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  1. Article ; Online: Exploring the role of ribosomal RNA modifications in cancer.

    López, Judith / Blanco, Sandra

    Current opinion in genetics & development

    2024  Volume 86, Page(s) 102204

    Abstract: Recent advances have highlighted the significant roles of post-transcriptional modifications in rRNA in various cancers. Evidence suggests that dysregulation of rRNA modifications acts as a common denominator in cancer development, with alterations in ... ...

    Abstract Recent advances have highlighted the significant roles of post-transcriptional modifications in rRNA in various cancers. Evidence suggests that dysregulation of rRNA modifications acts as a common denominator in cancer development, with alterations in these modifications conferring competitive advantages to cancer cells. Specifically, rRNA modifications modulate protein synthesis and favor the specialized translation of oncogenic programs, thereby contributing to the formation of a protumorigenic proteome in cancer cells. These findings reveal a novel regulatory layer mediated by changes in the deposition of rRNA chemical modifications. Moreover, inhibition of these modifications in vitro and in preclinical studies demonstrates potential therapeutic applications. The recurrence of altered rRNA modification patterns across different types of cancer underscores their importance in cancer progression, proposing them as potential biomarkers and novel therapeutic targets. This review will highlight the latest insights into how post-transcriptional rRNA modifications contribute to cancer progression and summarize the main developments and ongoing challenges in this research area.
    Language English
    Publishing date 2024-05-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2024.102204
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: A therapy PUSh for GBM.

    Morón-Calvente, Virginia / Blanco, Sandra

    Nature cancer

    2021  Volume 2, Issue 9, Page(s) 876–878

    MeSH term(s) Brain Neoplasms/diagnosis ; Glioblastoma/therapy ; Humans
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-021-00255-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues.

    Añazco-Guenkova, Ana M / Miguel-López, Borja / Monteagudo-García, Óscar / García-Vílchez, Raquel / Blanco, Sandra

    NAR cancer

    2024  Volume 6, Issue 1, Page(s) zcae012

    Abstract: Recent advancements have illuminated the critical role of RNA modifications in post-transcriptional regulation, shaping the landscape of gene expression. This review explores how tRNA modifications emerge as critical players, fine-tuning functionalities ... ...

    Abstract Recent advancements have illuminated the critical role of RNA modifications in post-transcriptional regulation, shaping the landscape of gene expression. This review explores how tRNA modifications emerge as critical players, fine-tuning functionalities that not only maintain the fidelity of protein synthesis but also dictate gene expression and translation profiles. Highlighting their dysregulation as a common denominator in various cancers, we systematically investigate the intersection of both cytosolic and mitochondrial tRNA modifications with cancer biology. These modifications impact key processes such as cell proliferation, tumorigenesis, migration, metastasis, bioenergetics and the modulation of the tumor immune microenvironment. The recurrence of altered tRNA modification patterns across different cancer types underscores their significance in cancer development, proposing them as potential biomarkers and as actionable targets to disrupt tumorigenic processes, offering new avenues for precision medicine in the battle against cancer.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ISSN 2632-8674
    ISSN (online) 2632-8674
    DOI 10.1093/narcan/zcae012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of m

    Nombela, Paz / Miguel-López, Borja / Blanco, Sandra

    Molecular cancer

    2021  Volume 20, Issue 1, Page(s) 18

    Abstract: RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA ... ...

    Abstract RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA processing and function, which in turn thoroughly shape distinct gene expression programmes. They affect diverse biological processes, and the correct deposition of many of these modifications is required for normal development. Alterations of their deposition are implicated in several diseases, including cancer. In this Review, we focus on the occurrence of N
    MeSH term(s) 5-Methylcytosine/metabolism ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Pseudouridine/metabolism ; RNA/metabolism ; RNA Processing, Post-Transcriptional/genetics
    Chemical Substances Pseudouridine (1445-07-4) ; RNA (63231-63-0) ; 5-Methylcytosine (6R795CQT4H) ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1476-4598
    ISSN (online) 1476-4598
    DOI 10.1186/s12943-020-01263-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Epigenetic and Epitranscriptomic Control in Prostate Cancer

    López, Judith / Añazco-Guenkova, Ana M. / Monteagudo-García, Óscar / Blanco, Sandra

    Genes. 2022 Feb. 18, v. 13, no. 2

    2022  

    Abstract: The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly ... ...

    Abstract The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer.
    Keywords DNA ; RNA ; androgen receptors ; carcinogenesis ; epigenetics ; genes ; prostatic neoplasms
    Language English
    Dates of publication 2022-0218
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020378
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer

    Rosace, Domenico / López, Judith / Blanco, Sandra

    RNA biology. 2020 Aug. 02, v. 17, no. 8

    2020  

    Abstract: The term small non-coding RNAs (ncRNAs) refers to all those RNAs that even without encoding for a protein, can play important functional roles. Transfer RNA and ribosomal RNA-derived fragments (tRFs and rRFs, respectively) are an emerging class of ncRNAs ...

    Abstract The term small non-coding RNAs (ncRNAs) refers to all those RNAs that even without encoding for a protein, can play important functional roles. Transfer RNA and ribosomal RNA-derived fragments (tRFs and rRFs, respectively) are an emerging class of ncRNAs originally considered as simple degradation products, which though play important roles in stress responses, signalling, or gene expression. They control all levels of gene expression regulating transcription and translation and affecting RNA processing and maturation. They have been linked to pivotal cellular processes such as self-renewal, differentiation, and proliferation. For this reason, mis-regulation of this novel class of ncRNAs can lead to various pathological processes such as neurodegenerative and development diseases, metabolism and immune system disorders, and cancer. In this review, we summarise the classification, biogenesis, and functions of tRFs and rRFs with a special focus on their role in immunity and cancer.
    Keywords biogenesis ; gene expression ; immune system ; immunity ; metabolism ; transfer RNA
    Language English
    Dates of publication 2020-0802
    Size p. 1196-1213.
    Publishing place Taylor & Francis
    Document type Article
    ISSN 1555-8584
    DOI 10.1080/15476286.2020.1737442
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer.

    Rosace, Domenico / López, Judith / Blanco, Sandra

    RNA biology

    2020  Volume 17, Issue 8, Page(s) 1196–1213

    Abstract: The term small non-coding RNAs (ncRNAs) refers to all those RNAs that even without encoding for a protein, can play important functional roles. Transfer RNA and ribosomal RNA-derived fragments (tRFs and rRFs, respectively) are an emerging class of ncRNAs ...

    Abstract The term small non-coding RNAs (ncRNAs) refers to all those RNAs that even without encoding for a protein, can play important functional roles. Transfer RNA and ribosomal RNA-derived fragments (tRFs and rRFs, respectively) are an emerging class of ncRNAs originally considered as simple degradation products, which though play important roles in stress responses, signalling, or gene expression. They control all levels of gene expression regulating transcription and translation and affecting RNA processing and maturation. They have been linked to pivotal cellular processes such as self-renewal, differentiation, and proliferation. For this reason, mis-regulation of this novel class of ncRNAs can lead to various pathological processes such as neurodegenerative and development diseases, metabolism and immune system disorders, and cancer. In this review, we summarise the classification, biogenesis, and functions of tRFs and rRFs with a special focus on their role in immunity and cancer.
    MeSH term(s) Disease Progression ; Gene Expression Regulation ; Humans ; Immunity/genetics ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; RNA Cleavage ; RNA Processing, Post-Transcriptional ; RNA, Small Untranslated/genetics ; RNA, Transfer/genetics
    Chemical Substances RNA, Small Untranslated ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1555-8584
    ISSN (online) 1555-8584
    DOI 10.1080/15476286.2020.1737442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Glia Crosstalk in Neuroinflammatory Diseases.

    Bernaus, Ada / Blanco, Sandra / Sevilla, Ana

    Frontiers in cellular neuroscience

    2020  Volume 14, Page(s) 209

    Abstract: Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain homeostasis. Glial cells play a central role in orchestrating these neuroinflammation processes in both deleterious and beneficial ways. These cellular responses ... ...

    Abstract Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain homeostasis. Glial cells play a central role in orchestrating these neuroinflammation processes in both deleterious and beneficial ways. These cellular responses depend on their intercellular interactions with neurons, astrocytes, the blood-brain barrier (BBB), and infiltrated T cells in the central nervous system (CNS). However, this intercellular crosstalk seems to be activated by specific stimuli for each different neurological scenario. This review summarizes key studies linking neuroinflammation with certain neurodegenerative diseases such as Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) and for the development of better therapeutic strategies based on immunomodulation.
    Language English
    Publishing date 2020-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2020.00209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Epigenetic and Epitranscriptomic Control in Prostate Cancer.

    López, Judith / Añazco-Guenkova, Ana M / Monteagudo-García, Óscar / Blanco, Sandra

    Genes

    2022  Volume 13, Issue 2

    Abstract: The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly ... ...

    Abstract The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer.
    MeSH term(s) Carcinogenesis/genetics ; Epigenesis, Genetic ; Epigenomics ; Humans ; Male ; Prostatic Neoplasms/genetics ; RNA/genetics
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Global and single-nucleotide resolution detection of 7-methylguanosine in RNA.

    D'Ambrosi, Silvia / García-Vílchez, Raquel / Kedra, Darek / Vitali, Patrice / Macias-Cámara, Nuria / Bárcena, Laura / Gonzalez-Lopez, Monika / Aransay, Ana M / Dietmann, Sabine / Hurtado, Antonio / Blanco, Sandra

    RNA biology

    2024  Volume 21, Issue 1, Page(s) 1–18

    Abstract: RNA modifications, ... ...

    Abstract RNA modifications, including
    MeSH term(s) Humans ; RNA/chemistry ; Nucleotides/metabolism ; Methylation ; Methyltransferases/genetics ; RNA Processing, Post-Transcriptional ; Guanosine/analogs & derivatives
    Chemical Substances RNA (63231-63-0) ; 7-methylguanosine (2140-77-4) ; Nucleotides ; Methyltransferases (EC 2.1.1.-) ; Guanosine (12133JR80S)
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2159587-2
    ISSN 1555-8584 ; 1555-8584
    ISSN (online) 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2024.2337493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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