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Article ; Online: Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion.

Hughes, Ellyn / Lauder, Sarah N / Smart, Kathryn / Bloom, Anja / Scott, Jake / Jones, Emma / Somerville, Michelle / Browne, Molly / Blainey, Andrew / Godkin, Andrew / Ager, Ann / Gallimore, Awen

Cancer immunology, immunotherapy : CII

2020  Volume 69, Issue 10, Page(s) 2063–2073

Abstract: Although metastatic disease is responsible for the majority of cancer deaths, tests of novel immunotherapies in mouse tumour models often focus on primary tumours without determining whether these therapies also target metastatic disease. This study ... ...

Abstract Although metastatic disease is responsible for the majority of cancer deaths, tests of novel immunotherapies in mouse tumour models often focus on primary tumours without determining whether these therapies also target metastatic disease. This study examined the impact of depleting Foxp3
MeSH term(s) Animals ; Female ; Forkhead Transcription Factors/metabolism ; Immunotherapy/methods ; Lung Neoplasms/immunology ; Lung Neoplasms/secondary ; Lung Neoplasms/therapy ; Lymphocyte Depletion/methods ; Lymphocytes, Tumor-Infiltrating/drug effects ; Lymphocytes, Tumor-Infiltrating/immunology ; Mice ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/therapy
Chemical Substances Forkhead Transcription Factors ; Foxp3 protein, mouse
Language English
Publishing date 2020-05-23
Publishing country Germany
Document type Journal Article
ZDB-ID 195342-4
ISSN 1432-0851 ; 0340-7004
ISSN (online) 1432-0851
ISSN 0340-7004
DOI 10.1007/s00262-020-02603-x
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