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Article: HIV/AIDS and infection control: the debate continues.

Black, K M

1999 Volume 65, Issue 8, Page(s) 428, 461

MeSH term(s)	Acquired Immunodeficiency Syndrome/prevention & control ; Canada ; HIV Infections/prevention & control ; Humans ; Infection Control, Dental ; Universal Precautions
Language	English
Publishing date	1999-09
Publishing country	Canada
Document type	Comment ; Letter
ZDB-ID	604786-5
ISSN	1488-2159 ; 0709-8936 ; 0008-3372
ISSN (online)	1488-2159
ISSN	0709-8936 ; 0008-3372
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Article: Infection control.

Black, K M

Journal (Canadian Dental Association)

1992 Volume 58, Issue 10, Page(s) 779

MeSH term(s)	Dental Equipment/economics ; Humans ; Infection Control/economics ; Journalism, Dental
Language	English
Publishing date	1992-10
Publishing country	Canada
Document type	Comment ; Letter
ZDB-ID	604786-5
ISSN	1488-2159 ; 0709-8936 ; 0008-3372
ISSN (online)	1488-2159
ISSN	0709-8936 ; 0008-3372
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Article: Conserved tryptophan in cytochrome c: importance of the unique side-chain features of the indole moiety.

Black, K M / Clark-Lewis, I / Wallace, C J

The Biochemical journal

2001 Volume 359, Issue Pt 3, Page(s) 715–720

Abstract: The absolute conservation of tryptophan at position 59 in cytochrome c is related to the unique chemical nature of its indole moiety. The indole side chain of Trp-59 possesses three salient features: bulk, hydrophobicity and the ability of its indole ... ...

Abstract	The absolute conservation of tryptophan at position 59 in cytochrome c is related to the unique chemical nature of its indole moiety. The indole side chain of Trp-59 possesses three salient features: bulk, hydrophobicity and the ability of its indole nitrogen to act as a hydrogen-bond donor. Crystallographic evidence identifies the indole nitrogen of Trp-59 as having a stabilizing hydrogen-bonding interaction with the buried carboxylate group of haem propionate 7. Side-chain bulk is also likely to be important because a Phe or Leu residue can replace Trp to give an at least partly functional protein, whereas the smaller Gly or Ser cannot. Semisynthetic analogues were designed to test the importance of the side-chain features of tryptophan by using a recently developed method for stereoselective fragment religation in yeast cytochrome c. Three yeast iso-1 cytochrome c analogues were produced in which Trp-59 was replaced by a non-coded amino acid: p-iodophenylalanine, beta-(3-pyridyl)-alanine or beta-(2-naphthyl)-alanine. Replacement of Trp-59 with these non-coded amino acids allows the reasons for its conservation to be analysed, because they vary with respect to size, hydrophobicity and hydrogen-bond potential. Our results show that decreasing the bulk and hydrophobicity of the side chain at position 59 has a profound but different impact on physicochemical and biological parameters from those of abolishing hydrogen-bond donor potential. This suggests that Trp-59 has both a local and a global stability effect by solvating a buried charge and by having a key role in the packing of the cytochrome c hydrophobic core.
MeSH term(s)	Cytochrome c Group/chemistry ; Cytochrome c Group/genetics ; Cytochrome c Group/metabolism ; Indoles/chemistry ; Models, Molecular ; Molecular Structure ; Oxidation-Reduction ; Oxidoreductases/metabolism ; Protein Structure, Tertiary ; Saccharomyces cerevisiae/chemistry ; Saccharomyces cerevisiae/enzymology ; Tryptophan/chemistry
Chemical Substances	Cytochrome c Group ; Indoles ; Tryptophan (8DUH1N11BX) ; Oxidoreductases (EC 1.-) ; succinate oxidase (EC 1.-)
Language	English
Publishing date	2001-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2969-5
ISSN	1470-8728 ; 0264-6021 ; 0006-2936 ; 0306-3275
ISSN (online)	1470-8728
ISSN	0264-6021 ; 0006-2936 ; 0306-3275
DOI	10.1042/0264-6021:3590715
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Article: The influence of different sitting positions on cervical and lumbar posture.

Black, K M / McClure, P / Polansky, M

Spine

1996 Volume 21, Issue 1, Page(s) 65–70

Abstract: Study design: This study used a repeated measures design to assess the effects of multiple sitting postures on various spinal angles. All subjects were tested in slouched, erect, forward inclined, and comfortable postures.: Objectives: The purposes ... ...

Abstract	Study design: This study used a repeated measures design to assess the effects of multiple sitting postures on various spinal angles. All subjects were tested in slouched, erect, forward inclined, and comfortable postures. Objectives: The purposes of this study were to evaluate the changes in head, cervical, lumbar, and pelvic postures in different sitting positions and also to determine if there is a relation between lumbar posture and cervical posture during sitting. Summary of background data: Clinicians commonly assert that head and neck position is strongly influenced by lumbar and pelvic position. A biomechanical model was developed that allowed detailed, quantitative description of head, neck, lumbar, and pelvic postures. This model enabled a distinction to be made between upper and lower cervical motions. Methods: Various spinal angles were measured in 30 healthy subjects in four sitting positions using a three-dimensional digitizing system. Reliability of the measurement procedure was determined using an intraclass correlation coefficient and the values for most angles was above 0.8. Results: With the exception of head orientation, analysis of variance revealed significant differences in spinal angles between different sitting positions. Head orientation appeared to be maintained by compensatory adjustments in both the upper and lower cervical spine and changes in lumbar posture were associated with compensatory changes in overall cervical position. As the lumbar spine moved toward extension, the cervical spine flexed and as the lumbar spine flexed the cervical spine extended. However, there was variation among subjects as to whether cervical spine adjustments occurred primarily in the upper or lower cervical region. Conclusions: Different sitting postures clearly resulted in changes in cervical spine position. Lumbar and pelvic position should be considered when control of cervical posture is desired.
MeSH term(s)	Adult ; Female ; Humans ; Lumbosacral Region ; Male ; Middle Aged ; Models, Biological ; Neck ; Pelvis ; Posture ; Software ; Spine/physiology
Language	English
Publishing date	1996-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/00007632-199601010-00015
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Article: Teaching family process and intervention.

Black, K M

Nursing outlook

1970 Volume 18, Issue 6, Page(s) 54–58

MeSH term(s)	Crisis Intervention ; Education, Nursing, Graduate ; Family Therapy ; Nurse-Patient Relations ; Psychiatric Nursing/education ; Socioeconomic Factors
Language	English
Publishing date	1970-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	300568-9
ISSN	1528-3968 ; 0029-6554
ISSN (online)	1528-3968
ISSN	0029-6554
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Zs.B 892: Show issues

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Article: An existential model for psychiatric nursing.

Black, K M

Perspectives in psychiatric care

1968 Volume 6, Issue 4, Page(s) 178–184

MeSH term(s)	Existentialism ; Nurse-Patient Relations ; Psychiatric Nursing
Language	English
Publishing date	1968
Publishing country	United States
Document type	Journal Article
ZDB-ID	391097-0
ISSN	0031-5990
ISSN	0031-5990
DOI	10.1111/j.1744-6163.1968.tb01484.x
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Zs.B 631: Show issues

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Article: Salivary gland tumors.

Fitzpatrick, P J / Black, K M

The Journal of otolaryngology

1985 Volume 14, Issue 5, Page(s) 296–300

Abstract: A retrospective review of 643 patients with salivary gland tumors seen between 1958-72 is reported. There were 328 malignant and 375 benign tumors. All patients with malignant tumors were assessed in a multidisciplinary head and neck clinic. The median ... ...

Abstract	A retrospective review of 643 patients with salivary gland tumors seen between 1958-72 is reported. There were 328 malignant and 375 benign tumors. All patients with malignant tumors were assessed in a multidisciplinary head and neck clinic. The median age for developing malignant tumors was 58 and there was a male to female ratio of 1.2:1. For benign tumors the median age was 46 years and the male to female ratio 0.8:1. Overall the primary tumor was controlled by the first planned treatment in 145 (44%) malignant tumors and in 253 (80%) benign tumors. The five and 10 year actuarial survival for malignant tumors was 59.4% and 45.6% respectively.
MeSH term(s)	Combined Modality Therapy ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Parotid Neoplasms/therapy ; Retrospective Studies ; Salivary Gland Neoplasms/mortality ; Salivary Gland Neoplasms/pathology ; Salivary Gland Neoplasms/therapy ; Submandibular Gland Neoplasms/therapy
Language	English
Publishing date	1985-10
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197688-6
ISSN	0381-6605
ISSN	0381-6605
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Zs.A 1130: Show issues

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Article: Cytokine priming of human basophils: description of allergen 'nonreleasers'.

Black, K M / Lussier, A M / Gion, W R / Kasaian, M T

International archives of allergy and immunology

1996 Volume 111, Issue 2, Page(s) 142–151

Abstract: Interleukins 3 and 5 and GM-CSF enhance histamine release from basophils triggered by various stimuli. In this report, we describe a subset of allergic patients whose basophils release histamine in response to allergen only when primed with cytokine. In ... ...

Abstract	Interleukins 3 and 5 and GM-CSF enhance histamine release from basophils triggered by various stimuli. In this report, we describe a subset of allergic patients whose basophils release histamine in response to allergen only when primed with cytokine. In the absence of cytokine, there is no detectable response to allergen. These patients, who represent 4-13% of the allergic population, cannot be distinguished by skin test reactivity or severity of allergic symptoms. Allergen nonreleasers tend to have lower titers of allergen-specific IgE than the majority of atopic subjects, but this difference is not significant (average titer of 29.8 for nonreleasers vs. 188 for typical allergies; p = 0.15). They release histamine normally with anti-IgE and with fMLP, indicating that basophils are responsive to signalling through the IgE receptor, and there is no intrinsic defect in degranulation. Thus, in these patients, the IgE-mediated release of inflammatory mediators from basophils is dependent on, rather than merely enhanced by, T cell cytokines. The relationship between these patients and the previously described anti-IgE 'nonreleasers' is discussed.
MeSH term(s)	Antibodies, Anti-Idiotypic/immunology ; Basophils/immunology ; Histamine Release/immunology ; Humans ; Hypersensitivity, Immediate/immunology ; Immunoglobulin E/analysis ; Immunoglobulin E/immunology ; Interleukin-3/genetics ; Interleukin-3/immunology ; Interleukin-5/immunology ; N-Formylmethionine Leucyl-Phenylalanine/immunology ; Receptors, IgE/immunology ; Recombinant Proteins/immunology ; Signal Transduction/immunology ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Anti-Idiotypic ; Interleukin-3 ; Interleukin-5 ; Receptors, IgE ; Recombinant Proteins ; Immunoglobulin E (37341-29-0) ; N-Formylmethionine Leucyl-Phenylalanine (59880-97-6)
Language	English
Publishing date	1996-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
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Article: Verbal recall and recognition following traumatic brain injury: a [0-15]-water positron emission tomography study.

Ricker, J H / Müller, R A / Zafonte, R D / Black, K M / Millis, S R / Chugani, H

Journal of clinical and experimental neuropsychology

2001 Volume 23, Issue 2, Page(s) 196–206

Abstract: Although several studies exist which have examined static functional neuroimaging following traumatic brain injury (TBI), controlled cognitive activation studies of episodic memory in this population have not been published. The present investigation ... ...

Abstract	Although several studies exist which have examined static functional neuroimaging following traumatic brain injury (TBI), controlled cognitive activation studies of episodic memory in this population have not been published. The present investigation studied verbal recall using [O-15]-water positron emission tomography (PET) in 5 individuals who sustained severe TBI (M GCS=6.8; M years post-injury=3.18), and 4 non-injured control participants. Statistical image analysis demonstrated changes in frontoparietal regional cerebral blood flow (rCBF) in both groups, but there were interesting differences between groups and across conditions. Frontal lobe rCBF changes in TBI patients were reduced during free recall but enhanced during recognition, when compared to controls. Changes in cerebellar rCBF were observed in the control group during free recall, but not in the TBI sample. In both groups, bifrontal rCBF increases were noted on recognition tasks. The present findings provide evidence of alterations in specific substrates involved in verbal recall following brain injury.
MeSH term(s)	Adult ; Brain/blood supply ; Brain/diagnostic imaging ; Brain/metabolism ; Brain Injuries/diagnostic imaging ; Brain Injuries/metabolism ; Brain Injuries/psychology ; Case-Control Studies ; Cues ; Female ; Humans ; Male ; Mental Recall ; Oxygen Radioisotopes ; Recognition (Psychology) ; Tomography, Emission-Computed/methods ; Verbal Learning
Chemical Substances	Oxygen Radioisotopes
Language	English
Publishing date	2001-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605982-x
ISSN	1744-411X ; 1380-3395 ; 0168-8634
ISSN (online)	1744-411X
ISSN	1380-3395 ; 0168-8634
DOI	10.1076/jcen.23.2.196.1204
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Zs.B 2393: Show issues

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Article: Synthetic peptides that mimic the binding site of horseshoe crab antilipopolysaccharide factor.

Kloczewiak, M / Black, K M / Loiselle, P / Cavaillon, J M / Wainwright, N / Warren, H S

The Journal of infectious diseases

1994 Volume 170, Issue 6, Page(s) 1490–1497

Abstract: Tachypleus antilipopolysaccharide (LPS) factor (TALF) is a protein of 102 amino acids in the lysate of amebocytes of Tachypleus tridentatus that binds bacterial LPS with high affinity and blocks its biologic activity in numerous assays. To elucidate the ... ...

Abstract	Tachypleus antilipopolysaccharide (LPS) factor (TALF) is a protein of 102 amino acids in the lysate of amebocytes of Tachypleus tridentatus that binds bacterial LPS with high affinity and blocks its biologic activity in numerous assays. To elucidate the minimal sequences that bind LPS, overlapping synthetic peptides based on the sequence of TALF were assessed for the ability to bind and neutralize LPS. TALF41-53 was the minimal sequence that bound LPS, as assessed by a slot blot capture assay. TALF29-59 bound LPS with the highest potency. TALF29-59 decreased LPS-induced coagulation of limulus amebocyte lysate, induction of cytokines from human monocytes, and LPS-induced lethality in sensitized mice. Synthetic peptides based on TALF or other LPS-binding proteins may be useful for the design of drugs for treatment of endotoxemia.
MeSH term(s)	Amino Acid Sequence ; Animals ; Antimicrobial Cationic Peptides ; Arthropod Proteins ; Binding Sites ; Cytokines/biosynthesis ; Dactinomycin ; Horseshoe Crabs/chemistry ; Humans ; Invertebrate Hormones/isolation & purification ; Invertebrate Hormones/metabolism ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/toxicity ; Mice ; Molecular Sequence Data ; Monocytes/metabolism ; Neutralization Tests ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/metabolism
Chemical Substances	Antimicrobial Cationic Peptides ; Arthropod Proteins ; Cytokines ; Invertebrate Hormones ; Lipopolysaccharides ; Peptides ; antilipopolysaccharide factor (Limulus) ; Dactinomycin (1CC1JFE158)
Language	English
Publishing date	1994-12
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/170.6.1490
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