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  1. Article ; Online: Participant Experience with Protocol Research Kidney Biopsies in the Kidney Precision Medicine Project.

    Victoria-Castro, Angela M / Corona-Villalobos, Celia P / Xu, Alan Y / Onul, Ingrid / Huynh, Courtney / Chen, Sarah W / Ugwuowo, Ugochukwu / Sarkisova, Natalya / Dighe, Ashveena L / Blank, Kristina N / Blanc, Victoria M / Rose, Michael P / Himmelfarb, Jonathan / de Boer, Ian H / Tuttle, Katherine R / Roberts, Glenda V

    Clinical journal of the American Society of Nephrology : CJASN

    2023  

    Abstract: Background: Kidney biopsies are procedures commonly performed in clinical nephrology and are increasingly used in research. In this study we aimed to evaluate the experiences of participants who underwent research kidney biopsies in the Kidney Precision ...

    Abstract Background: Kidney biopsies are procedures commonly performed in clinical nephrology and are increasingly used in research. In this study we aimed to evaluate the experiences of participants who underwent research kidney biopsies in the Kidney Precision Medicine Project (KPMP).
    Methods: KPMP research participants with acute kidney injury (AKI) or chronic kidney disease (CKD) were enrolled at nine recruitment sites in the United States between September 2019 to January 2023. At 28 days post-biopsy, participants were invited to complete a survey to share their experiences, including: motivation to participate in research; comprehension of informed consent; pain and anxiety during and after the biopsy procedure; overall satisfaction with KPMP participation; and impact of the study on their lives. The survey was developed in collaboration with the KPMP Community Engagement Committee and the Institute of Translational Health Sciences at the University of Washington.
    Results: 111 participants completed the survey, 23 enrolled for AKI and 88 for CKD. Median age was 61 (IQR 48-67) years, 43% were women, 28% were Black, and 18% were of Hispanic ethnicity. Survey respondents most commonly joined KPMP to help future patients (59%). The consent form was understood by 99% and 97% recognized their important role in the study. Pain during the biopsy was reported by 50%, at a median level of 1 (IQR 0-3) on a 0-10 scale. Anxiety during the biopsy was described by 64% at a median level of 3 (IQR 1-5) on a 0-10 scale. More than half conveyed that KPMP participation impacted their diet, physical activity, and how they think about kidney disease.
    Conclusions: KPMP survey respondents were most commonly motivated to participate in research protocol kidney biopsies by altruism, with excellent understanding of the informed consent process.
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Risk Factors for Heat-Related Illness in Washington Crop Workers.

    Spector, June T / Krenz, Jennifer / Blank, Kristina N

    Journal of agromedicine

    2015  Volume 20, Issue 3, Page(s) 349–359

    Abstract: Crop workers are at high risk of heat-related illness (HRI) from internal heat generated by heavy physical work, particularly when laboring in hot and humid conditions. The aim of this study was to identify risk factors for HRI symptoms in Washington ... ...

    Abstract Crop workers are at high risk of heat-related illness (HRI) from internal heat generated by heavy physical work, particularly when laboring in hot and humid conditions. The aim of this study was to identify risk factors for HRI symptoms in Washington crop workers using an audio computer-assisted self-interview (A-CASI) instrument that has undergone reliability and validity evaluation. A cross-sectional A-CASI survey of 97 crop workers in Washington State was conducted during the summer of 2013. Potential HRI risk factors in demographic, training, work, hydration, clothing, health, and environmental domains were selected a priori for evaluation. Mixed-effects logistic regression was used to identify risk factors for self-reported symptoms associated with heat strain and HRI (dizziness/light-headedness or heavy sweating) experienced at work in hot conditions. An increase in age was associated with a lower odds of HRI symptoms (odds ratio [OR] = 0.92; 95% confidence interval [CI] = 0.87-0.98). Piece rate compared with hourly payment (OR = 6.20; 95% CI = 1.11-34.54) and needing to walk for more than 3 minutes to get to the toilet, compared with less than 3 minutes (OR = 4.86; 95% CI = 1.18-20.06), were associated with a higher odds of HRI symptoms. In this descriptive study of risk factors for HRI symptoms in Washington crop workers, decreased age (and less work experience), piece rate pay, and longer distance to the toilet were associated with self-reported HRI symptoms. Modifiable workplace factors should be considered in HRI prevention efforts that are evaluated using objective measures in representative working populations.
    MeSH term(s) Adult ; Agricultural Workers' Diseases/etiology ; Crops, Agricultural ; Cross-Sectional Studies ; Farmers ; Female ; Health Surveys ; Heat Stress Disorders/etiology ; Hispanic Americans ; Humans ; Logistic Models ; Male ; Middle Aged ; Risk Factors ; Self Report ; Washington ; Workplace
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1289325-0
    ISSN 1545-0813 ; 1059-924X
    ISSN (online) 1545-0813
    ISSN 1059-924X
    DOI 10.1080/1059924X.2015.1047107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Risk Factors for Heat-Related Illness in Washington Crop Workers

    Spector, June T / Krenz, Jennifer / Blank, Kristina N

    Journal of agromedicine. 2015 July 3, v. 20, no. 3

    2015  

    Abstract: Crop workers are at high risk of heat-related illness (HRI) from internal heat generated by heavy physical work, particularly when laboring in hot and humid conditions. The aim of this study was to identify risk factors for HRI symptoms in Washington ... ...

    Abstract Crop workers are at high risk of heat-related illness (HRI) from internal heat generated by heavy physical work, particularly when laboring in hot and humid conditions. The aim of this study was to identify risk factors for HRI symptoms in Washington crop workers using an audio computer-assisted self-interview (A-CASI) instrument that has undergone reliability and validity evaluation. A cross-sectional A-CASI survey of 97 crop workers in Washington State was conducted during the summer of 2013. Potential HRI risk factors in demographic, training, work, hydration, clothing, health, and environmental domains were selected a priori for evaluation. Mixed-effects logistic regression was used to identify risk factors for self-reported symptoms associated with heat strain and HRI (dizziness/light-headedness or heavy sweating) experienced at work in hot conditions. An increase in age was associated with a lower odds of HRI symptoms (odds ratio [OR] = 0.92; 95% confidence interval [CI] = 0.87–0.98). Piece rate compared with hourly payment (OR = 6.20; 95% CI = 1.11–34.54) and needing to walk for more than 3 minutes to get to the toilet, compared with less than 3 minutes (OR = 4.86; 95% CI = 1.18–20.06), were associated with a higher odds of HRI symptoms. In this descriptive study of risk factors for HRI symptoms in Washington crop workers, decreased age (and less work experience), piece rate pay, and longer distance to the toilet were associated with self-reported HRI symptoms. Modifiable workplace factors should be considered in HRI prevention efforts that are evaluated using objective measures in representative working populations.
    Keywords confidence interval ; descriptive studies ; farm labor ; heat ; odds ratio ; regression analysis ; risk factors ; summer ; surveys ; sweating ; working conditions ; Washington
    Language English
    Dates of publication 2015-0703
    Size p. 349-359.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1289325-0
    ISSN 1545-0813 ; 1059-924X
    ISSN (online) 1545-0813
    ISSN 1059-924X
    DOI 10.1080/1059924X.2015.1047107
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications.

    Poggio, Emilio D / McClelland, Robyn L / Blank, Kristina N / Hansen, Spencer / Bansal, Shweta / Bomback, Andrew S / Canetta, Pietro A / Khairallah, Pascale / Kiryluk, Krzysztof / Lecker, Stewart H / McMahon, Gearoid M / Palevsky, Paul M / Parikh, Samir / Rosas, Sylvia E / Tuttle, Katherine / Vazquez, Miguel A / Vijayan, Anitha / Rovin, Brad H

    Clinical journal of the American Society of Nephrology : CJASN

    2020  Volume 15, Issue 11, Page(s) 1595–1602

    Abstract: Background and objectives: Native kidney biopsies are commonly performed in the diagnosis of acute kidney diseases and CKD. Because of the invasive nature of the procedure, bleeding-related complications are not uncommon. The National Institutes of ... ...

    Abstract Background and objectives: Native kidney biopsies are commonly performed in the diagnosis of acute kidney diseases and CKD. Because of the invasive nature of the procedure, bleeding-related complications are not uncommon. The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases-sponsored Kidney Precision Medicine Project requires that all participants undergo a kidney biopsy; therefore, the objective of this analysis was to study complication rates of native kidney biopsies performed using automated devices under kidney imaging.
    Design, setting, participants, & measurements: This is a systematic review and meta-analysis of the literature published from January 1983 to March 2018. The initial PubMed search yielded 1139 manuscripts. Using predetermined selection criteria, 87 manuscripts were included in the final analysis. A random effects meta-analysis for proportions was used to obtain combined estimates of complication rates. Freeman-Tukey double-arcsine transformations were used to stabilize variance as complications were rare.
    Results: A total of 118,064 biopsies were included in this study. Patient age ranged from 30 to 79 years, and 45% of patients were women. On the basis of our meta-analysis, pain at the site of biopsy is estimated to occur in 4.3% of biopsied patients, hematomas are estimated to occur in 11%, macroscopic hematuria is estimated to occur in 3.5%, bleeding requiring blood transfusions is estimated to occur in 1.6%, and interventions to stop bleeding are estimated to occur in only 0.3%. Death attributed to native kidney biopsy was a rare event, occurring only in an estimated 0.06% of all biopsies but only 0.03% of outpatient biopsies. Complication rates were higher in hospitalized patients and in those with acute kidney disease. The reported complications varied on the basis of study type and geographic location.
    Conclusions: Although the native kidney biopsy is an invasive diagnostic procedure, the rates of bleeding complications are low. Albeit rare, death can occur postbiopsy. Complications are more frequently seen after kidney biopsies of hospitalized patients with AKI.
    MeSH term(s) Blood Transfusion/statistics & numerical data ; Hematoma/etiology ; Hematuria/etiology ; Hemostasis, Surgical/statistics & numerical data ; Hospitalization ; Humans ; Image-Guided Biopsy/adverse effects ; Image-Guided Biopsy/mortality ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/pathology ; Pain/etiology ; Risk Factors
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Systematic Review
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.04710420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6584: Show issues Location:
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  5. Article ; Online: Rationale and design of the Kidney Precision Medicine Project.

    de Boer, Ian H / Alpers, Charles E / Azeloglu, Evren U / Balis, Ulysses G J / Barasch, Jonathan M / Barisoni, Laura / Blank, Kristina N / Bomback, Andrew S / Brown, Keith / Dagher, Pierre C / Dighe, Ashveena L / Eadon, Michael T / El-Achkar, Tarek M / Gaut, Joseph P / Hacohen, Nir / He, Yongqun / Hodgin, Jeffrey B / Jain, Sanjay / Kellum, John A /
    Kiryluk, Krzysztof / Knight, Richard / Laszik, Zoltan G / Lienczewski, Chrysta / Mariani, Laura H / McClelland, Robyn L / Menez, Steven / Moledina, Dennis G / Mooney, Sean D / O'Toole, John F / Palevsky, Paul M / Parikh, Chirag R / Poggio, Emilio D / Rosas, Sylvia E / Rosengart, Matthew R / Sarwal, Minnie M / Schaub, Jennifer A / Sedor, John R / Sharma, Kumar / Steck, Becky / Toto, Robert D / Troyanskaya, Olga G / Tuttle, Katherine R / Vazquez, Miguel A / Waikar, Sushrut S / Williams, Kayleen / Wilson, Francis Perry / Zhang, Kun / Iyengar, Ravi / Kretzler, Matthias / Himmelfarb, Jonathan

    Kidney international

    2021  Volume 99, Issue 3, Page(s) 498–510

    Abstract: Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The ... ...

    Abstract Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/therapy ; Adult ; Humans ; Kidney ; Precision Medicine ; Prospective Studies ; Proteomics ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Editorial ; Multicenter Study ; Research Support, N.I.H., Extramural
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.08.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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