Article: Induction of humoral responses to BHV-1 glycoprotein D expressed by HSV-1 amplicon vectors
Journal of Veterinary Science
(Mar 2012) Volume v. 13, Issue (1), Page(s) p. 59–65
Abstract: Herpes simplex virus type-1 (HSV-1) amplicon vectors are versatile and useful tools for transferring genes into cells that are capable of stimulating a specific immune response to their expressed antigens. In this work, two HSV-1-derived amplicon vectors ...
| Abstract | Herpes simplex virus type-1 (HSV-1) amplicon vectors are versatile and useful tools for transferring genes into cells that are capable of stimulating a specific immune response to their expressed antigens. In this work, two HSV-1-derived amplicon vectors were generated. One of these expressed the full-length glycoprotein D (gD) of bovine herpesvirus 1 while the second expressed the truncated form of gD (gDtr) which lacked the trans-membrane region. After evaluating gD expression in the infected cells, the ability of both vectors to induce a specific gD immune response was tested in BALB/c mice that were intramuscularly immunized. Specific serum antibody responses were detected in mice inoculated with both vectors, and the response against truncated gD was higher than the response against full-length gD. These results reinforce previous findings that HSV-1 amplicon vectors can potentially deliver antigens to animals and highlight the prospective use of these vectors for treating infectious bovine rhinotracheitis disease. |
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| Keywords | IMMUNISATION ; IMMUNIZATION ; INMUNIZACION |
| Language | English |
| Document type | Article |
| ISSN | 1229-845X |
| Database | AGRIS - International Information System for the Agricultural Sciences and Technology |
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