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Article ; Online: Pneumothorax Incidence with Normal Saline Instillation for Sealing the Needle Track After Computed Tomography-Guided Percutaneous Lung Biopsy.

Bourgeais, Geoffrey / Frampas, Eric / Liberge, Renan / Nicolas, Aymeric / Defrance, Claire / Blanc, François-Xavier / Coudol, Sandrine / Morla, Olivier

Cardiovascular and interventional radiology

2024

Abstract: Purpose: To determine whether instillation of normal saline solution for sealing the needle track reduces incidence of pneumothorax and chest tube placement after computed tomography-guided percutaneous lung biopsy.: Materials and methods: A total of ...

Abstract	Purpose: To determine whether instillation of normal saline solution for sealing the needle track reduces incidence of pneumothorax and chest tube placement after computed tomography-guided percutaneous lung biopsy. Materials and methods: A total of 242 computed tomography-guided percutaneous lung biopsies performed at a single institution were retrospectively reviewed, including 93 biopsies in which the needle track was sealed by instillation of 3-5 ml of normal saline solution during needle withdrawal (water seal group) and 149 biopsies without sealing (control group). Patient and lesion characteristics, procedure-specific variables, pneumothorax and chest tube placement rates were recorded. Results: Baseline characteristics were comparable in both groups. There was a statistically significant decrease in the pneumothorax rate (19.4% [18/93] vs. 40.9% [61/149]; p < 0.001) and a numerically lower chest tube placement rate without significant reduction (4.3% [4/93] vs. 10.7% [16/149]; p = 0.126) with using normal saline instillation for sealing the needle track versus not using sealant material. Using a multiple logistic regression analysis, using normal saline instillation to seal the needle track, having a senior radiologist as operator of the procedure and putting patients in prone position were significantly associated with a decreased risk of pneumothorax. The presence of emphysema along the needle track was significantly associated with an increased risk of pneumothorax. No complication was observed due to normal saline injection. Conclusion: Normal saline solution instillation for sealing the needle track after computed tomography-guided percutaneous lung biopsy is a simple, low-cost and safe technique resulted in significantly decreased pneumothorax occurrence and a numerically lower chest tube placement rate, and might help to reduce both hospitalization risks and costs for the healthcare system. Level of evidence 3 Non-controlled retrospective cohort study.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-023-03648-y
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Article: Comment on: Effects of time of initiation of antiretroviral therapy in the treatment of patients with HIV/TB co-infection, by Chelkeba L. et al.

Blanc, François-Xavier / Laureillard, Didier / Goldfeld, Anne E

Annals of medicine and surgery (2012)

2020 Volume 57, Page(s) 22–23

Language	English
Publishing date	2020-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2020.06.039
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Article ; Online: Bronchial smooth muscle cell in asthma: where does it fit?

Hassoun, Dorian / Rose, Lindsay / Blanc, François-Xavier / Magnan, Antoine / Loirand, Gervaise / Sauzeau, Vincent

BMJ open respiratory research

2022 Volume 9, Issue 1

Abstract: Asthma is a frequent respiratory condition whose pathophysiology relies on altered interactions between bronchial epithelium, smooth muscle cells (SMC) and immune responses. Those leads to classical hallmarks of asthma: airway hyper-responsiveness, ... ...

Abstract	Asthma is a frequent respiratory condition whose pathophysiology relies on altered interactions between bronchial epithelium, smooth muscle cells (SMC) and immune responses. Those leads to classical hallmarks of asthma: airway hyper-responsiveness, bronchial remodelling and chronic inflammation. Airway smooth muscle biology and pathophysiological implication in asthma are now better understood. Precise deciphering of intracellular signalling pathways regulating smooth muscle contraction highlighted the critical roles played by small GTPases of Rho superfamily. Beyond contractile considerations, active involvement of airway smooth muscle in bronchial remodelling mechanisms is now established. Not only cytokines and growth factors, such as fibroblats growth factor or transforming growth factor-β, but also extracellular matrix composition have been demonstrated as potent phenotype modifiers for airway SMC. Although basic science knowledge has grown significantly, little of it has translated into improvement in asthma clinical practice. Evaluation of airway smooth muscle function is still limited to its contractile activity. Moreover, it relies on tools, such as spirometry, that give only an overall assessment and not a specific one. Interesting technics such as forced oscillometry or specific imagery (CT and MRI) give new perspectives to evaluate other aspects of airway muscle such as bronchial remodelling. Finally, except for the refinement of conventional bronchodilators, no new drug therapy directly targeting airway smooth muscle proved its efficacy. Bronchial thermoplasty is an innovative and efficient therapeutic strategy but is only restricted to a small proportion of severe asthmatic patients. New diagnostic and therapeutic strategies specifically oriented toward airway smooth muscle are needed to improve global asthma care.
MeSH term(s)	Asthma/drug therapy ; Bronchodilator Agents ; Cytokines/metabolism ; Cytokines/therapeutic use ; Humans ; Monomeric GTP-Binding Proteins/metabolism ; Monomeric GTP-Binding Proteins/therapeutic use ; Myocytes, Smooth Muscle/metabolism ; Transforming Growth Factors/metabolism ; Transforming Growth Factors/therapeutic use
Chemical Substances	Bronchodilator Agents ; Cytokines ; Transforming Growth Factors (76057-06-2) ; Monomeric GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2022-09-13
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2022-001351
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Article ; Online: Contribution of Transcutaneous P

Georges, Thomas / Jaffré, Sandrine / Morin, Jean / Delbove, Agathe / Guyomarch, Béatrice / Alami, Hakim / Bretonnière, Cédric / Blanc, François-Xavier

Respiratory care

2023

Abstract: Background: More and more patients have obesity-hypoventilation syndrome (OHS) because of the increasing prevalence of obesity. The accuracy of transcutaneous P: Methods: A prospective monocentric pilot study was conducted from August 2018 to ... ...

Abstract	Background: More and more patients have obesity-hypoventilation syndrome (OHS) because of the increasing prevalence of obesity. The accuracy of transcutaneous P Methods: A prospective monocentric pilot study was conducted from August 2018 to November 2019. Patients with stable OHS and who were treated with home noninvasive ventilation for at least 6 months were eligible to participate. After oral consent, we performed both diurnal arterial blood gases and combined home oximetry and capnography. The primary end point was the presence of residual nocturnal hypoventilation, defined as P Results: A total of 32 subjects were included. Twenty-nine subjects with nocturnal P Conclusions: The assessment of P
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.10816
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Article: Does PaCO

Thomas, Audrey / Jaffré, Sandrine / Guardiolle, Vianney / Perennec, Tanguy / Gagnadoux, Frédéric / Goupil, François / Bretonnière, Cédric / Danielo, Vivien / Morin, Jean / Blanc, François-Xavier

Heliyon

2024 Volume 10, Issue 4, Page(s) e26437

Abstract: Background and objective: Non-invasive ventilation (NIV) improves survival of patients with chronic respiratory failure (CRF). Most often, pressure settings are made to normalize arterial blood gases. However, this objective is not always achieved due ... ...

Abstract	Background and objective: Non-invasive ventilation (NIV) improves survival of patients with chronic respiratory failure (CRF). Most often, pressure settings are made to normalize arterial blood gases. However, this objective is not always achieved due to intolerance to increased pressure or poor compliance. Few studies have assessed the effect of persistent hypercapnia on ventilated patients' survival. Data from the Pays de la Loire Respiratory Health Research Institute cohort were analyzed to answer this question. Study design and methods: NIV-treated adults enrolled between 2009 and 2019 were divided into 5 subgroups: obesity-hypoventilation syndrome (OHS), COPD, obese COPD, neuromuscular disease (NMD) and chest wall disease (CWD). PaCO Results: Data from 431 patients were analyzed. Median survival was 103 months and 148 patients died. Overall, PaCO Conclusion: Moderate residual hypercapnia under NIV does not negatively impact survival in CRF patients. In individuals with poor tolerance of pressure increases, residual hypercapnia can therefore be tolerated under long-term NIV. Larger studies, especially with a higher number of patients with residual PaCO
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26437
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Article ; Online: High performance of systematic combined urine LAM test and sputum Xpert MTB/RIF® for tuberculosis screening in severely immunosuppressed ambulatory adults with HIV.

Bonnet, Maryline / Gabillard, Delphine / Domoua, Serge / Muzoora, Conrad / Messou, Eugène / Sovannarith, Samreth / Nguyen, Duc Bang / Badje, Anani / Juchet, Sylvain / Bunnet, Dim / Borand, Laurence / Natukunda, Naome / Tran, Thị Hong / Anglaret, Xavier / Laureillard, Didier / Blanc, François-Xavier

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023

Abstract: Background: In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal. We assessed the performance of different tuberculosis screening approaches in severely ... ...

Abstract	Background: In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal. We assessed the performance of different tuberculosis screening approaches in severely immunosuppressed PWH enrolled in the guided-treatment group of the STATIS trial (NCT02057796). Methods: Ambulatory PWH with no overt evidence of tuberculosis and CD4 cell count <100/µL were screened for tuberculosis prior to antiretroviral therapy (ART) initiation with W4SS, chest X-ray, urine lipoarabinomannan (LAM) test and sputum Xpert MTB/RIF® (Xpert). Correctly and wrongly identified cases by screening approaches were assessed overall and by CD4 count threshold (≤50 and 51-99 cells/µL). Results: Of 525 enrolled participants (median CD4 cell count: 28/µL), 48 (9.9%) were diagnosed with tuberculosis at enrollment. Among participants with a negative W4SS, 16% had either a positive Xpert, a chest X-ray suggestive of tuberculosis or a positive urine LAM test. The combination of sputum Xpert and urine LAM test was associated with the highest proportion of participants correctly identified as tuberculosis (95.8%) and non-tuberculosis cases (95.4%), with proportions equally high among participants with CD4 counts above or below 50 cells/µL. Restricting the use of sputum Xpert, urine LAM test or chest X-ray to participants with a positive W4SS reduced the proportion of wrongly and correctly identified cases. Conclusions: There is a clear benefit to perform both sputum Xpert and urine LAM tests as tuberculosis screening in all severely immunosuppressed PWH prior to ART initiation, and not only in those with a positive W4SS. Clinical trials registration: NCT02057796.
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad125
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Immune alveolitis in interstitial lung disease: an attractive cytological profile in immunocompromised patients.

Moui, Antoine / Dirou, Stéphanie / Sagan, Christine / Liberge, Renan / Defrance, Claire / Arrigoni, Pierre-Paul / Morla, Olivier / Kandel-Aznar, Christine / Cellerin, Laurent / Cavailles, Arnaud / Eschapasse, Emmanuel / Morio, Florent / Gourraud, Pierre-Antoine / Goronflot, Thomas / Tissot, Adrien / Blanc, François-Xavier

BMC pulmonary medicine

2022 Volume 22, Issue 1, Page(s) 79

Abstract: Background: Bronchoalveolar lavage (BAL) is a major diagnostic tool in interstitial lung disease (ILD). Its use remains largely quantitative, usually focused on cell differential ratio. However, cellular morphological features provide additional ... ...

Abstract	Background: Bronchoalveolar lavage (BAL) is a major diagnostic tool in interstitial lung disease (ILD). Its use remains largely quantitative, usually focused on cell differential ratio. However, cellular morphological features provide additional valuable information. The significance of the "immune alveolitis" cytological profile, characterized by lymphocytic alveolitis with activated lymphocytes and macrophages in epithelioid transformation or foamy macrophages desquamating in cohesive clusters with lymphocytes, remains unknown in ILD. Our objective was to describe patients' characteristics and diagnoses associated with an immune alveolitis profile in undiagnosed ILD. Methods: We performed a monocentric retrospective observational study. Eligible patients were adults undergoing diagnostic exploration for ILD and whose BAL fluid displayed an immune alveolitis profile. For each patient, we collected clinical, radiological and biological findings as well as the final etiology of ILD. Results: Between January 2012 and December 2018, 249 patients were included. Mean age was 57 ± 16 years, 140 patients (56%) were men, and 65% of patients were immunocompromised. The main etiological diagnosis was Pneumocystis pneumonia (PCP) (24%), followed by drug-induced lung disease (DILD) (20%), viral pneumonia (14%) and hypersensitivity pneumonitis (HP) (10%). All PCP were diagnosed in immunocompromised patients while HP was found in only 8% of this subgroup. DILD and viral pneumonia were also commonly diagnosed in immunocompromised patients (94% and 80%, respectively). Conclusion: Our study highlights the additional value of BAL qualitative description in ILD. We suggest incorporating the immune alveolitis profile for the diagnosis and management of ILD, especially in immunocompromised patients, since it guides towards specific diagnoses.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Immunocompromised Host ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/immunology ; Lung Diseases, Interstitial/pathology ; Male ; Middle Aged ; Pulmonary Alveoli/pathology ; Retrospective Studies
Language	English
Publishing date	2022-03-05
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-022-01871-w
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Article ; Online: Evaluation of the Post-COVID-19 Functional Status (PCFS) Scale in a cohort of patients recovering from hypoxemic SARS-CoV-2 pneumonia.

Benkalfate, Naïla / Eschapasse, Emmanuel / Georges, Thomas / Leblanc, Camille / Dirou, Stephanie / Melscoet, Lise / Chéné, Anne-Laure / Horeau-Langlard, Delphine / Bry, Charlotte / Chambellan, Arnaud / Nicolas, Aymeric / Claire, Defrance / Liberge, Renan / Karakachoff, Matilde / Hardouin, Jean-Benoit / Blanc, François-Xavier / Lemarchand, Patricia

BMJ open respiratory research

2022 Volume 9, Issue 1

Abstract: Introduction: COVID-19 sequelae are numerous and multisystemic, and how to evaluate those symptomatic patients is a timely issue. Klok : Methods: PCFS Scale was evaluated in 121 patients together with quality of life and dyspnoea questionnaires, ... ...

Abstract	Introduction: COVID-19 sequelae are numerous and multisystemic, and how to evaluate those symptomatic patients is a timely issue. Klok Methods: PCFS Scale was evaluated in 121 patients together with quality of life and dyspnoea questionnaires, pulmonary function tests and CT scans. Results: We observed a high correlation with multiple questionnaires (Short Form-36, Hospital Anxiety and Depression Scale, modified Medical Research Council, end Borg Six-Minute Walk Test), making the PCFS Scale a quick and global tool to evaluate functional limitations related to various persistent symptoms following COVID-19 pneumonia. Discussion: The PCFS Scale seems to be a suitable instrument to screen for patients who will require careful follow-up after COVID-19 hypoxemic pneumonia even in the absence of pulmonary sequelae.
MeSH term(s)	COVID-19/complications ; Functional Status ; Humans ; Pneumonia/diagnosis ; Quality of Life ; SARS-CoV-2
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2021-001136
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Article ; Online: Incidence and risk factors of anastomotic complications after lung transplantation.

Delbove, Agathe / Senage, Thomas / Gazengel, Pierre / Tissot, Adrien / Lacoste, Philippe / Cellerin, Laurent / Perigaud, Christian / Danner-Boucher, Isabelle / Cavailles, Arnaud / Lepoivre, Thierry / Mugniot, Antoine / Nicolet, Johanna / Horeau-Langlard, Delphine / Groleau, Nicolas / Fedun, Yannick / Rozec, Bertrand / Magnan, Antoine / Roussel, Jean-Christian / Blanc, François-Xavier

Therapeutic advances in respiratory disease

2022 Volume 16, Page(s) 17534666221110354

Abstract: Background: Anastomotic complications are common after lung transplantation (1.4-33% of cases) and still associated with a high morbi-mortality.: Methods: The current study is a monocenter retrospective analysis of symptomatic anastomotic ... ...

Abstract	Background: Anastomotic complications are common after lung transplantation (1.4-33% of cases) and still associated with a high morbi-mortality. Methods: The current study is a monocenter retrospective analysis of symptomatic anastomotic complications (SAC) occurring after lung transplantation between 2010 and 2016, using the macroscopic, diameter, and suture (M-D-S) classification from consensus of French experts in bronchoscopy. The objectives were to determine incidence from surgery, risk factors, and impact of survival of SAC. We defined SAC as M-D-S abnormalities (stenosis ⩾ 50% or dehiscence) requiring bronchoscopic or surgical interventions. Results: A total of 121 patients were included. SAC occurred in 26.5% of patients ( Discussion: SAC occurred in 26.5% of patients. Donor lung infection was the only alterable identified factors. The increase rate of SAC in older patients above 50 years of age encourages in regular endoscopic monitoring.
MeSH term(s)	Aged ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Bronchi/surgery ; Bronchial Diseases ; Bronchoscopy/adverse effects ; Bronchoscopy/methods ; Constriction, Pathologic ; Humans ; Incidence ; Lung Transplantation/adverse effects ; Lung Transplantation/methods ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors ; Stents/adverse effects
Language	English
Publishing date	2022-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2476459-0
ISSN	1753-4666 ; 1753-4658
ISSN (online)	1753-4666
ISSN	1753-4658
DOI	10.1177/17534666221110354
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Article ; Online: COVID-19 Hampered Diagnosis of TB Infection in France, Italy, Spain and the United Kingdom.

García-García, José-María / Blanc, François-Xavier / Buonsenso, Danilo / Centis, Rosella / Codecasa, Luigi Ruffo / D'Ambrosio, Lia / Goletti, Delia / Gualano, Gina / Kunst, Heinke / Pontali, Emanuele / Tadolini, Marina / Tiberi, Simon / Ong, Catherine W M / Sotgiu, Giovanni / Migliori, Giovanni Battista

Archivos de bronconeumologia

2022 Volume 58, Issue 11, Page(s) 783–785

MeSH term(s)	Humans ; Spain/epidemiology ; COVID-19 ; Italy/epidemiology ; France/epidemiology ; United Kingdom ; Germany
Language	Spanish
Publishing date	2022-08-13
Publishing country	Spain
Document type	Case Reports
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2022.07.013
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