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  1. Article ; Online: Carlos D. Garcia, Agustin G. Crevillén, Alberto Escarpa (Eds): Carbon-based nanomaterials in analytical chemistry.

    Blanco-López, Maria Carmen

    Analytical and bioanalytical chemistry

    2019  Volume 411, Issue 15, Page(s) 3219–3220

    Language English
    Publishing date 2019-04-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-019-01785-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 69/97: Show issues
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  2. Article: Stability of Non-Ionic Surfactant Vesicles Loaded with Rifamycin S.

    Marchianò, Verdiana / Matos, Maria / Marcet, Ismael / Cabal, Maria Paz / Gutiérrez, Gemma / Blanco-López, Maria Carmen

    Pharmaceutics

    2022  Volume 14, Issue 12

    Abstract: These days, the eradication of bacterial infections is more difficult due to the mechanism of resistance that bacteria have developed towards traditional antibiotics. One of the medical strategies used against bacteria is the therapy with drug delivery ... ...

    Abstract These days, the eradication of bacterial infections is more difficult due to the mechanism of resistance that bacteria have developed towards traditional antibiotics. One of the medical strategies used against bacteria is the therapy with drug delivery systems. Non-ionic vesicles are nanomaterials with good characteristics for encapsulating drugs, due to their bioavailability and biodegradability, which allow the drugs to reach the specific target and reduce their side effects. In this work, the antibiotic Rifamycin S was encapsulated. The rifamycin antibiotics family has been widely used against
    Language English
    Publishing date 2022-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14122626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rapid and sensitive detection of E. coli O157:H7 by lateral flow immunoassay and silver enhancement.

    Bazsefidpar, Shayesteh / Serrano-Pertierra, Esther / Gutiérrez, Gemma / Calvo, Alberto Sánchez / Matos, María / Blanco-López, María Carmen

    Mikrochimica acta

    2023  Volume 190, Issue 7, Page(s) 264

    Abstract: The aim of this study was to develop a sensitive lateral flow immunoassay (LFIA) for the rapid detection of Escherichia coli (E. coli) O157:H7, a pathogen contributor to diseases and fatalities worldwide. Au nanoparticles with high stability, uniform ... ...

    Abstract The aim of this study was to develop a sensitive lateral flow immunoassay (LFIA) for the rapid detection of Escherichia coli (E. coli) O157:H7, a pathogen contributor to diseases and fatalities worldwide. Au nanoparticles with high stability, uniform size, and shape were synthesized and coated with heterobifunctional PEG polymer with carboxyl groups, and they were bioconjugated to be used as label in sandwich-LFIA. Then, a silver enhancement strategy was developed as an accessible, rapid, and cost-effective approach for signal amplification to reduce the limit of detection (LOD). The optimal results were achieved when a solution of silver nitrate and hydroquinone/citrate buffer was added to the strips for 4 min. This led to a decrease in the visual LOD from 2 × 10
    MeSH term(s) Food Microbiology ; Escherichia coli O157 ; Gold ; Reproducibility of Results ; Metal Nanoparticles ; Immunoassay/methods
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2023-06-19
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-023-05834-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Extracellular Vesicles: From Biology to Biomedical Applications.

    Serrano-Pertierra, Esther / Blanco-López, Maria Carmen

    Bioengineering (Basel, Switzerland)

    2019  Volume 6, Issue 3

    Abstract: Legend says that Philippides ran to Athens to announce the victory against the Persians in the Battle of Marathon [ ... ]. ...

    Abstract Legend says that Philippides ran to Athens to announce the victory against the Persians in the Battle of Marathon [...].
    Language English
    Publishing date 2019-09-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering6030079
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  5. Article ; Online: Nanoparticles for bioanalysis.

    Blanco-López, María Carmen / Rivas, Montserrat

    Analytical and bioanalytical chemistry

    2019  Volume 411, Issue 9, Page(s) 1789–1790

    Language English
    Publishing date 2019-02-28
    Publishing country Germany
    Document type Editorial
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-019-01680-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Bio-based starch nanoparticles with controlled size as antimicrobial agents nanocarriers

    Morán, Diana / Marefati, Ali / Luque, Susana / Schmidt, Marcus / Rayner, Marilyn / Blanco-López, María Carmen / Gutiérrez, Gemma / Matos, María

    2024  

    Keywords article ; Text ; ddc:540
    Language English
    Publishing date 2024-03-18
    Publisher Elsevier BV
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Paper-Based Working Electrodes Coated with Mercury or Bismuth Films for Heavy Metals Determination.

    Sánchez-Calvo, Alberto / Blanco-López, Maria Carmen / Costa-García, Agustín

    Biosensors

    2020  Volume 10, Issue 5

    Abstract: Paper-based carbon working electrodes were modified with mercury or bismuth films for the determination of trace metals in aqueous solutions. Both modification procedures were optimized in terms of selectivity and sensitivity for the determination of ... ...

    Abstract Paper-based carbon working electrodes were modified with mercury or bismuth films for the determination of trace metals in aqueous solutions. Both modification procedures were optimized in terms of selectivity and sensitivity for the determination of different heavy metals, aiming their simultaneous determination. Cd (II), Pb (II) and In (III) could be quantified with both films. However, Cu (II) could not be determined with bismuth films. The modification with mercury films led to the most sensitive method, with linear ranges between 0.1 and 10 µg/mL and limits of detection of 0.4, 0.1, 0.04 and 0.2 µg/mL for Cd (II), Pb (II), In (III) and Cu (II), respectively. Nevertheless, the bismuth film was a more sustainable alternative to mercury. Tap-water samples were analyzed for the determination of metals by standard addition methodology with good accuracy, by using a low-cost and easily disposable paper-based electrochemical platform. This system demonstrated its usefulness for monitoring heavy metals in water.
    MeSH term(s) Bismuth/chemistry ; Carbon/chemistry ; Electrodes ; Mercury/chemistry ; Paper ; Solutions ; Trace Elements/analysis ; Water/chemistry
    Chemical Substances Solutions ; Trace Elements ; Water (059QF0KO0R) ; Carbon (7440-44-0) ; Mercury (FXS1BY2PGL) ; Bismuth (U015TT5I8H)
    Language English
    Publishing date 2020-05-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios10050052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lipid-Polymer Hybrids Encapsulating Iron-Oxide Nanoparticles as a Label for Lateral Flow Immunoassays.

    Bazsefidpar, Shayesteh / Moyano, Amanda / Gutiérrez, Gemma / Matos, María / Blanco-López, María Carmen

    Biosensors

    2021  Volume 11, Issue 7

    Abstract: The feasibility of using Superparamagnetic Iron Oxide Nanoparticles (SPIONs) encapsulated by lipid-polymer nanoparticles as labels in lateral flow immunoassays (LFIA) was studied. First, nanoparticles were synthesized with average diameters between 4 and ...

    Abstract The feasibility of using Superparamagnetic Iron Oxide Nanoparticles (SPIONs) encapsulated by lipid-polymer nanoparticles as labels in lateral flow immunoassays (LFIA) was studied. First, nanoparticles were synthesized with average diameters between 4 and 7 (nm) through precipitation in W/O microemulsion and further encapsulated using lipid-polymer nanoparticles. Systems formulated were characterized in terms of size and shape by DLS (Nanozetasizer from Malvern) and TEM. After encapsulation, the average size was around (≈20 and 50 nm). These controlled size agglomerates were tested as labels with a model system based on the biotin-neutravidin interaction. For this purpose, the encapsulated nanoparticles were conjugated to neutravidin using the carbodiimide chemistry, and the LFIA was carried out with a biotin test line. The encapsulated SPIONs showed that they could be promising candidates as labels in LFIA test. They would be useful for immunomagnetic separations, that could improve the limits of detection by means of preconcentration.
    MeSH term(s) Biosensing Techniques ; Immunoassay ; Lipids ; Magnetic Iron Oxide Nanoparticles ; Polymers/chemistry
    Chemical Substances Lipids ; Polymers
    Language English
    Publishing date 2021-07-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios11070218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Microemulsion Synthesis of Superparamagnetic Nanoparticles for Bioapplications.

    Salvador, María / Gutiérrez, Gemma / Noriega, Sara / Moyano, Amanda / Blanco-López, María Carmen / Matos, María

    International journal of molecular sciences

    2021  Volume 22, Issue 1

    Abstract: Superparamagnetic nanoparticles have seen increased potential in medical and environmental applications. Their preparation is traditionally made by the coprecipitation method, with limited control over the particle size distribution. Microemulsion ... ...

    Abstract Superparamagnetic nanoparticles have seen increased potential in medical and environmental applications. Their preparation is traditionally made by the coprecipitation method, with limited control over the particle size distribution. Microemulsion methods could be advantageous due to the efficient control of the size, shape, and composition of the nanoparticles obtained. Water-in-oil (W/O) microemulsions consist of aqueous microdomains dispersed in a continuous oil phase, stabilized by surfactant molecules. These work as nanoreactors where the synthesis of the desired nanoparticles takes place through a co-precipitation chemical reaction. In this work, superparamagnetic magnetite nanoparticles with average diameters between 5.4 and 7.2 nm and large monodispersity have been synthesized through precipitation in a W/O microemulsion, with Cetyl Trimethyl Ammonium Bromide (CTAB) as a main surfactant, 1-butanol as a cosurfactant, and with 1-hexanol as the continuous oily phase. The optimization of the corresponding washing protocol has also been established since a strict control is required when using these materials for bioapplications. Their applicability in those has been proved by their encapsulation in liposomes, being tested as signal enhancers for lateral flow immunoassays by using the affinity neutravidin-biotin model system. Due to their magnetic behaviour, they were also tested for magnetic separation. These novel materials have been found to be useful for analytical applications requiring high sensitivity and the removal of interferences.
    MeSH term(s) Cell Separation/methods ; Emulsions ; Humans ; Liposomes/chemistry ; Magnetic Iron Oxide Nanoparticles/administration & dosage ; Magnetic Iron Oxide Nanoparticles/chemistry ; Surface-Active Agents/chemistry
    Chemical Substances Emulsions ; Liposomes ; Surface-Active Agents
    Language English
    Publishing date 2021-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22010427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Micropipette Tip-Based Immunoassay with Electrochemical Detection of Antitissue Transglutaminase to Diagnose Celiac Disease Using Staples and a Paper-Based Platform.

    González-López, Andrea / Blanco-López, María Carmen / Fernández-Abedul, M Teresa

    ACS sensors

    2019  Volume 4, Issue 10, Page(s) 2679–2687

    Abstract: In this work, 1-200 μL polypropylene micropipette tips were used as platforms for performing immunoassays after converting their inner surfaces on a capture zone for the analyte of interest. We have used a micropipette-tip immunoelectroanalytical ... ...

    Abstract In this work, 1-200 μL polypropylene micropipette tips were used as platforms for performing immunoassays after converting their inner surfaces on a capture zone for the analyte of interest. We have used a micropipette-tip immunoelectroanalytical platform for the detection of antitissue transglutaminase (IgA), the main biomarker for celiac disease. Modification of the tip wall with poly-l-lysine allowed adsorption of tissue transglutaminase (tTG), which will capture later anti-tTG (IgA) antibodies developed in celiac-affected people. A sandwich-type format was followed, incubating simultaneously the analyte and the detection antibody, labeled with horseradish peroxidase. With this new application for an extremely common lab material, we can perform quantitative analysis by dispensing the liquid into a low-cost and miniaturized staple-based paper electrochemical platform. The analytical signal was the reduction of the enzymatically oxidized substrate, recorded chronoamperometrically (
    MeSH term(s) Celiac Disease/diagnosis ; Electrochemical Techniques ; GTP-Binding Proteins/analysis ; GTP-Binding Proteins/chemistry ; GTP-Binding Proteins/immunology ; Horseradish Peroxidase/chemistry ; Humans ; Immunoassay ; Immunoglobulin A/immunology ; Paper ; Polylysine/chemistry ; Transglutaminases/analysis ; Transglutaminases/chemistry ; Transglutaminases/immunology
    Chemical Substances Immunoglobulin A ; Polylysine (25104-18-1) ; Horseradish Peroxidase (EC 1.11.1.-) ; transglutaminase 2 (EC 2.3.2.-) ; Transglutaminases (EC 2.3.2.13) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2019-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.9b01096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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