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Article: Effects of calcium channel blockers on pharmacologically induced contractions of rainbow trout (Oncorhynchus mykiss) intestine.

Burka, J F / Blair, R M / Chong, C / Hogan, J E

2013 Volume 8, Issue 6, Page(s) 521–527

Abstract: Calcium depletion/replacement studies were carried out to examine the role of calcium in contraction of trout intestinal smoot muscle in vitro. Three chemically distinct calcium channel blockers were used to determine whether voltage operated calcium ... ...

Abstract	Calcium depletion/replacement studies were carried out to examine the role of calcium in contraction of trout intestinal smoot muscle in vitro. Three chemically distinct calcium channel blockers were used to determine whether voltage operated calcium channels (VOCs) were involved in calcium entry with either agonist or depolarization-induced contractions. Contractions induced by depolarizing intestinal smooth muscle with potassium were totally dependent on extracellular calcium, whereas receptor-mediated responses to 5-hydroxytryptamine (5-HT) and carbachol also relied on calcium derived from intracellular stores. The calcium channel blockers, verapamil, nitrendipine, and diltiazem, all shifted the calcium-response curve for potassium to the right, supporting the existence of VOCs in trout intestinal smooth muscle. The calcium-response curve for 5-HT was also shifted to the right, suggesting that 5-HT can induce calcium uptake into the smooth muscle via VOCs, in addition to mobilizing intracellular calcium. Verapamil also appeared to block 5-HT receptors directly. Carbachol-induced contractions were only reduced by diltiazem at low concentrations of calcium (0.1-1 mM), suggesting that diltiazem has some other mechanisms of action than the other calcium channel blockers. Activation of muscarinic receptors may induce calcium entry through channels other than the VOCs, in addition to mobilizing intracellular calcium.
Language	English
Publishing date	2013-11-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	292907-7
ISSN	1573-5168 ; 0920-1742
ISSN (online)	1573-5168
ISSN	0920-1742
DOI	10.1007/BF00003410
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Article: Bovine corpus luteum: a historic overview and implications for future research.

Hansel, W / Blair, R M

Theriogenology

2006 Volume 45, Issue 7, Page(s) 1267–1294

Language	English
Publishing date	2006-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/0093-691x(96)00098-2
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Article: Composted and formulated poultry litters promote soil nutrient availability but not plant uptake or edamame quality

Blair, R. M. / Savin, M. C. / Chen, P.

Agronomy for sustainable development

2014 Volume 34, Issue 4, Page(s) 849

Language	English
Document type	Article
ZDB-ID	2182736-9
ISSN	0249-5627 ; 1774-0746
Database	Current Contents Nutrition, Environment, Agriculture

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Article: The inhibition of Escherichia coli by 1-penicillamine and its reversal by isoleucine, valine or leucine.

BLAIR, R M / APOSHIAN, H V

Biochimica et biophysica acta

2003 Volume 30, Issue 1, Page(s) 214–215

MeSH term(s)	Cysteine/analogs & derivatives ; Escherichia coli/drug effects ; Isoleucine ; Leucine/pharmacology ; Penicillamine ; Valine/pharmacology
Chemical Substances	Isoleucine (04Y7590D77) ; Leucine (GMW67QNF9C) ; Penicillamine (GNN1DV99GX) ; Valine (HG18B9YRS7) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2003-05-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/0006-3002(58)90276-2
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Article: Bovine corpus luteum: a historic overview and implications for future research

Hansel, W / Blair, R.M

Theriogenology. May 1, 1996. v. 45 (7)

1996

Abstract: It is often said that those who do not know history are likely to repeat it. Unfortunately, this truism applies to scientific as well as other endeavors. A classic case of loss of important information in the field of corpus luteum research was the ... ...

Abstract	It is often said that those who do not know history are likely to repeat it. Unfortunately, this truism applies to scientific as well as other endeavors. A classic case of loss of important information in the field of corpus luteum research was the finding of Ott and Scott (107) in 1910 that caprine corpora lutea contained an oxytocic substance. Wathes and Swann (144) rediscovered this fact for ewes in 1982. Unfortunately, failures to cite pertinent literature and inaccurate citations are becoming more frequent as the volume of literature on the corpus luteum expands. The problem has become more acute in recent years because of the widespread use of computer-based literature searches limited to relatively recent publications. The bovine corpus luteum has been used as a model for studying luteal function for several reasons. Among them are the large amount of tissue it provides and the relative ease with which accurately dated tissue can be obtained by its enucleation from the ovary through an incision in the anterior vaginal wall under epidural anesthesia (18). However, the bovine corpus luteum is unique and differs, even from that of the ewe, in a number of significant ways. As in many areas of biology, research has been influenced greatly by the techniques available at any given time. Early studies were based largely on histology and anatomy. Later, studies based on pituitary and ovarian hormone analysis became popular. This phase of research was rapidly followed by studies based on cell and tissue culture techniques, cell sorting techniques and the use of monoclonal antibodies to study the origin of luteal cells. More recently, advanced techniques in molecular biology, biotechnology and immunology have become the order of the day. A major objective of this paper is to piece together, in a generally chronological order, those research advances that were most influential in forming our current concepts of corpus luteum funtion. Unfortunately, many significant contributions can not be included, and readers will certainly differ as to their assessments of the significance of individual findings. However, many additional reports will be cited by other contributors to this issue in their more detailed papers targeted to specific areas of corpus luteum research. A second objective is to project current research trends into the future and, hopefully to pinpoint those areas that will yield the most needed information.
Keywords	cows ; corpus luteum ; luteolysis ; luteinization ; oxytocin ; hormone antagonists ; progesterone ; estradiol ; estrous cycle ; blood plasma ; prostaglandins ; in vitro culture ; granulosa cells ; estrus synchronization ; arachidonic acid ; cell membranes ; history ; luteinizing hormone ; inorganic ions ; calcium
Language	English
Dates of publication	1996-0501
Size	p. 1267-1294.
Document type	Article
Note	In the special issue: Special topics in theriogenology. 2. The bovine corpus luteum / edited by W. Hansel.
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
Database	NAL-Catalogue (AGRICOLA)

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Article: Studies of uterine secretions and products of primary cultures of endometrial cells in pigs.

Davis, D L / Blair, R M

Journal of reproduction and fertility. Supplement

1993 Volume 48, Page(s) 143–155

Abstract: The uterus plays a central role in the reproductive biology of mammals. Adaptation of the uterus from an oviparous to a viviparous nature required changes that involved production of a uterine environment that could support the development of the embryo ... ...

Abstract	The uterus plays a central role in the reproductive biology of mammals. Adaptation of the uterus from an oviparous to a viviparous nature required changes that involved production of a uterine environment that could support the development of the embryo and fetus. Production of a suitable environment includes the synthesis and secretion of products by the uterine endometrium. However, the uterine endometrium is not a single homogeneous unit, but rather consists of several cell populations. Recent accomplishments in cell culture techniques provide a means for examining the contributions and secretory control of different endometrial cell populations. Furthermore, it is possible to recombine specific cell types to study their interaction. It is clear that the luminal epithelium, glandular epithelium and endometrial stroma produce different secretory products. Some secretions (for example uteroferrin) are secreted by only one cell type; others (for example prostaglandins, PGs) are secreted by all types of cell. There is much to be learned about the functions and regulations of endometrial secretions and there are important aspects of the role of the endometrium in pregnancy that present concepts do not address. For example, there is no explanation for the required synchrony between the embryo and uterus before day 10 and the implications of control of the uterine environment by progesterone from day 4 to day 10 are not understood. Almost all of the uterine secretory proteins are produced after day 10. In this review, we consider the protein and prostaglandin products from the different cell populations of the pig endometrium and propose a model to explain the integration of multiple sources of PGs and multiple regulators of PG secretion. Our purpose is to facilitate a more complete understanding of the individual uterine cell populations and a better understanding of how these cell types interact to function as a complete unit.
MeSH term(s)	Animals ; Cells, Cultured ; Endometrium/cytology ; Endometrium/secretion ; Female ; Pregnancy ; Pregnancy, Animal/physiology ; Prostaglandins/secretion ; Proteins/secretion ; Swine/physiology ; Uterus/secretion
Chemical Substances	Prostaglandins ; Proteins
Language	English
Publishing date	1993
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ISSN	0449-3087
ISSN	0449-3087
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Article: Threshold analysis of selected dose-response data for endocrine active chemicals.

Blair, R M / Fang, H / Gaylor, D / Sheehan, D M

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2000 Volume 109, Issue 3, Page(s) 198–208

Abstract: Using a biologically relevant mathematical model, the Michaelis-Menten equation, we examined published data from endocrine active chemicals for evidence of no-threshold dose-response curves. Data were fit to a modified Michaelis-Menten equation which ... ...

Abstract	Using a biologically relevant mathematical model, the Michaelis-Menten equation, we examined published data from endocrine active chemicals for evidence of no-threshold dose-response curves. Data were fit to a modified Michaelis-Menten equation which accounted for total background response. Subsequently, the data sets were analyzed using non-linear regression in order to estimate the four parameters of interest (non-hormone controlled background (Bnh), maximum response (Rmax), endogenous hormone level (D0), and the dose at which a half-maximal response was observed (ED50)) and to determine the fit to the fully modified Michaelis-Menten equation. Subsequently, response data were adjusted to account for Bnh and then normalized to Rmax, while dose data were adjusted to account for D0 and then normalized to the ED50. This data set was combined into a single, composite data set and fit to the fully modified Michaelis-Menten equation. We examined 31 data sets (24 endpoints) from studies on 9 different chemical/hormone treatments. Twenty-six of the data sets fit the modified Michaelis-Menten equation with high multiple correlation coefficients (r>0.90). The normalized data demonstrated a good fit to the modified Michaelis-Menten equation. These results indicate that a variety of biological responses fit the modified Michaelis-Menten equation, which does not have a threshold dose term.
MeSH term(s)	Dose-Response Relationship, Drug ; Endocrine System/drug effects ; Endocrine System/metabolism ; Female ; Hormones/metabolism ; Humans ; Male ; Mathematical Computing ; Models, Chemical
Chemical Substances	Hormones
Language	English
Publishing date	2000-11-16
Publishing country	Denmark
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	93340-5
ISSN	1600-0463 ; 0903-4641
ISSN (online)	1600-0463
ISSN	0903-4641
DOI	10.1034/j.1600-0463.2001.090303.x
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Article: The role of lipoxygenase products of arachidonic acid metabolism in bovine corpus luteum function

Hansel, W. / Blair, R.M.

Reproduction in Domestic Animals (Germany)

1996

Institution	Louisiana State Univ., Baton Rouge (USA). Pennington Biomedical Research Center
Keywords	Ovarium ; Brunstzyklus ; Zelle ; Metabolismus ; Prostaglandin ; Kuh ; Lipoxygenase ; Progesteron ; Arachidonsaeure ; Oxytocin
Language	English
Edition	v. 31(3)
Document type	Article
ISSN	0936-6768
Database	ELFIS - Nutrition, agriculture and forestry information system

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Article: Growth and nonstructural carbohydrate content of southern browse species as influenced by light intensity

Blair, R.M

Journal of range management. Nov 1982. v. 35 (6)

1982

Title variant	Growth and nonstructural carbohydrate content of southern browse species as influenced by light intensity [Cornus florida, Ilex vomitoria, Lonicera japonica, nutrient quality].
Keywords	Cornus florida ; Ilex vomitoria ; Lonicera japonica
Language	English
Dates of publication	1982-11
Size	p. 756-760.
Document type	Article
ZDB-ID	410509-6
ISSN	0022-409X
ISSN	0022-409X
Database	NAL-Catalogue (AGRICOLA)

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Article: Electronic animal identification for controlling feed delivery and detecting estrus in gilts and sows in outside pens.

Blair, R M / Nichols, D A / Davis, D L

Journal of animal science

1994 Volume 72, Issue 4, Page(s) 891–898

Abstract: The objective of the present study was to evaluate the feasibility of delivering feed and detecting estrous behavior by computer-controlled equipment in a nonconfinement environment. In Exp. 1, gilts were assigned to treatment when detected pregnant by ... ...

Abstract	The objective of the present study was to evaluate the feasibility of delivering feed and detecting estrous behavior by computer-controlled equipment in a nonconfinement environment. In Exp. 1, gilts were assigned to treatment when detected pregnant by ultrasound at 30 to 35 d after artificial insemination. They were assigned to be fed individually in stalls once/day (0830) with a scoop (controls, n = 20) or with an electronic sow feeding station (ESF, n = 20). The ESF gilts received their feed in 98.6-g aliquots at 80-s intervals as they visited the feeding station. Control vs ESF gilts did not differ (P > .8) for backfat (2.2 vs 2.1 cm) or weight (170 vs 172 kg) before farrowing, total and live pigs/litter (9.3 and 8.7 vs 9.1 and 8.8), or litter birth weight (12.7 vs 12.1). In Exp. 2, proceptive behavior, as measured by visits to a boar's pen, were recorded electronically, and observed estrus was evaluated in two groups of sows during their first (n = 11) and second and third (n = 19) estrous cycles and in one group of gilts (n = 14). A partition prevented visual and physical contact between the boar and the visiting females except where the electronic estrus detection (EED) station was installed. Feed delivery software was used to monitor boar visitation even though no feed delivery equipment was present at the boar pen.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH term(s)	Animal Feed ; Animal Husbandry/methods ; Animal Identification Systems/veterinary ; Animals ; Eating ; Estrus Detection ; Female ; Housing, Animal ; Pregnancy ; Software ; Swine/physiology
Language	English
Publishing date	1994-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.2527/1994.724891x
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