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Article ; Online: Haemovigilance survey and screening strategy for arthropod-borne viruses in blood donors from Argentina.

Blanco, Sebastián / Marín, Ángeles Lorena / Frutos, María Celia / Barahona, Nubia Yandar / Rivarola, María Elisa / Carrizo, Luis Horacio / Spinsanti, Lorena / Gallego, Sandra Verónica

Journal of medical virology

2024 Volume 96, Issue 2, Page(s) e29476

Abstract: Arthropod-borne viruses (arboviruses) count among emerging infections, which represent a major challenge for transfusion safety worldwide. To assess the risk of arboviruses-transmission by transfusion (ATT), we performed a survey to evaluate the ... ...

Abstract	Arthropod-borne viruses (arboviruses) count among emerging infections, which represent a major challenge for transfusion safety worldwide. To assess the risk of arboviruses-transmission by transfusion (ATT), we performed a survey to evaluate the potential threat for transfusion safety. Samples were retrospectively and randomly collected from donors who donated during the peak of dengue incidence in Cordoba (years: 2016 and 2019-2022). A cost-efficient strategy for molecular screening was implemented with a nucleic acid test (NAT) configured with Flavivirus and Alphavirus-universal degenerated primers targeting conserved gene regions. Besides, we evaluated the neutralizing antibody (NAb) prevalence by plaque reduction neutralization test (PRNT). A total of 1438 samples were collected. Among the NAT-screened samples, one resulted positive for Flavivirus detection. Subsequent sequencing of the PCR product revealed Saint Louis Encephalitis Virus (SLEV) infection (GeneBank accession number OR236721). NAb prevalence was 2.95% for anti-Dengue, 9.94% anti-SLEV, 1.09% anti-West Nile Virus, and 0% anti-Chikungunya. One of the NAb-positive samples also resulted positive for IgM against SLEV but negative by ARN detection. This is the first haemovigilance study developed in Argentina that evaluates the potential risk of ATT and the first research to determine the prevalence of NAb against Flavivirus through PNRT to avoid possible cross-reactions between Ab against Flavivirus. Herein, the finding of one SLEV-viremic donor and the detection of anti-SLEV IgM in a different donor demonstrated a potential threat for transfusion safety and emphasized the need for increased vigilance and proactive measures to ensure the safety of blood supplies.
MeSH term(s)	Humans ; Arboviruses/genetics ; Blood Donors ; Argentina/epidemiology ; Retrospective Studies ; Flavivirus/genetics ; Encephalitis Virus, St. Louis/genetics ; Encephalitis, St. Louis ; Antibodies, Neutralizing ; Immunoglobulin M
Chemical Substances	Antibodies, Neutralizing ; Immunoglobulin M
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29476
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Article ; Online: Infection by human polyomaviruses JCPyV and BKPyV in blood donors of Argentina.

Frutos, María C / Blanco, Sebastián / Barahona, Nubia Yandar / Mangeaud, Arnaldo / Carrizo, Luis Horacio / Gallego, Sandra

Vox sanguinis

2023 Volume 118, Issue 8, Page(s) 695–699

Abstract: Background and objectives: A spectrum of blood-borne infectious agents may be transmitted through transfusion of blood components from asymptomatic donors. Despite the persistence of polyomaviruses in blood cells, no studies have been conducted in ... ...

Abstract	Background and objectives: A spectrum of blood-borne infectious agents may be transmitted through transfusion of blood components from asymptomatic donors. Despite the persistence of polyomaviruses in blood cells, no studies have been conducted in Argentina to assess the risk of transfusion infection. Materials and methods: We investigated BKPyV and JCPyV in 720 blood donors, using polymerase chain reaction (PCR) for a region of T antigen common to both viruses. Positive T-antigen samples were subjected to two additional PCR assays targeting the VP1 region. Viral genotypes were characterized by phylogenetic analysis. Results: Polyomaviruses were detected in 1.25% (9/720) of the blood samples selected; JCPyV was identified in 0.97% (7/720) and BKPyV in 0.28% (2/720) of them. Phylogenetic analysis showed that the JCPyV sequences clustered with 2A genotype and Ia of BKPyV. Conclusion: This study describes for the first time the prevalence of polyomavirus DNA in blood donors of Córdoba, Argentina. The polyomavirus DNAemia in healthy populations suggests that those viruses are present in blood components eligible for transfusion. Therefore, the epidemiological surveillance of polyomavirus in blood banks might be incorporated into haemovigilance programmes, to determine the infectious risk and implement newer interventions to ensure the safety of blood supplies, if required.
MeSH term(s)	Humans ; Polyomavirus/genetics ; JC Virus/genetics ; BK Virus/genetics ; Blood Donors ; Argentina/epidemiology ; Phylogeny ; Polyomavirus Infections/epidemiology
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	80313-3
ISSN	1423-0410 ; 0042-9007
ISSN (online)	1423-0410
ISSN	0042-9007
DOI	10.1111/vox.13485
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Article ; Online: Breakthrough infection by hepatitis B virus in a vaccinated blood donor: An emerging threat for transfusion safety in low-endemic countries?

Blanco, Sebastián / Castro, Gonzalo M / Sicilia, Paola E / Carrizo, Luis H / Gallego, Sandra V

Journal of medical virology

2023 Volume 96, Issue 2, Page(s) e29463

Abstract: We present the case of a breakthrough infection by hepatitis B virus (HBV), intending to warn about the challenge that HBV represents for transfusion safety. Virological markers for HBV infection were assayed during a blood donor screening by detection ... ...

Abstract	We present the case of a breakthrough infection by hepatitis B virus (HBV), intending to warn about the challenge that HBV represents for transfusion safety. Virological markers for HBV infection were assayed during a blood donor screening by detection of HBsAg, anti-HBc, and viral nucleic acid (HBV DNA) by a nucleic acid test (NAT). Additionally, samples were analyzed for detection of immunoglobulin M anti-HBc, HBeAg, anti-HBe, and anti-HBs. A first-time donor repeatedly tested positive for HBV DNA by NAT and nonreactive for HBV-serological markers of infection. He stated having completed the anti-HBV vaccination schedule; thus, study of anti-Hbs resulted in reactive at protective level (18 mIU/mL). The donor denied clinical symptoms of hepatitis and remained healthy during the follow-up period. 95 days postdonation, NAT was negative, seroconversion of anti-HBc ab was detected, and a significant increase in anti-HBs concentration was measured (>1000 mIU/mL). This is the first case of HBV-breakthrough infection reported in Argentina and to our knowledge, this potential threat to transfusion safety is novel in an HBV low-endemic region with high coverage of HBV vaccination. The occurrence of breakthrough infections challenges the current protocols for the identification of HBV-infected subjects, could be a source of silent HBV transmission.
MeSH term(s)	Male ; Humans ; Hepatitis B virus/genetics ; Breakthrough Infections ; Blood Donors ; DNA, Viral/genetics ; Hepatitis B Surface Antigens ; Hepatitis B Core Antigens ; Hepatitis B/diagnosis ; Hepatitis B/prevention & control ; Hepatitis B/epidemiology ; Hepatitis B Antibodies
Chemical Substances	DNA, Viral ; Hepatitis B Surface Antigens ; Hepatitis B Core Antigens ; Hepatitis B Antibodies
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29463
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Article ; Online: Human T-Lymphotropic virus type 1 infection in absence of tax gene: A challenge for molecular diagnosis.

Blanco, Sebastián / Frutos, María Celia / Balangero, Marcos César / Gallego, Sandra Verónica

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2021 Volume 90, Page(s) 104765

Abstract: This is the first report of HTLV-1 infection without detectable tax gene. Even though the tax gene of HTLV-1 presents high genetic stability, in the case presented here no sequence of tax was detected by three different and widely used molecular assays ... ...

Abstract	This is the first report of HTLV-1 infection without detectable tax gene. Even though the tax gene of HTLV-1 presents high genetic stability, in the case presented here no sequence of tax was detected by three different and widely used molecular assays targeting several sequences of the gene. Nevertheless, HTLV-1 pol and env genes and LTR region were properly detectable. Several PCRs targeting tax sequences have been developed and largely used for molecular diagnosis of HTLV infection since the tax gene of HTLV-1 is known to be well preserved and intolerant to changes or mutations. In the case reported here, molecular detection of the virus was challenging. HTLV prevalence is complex and in many regions remains unknown. The identification of HTLV-infected individuals is important to determine its actual prevalence and design strategies to reduce viral spread. The finding and communication of HTLV-1 defective-provirus strains is important and necessary to guide the selection of representative target sequences on HTLV genome to design molecular assays, highlighting that different sequences should be combined to ensure adequate diagnosis. The latter is especially relevant in cases when discordant results between serological and molecular assays. This report contributes to the knowledge of the overall molecular epidemiology of HTLV-1 and encourages the need of surveillance of HTLV-1 "missed tax gene profiles" and the evaluation of the impact of these defective viral variants on molecular diagnosis and human health.
MeSH term(s)	Adult ; Female ; Gene Products, tax/genetics ; Gene Products, tax/isolation & purification ; HTLV-I Infections/diagnosis ; Human T-lymphotropic virus 1/genetics ; Human T-lymphotropic virus 1/isolation & purification ; Humans
Chemical Substances	Gene Products, tax ; tax protein, Human T-lymphotrophic virus 1
Language	English
Publishing date	2021-02-09
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2021.104765
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Article: Human T-Lymphotropic virus type 1 infection in absence of tax gene: A challenge for molecular diagnosis

Blanco, Sebastián / Frutos, María Celia / Balangero, Marcos César / Gallego, Sandra Verónica

Infection, genetics, and evolution. 2021 June, v. 90

2021

Abstract	This is the first report of HTLV-1 infection without detectable tax gene. Even though the tax gene of HTLV-1 presents high genetic stability, in the case presented here no sequence of tax was detected by three different and widely used molecular assays targeting several sequences of the gene. Nevertheless, HTLV-1 pol and env genes and LTR region were properly detectable. Several PCRs targeting tax sequences have been developed and largely used for molecular diagnosis of HTLV infection since the tax gene of HTLV-1 is known to be well preserved and intolerant to changes or mutations. In the case reported here, molecular detection of the virus was challenging. HTLV prevalence is complex and in many regions remains unknown. The identification of HTLV-infected individuals is important to determine its actual prevalence and design strategies to reduce viral spread. The finding and communication of HTLV-1 defective-provirus strains is important and necessary to guide the selection of representative target sequences on HTLV genome to design molecular assays, highlighting that different sequences should be combined to ensure adequate diagnosis. The latter is especially relevant in cases when discordant results between serological and molecular assays. This report contributes to the knowledge of the overall molecular epidemiology of HTLV-1 and encourages the need of surveillance of HTLV-1 “missed tax gene profiles” and the evaluation of the impact of these defective viral variants on molecular diagnosis and human health.
Keywords	Primate T-lymphotropic virus 1 ; evolution ; genes ; genetic stability ; human health ; infection ; molecular epidemiology ; monitoring ; viruses
Language	English
Dates of publication	2021-06
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2021.104765
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Evaluating a Sigmoid Dark Energy Model to Explain the Hubble Tension

Torres-Arzayus, Sergio / Delgado-Correal, Camilo / Higuera-G., Mario-A. / Rueda-Blanco, Sebastian

2023

Abstract: In this study we analyze Type Ia supernovae (SNe Ia) data sourced from the Pantheon+ compilation to investigate late-time physics effects influencing the expansion history, $H(z)$, at redshifts $(z < 2)$. Our focus centers on a time-varying dark energy ( ... ...

Abstract	In this study we analyze Type Ia supernovae (SNe Ia) data sourced from the Pantheon+ compilation to investigate late-time physics effects influencing the expansion history, $H(z)$, at redshifts $(z < 2)$. Our focus centers on a time-varying dark energy (DE) model that introduces a rapid transition in the equation of state, at a specific redshift, $z_a$, from the baseline, $\Lambda = -1$, value to the present value, $w_0$, through the implementation of a sigmoid function. The constraints obtained for the DE sigmoid phenomenological parametrization have broad applicability for dynamic DE models that invoke late-time physics. Our analysis indicates that the sigmoid model provides a slightly better, though not statistically significant, fit to the SNe Pantheon+ data compared to the standard LCDM alone. The fit results, assuming a flat geometry and maintaining $\Omega_m$ constant at the 2018-Planck value of $0.3153$, are as follows: $H_0 = 73.3^{+0.2}_{-0.6}$ km s$^{-1}$ Mpc$^{-1}$, $w_{0} = -0.95^{+0.15}_{-0.02}$, $z_a = 0.8 \pm 0.46$. The errors represent statistical uncertainties only. The available SN dataset lacks sufficient statistical power to distinguish between the baseline LCDM and the alternative sigmoid models. A feature of interest offered by the sigmoid model is that it identifies a specific redshift, $z_a = 0.8$, where a potential transition in the equation of state could have occurred. The sigmoid model does not favor a DE in the phantom region ($w_0 < -1$). Further constraints to the dynamic DE model have been obtained using CMB data to compute the distance to the last scattering surface. While the sigmoid DE model does not completely resolve the $H_0$ tension, it offers a transition mechanism that can still play a role alongside other potential solutions. Comment: 12 pages, 5 figures
Keywords	Astrophysics - Cosmology and Nongalactic Astrophysics ; General Relativity and Quantum Cosmology
Subject code	612
Publishing date	2023-11-09
Publishing country	us
Document type	Book ; Online
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Article ; Online: Neurodegenerative disease in association with sexual transmission of human T-cell lymphotropic virus type 2 subtype b in Argentina.

Blanco, Sebastián / Barile, María Eugenia / Frutos, María Celia / Vicente, Ana Carolina Paulo / Gallego, Sandra Verónica

Transactions of the Royal Society of Tropical Medicine and Hygiene

2021 Volume 116, Issue 7, Page(s) 622–627

Abstract: Background: The aim of this study is to show that human T-cell lymphotropic virus type 2 (HTLV-2) infection produces symptoms resembling those described for HTLV-1-associated myeloneuropathy and to highlight the role of sexual transmission in the silent ...

Abstract	Background: The aim of this study is to show that human T-cell lymphotropic virus type 2 (HTLV-2) infection produces symptoms resembling those described for HTLV-1-associated myeloneuropathy and to highlight the role of sexual transmission in the silent dissemination of HTLV-2. Methods: Patient samples were tested by particle agglutination and indirect immunofluorescence assay. The HTLV type was defined by molecular techniques. Nucleotide sequence analysis of HTLV-2 long terminal repeat region, T cell CD3/CD4 and T cell CD3/CD8 counts and typing of human leucocyte antigen (HLA) alleles A, B, C and DRB1 were also performed. Results: HTLV-2 subtype b infection was confirmed in two blood donors and their sexual partners. Two patients exhibited distinctive signs and symptoms of progressive neurological disease. Three infected patients carried HLA-C04. Both patients with neurological disease also carried HLA-A31 and HLA-DRB107 alleles. Conclusions:* Herein we describe for the first time sexual transmission of HTLV-2 in a non-endemic region of Argentina, highlighting the relevance of this transmission route in HTLV-2 silent dissemination out of the clusters of endemicity. We also provide evidence that HTLV-2 infection causes symptoms resembling those described for HTLV-1-associated myeloneuropathy. The evidence presented herein points to the critical need for public health strategies to reduce the spread of this neglected infection.
MeSH term(s)	Argentina/epidemiology ; Human T-lymphotropic virus 2/pathogenicity ; Humans ; Neurodegenerative Diseases/virology ; Sexually Transmitted Diseases, Viral
Language	English
Publishing date	2021-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/trab173
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Article ; Online: Seronegative human T-cell lymphotropic virus 1 carriers in blood banks: A potential viral source for silent transmission?

Frutos, María C / Blanco, Sebastián / Balangero, Marcos / Carrizo, Luis Horacio / Santos Rocha, Anderson / Figueiredo Barbosa-Stancioli, Edel / Nates, Silvia / Gallego, Sandra

Vox sanguinis

2022 Volume 117, Issue 9, Page(s) 1090–1097

Abstract: Background and objectives: Transfusion-transmitted viruses count among the greatest threats to blood safety. In Argentina, current laws oblige testing all donated blood for the presence of antibodies against human T-cell lymphotropic viruses 1 and 2 ( ... ...

Abstract	Background and objectives: Transfusion-transmitted viruses count among the greatest threats to blood safety. In Argentina, current laws oblige testing all donated blood for the presence of antibodies against human T-cell lymphotropic viruses 1 and 2 (HTLV-1/2). In endemic zones of the country, a high rate of seronegative HTLV-1 individuals with clear evidence of infection because of symptoms and/or presence of tax sequences of HTLV-1 and/or IgG anti-Tax antibodies has been recently described. Migration from endemic to nonendemic zones of Argentina is very frequent. Materials and methods: During a 1-year period, in the blood bank of Córdoba city, we performed molecular screening of all donors who were born in or arose from endemic zones for HTLV-1/2 in Argentina and neighbouring countries. Results: By screening 219 bp of HTLV-1/2 tax gene, 0.6% (2/317) of the blood donors proved to be positive for HTLV-1 tax sequence. One of the donors presented anti-Tax antibodies, demonstrating the transcriptional activity of the tax gene, and the other donor was also positive for LTR and pol gene sequences. The HTLV-1 genetic analysis of the LTR sequence determined that it belonged to the Cosmopolitan subtype HTLV-1aA. Conclusion: These findings suggest potential limitations of some currently approved screening assays for HTLV-1 detection applied in some donor populations and the possibility of an HTLV-1 seronegative carrier state with the potential for silent transmission by blood.
MeSH term(s)	Blood Banks ; HTLV-I Infections/epidemiology ; Human T-lymphotropic virus 1/genetics ; Human T-lymphotropic virus 2/genetics ; Humans ; T-Lymphocytes
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	80313-3
ISSN	1423-0410 ; 0042-9007
ISSN (online)	1423-0410
ISSN	0042-9007
DOI	10.1111/vox.13329
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Article ; Online: Fetal and neonatal alloimmune thrombocytopenia: a late or missed diagnosis disease in fetal and perinatal health-care settings.

Blanco, Sebastián / Vega, Laura C / Carrizo, Luis H / Culasso, Jorge M / Gallego, Sandra V

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2020 Volume 35, Issue 2, Page(s) 263–268

Abstract: Introduction: Even though Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) has been recognized as the main cause of primary hemorrhagic morbidity and mortality in fetuses and newborns, screening programs to detect pregnancies at risk have not yet ... ...

Abstract	Introduction: Even though Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) has been recognized as the main cause of primary hemorrhagic morbidity and mortality in fetuses and newborns, screening programs to detect pregnancies at risk have not yet been implemented in any country. Moreover, in spite of increased concerns about maternal, fetal and neonatal health care in general, this potentially lethal disease is still underdiagnosed. The aim of this report is to highlight the importance of considering FNAIT in fetal and perinatal health-care settings and show the usefulness of molecular tools in early diagnosis of this clinical entity. Methods: DNA was extracted from whole blood from parents and newborns; genotyping was performed by Results: Patients 1 and 2 had severe thrombocytopenia due to incompatibility in HPA-1 and HPA-15, respectively. The third case was a thrombocytopenic neonate with severe bleeding complications other than ICH and in whom differential diagnosis between FNAIT and Von Willebrand congenital disease was necessary; incompatibility in HPA-15 was also demonstrated. Case 4 represents a missed diagnostic opportunity. Conclusion: This is the first report of FNAIT cases confirmed by molecular evidence and anti-HPA antibodies detection in Argentina. This report reinforces the relevance of early diagnosis of this clinical entity. Since the delay in FNAIT diagnosis could lead to severe consequences in the fetus and neonates, strategies to approach maternal, fetal, and perinatal health, as well as prevention policies aimed to reduce fetal and neonatal morbidity and mortality should focus on implementing programs to identify high-risk pregnancies and thus reduce thrombocytopenia-related complications in fetuses and newborns.
MeSH term(s)	Antigens, Human Platelet ; Female ; Fetus ; Humans ; Infant, Newborn ; Missed Diagnosis ; Pregnancy ; Prenatal Care ; Thrombocytopenia, Neonatal Alloimmune/diagnosis
Chemical Substances	Antigens, Human Platelet
Language	English
Publishing date	2020-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2020.1716713
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Article ; Online: Establishment of the first platelet-donor registry in Argentina.

Blanco, Sebastián / Frutos, Maria C / Carrizo, Luis H / Nogués, Nuria / Gallego, Sandra V

Blood transfusion = Trasfusione del sangue

2020 Volume 18, Issue 4, Page(s) 254–260

Abstract: Background: Platelet transfusions are necessary to prevent and treat haemorrhages in thrombocytopenic patients or those with severe platelet dysfunction. In Latin American countries, including Argentina, blood supplies from voluntary non-remunerated ... ...

Abstract	Background: Platelet transfusions are necessary to prevent and treat haemorrhages in thrombocytopenic patients or those with severe platelet dysfunction. In Latin American countries, including Argentina, blood supplies from voluntary non-remunerated blood donors remain dependent on family replacement donors, since altruistic repeat donors are exceptional and platelet donors are very scarce. The aim of this study was to recruit a group of frequent, voluntary, altruistic blood donors and determine their human platelet antigen (HPA)-genotype in order to establish the first registry of HPA-typed voluntary platelet donors in Argentina. Material and methods: In this study, we invited and recruited voluntary blood donors who attended the Fundación Banco Central de Sangre between July 2016 and July 2017. DNA was extracted from K2EDTA anticoagulated whole blood and genotyping was performed by polymerase chain reaction, using sequence-specific primers to type the HPA-1 to -6, -9 and -15 systems. A subset of samples was also tested using a commercial HPA-TYPE kit. Donors were invited to join the National Register of Haematopoietic Stem Cell Donors of Argentina. Results: A cohort of 500 platelet donors was recruited and characterised and a database with their personal information, including their genotype for the most relevant HPA alloantigens, was created. Eight of the 500 donors (1.6%) were HPA-1a negative. HPA allelic variants -4b, -6b and -9b were detected for the first time in our population. There was 100% concordance between our in-house assay and the commercial kits in the subset of 150 donor samples assayed in parallel. Discussion: The efforts made to recruit, characterise and register voluntary platelet donors will provide the first sustainable source of HPA and human leukocyte antigen-typed platelets for compatible transfusions in the country. Remarkably, we identified a higher percentage of HPA-1a-negative donors than previously detected in the Argentinean population.
MeSH term(s)	Alleles ; Antigens, Human Platelet/genetics ; Argentina ; Blood Donors ; Blood Platelets ; Genotyping Techniques ; Humans ; Platelet Transfusion ; Registries
Chemical Substances	Antigens, Human Platelet
Language	English
Publishing date	2020-06-04
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2135732-8
ISSN	2385-2070 ; 0041-1787 ; 1723-2007
ISSN (online)	2385-2070
ISSN	0041-1787 ; 1723-2007
DOI	10.2450/2020.0018-20
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In stock of ZB MED Cologne/Königswinter

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More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito