotonia (13), spastic quadriparesis (1), ataxia (9), dyskinesia (2)/ dystonia (7), and four non-ambulatory. Conclusions: This is the first report of a large series of patients with epilepsy due to SCN8A variants evaluated in a single multi-disciplinary clinic. By utilizing a more comprehensive and consistent evaluation, we clarify specific seizure and epilepsy types, describe a distinct epilepsy phenotype in a patient with a nonsense variant, delineate patterns of developmental delay, language, and swallow function (specifically anomic aphasia and flaccid dysarthria), identify and characterize movement disorders, report common findings on physical exam, and demonstrate clinical worsening with levetiracetam.
MeSH term(s)	Adolescent ; Anticonvulsants/therapeutic use ; Child ; Child, Preschool ; Cross-Sectional Studies ; Electroencephalography ; Epilepsy/drug therapy ; Epilepsy/genetics ; Female ; Humans ; Infant ; Male ; Mutation ; NAV1.6 Voltage-Gated Sodium Channel/genetics ; Seizures/drug therapy ; Seizures/genetics ; Young Adult
Chemical Substances	Anticonvulsants ; NAV1.6 Voltage-Gated Sodium Channel ; SCN8A protein, human
Language	English
Publishing date	2019-12-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632939-1
ISSN	1872-6844 ; 0920-1211
ISSN (online)	1872-6844
ISSN	0920-1211
DOI	10.1016/j.eplepsyres.2019.106261
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Zs.A 2193: Show issues

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Article ; Online: Impulsivity predicts the onset of DSM-IV-TR or RDC hypomanic and manic episodes in adolescents and young adults with high or moderate reward sensitivity.

Ng, Tommy H / Stange, Jonathan P / Black, Chelsea L / Titone, Madison K / Weiss, Rachel B / Abramson, Lyn Y / Alloy, Lauren B

Journal of affective disorders

2016 Volume 198, Page(s) 88–95

Abstract: Background: A growing body of research suggests that bipolar disorders (BD) are associated with high impulsivity. Using a multi-method approach, the current study provided the first examination of the hypothesis that impulsivity would prospectively ... ...

Abstract	Background: A growing body of research suggests that bipolar disorders (BD) are associated with high impulsivity. Using a multi-method approach, the current study provided the first examination of the hypothesis that impulsivity would prospectively predict shorter time to onset of DSM-IV-TR or RDC hypomanic or manic episodes in a sample selected based on reward sensitivity, a biobehavioral trait shown to predict onset and course of BD. Methods: 163 participants with high reward sensitivity and 114 participants with moderate reward sensitivity were followed every six months for an average of 2.68 years. Participants completed the Barratt Impulsiveness Scale - Version 11 (BIS-11), Balloon Analog Risk Task (BART), Beck Depression Inventory, Altman Self-Rating Mania Scale, and an expanded Schedule for Affective Disorders and Schizophrenia (exp-SADS) - Lifetime Version at baseline and were followed prospectively with the exp-SADS - Change Version to assess onset of hypomanic or manic episodes and treatment seeking for mood problems. Results: Cox proportional hazard regression analyses indicated that impulsivity as measured by a behavioral task (BART; OR=1.04, p=.03) and a self-report measure (BIS-11 Attentional Impulsiveness subscale; OR=1.16, p=.01) predicted shorter time to hypomania/mania onset, after controlling for baseline depressive and manic symptoms, family history of mood disorder, treatment seeking for mood problems, and reward sensitivity. Limitations: The study was limited by non-comprehensive assessment of impulsivity and unknown generalizability to clinical samples. Conclusions: Impulsivity confers vulnerability to hypomania or mania. Future studies would benefit from considering how impulsivity can be integrated into existing biopsychosocial models of BD.
MeSH term(s)	Adolescent ; Bipolar Disorder/diagnosis ; Bipolar Disorder/psychology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Impulsive Behavior ; Male ; Psychiatric Status Rating Scales ; Reward ; Young Adult
Language	English
Publishing date	2016-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2016.03.045
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